Mariana Medina-Sánchez

Mariana Medina-Sánchez
Leibniz Institute for Solid State and Materials Research Dresden | IFW Dresden · Institute for Integrative Nanosciences

Mechatronics Engineer, PhD

About

94
Publications
24,112
Reads
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3,131
Citations
Additional affiliations
January 2016 - present
Leibniz Institute for Solid State and Materials Research Dresden
Position
  • Group Leader
January 2014 - January 2016
Leibniz Institute for Solid State and Materials Research Dresden
Position
  • PostDoc Position
October 2009 - October 2013
Catalan Institute of Nanoscience and Nanotechnology
Position
  • PhD Student

Publications

Publications (94)
Conference Paper
Micro-and nanorobots have the potential to perform non-invasive drug delivery, sensing, and surgery in living organisms with the aid of diverse medical imaging techniques. To perform such actions with microrobots require high spatiotemporal resolution tracking methods with real-time closed-loop feedback. Photoacoustic imaging (PAI) has appeared to...
Conference Paper
Nowadays, 4D-printing lithography, based on two-photon polymerization (TPP), opens up a fascinating avenue to fabricate microscale structures with adaptive features. This technique enables the design of high-quality, freestanding 3D microstructures, made of smart materials, which offer the possibility to reconfigure and adapt according to their int...
Preprint
The Moebius strip, as a fascinating loop structure with one-sided topology, provides a rich playground for manipulating the non-trivial topological behavior of spinning particles, such as electrons, polaritons, and photons in both real and parameter spaces. For photons resonating in a Moebius-strip cavity, the occurrence of an extra phase, known as...
Article
Full-text available
Micromachines are small-scale human-made machines with remarkable potential for medical treatments, microrobotics and environmental remediation applications. However, meaningful real-world applications are missing. This is mainly caused by their small size leading to unintuitive physics of motion. Motivated by the aim of understanding the fundament...
Chapter
The ability to monitor molecular targets is crucial in fields ranging from healthcare to industrial processing to environmental protection. Devices employing biomolecules to achieve this goal are called biosensors. Over the last half century researchers have developed dozens of different biosensor approaches. In this chapter we analyze recent advan...
Article
Full-text available
Existing electronically integrated catheters rely on the manual assembly of separate components to integrate sensing and actuation capabilities. This strongly impedes their miniaturization and further integration. Here, we report an electronically integrated self-assembled microcatheter. Electronic components for sensing and actuation are embedded...
Article
Full-text available
Today’s smallest energy storage devices for in-vivo applications are larger than 3 mm ³ and lack the ability to continuously drive the complex functions of smart dust electronic and microrobotic systems. Here, we create a tubular biosupercapacitor occupying a mere volume of 1/1000 mm ³ (=1 nanoliter), yet delivering up to 1.6 V in blood. The tubula...
Article
Full-text available
The fast evolution of medical micro‐ and nanorobots in the endeavor to perform non‐invasive medical operations in living organisms has boosted the use of diverse medical imaging techniques in the last years. Among those techniques, photoacoustic imaging (PAI), considered a functional technique, has shown to be promising for the visualization of mic...
Article
Full-text available
Sperm-driven micromotors, consisting of a single sperm cell captured in a microcap, utilize the strong propulsion generated by the flagellar beat of motile spermatozoa for locomotion. It enables the movement of such micromotors in biological media, while being steered remotely by means of an external magnetic field. The substantial decrease in swim...
Article
Full-text available
In the last decades, additive manufacturing (AM), also called three-dimensional (3D) printing, has advanced micro/nano-fabrication technologies, especially in applications like lightweight engineering, optics, energy, and biomedicine. Among these 3D printing technologies, two-photon polymerization (TPP) is the technique which offers the highest res...
Article
Transparent Ti‐45Nb 3D microstructures offer an elegant way to study single bone cell‐implant material interactions and pore size effects in vitro. In article number 2005527, Mariana Medina‐Sánchez and co‐workers present this technology as an excellent tool to live monitor cell migration and adhesion behavior changes deriving from highly constricte...
Article
Full-text available
Titanium and its alloys are frequently used to replace structural components of the human body due to their high mechanical strength, low stiffness, and biocompatibility. In particular, the use of porous materials has improved implant stabilization and the promotion of bone. However, it remains unclear which material properties and geometrical cues...
Article
Full-text available
Different propulsion mechanisms have been suggested for describing the motion of a variety of chemical micromotors, which have attracted great attention in the last decades due to their high efficiency and thrust force, enabling several applications in the fields of environmental remediation and biomedicine. Bubble‐recoil based motion, in particula...
Article
Full-text available
The next generation of biomedical tools requires reshapeable electronics to closely interface with biological tissues. This will offer unique mechanical properties and the ability to conform to irregular geometries while being robust and lightweight. Such devices can be achieved with soft materials and thin‐film structures that are able to reshape...
Article
Full-text available
Analytical platforms based on impedance spectroscopy are promising for non-invasive and label-free analysis of single cells as well as of their extracellular matrix, being essential to understand cell function in the presence of certain diseases. Here, an innovative rolled-up impedimetric microfulidic sensor, called sensor-in-a-tube, is introduced...
Article
Full-text available
Systemic chemotherapy remains the backbone of many cancer treatments. Due to its untargeted nature and the severe side effects it can cause, numerous nanomedicine approaches have been developed to overcome these issues. However, targeted delivery of therapeutics remains challenging. Engineering microrobots is increasingly receiving attention in thi...
Preprint
Full-text available
Different propulsion mechanisms have been suggested for describing the motion of a variety of chemical micromotors, including the bubble-recoil mechanism, which has attracted great attention in the last decades due to its high efficiency and thrust force, enabling several applications in the fields of environmental remediation and biomedicine. Bubb...
Article
Full-text available
Cellular micromotors are attractive for locally delivering high concentrations of drug, and targeting hard-to-reach disease sites such as cervical cancer and early ovarian cancer lesions by non-invasive means. Spermatozoa are highly efficient micromotors perfectly adapted to traveling up the female reproductive system. Indeed, bovine sperm-based mi...
Article
Full-text available
Embryo transfer (ET) is a decisive step in the in vitro fertilization process. In most cases, the embryo is transferred to the uterus after several days of in vitro culture. Although studies have identified the beneficial effects of ET on proper embryo development in the earlier stages, this strategy is compromised by the necessity to transfer earl...
Article
Full-text available
In article number 2000843, Mariana Medina‐Sánchez and co‐workers demonstrate a spiralshaped micropropeller that can capture, transport, and release a zygote, actuated solely by an external rotating magnetic fi eld, as a noninvasive alternative concept to laparoscopy, that is, zygote intrafallopian transfer by micromotors. This procedure is envision...
Article
Medical microrobots (MRs) have been demonstrated for a variety of non-invasive biomedical applications, such as tissue engineering, drug delivery, and assisted fertilization, among others. However, most of these demonstrations have been carried out in in vitro settings and under optical microscopy, being significantly different from the clinical pr...
Article
Full-text available
We develop biohybrid magnetic microrobots by electrostatic self-assembly of nonmotile sperm cells and magnetic nanoparticles. Incorporating a biological entity into microrobots entails many functional advantages beyond shape templating, such as the facile uptake of chemotherapeutic agents to achieve targeted drug delivery. We present a single-step...
Preprint
Full-text available
The fast evolution of medical micro- and nanorobots in the endeavor to perform non-invasive medical operations in living organisms boosted the use of diverse medical imaging techniques in the last years. Among those techniques, photoacoustic (PA) tomography has shown to be promising for the imaging of microrobots in deep-tissue (ex vivo and in vivo...
Article
Full-text available
A cluster of motile and mature sperm previously immobilized on the BSA‐HA microflake is transported by a magnetically‐driven microhelix, which delivers the sperm‐loaded microflake close to the area of interest. Due to the presence of local proteases, the microflake is then hydrolyzed allowing the sperm release to finally reach the target location....
Article
Full-text available
An integrated system combining a magnetically‐driven micromotor and a synthetized protein‐based hyaluronic acid (HA) microflake is presented as a novel strategy for the in‐situ selection and transport of multiple motile sperm cells (ca. 50). The proposed system appeals for targeted sperm delivery in the reproductive system to assist fertilization o...
Article
Full-text available
Biohybrid micromotors propelled by motile cells are fascinating entities for autonomous biomedical operations on the microscale. Their operation under physiological conditions, including highly viscous environments, is an essential prerequisite to be translated to in vivo settings. In this work, a sperm‐driven microswimmer, referred to as a spermbo...
Article
Full-text available
By virtue of the well‐developed micro‐ and nanofabrication technologies and rapidly progressing surface functionalization strategies, silicon‐based devices have been widely recognized as a highly promising platform for the next‐generation lab‐on‐a‐chip bioanalytical systems with a great potential for point‐of‐care medical diagnostics. Herein, an ov...
Article
Full-text available
Microscale systems that can combine multiple functionalities, such as untethered motion, actuation and communication, could be of use in a variety of applications from robotics to drug delivery. However, these systems require both rigid and flexible components—including microelectronic circuits, engines, actuators, sensors, controllers and power su...
Article
Micromotors are recognized as promising candidates for untethered micromanipulation and targeted cargo-delivery in complex biological environments. However, their feasibility in the circulatory system has been limited due to the low thrust force exhibited by many of the reported synthetic micromotors, being not sufficient to overcome the high flows...
Article
Full-text available
Medical micromotors have the potential to lead to a paradigm shift in future biomedicine, as they may perform active drug delivery, microsurgery, tissue engineering, or assisted fertilization in a minimally invasive manner. However, the translation to clinical treatment is challenging, as many applications of single or few micromotors require real-...
Article
Full-text available
The development of functional microstructures with designed hierarchical and complex morphologies and large free active surfaces offers new potential for improvement of the pristine microstructures properties by the synergistic combination of microscopic as well as nanoscopic effects. In this contribution, dedicated methods of transmission electron...
Article
Full-text available
The ability to separate specific biological components from cell suspensions is indispensable for liquid biopsies, and for personalized diagnostics and therapy. This paper describes an advanced surface acoustic wave (SAW) based device designed for the enrichment of platelets (PLTs) from a dispersion of PLTs and red blood cells (RBCs) at whole blood...
Article
Full-text available
Sperm cells that cannot swim and orient properly compromise male fertility. Such defects are responsible for male infertility regardless of the actual quality of the most important content, the sperm's DNA. Synthetic micromotors are engineered devices that are able to swim in (body) fluids and microscopic environments, similar to flagellated cells...
Conference Paper
The emerging research field of functional micro devices and microbots aims at developing remote-controlled microsensors and actuators that can operate inside living organisms for biomedical applications. However, a significant gap remains in controlling with high accuracy such microdevices in complex environments. This is primarily due to the lack...
Article
The rapid advance of micro/nanofabrication technologies opens up new opportunities for miniaturized sensing devices based on novel three-dimensional (3D) architectures. Notably, microtubular geometry exhibits natural advantages for sensing applications due to its unique properties including the hollow sensing channel, high surface-volume ratio, wel...
Preprint
Medical imaging plays an important role in diagnosis and treatment of multiple diseases. It is a field under continuous development which seeks for improved sensitivity and spatiotemporal resolution to allow the dynamic monitoring of diverse biological processes that occur at the micro- and nanoscale. Emerging technologies for targeted diagnosis an...
Preprint
Cellular micromotors are attractive for locally delivering high concentrations of drug and targeting hard-to-reach disease sites such as cervical cancer and early ovarian cancer lesions by non-invasive means. Spermatozoa are highly efficient micromotors perfectly adapted to traveling up the female reproductive system. Indeed, bovine sperm-based mic...
Article
Full-text available
Using materials with properties similar to those of cells and microorganisms together with innovative fabrication methods, soft and smart microrobots can be developed, with increased adaptability and flexibility toward in vivo applications. These tiny robots are designed to carry out difficult tasks such as noninvasive microsurgery, diagnosis and t...
Article
Full-text available
Micro- and nano-motors are emerging as novel drug delivery platforms, offering advantages such as rapid drug transport, high tissue penetration and motion controllability. They can be propelled and/or guided by endogenous (i.e., chemotaxis) or exogenous stimuli (e.g., ultrasound, magnetic fields, light) toward the area of interest. Moreover, such s...
Article
The lab-in-a-tube device developed by Mariana Medina-Sánchez and co-workers in article number 1700193 consists of a transparent rolled-up tube with tunable diameter that can be adapted depending on the cell type under study. Different components are integrated into the structure, enabling cell capture, stimulation, and analysis. The measured signal...
Article
Full-text available
The growing interest in the design and fabrication of novel autonomous micro- and nanoparticles is motivated by the vast advances in their motion efficiency and their further implementation in both biomedical and environmental fields. The present review covers the motion principle and fabrication procedures of synthetic and hybrid particle-like mic...
Article
Due to the heterogeneity that exists even between cells of the same tissue, it is essential to use techniques and devices able to resolve the characteristics of single biological cells, such as morphology, metabolism, or response to drugs. To that end, different structures with sizes similar to that of individual cells have been developed in recent...
Article
Full-text available
A sperm-driven micromotor is presented as a targeted drug delivery system, which is appealing to potentially treat diseases in the female reproductive tract. This system is demonstrated to be an efficient drug delivery vehicle by first loading a motile sperm cell with doxorubicin hydrochloride (DOX-HCl, an anticancer drug), then guiding it, using a...
Article
Full-text available
The intriguing properties of self-assembled microtubular architectures open new possibilities to develop three-dimensional functional devices for molecule and cell analysis. [...]
Article
Full-text available
Micromotors are devices that operate at the microscale and convert energy to motion. Many micromotors are microswimmers, i.e., devices that can move freely in a liquid at a low Reynolds number, where viscous drag dominates over inertia. Hybrid biomicromotors are microswimmers that consist of both biological and artificial components, i.e., one or s...
Article
Despite all the efforts made over years to study the cancer expression and the metastasis event, there is not a clear understanding of its origins and effective treatment. Therefore, more specialized and rapid techniques are required for studying cell behaviour under different drug-based treatments. Here we present a quantum dot signalling-based ce...
Conference Paper
Biohybrid systems are promising solutions in micro- and nanobiotechnology due to the possibility to combine exciting biological properties of living microorganisms/cells (e.g. sensing and taxis mechanisms), and the controllability of man-made microstructures. Here we present the development of tubular and helical spermbots, a concept that refers to...
Article
We report biogenic micromotor design consisting of porous chalky elongated tubes (~60 µm length) coated with Fe-Pt for dual functionality i.e. metallic gold formation and rapid isolation. These autonomously propelled scavengers once introduced in the reaction environment, showed rapid bubble-propulsion followed by high-purity separation of the visu...
Article
In article no. 1606301, different approaches for integrating spermatozoa as functional components of microrobotic devices are discussed by Veronika Magdanz, Mariana Medina-Sánchez, and co-workers in article number 1606301. Different ways for remote-controlled guidance of single spermatozoa include rolled-up nanomembranes, which can unfold and relea...
Article
Scientists are designing microscopic devices — microbots and micromotors — to eventually move through the body to perform medical tasks. So far, most microbot experiments have been done in vitro under conditions very different from those in the human body. In our extended comment we call on microrobotics researchers, materials scientists and bioima...
Article
Full-text available
A sperm-driven micromotor is presented as cargo-delivery system for the treatment of gynecological cancers. This particular hybrid micromotor is appealing to treat diseases in the female reproductive tract, the physiological environment that sperm cells are naturally adapted to swim in. Here, the single sperm cell serves as an active drug carrier a...
Article
In recent years, the combination of synthetic micro- and nanomaterials with spermatozoa as functional components has led to the development of tubular and helical spermbots - microrobotic devices with potential applications in the biomedical and nanotechnological field. Here, the initial advances in this field are discussed and the use of spermatoz...
Presentation
Introduction The interdisciplinary field of microrobotics recently sparked interest especially in potential applications of mobile microscale devices that can operate remotely-controlled inside the human body. This study presents an approach towards such an application, namely assisted reproduction with the help of tiny sperm carriers, so-called sp...
Article
We report an ultrasensitive label-free DNA biosensor with fully on-chip integrated rolled-up nanomembrane electrodes in which the hybridization of complementary DNA strands (Avian Influenza Virus subtype H1N1) is selectively detected down to attomolar concentrations - an unprecedented level for miniaturized sensors without amplification. Impedimetr...