Marika Turek

• PhD in chemistry
• PhD at Jan Dlugosz University

http://www.archiwalna.ujd.edu.pl/shop/view/obliczenia-z-chemii-ogolnej-dla-kierunkow-chemicznych-medycznych-i-technicznych Z końcem 2024 roku nakładem Wydawnictwa UJD ukazał się podręcznik pt. „Obliczenia z chemii ogólnej dla kierunków chemicznych, medycznych i technicznych”, opracowany przez pracowników naszego Wydziału: dra Przemysława Siemiona...

This review focuses on optical properties of compounds in which at least one phosphonate group is directly attached to a heteroaromatic ring. Additionally, the synthesis and other applications of these compounds are addressed in this work. The influence of the phosphonate substituent on the properties of the described compounds is discussed and com...

The reaction of (ortho-acetalaryl)arylmethanols with various phosphines PR¹R²R³ (R¹ = R² = R³ = Ph; R¹ = R² = Ph, R³ = Me and R¹ = R² = Me, R³ = Ph) under acidic conditions (e.g., HCl, HBF4, TsOH) unexpectedly led to the formation of (10-hydroxy-9,10-dihydroanthr-9-yl)phosphonium salts instead of the corresponding anthryl phosphonium salts. The cyc...

The ecotoxicological impact of pharmaceuticals has received considerable attention, primarily focusing on active pharmaceutical ingredients (APIs) while largely neglecting the potential hazards posed by pharmaceutical excipients. Therefore, we analyzed the ecotoxicity of 16 commonly used pharmaceutical excipients, as well as 26 API–excipient and ex...

This annual review of the literature provides a comprehensive and critical survey of a vast field of study involving organophosphorus compounds, ranging from phosphines, their chalcogenide derivatives and phosphonium salts, phosphorus (III) acid derivatives, phosphorus (V) acids, penta- and hexa-coordinated phosphorus compounds, phosphazenes and re...

Most of commercial chiral herbicides is used as racemic mixtures, whereas the use of their optically active forms may be more effective and environmentally safer. For this reason, it is important to evaluate the ecotoxicity of each enantiomer separately because the seemingly inactive enantiomer may unintentionally be toxic to non-target organisms....

Physicochemical properties, in particular solubility and the associated bioavailability, are key factors in determining efficacy of poorly water-soluble drugs, which constitute 40% of new drugs in the market, and improving them is an important challenge for modern pharmacy. A recent strategy to achieve this goal is formation of stable co-amorphous...

Increasing consumption of angiotensin II receptor blockers (ARBs: valsartan, losartan potassium, telmisartan) is inevitably associated with their appearance in the environment and impact on aquatic and terrestrial organisms. Since the pharmaceuticals do not occur as pure substances in the environment, but as complex mixtures with other active pharm...

Phenoxyacetate herbicides, such as 2,4-D and MCPA, having a high toxicity to non-target organisms are commonly used for controlling broadleaf weeds in agriculture. However, novel and environmentally friendly analogs are constantly sought after. For this purpose, various substituents at the phenyl group have been tested to find the optimal balance b...

Wieloskładnikowe formy stałe leków cieszą się coraz większym zainteresowaniem ze strony przemysłu farma-ceutycznego. Główną ich zaletą jest zdolność do zwiększenia biodostępności leku poprzez poprawę jego właściwości fizyko-chemicznych, w szczególności rozpuszczalności. Poprawienie rozpuszczalności oraz biodostępności, które są kluczowymi czyn-nika...

2,2'-Thiodiacetic acid derivatives have a wide application potential, mainly in coordination chemistry. This research indicates that quaternary ammonium 2,2'-thiodiacetate salts may also be potent herbicidal agents used in agriculture. To provide a rationale for this statement, the toxic effect by a alkyl and aryl quaternary ammonium salts (QASs) o...

2,2'-Thiodiacetates with their excellent complexing properties may be used as metal extraction agents, fluorescent and superparamagnetic materials, antibacterial and anticancer medical agents, however there are no data concerning the environmental impact of 2,2'-thiodiacetates derivatives and data definying the potential hazard connected with their...

This study shows the design, synthesis and evaluation of eco(phyto)toxic and herbicidal activities of quaternary ammonium salts (QASs), derived from haloacetic acids, in context of the search for safer alternatives to the commonly used herbicide, N-(phosphonomethyl)glycine (glyphosate). The structure of the investigated QASs refers to the heteroato...

This comprehensive review describes methods for the preparation of 1-indanones published in original and patent literature from 1926 to 2017. More than 100 synthetic methods utilizing carboxylic acids, esters, diesters, acid chlorides, ketones, alkynes, alcohols etc. as starting materials, have been performed. This review also covers the most impor...

Background: Cancer is one of the most serious illnesses of our civilization. Therefore, scientists of different disciplines try to find new treatment strategies and new chemical molecules which might be useful in a cancer treatment. Objective: The goal of this work is to perform the most significant achievements in the area of chemotherapeutic t...