Mariana Pires Figueiredo- Doctor of Science - Chemistry
- Postdoctoral Researcher at Université Laval
Mariana Pires Figueiredo
- Doctor of Science - Chemistry
- Postdoctoral Researcher at Université Laval
About
33
Publications
2,565
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Citations
Introduction
Dr. Mariana Pires Figueiredo earned her BSc and PhD in Chemistry from the University of São Paulo (IQ-USP), Brazil, supported by FAPESP scholarships. Her doctoral work focused on inorganic particle–polymer composites for biomedical applications, with research internships in France and Spain. She has worked as a postdoctoral researcher at Université Laval (Québec, Canada), supported by a PBEEE (FRQ) scholarship, developing biomaterials for tissue regeneration and implant surface modification.
Current institution
Education
March 2016 - August 2021
University of São Paulo
Field of study
- Biomaterials, polymers, inorganic drug carriers
March 2015 - December 2017
University of São Paulo
Field of study
February 2012 - December 2015
University of São Paulo
Field of study
Publications
Publications (33)
This review explores each stage of Collagen type I (Coll-I) hydrogel development, highlighting how sourcing, extraction, solubilization, and modification (e.g . , blending, crosslinking, and composite formation) influence its gelation, and structural, mechanical, and biological properties. By clarifying key interrelations among these characteristic...
N–acetyl–L–cysteine (NAC), a derivative of the L–cysteine amino acid, presents antioxidant and mucolytic properties of pharmaceutical interest. This work reports the preparation of organic-inorganic nanophases aiming for the development of drug delivery systems based on NAC intercalation into layered double hydroxides (LDH) of zinc–aluminum (Zn2Al–...
The development of biomaterials has a substantial role in pharmaceutical and medical strategies for the enhancement of life quality. This review work focused on versatile biomaterials based on nanocomposites comprising organic polymers and a class of layered inorganic nanoparticles, aiming for drug delivery (oral, transdermal, and ocular delivery)...
The diterpenoid abietate (ABI) ion, the conjugate base of the phytochemical abietic acid, was intercalated into a series of layered double hydroxides (LDH) with Mg2FeyAl(1-y) composition envisioning the preparation of drug delivery systems. Experimental parameters were evaluated to achieve organic-inorganic hybrid iron-based LDH as single-phases en...
The layered hexaniobate of K4Nb6O17 composition and its derivatives comprise nanostructured materials that exhibit suitable properties for application in catalysis, electrochemistry, and energy, for instance. The exchange of K+ cations to obtain the acidic or protonic niobate form is the main route to originate appropriate precursors to promote the...
In this work, Layered Double Hydroxide (LDH) materials carrying the worldwide administered non-steroidal anti-inflammatory drug naproxen (NAP), and the sodium naproxen salt for comparison, were studied by computational approaches aiming to model the structure of hybrid LDH-drug and shed light on NAP intercalation process. Atomic modelling calculati...
In this work, Al cation was gradually replaced by FeIII in the composition of Layered Double Hydroxides (LDH) and systematically investigated for LDH application as drug carriers, ultimate aiming to improve their biointegration. The incorporation of FeIII into LDH layers, as well the intercalation of organic anions in the iron‐based materials, is c...
This work developed an innovative membrane based on the high-performance PEBAX®2533 (PEBA) block copolymer and particles of iron-based layered double hydroxide (LDH) (Mg4FeAl layer composition) intercalated with phytotherapeutic abietate anions (ABI); both guest and host species are active in the promotion of wound healing. The presence of conjugat...
Layered Double Hydroxides (LDHs) are considered promising materials to compose pharmaceutical formulations and medical devices mainly by their capacity to act as carriers for anionic bioactive species. LDHs are mostly composed by Mg2+ and Zn2+ as divalent cations and Al3+ (exogenous) as trivalent cation. The substitution of aluminium by an endogeno...
Layered Double Hydroxides (LDH) and related nanocomposites have attracted much attention for biomedical applications and the development of LDH drug carriers composed by endogenous metals, such as iron, is of obvious interest. However, most of the studies reported so far on iron-containing LDH, mainly focusing on the applications, suffer from insuf...
This work presents the development of multifunctional therapeutic membranes based on a high-performance block copolymer scaffold formed by polyether (PE) and polyamide (PA) units (known as PEBA) and layered double hydroxide (LDH) biomaterials, with the aim to study their uses as wound dressings. Two LDH layer compositions were employed containing M...
This short-term course addresses materials such as Clay and Clay minerals, Layered Double Hydroxides (LDH), Layered Niobates, and Graphite/Graphene focusing on their structure and properties. The short-term course also presents methods for modulating properties of different layered materials, as well as materials applications. The authorship of thi...
Nowadays polymer dressings are expected to possess multiply functions. Besides acting as physical barriers, dressings may provide for the injured tissue species able to turn wound healing process faster and painless. In this way, dressings can be designed aiming to enable the release of drugs. The possibility to modulate drug release kinetics is a...
This work is concerned with the development and characterization of polylactic acid (PLA) – Layered Double Hydroxides (LDHs) membranes able to modulate drug release. In this way, membranes were prepared by deposition of successive electrospun PLA and electrosprayed LDHs layers, with different fibers thickness in order to obtain a thinner (approach...
This work is concerned with the development and characterization of polymer-layered double hydroxides (LDHs) composites for application as surgical and post-surgical devices. LDHs are able to encapsulate negatively charged bioactive species and to propitiate its prolonged release. Besides, these materials may interfere positively in tissues regener...
This work explores the synthesis, physicochemical characterization, and in vivo biocompatibility of iron-based layered double hydroxides (LDHs) with molar ratio M²⁺/(Fe³⁺ + Al³⁺) equal to 2, Fe³⁺/Al³⁺ equal to 1, and chloride anions as charge-compensating ion (abbreviated Mg4FeAl-Cl and Zn4FeAl-Cl) prepared by the coprecipitation method. The higher...
Inclusion compounds have been studied for pharmaceutical formulations in order to transcend adverse drug characteristics as low solubility, decomposition and side effects from administration. Layered double hydroxides (LDHs) possess great potential to act in drug storage and as delivery systems. This class of materials has the general formula [MII(...
This short-term course aims to provide chemical concepts involved in the saponification reaction, i.e. in the synthesis of soap from the alkaline hydrolysis of esters or triglycerides, such as cooking oil. In addition, the course consisted also of a practical laboratory class, where students prepare their own soaps. Finally, the course aims to prov...
