Marienke van Middelkoop

Erasmus MC | Erasmus MC · Department of General Practice

Objective To identify and quantify potential risk factors for osteoarthritis (OA) following traumatic knee injury.Design Systematic review and meta-analyses that estimated the odds of OA for individual risk factors assessed in more than four studies using random-effects models. Remaining risk factors underwent semiquantitative synthesis. The modifi...

Objective To study potential surrogate outcomes for OA incidence by evaluating the association of short-term changes in clinical and imaging biomarkers with long-term clinical knee OA incidence. Design Middle-aged w omen with overweight/obesity, but free of knee symptoms were recruited through their general practitioners. At baseline, after 2.5 ye...

Objective: To examine the association between 3D patellar shape and 1) isolated MRI-based patellofemoral osteoarthritis (PFOA), 2) the morphological features of PFOA, and 3) the clinical symptoms of PFOA. Design: Magnetic resonance imaging (MRI) data from 66 women with isolated MRI-based PFOA and 66 age- and BMI-matched healthy women were select...

Objective: To identify the incidence and characteristics associated with a higher injury risk in recreational runners who suffered a running-related injury (RRI) in the previous 12 months. Design: Prospective cohort study among recreational runners who registered for a Dutch running event (5-42.2 km) and suffered an RRI in the 12 months before i...

Purpose: To systematically review all studies that evaluated the association between physical activity (PA) levels and knee osteoarthritis (OA) features on MRI in non-OA subjects. Methods: Inclusion criteria for prospective studies: 1. Non-OA subjects. 2. Average age: 35-80 years. 2. Any self-reported / objective PA. 3. Eligible MRI outcomes: OA...

Overgewicht op jonge leeftijd is een risicofactor voor overgewicht en chronische ziekten op latere leeftijd. Voor huisartsen is er alle reden om hun signalerende rol bij kinderen met overgewicht beter te gaan invullen. Huisartsen zelf vinden dat, en de ouders van deze kinderen verwachten het. Vaker lengte en gewicht meten, het overgewicht bespreekb...

De ziekte van Osgood-Schlatter komt veel voor bij fysiek actieve kinderen en adolescenten. Ze krijgen pijn in een knie tijdens of na het sporten. Dat kan op die leeftijd grote invloed hebben op de lichamelijke en psychische gesteldheid. De klachten verdwijnen meestal vanzelf als de patiënt rust houdt en de knie belast op geleide van de pijn, maar h...

Background Plantar heel pain (PHP) is a common cause of foot complaints, for which treatment with custom-made insoles is frequently applied. So far few studies have investigated patient characteristics that predict response to these treatments. The aim of this secondary exploratory analysis was twofold; firstly, to identify patient characteristics...

The goal of the OPTIKNEE consensus is to improve knee and overall health, to prevent osteoarthritis (OA) after a traumatic knee injury. The consensus followed a seven-step hybrid process. Expert groups conducted 7 systematic reviews to synthesise the current evidence and inform recommendations on the burden of knee injuries; risk factors for post-t...

Background Running is a popular sport with widely recognized health benefits. Given the high rates of knee injury in runners and the growing prevalence of knee osteoarthritis (KOA), it may be useful to assess perceptions about running and knee joint health. Purpose The objectives of this study were to (1) explore and compare the perceptions of the...

Background Children with overweight and obesity in socially deprived areas (SDAs) are less likely to complete and be compliant to a weight-loss programme. Objectives To identify factors associated with dropout and compliance of a multidisciplinary weight-loss programme in SDA. Methods This prospective longitudinal cohort study included children (...

Introduction Variable eligibility criteria across studies on plantar heel pain may result in compromising the generalisability of meta-analyses when heterogeneity is not accounted for. We aimed to explore: (i) heterogeneity of participant eligibility criteria in studies that have investigated plantar heel pain, and (ii) associations between key eli...

Objective To identify and quantify potential risk factors for osteoarthritis (OA) following traumatic knee injury. Design Systematic review and meta-analyses that estimated the odds of OA for individual risk factors assessed in more than four studies using random-effects models. Remaining risk factors underwent semiquantitative synthesis. The modi...

Background Patellofemoral OA is a strong risk factor for progression to generalized whole knee OA, but it is unknown whether involvement of the patellofemoral joint in early radiographic OA (ROA) is associated with risk of undergoing future knee arthroplasty. This is clinically relevant because patellofemoral OA likely requires a different treatmen...

Background Currently, there is no cure for osteoarthritis (OA). Therapeutic exercise is recommended in all international guidelines to improve pain and function (1). However, randomised controlled trials (RCTs) investigating therapeutic exercise showed that, on average, effect sizes are small to moderate compared to non-exercise controls (2-3). Bet...

Background Patellofemoral pain (PFP) affects one-quarter of adolescents, yet there are few evidence-informed recommendations to treat PFP in this population. HAPPi Kneecaps! is a randomised, controlled, participant- and assessor-blind, parallel-group feasibility trial of shoe inserts for adolescents with PFP. The aim of this qualitative study was t...

Musculoskeletal complaints are common in pre-professional and professional classical violinists and these complaints can affect violinists’ performance. Therefore, it is important to identify the factors that contribute to healthy performance in this population. Qualitative studies with a variety of stakeholders are able to provide insights from di...

Background The purpose of the present study was to explore the feasibility of collecting GPS data and the usability of GPS data to evaluate associations between the training load and onset of running-related knee injuries (RRKIs). Methods Participants of the INSPIRE-trial, a randomized-controlled trial on running injury prevention, were asked to p...

Om het aantal verwijzingen naar tweedelijnszorg orthopedie terug te dringen zijn in Nederland diverse anderhalvelijnszorgpilotprojecten voor knie- en heupartrose opgezet. In een aantal van deze projecten leveren orthopeden consulten in de huisartsenpraktijk. Uit een evaluatie van 3 van deze pilotprojecten blijkt dat ze de multidisciplinaire communi...

Background: Cam morphology contributes to the development of hip osteoarthritis (OA) but is less studied in the general population. This study describes its associations with clinical and imaging features of hip OA. Methods: Anteroposterior hip radiographs of 1019 participants from the Tasmanian Older Adult Cohort (TASOAC) were scored at baselin...

Introduction Obesity is the most important modifiable risk factor for knee osteoarthritis (KOA). Especially in an early stage of the disease, weight loss is important to prevent further clinical and structural progression. Since 2019, general practitioners (GPs) in the Netherlands can refer eligible patients to a combined lifestyle intervention (GL...

Objectives The aim of this study was to examine the effectiveness of an enhanced online injury prevention programme on the number of running-related injuries (RRIs) in recreational runners. Methods We conducted a randomised-controlled trial in runners who registered for running events (distances: 10–42.195 km) in the Netherlands. Adult runners who...

Purpose To investigate the spinopelvic alignment and vertebral shape in children, and associations with body composition and structural spinal abnormalities on magnetic resonance imaging (MRI). Methods We performed a cross-sectional study embedded in the Generation R Study, a prospective population-based birth cohort. Pelvic incidence and vertebra...

Introduction It is unclear why some people develop osteoarthritis after knee trauma and others don’t. This study identified risk factors for osteoarthritis following knee trauma. Materials and Methods After protocol registration, 5 databases were searched to 09–2021. RCTs and cohort studies assessing risk factors for symptomatic or structural oste...

Introduction Hand osteoarthritis (OA) is a common joint disorder in the adult population. No cure for hand OA is known yet, but treatment aims to reduce symptoms. Non-surgical and non-pharmacological therapy interventions can include splinting, patient education, and strengthening and range of movement exercises. However, it is still unclear which...

Background Patellofemoral pain (PFP) affects one-quarter of adolescents, yet there are few evidence-informed recommendations to treat PFP in this population. HAPPi Kneecaps! is a randomised, controlled, participant- and assessor-blind, parallel-group feasibility trial of shoe inserts for adolescents with PFP. The aim of this qualitative study was t...

Background Patellofemoral pain (PFP) affects one-third of adolescents and can persist into adulthood, negatively impacting health and quality of life. Foot orthoses are a recommended treatment for adults with PFP, but have not been evaluated in adolescents. The primary objective was to determine the feasibility of conducting a full-scale randomised...

Background: Osgood-Schlatter disease (OSD) is a non-traumatic knee problem that primarily observed in sports active children and adolescents between the age of 8 and 15. Aim: The objective of this study was to determine the incidence of OSD and to gain insight into the management of children and adolescents with OSD in general practice. Design...

Objectives: To evaluate the cost-effectiveness of custom-made insoles compared with general practitioner (GP)-led usual care after 26 weeks of follow-up in individuals with plantar heel pain (PHP) from a societal perspective. Design: Cost-effectiveness analysis of a double-blinded randomised controlled trial. Setting: General practice in the N...

Background Ankle injuries are common injuries among pre-professional dancers. An overview of the incidence and risk factors is however lacking. Objective To examine the incidence and risk factors of ankle injuries among contemporary pre-professional dancers. Design Prospective cohort study. Setting Codarts University of the Arts, Rotterdam, The...

Background The INSPIRE trial examined in 2017 the effect of an online injury prevention program on the number of running-related injuries (RRI). Although this program showed no effect on the number of injuries, new insights from this study were used to design an enhanced prevention program. Objective To examine the effectiveness of an online injur...

Background Ankle sprains are one of the most frequent injuries of the musculoskeletal system. No optimal treatment strategy has proven to be effective in general practice, however promising results were achieved in a preventive trial among athletes Objective To examine the effectiveness of an unsupervised e-health supported neuromuscular training...

Background Children and adolescents with overweight are known to have lower Quality of Life (QoL) compared to peers with a normal weight. QoL is a broad concept and is associated with many factors. A better understanding of the factors associated with QoL in children and adolescents and their impact on the association between overweight/obesity and...

Objectives: To evaluate the impact of running-related injuries (RRIs) on activities of daily living (ADL), work, healthcare utilization and estimated costs. Design: Prospective cohort study with data from a randomized controlled trial. Methods: Adult recreational runners who registered for a running event (distances 5 km to 42 km) were include...

Background: Patellofemoral pain (PFP) affects one-third of adolescents and can persist into adulthood, negatively impacting health and quality of life. Foot orthoses are a recommended treatment for adults with PFP, but have not been evaluated in adolescents. The primary objective was to determine the feasibility of conducting a full-scale randomise...

Introduction: Symptomatic treatments for osteoarthritis (OA) provide only small-to-moderate efficacy over placebo in randomised controlled trials (RCTs). Treatment guidelines therefore have emphasised the need to identify predictors of treatment response through subgroup and multiple regression analysis. Individual participant data (IPD) meta-anal...

Plantaire hielpijn is een veelvoorkomende voetklacht met veel impact. Er zijn verschillende interventies mogelijk, waaronder op maat gemaakte inlegzolen. Die laatste zijn duur (100-150 euro) en er is geen evidence voor. In dit gerandomiseerde gecontroleerde onderzoek met 185 deelnemers bleek dat een op maat gemaakte zool in eerste instantie geen to...

Background To evaluate intermediate care for knee and hip osteoarthritis (KHOA) in the general practice that incorporate specialist services into general practice to prevent unnecessary referrals to hospitals. Methods We used a mixed methods approach including semi-structured interviews, patient experience questionnaires and data from medical reco...

Patellofemoral pain is a common and often debilitating musculoskeletal condition. Clinical translation and evidence synthesis of patellofemoral pain research are compromised by heterogenous and often inadequately reported study details. This consensus statement and associated checklist provides standards for REPORTing of quantitative PatelloFemoral...

Objective Osteophytes, also small ones, are an important imaging feature of OA. However, due to their high prevalence on MR, the question has arisen whether these are truly pathophysiologic features of early OA, a result of physiologic aging, or rather a merely transient phenomenon. The aim of this study was to explore the prevalence of osteophytes...

Objectives This study examines the incidence of ankle injuries and identifies ankle injury risk among contemporary preprofessional dancers. Methods A total of 91 first-year contemporary preprofessional dancers were prospectively followed during one academic year. Self-reported ankle injuries, assessed with the Oslo Sports Trauma Research Centre qu...

To provide an overview of quality indicators (QIs) for knee and hip osteoarthritis (KHOA) care and to highlight differences in healthcare settings. A database search was conducted in MEDLINE (PubMed), EMBASE, CINAHL, Web of Science, Cochrane CENTRAL and Google Scholar, OpenGrey and Prospective Trial Register, up to March 2020. Studies developing or...

Background Plantar heel pain (PHP) is a common cause of foot complaints, for which treatment with custom-made insoles is frequently applied. So far few studies have investigated patient characteristics that predict response to these treatments. The aim of this secondary exploratory analysis was twofold; firstly, to identify patient characteristics...

Purpose: Alterations in bone shape are not only associated with the presence of radiographic OA, they are predictive of tibiofemoral OA onset and have even been proposed as a biomarker for tibiofemoral OA progression. Such biomarkers for early OA detection and progression are essential in the developing successful and early OA interventions. There...

Introduction Knee osteoarthritis (OA) is a prevalent and disabling musculoskeletal condition. Biomechanical factors may play a key role in the aetiology of knee OA, therefore, a broad class of interventions involves the application or wear of devices designed to mechanically support knees with OA. These include gait aids, bracing, taping, orthotics...

Background Sitting-related pain is a common feature of patellofemoral pain (PFP). However, little is known regarding features associated with sitting-related PFP. The aim of this study was to determine whether sitting-related PFP is associated with patellofemoral alignment, morphology and structural magnetic resonance imaging (MRI) features of the...

Background: Patellofemoral pain (PFP) is a common knee condition and possible precursor of knee osteoarthritis (OA). Inflammation, leading to an increased perfusion, or increased volume of the infrapatellar fat pad (IPFP) may induce knee pain. The aim of the study was to compare quantitative dynamic contrast-enhanced magnetic resonance imaging (DC...

Background: Patellofemoral pain (PFP) is a common cause of knee pain in adolescents, but there are limited evidence-based treatment options for this population. Foot orthoses can improve pain and function in adults with PFP, and may be effective for adolescents. The primary aim of this study is to determine the feasibility of conducting a full-sca...

Objective: To gain insight into the prevalence and characteristics of physical health problems and mental health problems in first-, second- and third-year conservatoire students of the classical music department. Also, differences in mental health and general health were investigated between students with playing-related musculoskeletal disorders...

Patellofemoral pain (PFP) and patellofemoral osteoarthritis (PFOA) are common, persistent conditions that may lie along a pathological spectrum. While evidence supports exercise-therapy as a core treatment for PFP and PFOA, primary care physicians commonly prescribe medication, or refer for surgical consults in persistent cases. We conducted a syst...

Objective To evaluate the effectiveness of interventions to reduce the risk of incident patellofemoral pain. Design Systematic review and meta-analysis, with strength of evidence evaluated separately for each intervention type. Data sources MEDLINE, EMBASE, CINAHL, Web of Science and SPORTDiscus. Eligibility criteria for selecting studies Random...

The Outcome Measures in Rheumatology workgroup (OMERACT), together with the Osteoarthritis Research Society International (OARSI) developed the OMERACT-OARSI responder criteria. These criteria are used to determine if a patient with osteoarthritis (OA) ‘responds’ to therapy, meaning experiences a clinically relevant effect of therapy. Recently, mor...

Background Achilles tendinopathy(AT) occurs in half of elite runners. AT is a difficult to treat tendon disease, which may progress from new‐onset to a chronic state. It is unknown how many runners with new‐onset AT develop persisting symptoms and which prognostic factors are associated with this course. Objective To describe how many runners deve...

BACKGROUND CONTEXT Several spinal abnormalities have been studied using magnetic resonance imaging (MRI). However, in children these studies were sparsely performed in general populations. Examining young children's spines is important since the shape of the bone is largely determined during the growth spurt. Furthermore, it is so far unknown if as...

Objectives To explore changes in running behavior due to the Coronavirus Disease 2019 (COVID-19) pandemic, assess presence of symptoms suggestive for COVID-19 and identify whether there is an association between running behavior and COVID-19. Design Prospective cohort study. Methods For this study we used a cohort of runners participating in an o...

Objective: To investigate the consequences and prognostic factors of running-related knee injuries (RRKIs) among recreational runners. Design: Prospective cohort study. Setting: This study is part of a randomized-controlled trial (RCT) on running injury prevention among recreational runners. At baseline during registration for a running event...

Background: The aim of this study was to investigate the differences in objectively measured physical activity and in self-reported physical activity between overweight and normal-weight children. Methods: Data from a prospective cohort study including children, presenting at the participating general practices in the south-west of the Netherlan...

Objectives: To compare custom-made insoles to sham insoles and general practice (GP)-led usual care in terms of pain at rest and during activity at 12 weeks follow-up in individuals with plantar heel pain. Methods: In this randomised clinical trial 185 patients aged 18 to 65 years, with a clinical diagnosis of plantar heel pain for at least 2 we...