Marija Gencic

Marija Gencic
University of Niš | NIS · Department of Chemistry (PMF)

PhD

About

42
Publications
9,654
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348
Citations
Additional affiliations
April 2014 - present
University of Niš
Position
  • Research Assistant

Publications

Publications (42)
Article
Immortelle (Helichrysum italicum, Asteraceae) essential oil has been widely used in alternative medicine to accelerate wound healing, as well as in cosmetic products to stimulate skin regeneration and to reduce the appearance of wrinkles. It is also considered a natural and safe culinary spice that could also be applied in the food industry as a pr...
Article
Herein n ‐, iso ‐ and anteiso ‐series of very‐long‐chained (VLC) alkanes (C 21 ‒C 35 ), fatty acid benzyl esters (FABEs; C 20 ‒C 32 ), and 2‐alkanones (C 23 ‒C 35 ) were identified in the wax of Primula veris L. and P. acaulis (L.) L. (Primulaceae). For the very first time in a sample of natural origin, the presence of iso ‐ and anteiso ‐VLC FABEs...
Article
Full-text available
Esters of angelic, senecioic and tiglic acids with various saturated/ unsaturated/aromatic alcohols contribute to the aroma of many essential oils. However, mass spectrometry with electron-impact ionization sometimes fails to distinguish these regio-/geometric isomers and this was the case with the minor constituent of Helichrysum italicum (immorte...
Article
Motivated by the ethnopharmacological application of Inula helenium, in the present study, the anticandidal potential of hydrodistilled root I. helenium essential oil was investigated by a microdilution method and the obtained minimal inhibitory concentrations (MICs) were further used to explore its synergistic potential. Additionally, the mode of...
Article
The effects of basil (Ocimum basilicum) and sage (Salvia officinalis) essential oils on selected virulence factors (biofilm formation, mature biofilm resistance, motility, and pyocyanin production) of Pseudomonas aeruginosa clinical isolates were evaluated in the present study for the first time. The two essential oils were chemically characterized...
Article
Full-text available
Great progress in the fight against malaria has been made in the last decade. Nevertheless, the development of resistance to almost all commonly used antimalarial drugs poses a major threat to the sustainability of this progress and highlights the need for the discovery of novel potent and inexpensive antimalarials to stay one step ahead. After the...
Conference Paper
Full-text available
The essential oil of immortelle, Helichrysum italicum (Asteraceae), has a long application for wound healing. Nowadays, it is one of the most popular essential oils in cosmetics as it may stimulate blood circulation and regeneration of the skin, and reduce the appearance of fine lines and wrinkles. However, several chemotypes of H. italicum, charac...
Article
Objective: The effects of AMA and maternal dietary habits during pregnancy and lactation on breast milk composition have not been investigated in south-eastern Europe and in the Balkans. This study was designed to compare the content of retinol and β-carotene in colostrum and mature milk samples obtained from different MA groups and to assess its...
Article
Full-text available
Streptomyces sp. NP10 was previously shown to synthesize large amounts of free fatty acids (FFAs). In this work, we report the first insights into the biosynthesis of these fatty acids (FAs) gained after genome sequencing and identification of the genes involved. Analysis of the Streptomyces sp. NP10 draft genome revealed that it is closely related...
Article
Two novel β-diketones, 2,6,9-trimethyl-8-decene-3,5-dione (A) and 3,7,10-trimethyl-9-undecene-4,6-dione (B), were identified from the renowned medicinal plant Hypericum perforatum L. The structures of β-diketones A and B were corroborated by syntheses (4 steps starting from methyl acetoacetate, overall yields 30% and 23%, respectively). In solution...
Article
Neurotoxic thujones (α- and β-diastereoisomers) are common constituents of plant essential oils. In this study, we employed a statistical approach to determine the contribution of thujones to the overall observed behaviour-modulating and toxic effects of essential oils (Salvia officinalis L., Artemisia absinthium L., Thuja occidentalis L. and Tanac...
Conference Paper
Full-text available
The usage of St. John's worth, Hypericum perforatum L. (HP), Hypericaceae, more specifically of the non-volatile constituents of the plant, in the treatment of a variety of health disorders, is well known. The aim of this study was to evaluate the effect of the essential oil of HP on the behaviour of mice in several standard anxiety models. The ess...
Article
Herein, the results of the first study of the volatile and alkane profiles of Cephalaria ambrosioides Roem. & Schult. (Caprifoliaceae, subfamily Dipsacaceae) were reported. The GC-FID and GC/MS analyses of the essential oils hydrodistilled from leaves and stems (CA1) and flowers (CA2) of C. ambrosioides allowed the identification of 284 different c...
Conference Paper
Full-text available
For decades thujone diastereoisomers have been regarded as key toxic ingredients of many essential oils, mainly on the basis of past notoriety initiated by the disputed phenomenon of "absinthism" 1. Neurotoxicity of thujones was demonstrated in several animal models with convulsions as the most prominent symptom 2. In this work, we evaluated the ef...
Conference Paper
Full-text available
The usage of St. John's worth, Hypericum perforatum L., Hypericaceae, (abbreviated as HP), more specifically of the non-volatile constituents of the plant, in the treatment of a variety of health disorders, is well known, while its predominant usage for the management of depression is best documented. The aim of this study was to evaluate the effec...
Article
Full-text available
The use of lanthanide complexes for resolving intricate NMR signals and, in the case of chiral ligands, for determining enantiomeric excess has progressively decreased in the last 30 years. Recently, a sesquiterpene aldehyde from Inula helenium with a possible potent antistaphylococcal activity remained unidentified due to the impossibility to sepa...
Article
Background In Serbia, delicatessen fruit alcoholic drinks are produced from autochthonous fruit-bearing species such as: cornelian cherry, blackberry, elderberry, wild strawberry, European wild apple, European blueberry and blackthorn fruits. There are no chemical data on many of these and herein we analyzed volatile minor constituents of these rar...
Article
Full-text available
Herein, a novel soil bacterium Streptomyces sp. NP10 able to grow outside usual streptomycetes optimum conditions (e.g., at Q1 4 °C, pH 9 and high NaCl concentration), exhibiting atypical hemolytic, DNAse, and cellulolytic activities, is described. This strain produces and excretes into the growth medium large amounts of free long-chain fatty acids...
Article
Full-text available
A predominantly odd-numbered, Gaussian-like distribution of the relative amounts of 3-methyl-2-alkanones, from I. helenium root essential oil, was observed. This distribution pattern indicates that their biosynthesis is related to that of fatty acids and related compounds. Simple (non-branched) 2-alkanones also show an odd carbon number prevalence...
Article
Recently, a potent anti-staphylococcal activity of Inula helenium L. (Asteraceae) root essential oil was reported. Also, bioassay guided fractionation of the oil pointed to eudesmane sesquiterpene lactones and a series of unidentified constituents as the main carriers of the observed activity. To identify nine new constituents (long-chain 3-methyl-...
Article
Two variants of a new pathway for the synthesis of (AE)-curcumene ether are described. The key steps in these procedures are intramolecular cyclizations of 6-methyl-2-(4-methylphenyl)hept-6-en-2-ol and 2-methyl-6-(4-methylphenyl)hept-6-en-2-ol by means of an electrochemically generated phenylselenyl cation. This synthetic approach provides signific...
Article
Herein, we report, for the first time, the results of detailed chemical and statistical analyses of the essential oils from the roots of two Echinops species (Asteraceae), E. bannaticus Rochel ex Schrad., and E. sphaerocephalus L., from the weed flora of Serbia. Among 106 and 81 constituents, respectively, S-containing polyacetylene compounds and t...
Article
A reversed-phased HPLC method with fluorescence detection was optimized and validated for determination of DOXY in human saliva and gingival crevicular fluid (GCF) with tetracycline as internal standard. Single step extraction with acetonitrile for both types of samples was performed. The separation was achieved at Zorbax Extend-C18 analytical colu...
Article
Full-text available
The first synthesis of coniine, a neurotoxic piperidine alkaloid found in poison hemlock (Conium maculatum L.), was performed back in 1886 by Ladenburg. Since that time, numerous different approaches to the synthesis of this and related alkaloids (2-alkylpiperidines) have been developed. Nowadays, the enantioselective/specific synthesis of coniine...
Article
Full-text available
The first synthesis of coniine, a neurotoxic piperidine alkaloid found in poison hemlock (Conium maculatum L.), was performed back in 1886 by Ladenburg. Since that time, numerous different approaches to the synthesis of this and related alkaloids (2-alkylpiperidines) have been developed. Nowadays, the enantioselective/specific synthesis of coniine...
Article
Full-text available
The detailed analyses of the volatile essential oil and lipid profiles of the aerial parts from the blooming and fruit-forming stages of both ripe and unripe fruit of Lycopus europaeus (Lamiaceae) are presented. Both of these profiles are distinguished by components with a restricted occurrence in the Plant Kingdom. These rare compounds include (E)...
Article
2-Pentylpiperidine, named conmaculatin, a novel volatile alkaloid related to coniine was identified from the renowned toxic weed Conium maculatum L. (Apiaceae). The structure of conmaculatin was corroborated by synthesis (8 steps starting from cyclohexanol, overall yield 12%). Conmaculatin's strong peripheral and central antinociceptive activity in...
Article
Full-text available
The purpose of this study was to investigate the inhibitory/bactericidal activity and cell membrane effects of the hydrodistilled essential oil of Inula helenium L. roots against Staphylococcus aureus. Additionally, detailed chemical investigation was done in order to pinpoint the most active oil constituents and also the parts of these molecules r...
Article
A new acetylated highly oxygenated abietane-type diterpenoid named euroabienol was isolated in pure state from Lycopus europaeus L. (Lamiaceae) fruits and its structure elucidated through both extensive spectral and chemical means. The presence of a phenolic C ring with a rare substitution pattern in euroabienol and its high relative amount in the...
Article
A new acetylated highly oxygenated abietane-type diterpenoid named euroabienol was isolated in pure state from Lycopus europaeus L. (Lamiaceae) fruits and its structure elucidated through both extensive spectral and chemical means. The presence of a phenolic C ring with a rare substitution pattern in euroabienol and its high relative amount in the...
Article
Full-text available
In families of benzenoid isomers, the species with the greatest and smallest value of the Kekulé structure count (K) possess, respectively, the greatest and smallest thermodynamic stability and, respectively, the smallest and greates reactivity. In this paper the structure of the isomers with extremal K-values for the benzenoid molecules A = A(a,b,...

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Project (1)
Project
The project encompasses natural products chemistry, both the analysis and synthesis (with an emphasis on the synthesis part), the development of heterogeneous catalysts for various reactions and biological activity testing. We aim to create a large set of compounds possibly biologically active that would be obtained either by classical chemistry or by synthesis over appropriate catalysts.