Mariane Lutz

Universidad de Valparaíso (Chile) | CINV · Interdisciplinary Center for Health Studies CIESAL

This article describes and analyzes various aspects related to the neurobiology of disorganized attachment (DA), which is associated with personality, eating, affective, dissociative, and addictive disorders. We included primary studies in humans, published in PubMed from 2000 to 2022. Eight genetic and one epigenetic study were considered. Three m...

Background: Both perfectionism and social anxiety have been described in patients with eating disorders (ED) and medical students. Academic stress also can increase the risk of developing ED. Aim: To analyze the dimensions of perfectionism, social anxiety, and academic stress associated with the risk of developing ED in female medical students. Mat...

Resumen El envejecimiento del sistema inmune o «inmunosenescencia» afecta a la respuesta inmune viral en el adulto mayor, sobre todo si existe fragilidad. Algunos hallazgos destacan un desbalance en los mecanismos pro- y antiinflamatorios, una menor producción y diversificación de linfocitos T, alteración de la inmunovigilancia y en la síntesis de...

Food choice impacts human health and planetary sustainability. The feeding patterns that reduce risk factors for noncommunicable diseases and various mortality causes are recognized as healthy eating habits. The average world population is far from reaching these habits due to the lack of access to healthy foods and a high prevalence of malnutritio...

Background: The importance of foods or food constituents in mental health is increasingly recognized, and “nutritional psychiatry” is a growing discipline. Objective: This narrative review aims to present work supporting associations between food or food constituents and mental health, specifically depressive disorders. Methods: The data presented...

The intake of quinoa (Chenopodium quinoa Willd) has increased worldwide. Its revival has renewed interest in its composition and nutritional value. The aim of this study was to determine the contents of moisture, ash, protein, and some minerals (Fe, Zn and Cu) of ten varieties of Chilean quinoa grown in various geographical zones, using validated a...

Cardiovascular disease (CVD) is the leading cause of death throughout the world. A major risk factor for CVD is platelet aggregation. Various plant extracts exhibit anti-aggregatory action in vitro. The dietary intake of traditional plant crops such as quinoa (Chenopodium quinoa Willd) and lupin (Lupinus spp., Fabaceae family), highly recognized fo...

Los adultos mayores (AM) presentan multimorbilidad y son vulnerables a las consecuencias de la polifarmacia, incluyendo las prescripciones potencialmente inadecuadas (PPI). El objetivo del estudio fue caracterizar a un grupo de AM de un centro de atención primaria de Chile, conocer su terapia farmacológica y pesquisar posibles interacciones medicam...

Gender is a psychosocial construct referring to the socially built roles, behaviors, expressions and identities of girls, women, boys, men and people with gender diversity, while sex is related to the biological attributes of a woman or a man. Even though the terms "sex" and "gender" are often used in a binary way, there is considerable diversity i...

Resumen El género es una construcción psicosocial referida a los roles, comportamientos, ex-presiones e identidades socialmente construidos de niñas, mujeres, niños, hombres y personas con diversidad de género, mientras que el sexo se relaciona con los atributos biológicos de una mujer o un hombre. Aun cuando los términos "sexo" y "género" suelen u...

El género es una construcción psicosocial referida a los roles, comportamientos, expresiones e identidades socialmente construidos de niñas, mujeres, niños, hombres y personas con diversidad de género, mientras que el sexo se relaciona con los atributos biológicos de una mujer o un hombre. Aun cuando los términos "sexo" y "género" suelen utilizarse...

Medicines are an economic good and a fundamental component of public and private health spending and decision-making. Assurance of their quality, efficiency, and safety is essential. In Chile, the wide variety of available drugs, including innovator products, and generics-some of which are certified as bioequivalent, while others are not-creates a...

Medicines are an economic good and a fundamental component of public and private spending and health decision-making. Assurance of their quality, efficiency and safety is essential. However, the variety of products on the Chilean market, including innovative and generic products—the latter accounted for by many products that are certified as bioequ...

RESUMEN Introducción: El envejecimiento de la población trae con-sigo nuevos desafíos en la búsqueda de formas de superar sus vulnerabilidades. Objetivo: Co-diseñar un sistema piloto de entrega de pre-paraciones alimentarias variadas y saludables para adultos mayores (AM) de 60 años, autovalentes, en un Centro de Salud Familiar en Valparaíso, Chile...

Resumen Las revisiones sistemáticas de literatura constituyen una de las principales metodologías utilizadas en la validación de las propiedades saludables de los alimentos, o factores alimentarios, que afectan la fisiología humana. Esta herramienta, basada en la evidencia obtenida a través de ensayos clínicos aleatorizados realizados con un diseño...

Systematic literature reviews are one of the main methodologies used to substantiate the health properties of foods and food constituents purported to affect human physiology. This tool is based on scientific evidence obtained from correctly performed randomized controlled trials. Systematic reviews make it possible to conclude whether there is a c...

The population of older adults is growing globally. This increase has led to an accumulation of chronic illnesses, so-called age-related diseases. Diet and nutrition are considered the main drivers of the global burden of diseases, and this situation applies especially to this population segment. It relates directly to the development of coronary h...

We examined the ability of tomato pomace extract (by-product) to affect platelet aggregation in healthy humans (clinical pilot study). In phase 1 the tolerance of participants (n = 15; 5 per dose level) ingesting tomato pomace extract across three dose levels (1, 2.5, and 10 g) was evaluated. Phase 2 was a single-blind, placebo-controlled, parallel...

The population is now living longer during the period classified as "elderly" (60 years and older), exhibiting multimorbidity associated to the lengthening of the average life span. The dietary intake of phenolic compounds (PC) may affect the physiology, disease development and progression during the aging process, reducing risk factors of age rela...

Background: Pine nus have an outstanding nutritional value. Objective: To evaluate the effect of the intake of pine nuts on body and organ weight gain in rats fed a high fat diet. Materials and Methods: 24 male Sprague Dawley rats were fed control diet, high fat diet, or high fat with 2 % pine nuts, (n=8 per group). After 28 days the animals were w...

The aim of the study was to analyze the proximate composition of pine nuts harvested from 15 growing areas in Chile, Argentina, Italy, Spain, Turkey, and Israel. The main component was fat, followed by protein. Pine nuts from Chile and Argentina were similar, zones with the highest thermal oscillation and rainfall. Italian pine nuts had the highest...

Pine nut (Pinus pinea L.) is a nutritious, expensive tree nut. During storage, it is exposed to a wide range of environmental deteriorative conditions. This study describes the oxidative stability of pine nuts kept in pouches made of three different packaging materials and stored at three different temperatures. The packaging materials evaluated we...

ABSTRACT The consumption of quinoa (Chenopodium quinoa Willd.) has been steadily increasing due to its high nutritional value and health benefits associated with its high antioxidant capacity. The objective of this study was to determine the contents of dietary fiber, polyphenols, flavonoids and isoflavones, and how they contribute to the antioxida...

The aim of the study was to analyze the proximate composition of pine nuts harvested from 15 growing areas in Chile, Argentina, Italy, Spain, Turkey, and Israel. The main component was fat, followed by protein. Pine nuts from Chile and Argentina were similar, zones with the highest thermal oscillation and rainfall. Italian pine nuts had the highest...

Pinus pinea L. produces highly valued commercial pine tree nuts. It is endemic to the Mediterranean Basin, where pine nuts are part of the Mediterranean diet. The aim of the study was to compare the chemical composition of pine nuts harvested from 15 growing areas, distributed in Chile (3), Argentina (2), Italy (3), Spain (1), Turkey (3), and Israe...

Pine nut (Pinus pinea L.) is a nutritious, expensive tree nut. During storage, it is exposed to a wide range of environmental deteriorative conditions. This study describes the oxidative stability of pine nuts kept in pouches made of three different packaging materials and stored at three different temperatures. The packaging materials evaluated we...

Quinoa (Chenopodium quinoa Willd.) is a basic food in pre‐hispanic Andean communities, used not only as a food but also for medicinal purposes. The interest in quinoa has increased because of its plasticity to adapt to environmental conditions: it tolerates frost, salinity and drought; it grows on marginal and arid soils and high altitudes. The nut...

Mediterranean pine nuts are recognized for their high nutritional value and healthy benefits. The aim of the study was to analyze the composition of pine nuts harvested from Pinus pinea L. across three different geographic macrozones in Chile. Proximate analysis, minerals, fatty acid composition, phytosterols, tocopherols, vitamin C, phenolic compo...

Background: Chilean school children present a high prevalence of cardiovascular risk (CVR) factors related with bad eating practices and sedentary habits, including overweight and obesity. Objective: to evaluate the impact on RCV of improving the quality of meals delivered by State programs for school children and optimizing their physical activity...

Since obesity and overweight became health issues, tree nuts became considered as unhealthy, due to their high fat content. Their high energy density has been pointed as a major factor in body weight gain. However, nuts have been part of the traditional diet in many geographical areas for centuries and in the last decades various laboratory assays,...

Betalaínas são pigmentos de frutos que possuem propriedades benéficas à saúde. Para isolamento dos pigmentos, o suco deve ser separado da polpa da fruta, que contém biopolímeros. O objetivo deste estudo foi clarificar o suco de figo da índia utilizando microfiltração para obtenção de um suco clarificado contendo betalaínas. Para isso, duas membrana...

The Chilean National School Feeding Program (NSFP) delivers breakfast and lunch meals that supply 250 and 450 kcal, respectively, along the country. In the last decades, a significant increase of obesity has been observed in primary education children, and it involves risk factors of non-communicable diseases. The dietary intake of foods containing...

Chilean children attending basic schools exhibit a high prevalence of overweight and obesity, and may present hypertension associated with an excessive sodium intake. The aim of the study was to measure the sodium content of the servings provided by the National Schools Feeding Program to first grade children attending public schools in Quillota du...

The study evaluated the impact of dehydration on the total phenolic content (TPC) and antioxidant capacity (AC) of fruits and vegetables (F&V). Fresh small fruits (berries) had the highest TPC, anthocyanin contents, and AC (2,2-diphenyl-1-picrylhydrazyl (DPPH) and oxygen radical absorbance capacity (ORAC)). The lowest TPC were observed in carrot an...

A high number of potentially bioactive compounds has been identified in grapes, including anthocyanins, catechins, ellagic acid, lutein, lycopene, quercetin, resveratrol, many of which are potent antioxidants. Phenolic compounds are the main bioactives contained in grapes, and may exert beneficial effects by acting as direct or indirect antioxidant...

D esde hace varios años, en el Ins-tituto Forestal (INFOR) se ha estado estudian-do la historia de la presencia del pino piñonero o pino Mediterráneo (Pinus pinea L.) en Chile. Este pino, de origen europeo, fue traído al país a principios del siglo XX por inmigran-tes italianos, principalmente con fines ornamentales, y en algunas zonas se utilizó p...

The bioavailability of major phenolics in Autumn Royal grape juice was measured in 16 subjects distributed into two groups: the experimental group (n = 8 receiving 300 mL of juice) and the placebo group (n = 8 receiving 300 mL of artificial beverage). Blood was obtained before and after 30, 90, 180, and 300 min after juice or placebo intake and 24-...

Research, development and innovation (R+D+i) in food and nutrition sciences have exhibited different goals through the years. The current challenges in these areas are represented basically by significant modifications in dietary habits associated to the epidemiological changes observed in the last decades, characterized by a high prevalence of non...

Antecedentes: en la actualidad ha cobrado gran relevancia el conocimiento de los compuestos bioactivos alimentarios beneficiosos para la salud. Estos deben acceder a los tejidos a través de la circulación sanguínea, y su biodisponibilidad depende de múltiples factores. Objetivo: describir algunos aspectos relevantes relacionados con la evaluación d...

Background: The knowledge of bioactive phytochemicals contained in foods, which may exert beneficial health effects, is of great importance in current nutrition. Bioactive phytochemicals must reach the tissues in which they act through the blood circulation, and their bioavailability depends on various factors. Aim: To describe some relevant issues...

The contents of bioactive compounds of quinoa (Chenopodium quinoa Willd.) are poorly known. We analyzed two isoflavones (daidzein and genistein) by HPLC in three local ecotypes of quinoa seeds from three different geographical and genetic regions in Chile: (a) Extreme North, with prevailing conditions of high temperature and dryness (local ecotype...

The bioavailability of major phenolics in Autumn Royal grape juice was measured in 16 subjects distributed into two groups: the experimental group (n=8 receiving 300mL of juice) and the placebo group (n=8 receiving 300mL of artificial beverage). Blood was obtained before and after 30, 90, 180, and 300min after juice or placebo intake and 24-h urine...

Apples have been identified as one of the main dietary sources of antioxidants, namely phenolic compounds. Apple peel constitutes a waste of dried apple manufacture, although it contains more phenolics than the fruit pulp. This fraction can be preserved by drying. However, it is important to consider that the dehydrated product obtained requires pr...

Grapes (Vitis vinifera L.) are a source of phenolics and exhibit a high antioxidant capacity. In this study, the total phenolics content and the antioxidant capacity of ground grapes, juice, and skin fractions of two varieties of red grapes widely produced in Chile (Cabernet Sauvignon and País) were analyzed and specific phenolics (caffeic acid, ga...

Although Chile lacks a formal regulatory definition for functionalfoods, the term is currently used to designate foods that exert beneficial properties for health due to their content of bioactive ingredients. The Chilean food legislation includes a list of 18 health claims that may be associated to the consumption of a number offoods that exert be...

Statistical tools were used to analyze membrane fouling occurring during ultrafiltration (UF) of clarified grape juice. Experimental flux data were correlated to dead-end and crossflow filtration models. The UF experiments were performed at 30 and 40 °C for an 8-kDa multitubular ceramic membrane and also at 30 °C for a 1-kDa membrane to determine t...

Apple peel, a waste product from dried apple manufacture, has a high content of bioactive phenolic compounds. In Chile ca. 9000 ton of apple peel are generated each year. To obtain a novel food ingredient, we compared three drying processes on Granny Smith apple peel: oven (60°C), drum dryer (110°C), and freeze drying. The influence of each drying...

We hypothesize that the Ferric Reducing Antioxidant Power (FRAP) assay that follows the reaction of Fe(3+)-TPTZ at 593 nm underestimates the antioxidant capacity of fruits, since the standardized time of the reaction (4 min) is not enough to titrate all the reducing compounds available. We measured FRAP, total phenolics and anthocyanins content in...

Unlabelled: Grapes (Vitis vinifera L.) possess health-promoting effects attributed to their supply of a wide variety of bioactive phenolics. Juice and skin fractions of 4 varieties of table grapes: Red Globe, Crimson Seedless, Autumn Royal, and Ribier were prepared to determine and compare their total phenolics content, antioxidant capacity (DPPH,...

Artichoke is a traditionally consumed vegetable in many countries. In the past decade, the immature (baby) variety has been successfully introduced in the international food markets. The aim of this study is to compare the chemical composition and antioxidant properties of mature and baby artichokes, in raw state and after cooking. For this purpose...

Functional foods (FF) are aimed to exert beneficial health effects. The isoflavones daidzein and genistein are bioactive phytoestrogens that may act as functional food ingredients. This study measured urinary excretion of these isoflavones contained in a powdered novel FF oriented to the elderly population, ready to consume as such or included into...

Functional foods (FF) should be consumed on a regular basis in order to exert their benejicial effects on health, reducing the risk of non-transmissible chronic diseases. We developed three powdered FF oriented to the elderly. The aint ofthis study was to develop a series of culinary preparations including one of the three new FF and evalúate their...

Current nutrition is focused mainly on the prevention of chronic non transmissible diseases, whose ethiology is influenced by the quality of diet and lifestyles. Consumers are becoming increasingly aware of their self-care and expect to reach or maintain their health and welfare through the foods they eat. In response to this demand, there has been...

Without Abstract

Nervous system is second to adipose tissue in containing the highest lipid concentration. Membrane phospholipids possess a high content of long chain polyunsaturated fatty acids (LCPUFA) of the n-3 and n-6 families, derived from the corresponding essential fatty acids. Docosahexaenoic acid (22:6n-3) is found in the highest concentrations in the gra...

The aim of the study was to examine effects of feeding diets containing different oils and antioxidant vitamins supplementation on the fatty acid composition of hepatic microsomal phospholipids in the rat. Forty-eight male Sprague Dawley rats were fed for 20 days diets containing 15% corn, olive, fish, or hazelnut oil, without or with the addition...

This study was undertaken to compare the effects of four oils: corn (C), olive (O), hazelnut (H) or fish (F), and the intake of two supplements: cholesterol, 1% (Ch) or dl-alpha-tocopherol acetate, 500 mg/kg, and beta-carotene, 30 mg/kg (V), on liver microsomal fluidity, cyt P450 content and aniline hydroxylase (AH), aminopyrine-N-dimethylase (AND)...

We examined the effects of vitamin supplement on the vascular smooth muscle response of rats fed four different oil diets, after a 20-day feeding period. Male Sprague Dawley rats were fed diets containing 15% of each hazelnut, corn, olive or fish oils, with/without 30 mg/kg beta-carotene and 500 mg/kg dl-alpha-tocopherylacetate. After the feeding p...

The experiment was designed to elucidate the effects of feeding four dietary oils (corn, hazelnut, olive, and fish), and cholesterol supplementation on plasma, liver lipids, and aortic smooth muscle response to drugs. Male Sprague Dawley rats were fed semipurified diets containing one of the above oils (15% wt/wt), either with or without cholestero...

The present investigation was designed to evaluate the comparative effects of the intake of a mixture of vegetable oils (peanut and rapeseed oils, 1:1) or salmon oil on the fatty acid relative composition of myelin and synaptosomes in rats. On the second generation of Wistar rats fed semipurified diets containing 6% (wt/wt) vegetable oils mixture o...

Sea-lion oil (SO) is used as a dietary supplement in the treatment of cardiovascular disease. The effects of SO on plasma lipid concentration and liver lipid histochemistry were compared with those of corn oil (CO). Male Sprague-Dawley rats were fed diets containing 15% (w/w) SO or CO with or without 1% cholesterol for 25 days. Compared with rats f...

The comparative effects of dietary level and time of feeding corn (CO) and rose hip (RHO) oils on bile and plasma lipid composition were studied. 48 males Sprague Dawley rats were divided in two groups fed semipurified diets containing CO or RHO as the only lipid source. Groups of 6 rats were fed ad libitum diets containing 5% or 15% vegetable oil...

The chemical composition, nutritional and toxicological evaluation of Nannochloropsis sp. were determined. The algal biomass was produced in a 63 L, 4 cm diameter fotobioreactor under outdoor conditions was enriched sea water medium. Its chemical composition was (g/100 g): proteins 40, lipids 25.5, crude fiber 5, N.N.E. 11.5, ash 10. The most abund...

Pharmacologic doses of ethinylestradiol are known to cause intrahepatic cholestasis in the rat. This is associated with a decrease in liver plasma membranes fluidity and a modification of the activity of membrane-bound enzymes related to bile flow. The intake of a diet containing highly polyunsaturated fats could modify the effects of estrogen, by...