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Introduction
Publications
Publications (16)
Autonomic nervous system (ANS) imbalance manifesting as cardiac autonomic neuropathy in the diabetic population is an important predictor of cardiovascular events. Symptoms and signs of ANS dysfunction, such as resting heart rate elevations, diminished blood pressure responses to standing, and altered time and frequency domain measures of heart rat...
Here we review some seldom-discussed presentations of diabetic neuropathy, including large fiber dysfunction and peripheral autonomic dysfunction, emphasizing the impact of sympathetic/parasympathetic imbalance. Diabetic neuropathy is the most common complication of diabetes and contributes additional risks in the aging adult. Loss of sensory perce...
Peripheral nerves (PN) consist of small and large fibers (1). The small fibers represent 80% of PN and are long, thin, with little or no myelin. They are, therefore, more fragile and the first to be damaged in many pathological processes (2–5). The current clinical diagnostic methods mainly assess large fibers (6). Similarly the gold standard neuro...
A neuropathic disorder associated with diabetes that includes manifestations in the peripheral components of the autonomic nervous system. Diabetic autonomic neuropathy affects sensory, motor, and vasomotor fibers innervating a large number of organs (e.g., cardiovascular, gastrointestinal, and genitourinary). Diabetic autonomic neuropathy is among...
Diabetic neuropathy (DN) is the most common form of neuropathy in developed countries and may affect about half of all patients with diabetes (DM), contributing to substantial morbidity and mortality and resulting in a huge economic burden. DN encompasses multiple different disorders involving proximal, distal, somatic, and autonomic nerves. It may...
Sudorimetry technology has evolved dramatically, as a rapid, non-invasive, robust, and accurate biomarker for small fibers that can easily be integrated into clinical practice. Though skin biopsy with quantitation of intraepidermal nerve fiber density (IENFD) is still currently recognized as the gold standard in the evaluation, sudorimetry may yiel...
Introduction:
Chronic inflammatory demyelinating polyneuropathy (CIDP) is eleven times more common among people with diabetes than the general population and is treatable with appropriate immunotherapy. Treatment response is usually measured clinically (symptomatic and functional improvement). We present a case of a patient with type 2 diabetes (T...
Early stages of chemotherapy-induced peripheral neurotoxicity (CIPN) are poorly investigated due to the lack of simple tool.
SUDOSCAN is a simple, quick (<3 minutes), non-invasive and quantitative method to assess small fiber neuropathy, based on
an electrochemical reaction between sweat chlorides and stainless-steel electrodes. This study aimed to...
Diabetic neuropathy (DN) is the most common and troublesome complication of diabetes mellitus, leading to the greatest morbidity and mortality and resulting in a huge economic burden for diabetes care. The clinical assessment of diabetic peripheral neuropathy and its treatment options are multifactorial. Patients with DN should be screened for auto...
Objective:
Sudomotor dysfunction may be an early detectable abnormality in diabetic small fiber neuropathy. The aim of this study was to evaluate the efficacy of Sudoscan™ (Impeto Medical, Paris, France) in detecting diabetic neuropathy (DN), in comparison with other standardized tests, in patients with diabetes mellitus (DM).
Subjects and method...
In this review of thermoregulatory function in health and disease, we review the basic mechanisms controlling skin blood flow of the hairy and glabrous skin and illustrate the major differences in blood flow to glabrous skin, which is, in essence, sympathetically mediated, while hairy skin is dependent upon neuropeptidergic signals, nitric oxide, a...
Distal symmetric polyneuropathy (DSPN) and cardiac autonomic neuropathy (CAN) are major chronic complications of diabetes and are associated with loss of quality-of-life (QOL) [ 1 ] and increased morbidity and mortality [ 2, 3 ]. Diabetes is known to be a major cause of peripheral neuropathy [ 4 ]. Neuropathy was considered a chronic complication o...
