Mariano Sanz

Mariano Sanz
Complutense University of Madrid | UCM · Department of Stomatology III (Medicine and Orofacial Surgery)

MD, DDS, DrMed

About

550
Publications
175,076
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24,416
Citations
Additional affiliations
November 1987 - present
Complutense University of Madrid
Position
  • Professor and Chairman of Periodontology

Publications

Publications (550)
Article
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Multiple toothbrush designs have been developed to enhance dental biofilm removal and decrease bacterial contamination and retention over time. Therefore, the aim of this clinical study was to compare the efficacy of a prototype of a new double-sided thermoplastic polyurethane-based toothbrush with that of a conventional nylon-bristle toothbrush. A...
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No microbiological criteria were included in the 2018 EFP-AAP classification of periodontal diseases that could be used to differentiate between stages and grades. Furthermore, differences in the subgingival microbiome depending on stage and grade have not been established. Sixty subgingival biofilm samples were collected in Spain (n = 30) and Colo...
Article
Objectives: This in-vitro investigation was aimed to evaluate the cleaning ability of four mechanical devices designed for decontaminating implant surfaces MATERIAL AND METHODS: Ninety-six implants were coated with permanent ink and inserted into 3D-printed resin blocks simulating three different intraosseous defect configurations (types Ib, Ic an...
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Background: The aim of this study, a prospective case series, was to evaluate the clinical, microbiological, and biochemical impact of the surgical treatment of peri-implantitis. Methods: Thirty subjects with diagnosis of peri-implantitis were treated following a surgical protocol including access flaps, surface decontamination with ultrasonics and...
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Aim: The present multi-centre randomized clinical trial with 12 months of follow-up aimed at studying the added effect of sub-marginal instrumentation before surgical treatment of peri-implantitis. Materials and methods: Forty-two patients diagnosed with peri-implantitis were recruited. After a behavioural intervention phase including oral hygie...
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Aim: To evaluate the clinical outcome and the associated factors of a treatment protocol for peri-implant mucositis. Materials and methods: Patients were evaluated 30 months after a treatment protocol including professional mechanical debridement and modification of the prosthesis contours to improve access for biofilm control. Clinical performa...
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Background: The aim of this study is to analyze if the results of the Oral Health Impact Profile-14 questionnaire (OHIP-14) in patients with primary Sjögren's syndrome (pSS) are correlated with salivary flow and level of xerostomia. Methods: This observational cross-sectional study was conducted in sixty-one patients (60 women, one man, mean age...
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Background In previous studies, COVID-19 complications were reported to be associated with periodontitis. Accordingly, this study was designed to test the hypothesis that a history of periodontal therapy could be associated with lower risk of COVID-19 complications. Methods A case–control study was performed using the medical health records of COV...
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Objectives To evaluate the efficacy of a gel-containing propolis extract, nanovitamin C, and nanovitamin E as adjuvants to professional plaque removal on desquamative gingivitis (DG). Materials and methods A randomized clinical trial was conducted on patients suffering DG due to mucocutaneous diseases. Patients received professional supragingival...
Article
Since the beginning of 2020, the entire global health care system has been severely challenged by the outbreak of coronavirus 2019 disease (COVID-19). Robust evidence has demonstrated a more severe course of COVID-19 in the presence of several comorbidities, such as cardiovascular diseases, diabetes mellitus, and obesity. Here, we critically apprai...
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Background: The recently published clinical practice guideline (CPG) for the treatment of periodontitis in stages I-III provided evidence-based recommendations for the treatment of periodontitis patients, defined according to the 2018 classification. Stage IV periodontitis shares the severity and complexity characteristics of stage III periodontit...
Article
Objectives: To assess the literature on (i) the relevance of the presence of a minimum dimension of keratinized peri-implant mucosa (KPIM) to maintain the health and stability of peri-implant tissues, and; (ii) the surgical interventions and grafting materials used for augmenting the dimensions of the KPIM when there is a minimal amount or absence...
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Objectives The purpose of this study was to evaluate the clinical and microbiological impact of adjunctive metronidazole to periodontal surgery. Materials and methods Systemically healthy patients, with stages III–IV, grades B–C periodontitis, were randomly assigned to receive metronidazole or placebo adjunctive to periodontal surgery, after subgi...
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Background The objective was to qualitatively and quantitatively describe the subgingival cultivable bacteria in Albanian subjects and to compare it with a similar Spanish population. Materials and methods Consecutive patients, diagnosed as periodontitis in stages I–II or III–IV, and as periodontally healthy or with gingivitis, were studied clinic...
Article
Aim: To evaluate the inter-examiner reliability in classifying periodontitis using the 2018 Classification of Periodontal Diseases, when used by postgraduate students, academics and specialist clinicians trained in European Federation of Periodontology (EFP) and American Academy of Periodontology (AAP) postgraduate accredited programs. Material a...
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(1) Background: To investigate the effect of a xenogeneic collagen matrix (CMX) seeded with autologous gingiva-derived mesenchymal cells (GMSCs) when combined with a coronally advanced flap (CAF) in the treatment of localized gingival recession type 1 (RT1). (2) Methods: Dehiscence-type defects were created in seven dogs. GMSCs were isolated, trans...
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Open and closed sinus lifting procedures are predictable to augment the bone needed for appropriate implant placement in the posterior maxilla in cases of reduced bone availability. However, these techniques are not exempt of comorbidities and complications. In the case of open sinus lifting, the perforation of the Schneiderian membrane during oste...
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Bone regenerative interventions aimed to restore a deficient alveolar ridge, such as the use of block grafts or through the application of guided bone regeneration principles, have reported positive outcomes in the published scientific literature. These interventions, however, are invasive, and hence, intra-surgical and/or post-surgical complicatio...
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This investigation aimed to evaluate the antibacterial effect of polymeric nanoparticles (NPs), functionalized with calcium, zinc, or doxycycline, using a subgingival biofilm model of six bacterial species (Streptococcus oralis,Actinomyces naeslundii, Veillonela parvula, Fusobacterium nucleatum, Porphyromonas gingivalis, and Aggregatibacter actinom...
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Aim To evaluate the radiological, clinical and microbiological outcomes of implants with a hybrid surface macro-design in patients with history of periodontitis. Material and Methods The study was designed as a 12-month, parallel-arm, randomized controlled trial where patients with history of treated periodontitis in need of dental implants for si...
Article
Objectives To evaluate the antibiofilm and antibacterial effects of a new brushing solution concept, in a validated peri-implant biofilm model. Materials and methods A multispecies in vitro biofilm model, including Streptococcus oralis, Actinomyces naeslundii, Veillonella parvula, Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis and...
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Current periodontal regenerative therapies aim at restitution ad integrum of the periodontal attachment apparatus, which involves periodontal ligament, root cementum, and alveolar bone. Guided tissue regeneration, bioactive agents and bone replacement grafts have been utilized in an attempt to fully restore the lost periodontal tissues. But their p...
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Aim The aim of this study was to evaluate the efficacy of a xenogeneic collagen matrix to augment the width of keratinized mucosa (KM), concomitantly to the surgical treatment of peri-implantitis, when compared to the use of an autologous soft tissue graft. Material and Methods In this 12-month parallel-arm randomized controlled clinical trial, pa...
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Rheumatoid arthritis and periodontitis are chronic inflammatory diseases defined respectively by the destruction of the articular cartilage and tooth‐supporting periodontal tissues. Although the epidemiologic evidence for an association between these two diseases is still scarce, there is emerging scientific information linking specific bacterial p...
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Aim To assess the changes in peri-implant soft tissue levels after the surgical treatment of peri-implantitis. Methods Randomized controlled trials, controlled clinical trials, cohort studies and case series, evaluating the changes in the position of the mucosal margin before and after surgical treatment of peri-implantitis, were searched. Seconda...
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Objectives: Peri-implant tissue maintenance and treatment is becoming a serious challenge in implantology. With increasing numbers of implants being placed, more cases of peri-implant mucositis and peri-implantitis is seen. A digital survey on peri-implant disease management was issued to experts in periodontology and implantology to identify the t...
Article
OBJECTIVES The task of working Group 2 at the 6th Consensus Meeting of the European Association for Osseointegration was to comprehensively assess the effects of soft tissue augmentation procedures at dental implant sites on clinical, radiographic and patient-reported outcome measures (PROMs) including an overview on available outcome measures and...
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Background Classification of the periodontal conditions is indispensable for epidemiological data in order to guide situational awareness and therapeutic strategies. The new classification of periodontal diseases and conditions introduced by the American Academy of Periodontology and the European Federation of Periodontology (AAP/EFP), however, has...
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The aim of this review was to update the evidence of new approaches to non-surgical therapy (NSPT) in the treatment of periodontitis. Preclinical and clinical studies addressing the benefits of adjunctive antimicrobial photodynamic therapy, probiotics, prebiotics/synbiotics, statins, pro-resolving mediators, omega-6 and -3, ozone, and epigenetic th...
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The objective was to characterize and compare the subgingival microbiota in patients diagnosed according to the World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions 2018. For this cross-sectional study, Spanish and Colombian subjects (characterized as health/gingivitis, periodontitis in stages I-II or stages...
Article
Background: A new periodontitis classification was recently introduced involving multidimensional staging and grading. The Study's aim was to assess if individuals well-trained in periodontics consistently used the new classification for patients with severe periodontitis. The secondary goal was to identify "gray zones" related to classifications....
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Objectives Evaluate the dimensions and morphology of peri-implant tissues around a modified dental implant designed with tissue level connection and a convergent transmucosal neck, when compared with a conventional bone level implant connected to a cylindrical machined titanium abutment. Material and methods Eight experimental animals were used fo...
Article
Purpose: To investigate the subgingival microbiological profiles of patients with periodontitis, to determine their stage and grade scores and to evaluate the differences in the microbiota among different stages and grades. Materials and methods: Sixty-seven (n = 67) periodontitis patients were selected. Periodontitis staging and grading, following...
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Objective To assess the efficacy of three mechanical decontamination methods in four types of commercially available implants. Material and methods Ninety-six implants of four commercial brands with different designs (regarding thread depth and thread pitch) were soaked in a surrogate biofilm (ink) and air-dried. Circumferential standardized peri-...
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Objectives The aim was to evaluate the rate of bone loss progression during experimentally induced peri-implantitis using two different implant-abutment connections in implants with identical surface topography. Material and methods Forty-eight Regular Neck tissue-level SLA implants with a matching implant to abutment connection (TL) and 36 bone-l...
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Objectives The purpose of this experimental in vivo investigation was to evaluate the influence of modifying the implant surface by adding a monolayer of multi-phosphonate molecules on the development of experimental peri-implantitis. Material and methods Eight beagle dogs received 5 tests and 5 control implants each following a split-mouth design...
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Objectives To study whether there is an association between caries and periodontitis in a representative sample from employed Spanish adults. Materials and methods This cross-sectional study is part of a wide epidemiological survey (WORALTH, Workers’ ORAL healTH). Oral examination was carried out in 5130 dentate subjects. Periodontal status was as...
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Objective To evaluate the hard tissue volumetric and soft tissue contour linear changes in implants with two different implant surface characteristics after a ligature-induced peri-implantitis.Material and methodsIn eight beagle dogs, implants with the same size and diameter but distinct surface characteristics were placed in the healed mandibular...
Article
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Objectives The task of working Group 2 at the 6th Consensus Meeting of the European Association of Osseointegration was to comprehensively assess the effects of soft tissue augmentation procedures at dental implant sites on clinical, radiographic, and patient-reported outcome measures (PROMs) including an overview on available outcome measures and...
Article
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Objectives Purpose of this experimental in-vivo investigation was to evaluate the influence of modifying the implant surface by adding a monolayer of multi-phosphonate molecules on the de novo bone formation and osseointegration. Material and Methods The study was designed as an animal pre-clinical trial with intra-animal control and two healing p...
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COVER ILLUSTRATION: The cover image is based on the Original Article Immunohistochemical characteristics of lateral bone augmentation using different biomaterials around chronic peri‐implant dehiscence defects An experimental in vivo study by Ui‐Won Jung et al., https://doi.org/10.1111/clr.13726.
Article
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En esta ocasión, se convocó al Prof. Mariano Sanz, coautor del artículo recientemente publicado acerca de la relación entre periodontitis y el mayor riesgo de padecer complicaciones de COVID-19, a fin de que comparta su mirada sobre este relevante hallazgo.
Article
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Objectives To evaluate the efficacy of a 0.03% chlorhexidine (CHX) and 0.05% cetylpyridinium chloride (CPC) mouth rinse, as an adjunct to professional plaque removal (PPR) and mechanical hygiene, in the treatment of peri-implant mucositis (PiM) and gingivitis.Material and methodsPatients displaying PiM in, at least, one implant were included in thi...
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Objective To assess the contour and volumetric changes of hard and soft tissues after guided bone regeneration (GBR) using two types of barrier membranes together with a xenogeneic bone substitute in dehiscence-type defects around dental implants.Material and methodsIn 8 Beagle dogs, after tooth extraction, two-wall chronified bone defects were dev...
Article
Objective: To determine the efficacy of a gel containing propolis extract, nanovitamin C and nanovitamin E as adjuvant to mechanical debridement in the treatment of peri-implant mucositis (PM). Background: Propolis has anti-inflammatory and antibacterial effect that may improve peri-implant health. Methods: A randomized, double-blind study was...
Article
Aim To identify loci associated with stages III/IV, grade C periodontitis (PIII/IV‐C) through a genome wide association study (GWAS). Materials And Methods 441 Caucasian Spanish PIII/IV‐C cases from the SEPA Network of Research Clinics and 1141 controls from the Banco Nacional de ADN were genotyped with “Axiom Spain Biobank Array”, which contains...
Article
Aim To investigate the immunohistochemical characteristics of a highly porous synthetic bone substitute and a cross‐linked collagen membrane for guided bone regeneration. Methods Three experimental groups were randomly allocated at chronic peri‐implant dehiscence defect in 8 beagle dogs: (i) biphasic calcium phosphate covered by a cross‐linked col...
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The aim of this study was to evaluate the potential anti-biofilm and antibacterial activities of Streptococcus downii sp. nov. To test anti-biofilm properties, Streptococcus mutans, Actinomyces naeslundii, Veillonella parvula, Fusobacterium nucleatum, Porphyromonas gingivalis, and Aggregatibacter actinomycetemcomitans were grown in a biofilm model...
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Microbial biofilm modeling has improved in sophistication and scope, although only a limited number of standardized protocols are available. This review presents an example of a biofilm model, along with its evolution and application in studying periodontal and peri-implant diseases. In 2011, the ETEP (Etiology and Therapy of Periodontal and Peri-I...
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Background: COVID-19 is associated with an exacerbated inflammatory response that can result in fatal outcomes. Systemic inflammation is also a main characteristic of periodontitis. Therefore, we investigated the association of periodontitis with COVID-19 complications. Methods: A case-control study was performed using the national electronic he...
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The aim was to study the subgingival microbiota in subjects with Down syndrome (DS) with different periodontal health status, using cultural and molecular microbiological methods. In this cross-sectional study, DS subjects were selected among those attending educational or occupational therapy centers in Galicia (Spain). Medical histories, intraora...
Article
Aim To analyse, through a preclinical in vivo model, the possible mechanisms linking depression and periodontitis at behavioural, microbiological and molecular levels. Materials and methods Periodontitis (P) was induced in Wistar:Han rats (oral gavages with Porphyromonas gingivalis and Fusobacterium nucleatum) during 12 weeks, followed by a 3‐week...
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The last 20 years has seen a shift in medical education from printed analogue formats of knowledge transfer to digital knowledge transfer via media platforms and virtual learning environments. Traditional university medical teaching was characterised by lectures and printed textbooks, which to a degree still have an important role to play in knowle...
Article
Purpose: To investigate the subgingival microbiological profiles of patients with periodontitis, to determine their stage and grade scores and to evaluate the differences in the microbiota among different stages and grades. Materials and Methods: Sixty-seven (n = 67) periodontitis patients were selected. Periodontitis staging and grading, followi...
Article
Aim To evaluate the prevalence of buccal peri‐implant soft tissue dehiscence (PISTD) in anterior implants and to identify the risk/protective indicators of PISTD in implants not suffering peri‐implantitis. Materials and methods 240 randomly selected patients from a university clinic database were invited to participate in the present cross‐section...
Article
Objectives The aim of the present study was to evaluate the diagnostic accuracy of clinical and radiographic evaluations made at a single time point during follow‐up in identifying (i) a history of peri‐implant bone loss and (ii) the presence of peri‐implantitis. Material & Methods 427 patients provided with implant‐supported reconstructions 9 yea...
Article
Objectives The aim of the present study was to evaluate whether clinical findings at implant sites are relevant as screening tests for a history of marginal bone loss. Material & Methods 427 patients provided with implant‐supported reconstructions 9 years earlier were evaluated clinically (probing pocket depth (PPD), bleeding on probing (BoP)) and...
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Aim To evaluate the efficacy of different screening protocols for undiagnosed hyperglycaemia in a Research Network of Dental Clinics coordinated by the Spanish Society of Periodontology (SEPA). Material and Methods A total of 1143 patients were included in the study. Participants filled a questionnaire considering diabetes risk factors (FINDRISC)...
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Objective To retrospectively assess the interproximal bone loss (CBL) in external hexagon implants (EHI), with different surface micro‐topography, placed in the posterior mandible in patients with a history of periodontitis undergoing supportive periodontal care. Material and methods 268 consecutive patients received 755 EHI implants in the mandib...
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Introduction Evidence of an association between periodontitis and MetS (metabolic syndrome) remains controversial. The objective of this study is to evaluate the association between periodontitis and MetS in a cross‐sectional population survey. Material and Methods WORALTH (Workers’ ORAL healTH) Study is a cross‐sectional survey, conducted on a re...
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Aim This randomized controlled trial aimed to assess the efficacy of a two‐stage crown lengthening intervention (SCL) in the aesthetic zone compared with a one‐stage crown lengthening procedure (CCL). Materials and methods Thirty subjects were randomly assigned to either SCL (n = 15) or CCL (n = 15) groups. SCL consisted of full‐thickness flaps fo...