Marie VallierMicrobiome Horizons
Marie Vallier
PhD
Co-founder at Microbiome Horizons (in creation)
About
50
Publications
5,200
Reads
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483
Citations
Introduction
Microbiome Horizons aims to provide high-quality scientific and bioinformatics support in microbiome research. Currently in development, our mission is to offer tailored expertise in bioinformatics, microbiology, and research training for a diverse audience, both nationally and internationally
Additional affiliations
June 2021 - July 2024
Position
- Researcher
Description
- Valbiotis is a French scientific research laboratory specializing in the development and commercialization of dietary supplements for the prevention and management of metabolic disorders underlying cardiovascular diseases.
August 2018 - May 2021
January 2013 - May 2017
Education
January 2013 - May 2017
September 2009 - September 2012
September 2007 - July 2009
Publications
Publications (50)
Introduction
Totum-070 is a combination of five plant extracts enriched in polyphenols to target hypercholesterolemia, one of the main risk factors for cardiovascular diseases. The aim of this study was to investigate the effects of Totum-070 on cholesterol levels in an animal model of diet-induced hypercholesterolemia.
Methods
C57BL/6JOlaHsd male...
Atherosclerotic cardiovascular disease is the leading cause of mortality worldwide, and hypercholesterolemia is a central risk factor for atherosclerosis. This study evaluated the effects of Totum-070, a plant-based polyphenol-rich supplement, in hamsters with high-fat diet (HFD)-induced dyslipidemia. The molecular mechanisms of action were explore...
Inflammatory bowel disease (IBD) is a persistent inflammatory condition that affects the gastrointestinal tract and presents significant challenges in its management and treatment. Despite the knowledge that within-host bacterial evolution occurs in the intestine, the disease has rarely been studied from an evolutionary perspective. In this study,...
Objective
Inflammatory bowel disease (IBD) is a persistent inflammatory condition affecting the gastrointestinal tract, presenting significant challenges in its management and treatment. Despite the knowledge that within-host bacterial evolution occurs in the intestine, the disease has so far rarely been studied from an evolutionary perspective. In...
Abstract: Non-alcoholic fatty-liver is a highly prevalent condition that, if untreated, can progress to non-alcoholic steatohepatitis (NASH). An interplay of western diet and gut microbiota has been reported to be involved in its development, but the role of the gut microbiota remains poorly described. In this context, plant extracts, rich in a gre...
Objective
To assess whether gut microbiota composition is associated with patient characteristics and may have predictive value on the response to TNF inhibitor (TNFi) treatment in axial spondyloarthritis (AxSpA).
Methods
The study involved 61 patients fulfilling the Assessment of SpondyloArthritis International Society classification criteria for...
Infectious disease is widely considered to be a major driver of evolution. A preponderance of signatures of balancing selection at blood group-related genes is thought to be driven by inherent trade-offs in susceptibility to disease. B4galnt2 is subject to long-term balancing selection in house mice, where two divergent allele classes direct altern...
Introduction: Arterial Hypertension (AHT) is a major cause of premature death worldwide. Totum-854 (T-854) is a polyphenol-rich botanical composition dedicated to reduce the risk of developing AHT. We assessed its chronic effects on blood pressure in spontaneous hypertensive rats (SHR) and studied mechanisms of action involved.
Methods: SHR rats re...
Introduction and purpose
Arterial Hypertension (AHT) is a major cause of premature death worldwide. We have developed Totum-854 (T-854), a polyphenol-rich botanical composition to reduce the risk of developing AHT. We assessed the acute and chronic effects on blood pressure in spontaneous hypertensive rats (SHR).
Method
Acute protocol: 12-week-old...
Objective:
Arterial Hypertension (AHT) is a major cause of premature death worldwide. We have developed Totum-854 (T-854), a polyphenol-rich botanical composition to reduce the risk of developing AHT. We assessed the acute and chronic effects on blood pressure in spontaneous hypertensive rats (SHR).
Design and method:
Acute protocol: 12-week-old...
Nutrition appears to be an important environmental factor involved in the onset of inflammatory bowel diseases (IBD) through yet poorly understood biological mechanisms. Most studies focused on fat content in high caloric diets, while refined sugars represent up to 40% of caloric intake within industrialized countries and contribute to the growing...
The recently founded Max Planck PostdocNet brings together postdoctoral researchers (or postdocs) from the Max Planck Society (MPS), provides representation for the postdoctoral community across all Max Planck Institutes (MPI) and associated institutes, and advocates for their interests on their behalf.
At the 2019 founding meeting, MPS postdocs qu...
The rise of antimicrobial resistance (AMR) in bacterial pathogens is acknowledged by the WHO as a major global health crisis. It is estimated that in 2050 annually up to 10 million people will die from infections with drug resistant pathogens if no efficient countermeasures are implemented. Evolution of pathogens lies at the core of this crisis, wh...
The house mouse is a key model organism in skin research including host–microbiota interactions, yet little is known about the skin microbiota of free-living mice. It is similarly unclear how closely laboratory mice, which typically live under exceptionally hygienic conditions, resemble the ancestral state of microbial variation in the wild. In thi...
Background
The response to TNF-blockers in axial spondyloarthritis (AxSpA) is at least partially influenced by HLA-B27 through a still poorly understood mechanism.
Objectives
Given that HLA-B27 regulates the gut microbiota composition in rats1,2, we seek to evaluate the predictive value of the gut microbiota composition in AxSpA patients on their...
Background
The MHC class I and II loci mediate the adaptive immune response and belong to the most polymorphic loci in vertebrate genomes. In fact, the number of different alleles in a given species is often so large that it remains a challenge to provide an evolutionary model that can fully account for this.
Results
We provide here a general surv...
Mutations in mitochondrial DNA (mtDNA) lead to heteroplasmy, i.e., the intracellular coexistence of wild-type and mutant mtDNA strands, which impact a wide spectrum of diseases but also physiological processes, including endurance exercise performance in athletes. However, the phenotypic consequences of limited levels of naturally arising heteropla...
Background
B4galnt2 is a blood group-related glycosyltransferase that displays cis-regulatory variation for its tissue-specific expression patterns in house mice. The wild type allele, found e.g. in the C57BL/6 J strain, directs intestinal expression of B4galnt2, which is the pattern observed among vertebrates, including humans. An alternative alle...
Mutations in mitochondrial DNA (mtDNA) lead to heteroplasmy, i.e. the intracellular coexistence of wild-type and mutant mtDNA strands, which impact a wide spectrum of diseases but also physiological processes, including endurance exercise performance in athletes. However, the phenotypic consequences of limited levels of naturally-arising heteroplas...
Our results provide novel evidence linking faecal microbiota composition to the occurrence of abdominal pain and its frequency, duration and intensity in the general population.
The composition of human as well as animal microbiota has increasingly gained in interest since metabolites and structural components of endogenous microorganisms fundamentally influence all aspects of host physiology. Since many of the bacteria are still unculturable, molecular techniques such as high-throughput sequencing have dramatically increa...
Recent evidence suggests that natural selection operating on hosts to maintain their microbiome contributes to the emergence of new species, that is, the ‘hologenomic basis of speciation’. Here we analyse the gut microbiota of two house mice subspecies, Mus musculus musculus and M. m. domesticus, across their Central European hybrid zone, in additi...
Questions
Questions (2)
Dear colleagues,
After more than a decade in academic and industrial research focused on microbial ecology and genetics, I am pleased to share an exciting new step in my career. Together with Joris Arfi-Crémieux, a skilled quality engineer and project manager, I am launching Microbiome Horizons. Our goal is to provide expert consulting services tailored to microbiota research, offering support in study design, bioinformatics analysis, and beyond.
To better address the needs of the research community, we are conducting a survey to gather insights that will help us refine our services. Your input would be invaluable in shaping an offer that best aligns with the challenges and requirements of microbiome studies.
If you have a few minutes, we would be grateful if you could share your perspectives via our questionnaire.
Thank you in advance for your valuable feedback,
The Microbiome Horizons team
Link to the questionnaire :
I am new to cyclic data analysis, and some collaborators suggested the use of JTK to test for rhythmicity in data.
I have metabolite quantities in mice feces across 20h (sampled every 4h), and I want to know which are cycling and which do not. I chose to test this with the MetaCycle package in R, because the metad3d function, which takes individuals data and integrate them in a global test, seemed better than looking at means across individuals. I tried running it with JTK and ARS, but I get opposite results: with JTK nothing reaches significance (and it's really far, most p-values are above 0.8), and in ARS pretty much everything is significant (and most p-values are below 0.01). I know that different statistics are bound to yield different results, but they should still be pointing in the same direction.
Does anybody has an idea why I get such opposite results ?
