Mariia Zharova

Mariia Zharova
Pirogov Russian National Research Medical University | RNRMU · Faculty of Therapy

Master of Science

About

19
Publications
1,296
Reads
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21
Citations
Citations since 2016
18 Research Items
21 Citations
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20162017201820192020202120220123456

Publications

Publications (19)
Poster
Full-text available
Introduction: Antibodies to soluble liver antigen were discovered in 1987. Despite that fact, their wide use is limited due to hard to use diagnostic assays such as immunoassays – ELISA and Western blotting. These assays are the tests of choice to detect SLA/LP antibodies in patients with autoimmune hepatitis. About 30% of patients with AIH have S...
Poster
Full-text available
Background and Aims: Treatment of chemotherapy-induced hepatotoxicity (CIH) is a pressing challenge for oncology and gastroenterology. To study the efficacy of several hepatoprotectors in CIH. Method: 144 patients with a tumor of one of the three localizations (breast cancer, colorectal cancer, and prostate cancer) received 912 courses of chemoth...
Poster
Full-text available
Background and Aims: Approximately 1.3 million people die from liver cancer worldwide every year. Liver cancer is typically diagnosed late in its course, and the median survival following diagnosis is about 6 to 20 months. Hence early diagnosis and treatment are crucial. We analyze the medical histories of patients with liver cancer of FSBI from...
Article
Full-text available
This publication is the first article in a series about the basics of evidence-based medicine, which is regularly published in this journal. We hope to provide a useful tool to implement an evidence-based approach in our colleagues’ daily practice. We begin the series with the history of evidence-based medicine development and clarifying basic term...
Article
Full-text available
Objective of the Review: To discuss changes in intestinal microbiota in various diseases. Key Points. Microbial intestinal imbalance plays an important role in pathogenesis and/or progression of a number of diseases, namely of Clostridium difficile-associated disorders, intestinal inflammations, obesity, colorectal cancer, autistic disorders and ot...
Article
Analysis of the results showed that out of 6033 participants, 2745 used hydroxychloroquine (HCQ) as COVID-19 prophylaxis. The incidence of COVID-19 was 7.87%. There was no difference in COVID-19 incidence in control and the main groups. 64.4% of participants had a mild form of COVID-19, 1.7% - severe form. Severe side effects have not been reported...
Article
Full-text available
Background. The fi rst clinical case of autoimmune hepatitis (AIH) was described in 1951, and in the 1970s, several randomized clinical trials proved the eff ectiveness of glucocorticosteroids in the treatment of AIH. Nonetheless, this disease remains a mystery to clinicians due to its rarity and heterogeneity. Aim. To describe the clinical case of...
Article
The new coronavirus (SARS-CoV-2) poses a serious threat to public health worldwide. From the moment of its finding to the present, the incidence of new cases is only increasing. So far, no drugs were proven to have antiviral activity in clinical practice. Many drugs have already gone a path from in vitro studies to randomized clinical trials in viv...
Poster
Full-text available
Background. The observational prospective study initiated by the European Registry on the management of Helicobacter pylori infection (Hp-EuReg) showed that the effectiveness of eradication therapy in Russia is suboptimal. The effectiveness of the classic triple therapy for 14-day was 86.7%, and for 7-day - 67.6%. This study was performed in an adu...
Article
Full-text available
Objective of the Review: To analyze data in the international literature on immunobiological medications for inflammatory bowel disease (IBD) and the treatment of IBD in pediatric patients. Key Points: The global prevalence of IBD is about 0.3%, which causes significant economic losses, both direct and indirect. Since the 1990s, the therapeutic par...
Article
Full-text available
Objective of the Review: To describe worldwide experience in colorectal cancer (CRC) prevention and analyze the data from a survey of physicians who participated in the QuaCol program in Russia in 2016 and 2017. Key Points: The implementation of CRC national screening programs in more than 20 countries of the European Union has resulted in a reduct...
Conference Paper
Full-text available
O1: Assessing the protective effect of dexrazoxane against doxorubicin-induced toxicity in HL-1 cardiomyocytes Yvonne Sweeney, Hugh O’Neill, Garry Duffy O2: Role of KCNQ1 in epithelial barrier repair Daniel Creegan, Viviana Bustos, Brian J. Harvey O3: The suitability of non-small cell lung cancer cytology preparations for the analysis of anaplastic...
Article
Full-text available
Background: Cell free circulating DNA (cfDNA) in blood is known to be a tumor marker however there is no information about its concentration in cerebrospinal fluid (CSF) in control and in emotional stress (ES). The aim of the study was to determine level of cfDNA in CSF of rats with different resistance to stress before and after ES. Methods: A tot...
Article
Full-text available
To study demyelination and remyelination processes and their response to different drugs, a protocol for modeling multiple sclerosis using the copper chelator cuprizone was developed. Magnetic resonance imaging confirmed the presence of demyelination lesions on week 4 of 0.6% cuprizone-containing diet. Immunohistochemical staining with polyclonal a...

Questions

Question (1)
Question
I wonder if someone could explain to me how to interpret GA-MAP dysbiosis test. I know that the analysis based on the 16s rRNA sequencing but could not figure out what practical information it can give for a clinician.

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