Marianna Rossetti

Marianna Rossetti
University of Rome Tor Vergata | UNIROMA2 · Dipartimento di Scienze e Tecnologie Chimiche

About

15
Publications
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215
Citations
Introduction
I am a post-doctoral researcher in the Chemistry Department of the University of Rome Tor Vergata. My research interests include functional DNA nanotechnology, biosensors and drug release applications. My post-doc fellowship is currently funded by the “Umberto Veronesi Foundation“.

Publications

Publications (15)
Article
Full-text available
The development of artificial vesicles into responsive architectures capable of sensing the biological environment and simultaneously signaling the presence of a specific target molecule is a key challenge in a range of biomedical applications from drug delivery to diagnostic tools. Herein, the rational design of biomimetic DNA‐grafted quatsome (QS...
Article
Full-text available
Electrochemiluminescence (ECL) is a powerful transduction technique that has rapidly gained importance as a powerful analytical technique. Since ECL is a surface-confined process, a comprehensive understanding of the generation of ECL signal at a nanometric distance from the electrode could lead to several highly promising applications. In this wor...
Article
We demonstrate here a homogeneous assay, named NanoHybrid, for monoclonal antibody quantification directly in serum samples in a single step format. NanoHybrid is composed of both synthetic peptide nucleic acids (PNA) and nucleic acid strands conjugated to recognition elements and optical labels and is designed to allow a fast fluorescence quantifi...
Article
The spatial colocalization and the nanoscale confinement of functional biomolecules in natural systems are widespread mechanisms that regulate a number of cell activities. This, alongside recent progresses in DNA nanotechnology, represents a source of inspiration for the design of artificial, nucleic acid‐based systems with programmable properties....
Article
Full-text available
Rapid and easy‐to‐use platforms for antibody detection are likely to improve molecular diagnostics and immunotherapy monitoring. However, current technologies require multi‐step, time‐consuming procedures that limit their applicability in these fields. Inspired by Nature, which often achieves regulation of reaction rates and binding affinity throug...
Article
Sensing in close quarters: A nucleic acid‐based electrochemical platform able to measure levels of immunoglobulins of type G and E (IgG and IgE) directly in blood serum and other bodily fluids was developed. The antibody detection exploits effective molarity effects that are induced by the spatial confinement of electrochemically active DNA‐based s...
Article
Full-text available
The fundamental concept of effective molarity is observed in a variety of biological processes such as protein compartmentalization within organelles, membrane localization and signaling paths. To control molecular encountering and promote effective interactions, Nature places biomolecules in specific sites inside the cell in order to generate a hi...
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Full-text available
The emerging field of RNA nanotechnology harnesses the versatility of RNA molecules to generate nature-inspired systems with programmable structure and functionality. Such methodology has therefore gained appeal in the fields of biosensing and diagnostics, where specific molecular recognition and advanced input/output processing are demanded. The u...
Article
DNA-based switches are structure-switching biomolecules widely employed in different bioanalytical applications. Of particular interest are DNA–based switches whose activity is regulated through the use of allostery. Allostery is a naturally occurring mechanism in which ligand binding induces the modulation and fine control of a connected biomolecu...
Article
A nonconventional strategy in DNA nanodevice activation is determined by F. Ricci, J. Hong, and co-workers on page 5572, using a graphene and DNA based electro-responsive multilayer nanofilm by means of layer-by-layer assembly. The nanofilm onto a chip-electrode controls spontaneous conformational change of the DNA nanodevice via controlled release...
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Full-text available
A method to control activation of a DNA nanodevice by supplying a complementary DNA (cDNA) strand from an electro-responsive nanoplatform is reported. To develop functional nanoplatform, hexalayer nanofilm is precisely designed by layer-by-layer assembly technique based on electrostatic interaction with four kinds of materials: Hydrolyzed poly(β-am...
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Full-text available
Here we demonstrate the rational design of a new class of DNA-based nanoswitches which are allosterically regulated by specific biological targets, antibodies and transcription factors, and are able to load and release a molecular cargo (i.e. doxorubicin) in a controlled fashion. In our first model system we rationally designed a stem-loop DNA-nano...
Article
Full-text available
A versatile platform for the one-step fluorescence detection of both monovalent and multivalent proteins has been developed. This system is based on a conformation-switching stem-loop DNA scaffold that presents a small-molecule, polypeptide, or nucleic-acid recognition element on each of its two stem strands. The steric strain associated with the b...

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