Marie-Elaine Metras

Marie-Elaine Metras
CHU Sainte-Justine · Department of Pharmacy

About

37
Publications
1,954
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123
Citations
Citations since 2017
21 Research Items
97 Citations
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2017201820192020202120222023051015202530

Publications

Publications (37)
Article
Full-text available
Despite ongoing international efforts, many drugs administered to children must be compounded from dosage forms designed for adults because they remain unavailable in commercial formulations that suit their needs. Even though oral drug compounding is common in pediatrics, the extent of this practice has not been well described in recent years. This...
Article
BACKGROUND Plexiform neurofibromas (PN) are observed in up to 50% of patients with neurofibromatosis type 1 (NF1). Trametinib has been used widely to treat PN but limited data has been reported on its efficacy within a clinical trial. METHODS This ongoing multicenter phase II trial includes patients with pediatric low-grade glioma and PN. Patients...
Preprint
BACKGROUND Asthma is one of the most prevalent chronic diseases of childhood, affecting 1 in 10 children, and over 3 million Canadians. Asthma disproportionately affects children with lower socio-economic status (SES) who have higher prevalence of asthma, heavier symptom burdens, higher rates of ED visits, and hospital admissions. Controller medica...
Article
Aim: To evaluate clinicians' and patients' perceptions of pharmacogenetic testing in a clinical setting. Materials & methods: This is a pragmatic mixed-method prospective observational study. Hospital pharmacists and neurologists participated in focus groups regarding pharmacogenetic testing; patients who received pharmacogenetic testing and their...
Article
Full-text available
BACKGROUND: Plexiform neurofibromas (PN) are found in up to 50% of patients with neurofibromatosis type 1 (NF1). Trametinib has been used widely to treat PN but limited data has been reported on its efficacy within a clinical trial. METHODS: This ongoing multicenter phase II trial includes patients with pediatric low-grade glioma and PN. The primar...
Article
Full-text available
Inadequate nutritional rehabilitation of severely malnourished adolescents with Anorexia Nervosa (AN) increases the risk of medical complications. There is no consensus on best practices for inpatient nutritional rehabilitation and medical stabilization for severe AN. This study aimed to elaborate an admission protocol for adolescents with severe A...
Article
Full-text available
BACKGROUND Pediatric low-grade gliomas (PLGG) are the most frequent brain tumors in children. It is known that the majority of PLGG have activation of the MAPK/ERK pathway. METHODS This ongoing multicenter phase II trial includes three progressing/refractory PLGG groups: NF1 patients, KIAA1549-BRAF fusion patients and patients with other activatio...
Article
Full-text available
BACKGROUND Pediatric low-grade gliomas (PLGG) are the most frequent brain tumors in children. It is known that the majority of PLGG have activation of the MAPK/ERK pathway. METHODS This ongoing multicenter phase II trial includes three progressing/refractory PLGG groups: NF1 patients, KIAA1549-BRAF fusion patients and patients with other activatio...
Article
Objectives Non-adherence to anti-infective therapy contributes to treatment failure and the emergence of bacterial resistance. This study aimed to assess at-home adherence, by paediatric patients, to oral anti-infective (OAI) therapy prescribed for treatment of acute infections and to explore the factors contributing to non-adherence. Methods This...
Article
RÉSUMÉ Contexte : Le rôle du pharmacien au sein de l’équipe multidisciplinaire est souvent méconnu. Diverses interventions peuvent être mises en place pour promouvoir le rôle du pharmacien en milieu hospitalier auprès des familles, des patients et des autres professionnels de la santé. Peu d’études décrivent la faisabilité et évaluent l’impact de c...
Article
Delirium is associated with significant negative outcomes, yet it remains underdiagnosed in children. We describe the impact of implementing a pain, agitation, and delirium (PAD) bundle on the rate of delirium detection in a pediatric intensive care unit (PICU). This represents a single-center, pre-/post-intervention retrospective and prospective c...
Article
Full-text available
BACKGROUND Pediatric low-grade gliomas (PLGG) are the most frequent brain tumors in children. It is now known that the majority of PLGG have activation of the MAPK/ERK pathway. We hypothesize that we will observe responses in recurrent/refractory PLGG treated with trametinib. METHODS This is a multicenter phase II including three progressing/refra...
Article
Full-text available
BACKGROUND Pediatric low-grade gliomas (PLGG) are the most frequent brain tumors in children. It is known that the majority of PLGG have activation of the MAPK/ERK pathway. METHODS This multicenter phase II included three progressing/refractory PLGG groups: NF1 patients, KIAA1549-BRAF fusion patients and patients with other activation of the MAPK/...
Article
Introduction: Pharmacogenetics represents an opportunity in pharmaceutical practice. There are many documentary resources to support the pharmacist's work in this area. Objective: To compare the recommendations for carrying out pharmacogenetic tests from a documentary source in three countries: the United States, Canada and United France. Metho...
Article
Full-text available
Background: Pediatric low-grade gliomas (PLGG) are the most frequent brain tumors in children. Up to 50% will be refractory to conventional chemotherapy. It is now known that the majority of PLGG have activation of the MAPK/ERK pathway. The same pathway is also activated in plexiform neurofibromas (PNs) which are low-grade tumors involving periphe...
Article
Objective: Little is known about pregnancy outcomes among women who have acquired human immunodeficiency virus (HIV) through perinatal infection and survived into adulthood. The objectives of this study were to describe pregnancy outcomes among women with perinatal HIV infection (PHIV) in Canada and to identify potential challenges in the preventi...
Article
Objective To describe the problems faced by young patients and their parents when obtaining and using compounded drugs. Methods This prospective observational descriptive study included patients 0 to 21 years of age who were discharged from a mother–child tertiary hospital with a prescription containing at least one compounded drug between Februar...
Article
The recent approval of raltegravir granules for suspension in the newborn population offers a new option for the antiretroviral prophylaxis of newborns for the prevention of perinatal transmission. However, there are little data on its use in preterm infants, nor on outcomes following its use as empiric HIV therapy for newborns subsequently found t...
Article
Full-text available
BACKGROUND: Many commonly used drugs are not commercially available in forms suitable for children. Therefore, pharmacies create new compounds by adding excipients to existing adult formulations, often by crushing tablets and creating suspensions. Timely safe delivery of compounded drugs is challenging but very little is known about the problems fa...
Article
Introduction: Clinical pharmacy has developed since the 1960s in North America, with large disparities in the presence of decentralized pharmacists in hospital units between healthcare programs. Decentralized pharmacists have been present in pediatrics since the 1970s. The main objective of this study was to describe the steps used to upgrade the...
Article
Résumé Introduction Il n’existe pas de normes de pratiques déterminant le nombre minimum de pharmaciens devant exercer au chevet des patients au sein des différents programmes de soins offerts dans le réseau de santé. Notre objectif était de mettre à jour le niveau de la pratique pharmaceutique en VIH/SIDA au sein d’une clinique ambulatoire pédiat...
Article
Introduction : Il n’existe pas de normes de pratiques déterminant le nombre minimum de pharmaciens devant exercer au chevet des patients au sein des différents programmes de soins offerts dans le réseau de santé. Notre objectif était de mettre à jour le niveau de la pratique pharmaceutique en VIH/SIDA au sein d’une clinique ambulatoire pédiatrique....
Article
Purpose Compare training required for specialization in hospital pharmacy in France and Quebec: internship and residency. Materials and methods Descriptive comparative study. A list of relevant themes was established after a review of key websites and literature. A panel of three French interns, a Quebec hospital pharmacy resident and one teaching...
Article
Background During a one-year internship in a Quebec teaching hospital, a group of French pharmacy interns explored the similarities and differences in training. Purpose To compare the training required for hospital pharmacy practise in France and in Quebec. Materials and Methods This is a descriptive comparative study. A list of relevant themes was...

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