Marie Christine Brotherton

Marie Christine Brotherton
Laval University | ULAVAL

About

36
Publications
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Introduction

Publications

Publications (36)
Article
Full-text available
This study explores the challenges faced by responsible investment and shareholder activism practitioners in integrating sustainability by means of proxy voting as shareholder engagement strategy. Proxy voting guidelines that sometimes include sustainability provisions are applied in a very elastic and inconsistent way. Proxy voting agents are expe...
Article
The objective of this article is to analyze the neutralization techniques that organizations involved in the promotion and use of pesticides use in order to respond to the sustainability-related stigma they face. This study is based on a qualitative content analysis of 77 briefs submitted to a public hearing organized by the National Assembly of Qu...
Article
The objective of this study is to analyze the institutional logics underlying pesticide use and the resistance displayed by organizations in this sector against social pressures to reduce the use of these substances. This in‐depth study of a public hearing on pesticides set up by the National Assembly of Quebec (Canada) in 2019 shows the often very...
Article
The objective of this study is to investigate the interfirm comparability of climate performance disclosed in the sustainability reports produced by car manufacturers that have been criticized over the past few years. The in‐depth content analysis of the data disclosed by 17 car manufacturers over the period of 2014 to 2017, covering the five main...
Article
Full-text available
This article analyzes the main neutralization techniques used in car manufacturers’ sustainability reports to disclose on the Dieselgate scandal. We conduct a conventional qualitative content analysis of 72 sustainability reports, covering the period 2013-2017, from 15 car manufacturers that were accused of unethical behaviors related to the measur...
Article
Full-text available
Purpose The purpose of this paper is to explore the practices, challenges and ethical issues underlying the fabric and dissemination of corporate sustainability ratings. Design/methodology/approach Based on 36 semi-structured interviews with sustainability rating practitioners, the study shows the trade-offs, ethical judgments and customizable asp...
Article
Full-text available
The objective of this study was to analyze the early COVID-19 crisis management practices implemented in organizations based on a scoping review of relevant business articles published on this issue in newspapers and magazines between March and May 2020. In total, after applying inclusion and exclusion criteria on 2707 potentially relevant articles...
Article
Full-text available
The objective of this paper is to investigate the rigorousness and reliability of sustainability rating agencies' evaluation of corporate sustainability risks. Using grounded theory, this study conducts a qualitative analysis of 32 semi‐structured interviews with practitioners involved in this activity and shows the trade‐offs and rational myths un...
Article
Full-text available
The objective of this paper is to analyze the impression management strategies that practitioners in the sustainability rating industry use to build confidence in the reliability of ratings and explain these ratings’ lack of convergence. Based on semi-structured interviews with 36 practitioners, this study sheds more light on the socially construct...
Article
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Purpose The purpose of this paper is to examine the professionalism and professionalization of sustainability assurance providers based on the experiences and perceptions of auditors involved in this activity. Design/methodology/approach The empirical study was based on 38 semi-directed interviews conducted with assurance providers from accounting...
Article
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The objective of this paper is to investigate how indigenous peoples’ involvement can improve the environmental management practices of organizations in the natural resource extraction sector. Based on a qualitative study and semi-structured interviews with 33 respondents, this study sheds more light on the environmental involvement of a particular...
Article
Full-text available
The objective of this paper is to explore the initiatives for community engagement with indigenous people implemented by extractive organizations and their possible alignment with the integrative framework of the 2030 Agenda for sustainable development. A qualitative study based on 33 semi-directed interviews with practitioners and experts in manag...
Article
Full-text available
This article presents an analysis of the opinions of assurance providers regarding the quality and the limitations of sustainability reports and their recommendations to improve them using the Global Reporting Initiative (GRI) as a framework. The qualitative content analysis of 301 assurance statements for sustainability reports from mining and ene...
Article
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This paper presents an empirical examination of the role of employee involvement in the internalization of corporate biodiversity management. A qualitative study in natural resource companies was conducted, based on semi‐directive interviews with managers, consultants, and experts in this area. The findings show that employee involvement is essenti...
Article
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The objective of this paper is to analyze the meaning, manifestations and practical implications of connectedness to nature in natural resources companies. This research is motivated by the lack of scholarly works aimed to analyze the organizational applications of the connectedness to nature concept. A qualitative and exploratory study based on se...
Article
Full-text available
Author Summary Miltefosine and amphotericin B are two leading molecules in the fight against the vector-borne disease Leishmaniasis. We demonstrate here that different point mutations in a P-type ATPase could play an important role in resistance, not only to miltefosine, but also to amphotericin B. Furthermore, macrophage-infecting amastigotes that...
Data
SNPs deduced from the sequencing of LdiAmB1000.1 and absent from the sequencing of its Ldi263WT parent. (PDF)
Data
Characterisation of the PE species containing C19Δ in total lipid extracts from Ldi263 wt. (A) ES-MS/MS parents of 295 m/z (C19Δ acyl fragment) in negative mode (600–1000 m/z). (B-G) are daughter ion ESI-MS/MS spectra of ions identified in S6A Fig: 716, 730, 744, 774, 788, 802 m/z respectively. (PDF)
Data
Graphical representation of the different mutations identified in MT for three Leishmania drug resistant strains. The diagram includes the different conserved protein domains identified for the MT (GenBank: AAQ82704.1). (TIF)
Data
Preliminary study for the characterization of mutant L. major Friedlin AmB1080.3. (A) EC50 determination curves in the presence of miltefosine for LmF wt+mock (9.05 ± 0.89 μM), AmB1080.3+mock (54.84 ± 5.30 μM) and AmB1080.3+MT (4.43 ± 0.62 μM) cell lines over 72 h. (B) EC50 determination curves in the presence of amphotericin B for LmF wt+mock (0.1...
Data
Identification of abundance changes to the membrane lipids in AmB- and MF-resistant parasites. Negative ion ES-MS survey scans (600–1000 m/z) of total lipid extracts from Ldi263 wt (A upper panel), MF200.5 (B upper panel), AmB1000.1 (C upper panel) and AmB1000.1+MT (D upper panel). Positive ion ES-MS survey scans (600–1000 m/z) of total lipid extra...
Data
Example of total ion chromatogram of derivatised fatty acids from lipid extracts of L. infantum 263 wild-type. (A) Chromatogram including all the FAMES species with retention times spanning from 26.00 to 50.00 min for mid log phase parasites for each strain detailed in Table 1. (B) Magnification of the chromatogram for the identification of the spe...
Data
Mass spectrometric analysis of phosphatidylethanolamine species containing cyclopropyl fatty acid in Leishmania infantum. (PDF)
Data
Effect of the transfection of an episomal copy of the wild-type gene LinJ.16.1240 in the AmB1000.1 mutant background. (A) EC50 determination curves in the presence of amphotericin B for Ldi263 wt (62.01 ± 5.00 nM), AmB1000.1 (1.97 ± 0.04 μM) and AmB1000.1+LinJ.16.1240 (1.89 ± 0.11 μM) cell lines over 72 h. (B) EC50 determination curves in the prese...
Data
High resolution orbitrap mass spectrometry survey scans (600–1000 m/z) of total lipid extracts from Ldi263 wt; negative ion mode (A), positive ion mode (B). (PDF)
Data
GC-MS Sterol Analysis of Leishmania strains. TIC of chromatogram 39.50–43.50 min for (A) Ldi263, (B) MF200.5, (C) AmB1000.1, (D) AmB1000.1+MT. Numbered peaks refer to Table 4 for identification. (TIF)
Data
Estimated ploidy for Ldi263AmB1000.1 and its WT parent (Ldi263WT). (PDF)
Article
Basic proteins, an important class of proteins in intracellular organisms such as Leishmania, are usually underrepresented on 2D gels. This chapter describes a method combining basic proteins fractionation using Free flow electrophoresis in isoelectric focusing mode (IEF-FFE) followed by protein separation using two-dimensional gel electrophoresis...
Article
Full-text available
Amphotericin B (AmB) in its liposomal form is now considered as either first- or second-line treatment against Leishmania infections in different part of the world. Few cases of AmB resistance have been reported and resistance mechanisms toward AmB are still poorly understood. This paper reports a large-scale comparative proteomic study in the cont...
Article
Full-text available
Antimonials remain the primary antileishmanial drugs in most developing countries. However, drug resistance to these compounds is increasing and our understanding of resistance mechanisms is partial. In the present study, quantitative proteomics using stable isotope labelling of amino acids in cell culture (SILAC) and genome next generation sequenc...
Article
Full-text available
Objectives: To identify non-penicillin-binding protein (PBP) mutations contributing to resistance to the third-generation cephalosporin cefotaxime in Streptococcus pneumoniae at the genome-wide scale. Methods: The genomes of two in vitro S. pneumoniae cefotaxime-resistant isolates and of two transformants serially transformed with the genomic DN...
Article
Membrane and high molecular weight (HMW) proteins tend to be underrepresented in proteome analyses. Here, we optimized a protocol designed for the extraction and purification of membranes from the protozoan parasite Leishmania using a combination of serial centrifugation and free-flow zone electrophoresis (ZE-FFE). We also enriched for Leishmania H...
Article
Prior analyses of the proteome of the protozoan parasite Leishmania have underrepresented basic proteins. Here, we applied protein fractionation by isoelectric point (pI) using free-flow electrophoresis (FFE) to study stage-specific expression of basic proteins in this pathogen. Overall, we resolved 2469 protein spots in both the flagellated promas...

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