
Marianne ChapleauLife Molecular Imaging
Marianne Chapleau
PhD Clinical Neuropsychology
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46
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Publications (46)
Background/Objectives. Alzheimer’s disease (AD) and semantic dementia (SD) have distinct episodic memory profiles despite the hippocampal atrophy that characterizes both diseases. The aim of this study was to delineate the pattern of gray matter (GM) atrophy associated with AD and SD as well as any differences in these patterns by pooling together...
The goal of the study was to determine whether the semantic variant of primary progressive aphasia (svPPA) affects the intrinsic connectivity network anchored to left and right anterior hippocampus, but spares the posterior hippocampus. A resting‐state functional connectivity MRI (rs‐fcMRI) study was conducted in a group of patients with svPPA and...
Background
Increasing evidence shows that the semantic variant of primary progressive aphasia (svPPA) is characterized by hippocampal atrophy. However, less is known about disease-related morphological hippocampal changes. The goal of the present study is to conduct a detailed characterization of the impact of svPPA on global hippocampus volume and...
Background
Posterior Cortical Atrophy (PCA) is a clinical syndrome characterized by progressive visuospatial and visuoperceptual impairment. As the neurodegenerative disease progresses, patients lose independent functioning due to the worsening of initial symptoms and development of symptoms in other cognitive domains. The timeline of clinical prog...
Florbetaben (FBB) is a radiopharmaceutical approved by the FDA and EMA in 2014 for the positron emission tomography (PET) imaging of brain amyloid deposition in patients with cognitive impairment who are being evaluated for Alzheimer’s disease (AD) or other causes of cognitive decline. Initially, the clinical adoption of FBB PET faced significant b...
Background and Objectives. Posterior Cortical Atrophy (PCA) is a clinical syndrome characterized by progressive visuospatial and visuoperceptual impairment. As the neurodegenerative disease progresses, patients lose independent functioning due to the worsening of initial symptoms and development of symptoms in other cognitive domains. The timeline...
Background and objectives:
Cavum septum pellucidum (CSP) is a common but nonspecific MRI finding in individuals with prior head trauma. The type and extent of head trauma related to CSP, CSP features specific to head trauma, and the impact of brain atrophy on CSP are unknown. We evaluated CSP cross-sectionally and longitudinally in healthy and cli...
The accumulation of tau abnormality in sporadic Alzheimer’s disease is believed typically to follow neuropathologically defined Braak staging. Recent in-vivo PET evidence challenges this belief, however, as accumulation patterns for tau appear heterogeneous among individuals with varying clinical expressions of Alzheimer’s disease. We, therefore, s...
Background
Neuropathological studies defined the paradigm that tau—the pathological hallmark of Alzheimer’s disease (AD)—spreads homogenously across individuals from the medial temporal lobe to the neocortex. This staging system is referred to as Braak stages. However, neuroimaging studies have since highlighted significant inter‐regional and inter...
Background
The presence of multiple pathologies is the rule and not the exception in Alzheimer’s disease (AD). The goal of this study was to assess whether 18F fluorodeoxyglucose (FDG) PET can provide information about the presence of non‐AD pathologies in autopsy‐proven AD patients.
Method
Our cohort included 55 patients with antemortem FDG‐PET a...
Background
Posterior cortical atrophy (PCA) is a clinically defined syndrome characterized by impairment in higher‐order visual processing due to neurodegeneration of posterior brain regions (occipito‐parietal and occipito‐temporal areas). Previous findings have reported broader cognitive impairment profiles, but their association with neural corre...
Background
Posterior cortical atrophy (PCA) is a neurodegenerative disorder of visuospatial and visuoperceptual impairment with high association to underlying Alzheimer’s disease (AD) pathology. In contrast to typical amnestic AD, risk factors for PCA remain largely unknown. Previously, we observed higher rates of neurodevelopmental differences in...
Background
Patients presenting with distinct clinical variants of Alzheimer’s disease (AD) present differential patterns of tau pathology measured with positron emission tomography (PET). Yet, a single set of brain regions like a temporal meta‐ROI is often chosen to study the association between cognition and tau. Instead, we aimed to map the assoc...
Background
The presence of multiple pathologies is the rule and not the exception in Alzheimer’s disease (AD). The goal of this study was to assess whether 18F fluorodeoxyglucose (FDG) PET can provide information about the presence of non‐AD pathologies in autopsy‐proven AD patients.
Method
Our cohort included 55 patients with antemortem FDG‐PET a...
Background
Neuropathological studies defined the paradigm that tau—the pathological hallmark of Alzheimer’s disease (AD)—spreads homogenously across individuals from the medial temporal lobe to the neocortex. This staging system is referred to as Braak stages. However, neuroimaging studies have since highlighted significant inter‐regional and inter...
Background
Patients presenting with distinct clinical variants of Alzheimer’s disease (AD) present differential patterns of tau pathology measured with positron emission tomography (PET). Yet, a single set of brain regions like a temporal meta‐ROI is often chosen to study the association between cognition and tau. Instead, we aimed to map the assoc...
Posterior cortical atrophy (PCA) is a rare neurodegenerative condition characterized by progressive visual and visuospatial dysfunction. The consensus criteria state that patients should present “relatively spared behavior and personality” in early stages. However, limited research has focused on these symptoms in PCA. This study compared 157 patie...
The spread of tau abnormality in sporadic Alzheimer's disease is believed typically to follow neuropathologically defined Braak staging. Recent in-vivo positron emission tomography (PET) evidence challenges this belief, however, as spreading patterns for tau appear heterogenous among individuals with varying clinical expression of Alzheimer's disea...
Introduction:
Posterior Cortical Atrophy (PCA) is a neurodegenerative disorder characterized by impairment of higher-order visual processing in the setting of progressive atrophy of the parietal and occipital lobes. The underlying pathology is variable but most commonly Alzheimer's disease. The majority of individuals develop symptoms before 65 ye...
Purpose of review
The study aims to provide a summary of recent developments for diagnosing and managing posterior cortical atrophy (PCA). We present current efforts to improve PCA characterisation and recommendations regarding use of clinical, neuropsychological and biomarker methods in PCA diagnosis and management and highlight current knowledge...
Posterior cortical atrophy (PCA) is a clinically defined syndrome characterized by impairment in higher‐order visual processing. The underlying pathology in PCA is most commonly Alzheimer’s disease (AD), but large‐scale biomarker and neuropathological studies are lacking. In this ongoing project we aim to describe demographic, clinical, biomarker a...
Mutations in microtubule‐associated protein tau (MAPT), granulin (GRN), and hexanucleotide expansion repeat in the open reading frame of chromosome 9 (C9orf72) are found in 60% of familial frontotemporal dementia (FTD) cases. The current study aims to delineate brain regions with reduced glucose metabolism in patients with genetic FTD in comparison...
Importance:
Preventive trials of anti-amyloid agents might preferably recruit persons showing earliest biologically relevant β-amyloid (Aβ) binding on positron emission tomography (PET).
Objective:
To investigate the timing at which Aβ-PET binding starts showing associations with other markers of Alzheimer disease.
Design, setting, and particip...
Importance:
National Institute on Aging-Alzheimer's Association (NIA-AA) workgroups have proposed biological research criteria intended to identify individuals with preclinical Alzheimer disease (AD).
Objective:
To assess the clinical value of these biological criteria to identify older individuals without cognitive impairment who are at near-te...
Imaging of amyloid deposition using PET has been available in research studies for 2 decades and has been approved for clinical use by the U.S. Food and Drug Administration, the European Medicines Agency, and other regulatory agencies around the world. Amyloid PET is a crucial tool for the diagnosis of Alzheimer disease, as it allows the noninvasiv...
BACKGROUND
Mindfulness, defined as non-judgmental awareness of the present moment, has been associated with an array of mental and physical health benefits. Mindfulness may also represent a protective factor for Alzheimer’s disease (AD). Here, we tested the potential protective effect of trait mindfulness on cognitive decline and AD pathology in ol...
Background
Mindfulness refers to the ability to engage in non‐judgmental awareness of the present moment. This psychological trait is gaining increased attention in both scientific and general public settings, given its association with an array of health benefits. While psychological traits such as depression, anxiety, and neuroticism have been as...
Background
The pattern of tau‐PET deposition might not always follow the classical post‐mortem Braak stages (Vogel et al, 2020). Yet, most current studies use a temporal meta‐ROI to calculate tau‐PET abnormality. We assessed inter‐individual patterns of tau binding across the spectrum of late‐onset Alzheimer’s disease (AD). We computed a score repr...
BACKGROUND AND OBJECTIVES
Mindfulness, defined as non-judgmental awareness of the present moment, has been associated with an array of mental and physical health benefits, including improved cognitive functioning and changes to brain structure and function. Mindfulness may also represent a protective factor for Alzheimer’s disease (AD). Here, we te...
L’augmentation de la prévalence des démences est un problème majeur d’intérêt international. À la différence du vieillissement normal, la démence désigne l’affaiblissement progressif de l’ensemble des fonctions intellectuelles : mémoire, attention, jugement, capacité de raisonnement et les perturbations de conduite qui en résultent. Mondialement, o...
Patients with Alzheimer's disease (AD)and semantic variant primary progressive aphasia (svPPA)can present with similar language impairments, mainly in naming. It has been hypothesized that these deficits are associated with different brain mechanisms in each disease, but no previous study has used a network approach to explore this hypothesis. The...
High angular resolution diffusion imaging (HARDI)-based tractography has been increasingly used in longitudinal studies on white matter macro- and micro-structural changes in the language network during language acquisition and in language impairments. However, test-retest reliability measurements are essential to ascertain that the longitudinal va...
While the semantic variant of primary progressive aphasia (svPPA) is characterized by a predominant semantic memory impairment, episodic memory impairments are the clinical hallmark of Alzheimer's disease (AD). However, AD patients also present with semantic deficits, which are more severe for semantically unique entities (e.g. a famous person) tha...
Cognitive and computational models of reading aloud agree on the existence of two procedures for reading. Pseudowords (e.g., atendier) are correctly read through subword processes only while exception words (e.g., pint) are only correctly read via whole-words processes. Regular words can be correctly read by means of either way. Previous behavioral...
Background
Successful reading can be achieved by means of two different procedures: sub‐word processes for the pronunciation of words without semantics or pseudowords (PW) and whole‐word processes that recruit word‐specific information regarding the pronunciation of words with atypical orthography‐to‐phonology mappings (exception words, EW).
Metho...