
Marie Gombert LabedensSRI International | SRI · Centre for Health Sciences
Marie Gombert Labedens
PhD
Investigating biological rhythms and sleep in human health | circadian and menstrual rhythms, sleep, metabolic health
About
23
Publications
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Introduction
Investigating the importance of sleep in human health at SRI International (USA).
Biochemistry Degree at the University of La Rochelle (France) and Master of digestive health and nutrition at the University of Toulouse (France), PhD on circadian rhythms and metabolic health from the University of Valencia (Spain).
Publications
Publications (23)
Circadian rhythms are the changes in biological processes that occur on a daily basis. Among these processes are reactions involved in metabolic homeostasis. Circadian rhythms are structured by the central clock in the suprachiasmatic nucleus of the hypothalamus via the control of melatonin expression. Circadian rhythms are also controlled by the p...
The etiology of digestive pathologies such as irritable bowel syndrome (IBS), inflammatory bowel diseases (IBD) and cancer is not yet fully understood. In recent years, several studies have evidenced circadian variations in mechanisms involved in digestive health. In situations of disturbed circadian rhythms (chronodisruption) where the central clo...
Objective:
Cesarean section rates are increasing in developed countries and could be performed as an emergency or elective procedure. Our research aim was to determine whether elective cesarean section influences the melatonin content, the main circadian hormone, in human milk.
Methods:
Twenty-one women after vaginal delivery and 18 women after el...
Melatonin (pg/ml) Time of collection respective to sleep onset (hours) Melatonin variation over evening (0 = sleeping time) 0 2 4 6 8 10 12 During the week During the weekend Sleep duration (hours) Sleep duration * MODIFIED MELATONIN PROFILE, SHORTER SLEEPING TIME AND POORER SLEEP QUALITY IN CHILDREN WITH OBESITY Introduction Sleep and circadian rh...
The aim of this review is to describe adolescent nutritional requirements from a scientific, nutritional, and psychosocial point of view, emphasizing the main risks of malnutrition at this age. Currently, too many teenagers are alone at home and prepare their own meals. The influence of friends replaces parental rules. The habits of adolescents are...
Introduction: Autism Spectrum Disorder (ASD) is characterized by deficits in social cognition, self-referential processing, and restricted repetitive behaviors. Despite the established clinical symptoms and neurofunctional alterations in ASD, definitive biomarkers for ASD features during neurodevelopment remain unknown. In this study, we aimed to e...
Objective
Adolescent females frequently experience internalizing symptoms like sadness and anxiety during this developmental period of hormonal, emotional, and sleep changes. However, the interaction between sleep, menstruation-related challenges, and internalizing symptoms is not currently understood.
Methods
Data from 2814 postmenarcheal female...
Most studies about the menstrual cycle are laboratory-based, in small samples, with infrequent sampling, and limited to young individuals. Here, we use wearable and diary-based data to investigate menstrual phase and age effects on finger temperature, sleep, heart rate (HR), physical activity, physical symptoms, and mood. A total of 116 healthy fem...
The menstrual cycle is a loop involving the interplay of different organs and hormones, with the capacity to impact numerous physiological processes, including body temperature and heart rate, which in turn display menstrual rhythms. The advent of wearable devices that can continuously track physiological data opens the possibility of using these p...
Introduction
In today’s digital landscape, social media features prominently in adolescents’ social interactions and information consumption, influencing their development, potentially altering brain processes. Research shows a bidirectional relationship between social media use and both sleep health and brain activities, especially in executive co...
Introduction
Numerous physiological processes display menstrual cycle variations, including body temperature. The advances in quality and accessibility of wearables facilitate collecting time series of physiological data, including skin temperature during sleep. The cosinor method, frequently used in circadian rhythms biology, may be a useful tool...
Diabetes mellitus during pregnancy is a common complication of gestation, but its effects on the offspring’s development are poorly understood. Recently, some studies reported that gestational diabetes mellitus (GDM) impairs cerebellar development, and some genetic alterations have been described as consequences. Cerebellum, one of the hindbrain de...
Although weekend recovery sleep is common, the physiological responses to weekend recovery sleep are not fully elucidated. Identifying molecular biomarkers that represent adequate versus insufficient sleep could help advance our understanding of weekend recovery sleep. Here, we identified potential molecular biomarkers of insufficient sleep and def...
Obesity is a multifactorial disease whose onset and development are shaped by the individual genetic background. The melanocortin 4 receptor gene (MC4R) is involved in the regulation of food intake and energy expenditure. Some of the single nucleotide polymorphisms (SNPs) of this gene are related to obesity and metabolic risk factors. The present s...
Introduction
Sleep is an essential part of women’s health and well-being. Hormonal fluctuations that occur across the menstrual cycle or when approaching menopause might affect sleep quality. Most studies rely on self-reported data, or laboratory measures in small samples, to examine changes in sleep across the menstrual cycle. Here, we investigate...
Introduction
Insufficient sleep and circadian rhythm alterations are associated with metabolic disorders including obesity, with increasing evidence that these associations can emerge in childhood. In parallel, screen media access in the bedroom at night has negative effects on circadian rhythms, sleep, and other behaviors, which can contribute to...
Mental illness is alarmingly on the rise, and circadian disruptions linked to a modern lifestyle may largely explain this trend. Impaired circadian rhythms are associated with mental disorders. The evening chronotype, which is linked to circadian misalignment, is a risk factor for severe psychiatric symptoms and psychiatric metabolic comorbidities....
Melatonin, the hormone of circadian rhythm regulation, is involved in the modulationof mitochondrial activity through its antioxidant and anti-inflammatory properties. Alteration ofcircadian rhythms such as sleep is related to obesity and metabolic pathogenesis in adulthood,but studies during childhood are scarce. The present study investigated the...
Breastfeeding protects against adverse cardiovascular outcomes in the long term. Melatonin is an active molecule that is present in the breast milk produced at night beginning in the first stages of lactation. This indoleamine appears to be a relevant contributor to the benefits of breast milk because it can affect infant health in several ways. Th...
Introduction: People with any psychiatric disorder tend to have difficulties in responding sexually. However, sexual dysfunction (SD) is usually under-recognized, even the tightly hormonal and neuronal common connexions through the brain-sex axis. Multiple sources of resistance to comprehensive SD assessment and intervention efforts persist to impr...
Inflammatory bowel disease (IBD) comprises a group of chronic, immune system-mediated inflammatory diseases that primarily affect the gastrointestinal tract. The pathogenesis of the intestinal lesions in IBD remains elusive, but the inflammation process could be the result of dysfunction of the innate and adaptive immune systems induced by genetic...