Marian Paluch

• Prof.
• Head of Department at University of Silesia in Katowice

The concept of density scaling, which perfectly works for many real van der Waals liquids and polymers, is examined for two quasi-real model systems to elucidate the origin of the density scaling exponent. Examined systems comprise the same, purely repulsive atoms that interact via the potential of the Inverse Power Law form that implies a perfect...

The effects of alkyl chain length on the crystallization kinetics and ion mobility of tetraalkylphosphonium, [P666,n][TFSI], (n = 2, 6, 8, and 12) ionic liquids were studied by differential scanning calorimetry (DSC) and broadband dielectric spectroscopy (BDS) over a wide temperature range. The liquid–glass transition temperature (Tg) and ion dynam...

A reversible, first-order transition separating two liquid phases of a single-component material is a fascinating yet poorly understood phenomenon. Here, we investigate the liquid–liquid transition (LLT) ability of two tetraalkylphosphonium ionic liquids (ILs), [P666,14]Cl and [P666,14][1,2,4-triazolide], using differential scanning calorimetry and...

In this study, we employed dielectric spectroscopy to investigate the effect of temperature and pressure on the ion dynamics of phosphonium ionic liquids (ILs) differing by the length of an alkyl chain, [P666,n][TFSI] (n = 2, 6, 8, 12). We found that both temperature and pressure dependence of dc-conductivity (σdc) determined for all examined ILs h...

In this article, we unravel the problem of interpreting the density scaling exponent for the polyatomic molecules representing the real van der Waals liquids. Our studies show that the density scaling exponent is a weighted average of the exponents of the repulsive terms of all interatomic interactions that occur between molecules, where the potent...

Although the first-order liquid–liquid phase transition (LLT) has been reported to exist in various systems (i.e., phosphorus, silicon, water, triphenyl phosphite, etc.), it is still one of the most challenging problems in the field of physical science. Recently, we found that this phenomenon occurs in the family of trihexyl(tetradecyl)phosphonium...

In this paper, we directly verify the methods of determining the free volumes proposed in the literature. Using the computer simulations of the molecular dynamics for two quasi-real model systems we estimate, in the possibly most direct way, the excluded volume, which is a quantity crucial for the calculation of the free volume. The values of the e...

The stability of amorphous drugs is among the main challenges in the development of solid dosage forms. This paper examines the effect of storage conditions (25 °C/60% RH and 40 °C/75% RH) and different packaging materials, i.e., polystyrene containers and PVC/Al blisters, on the crystallinity and dissolution characteristics of solid dispersions co...

In this paper, the steric hindrance effect related to the presence of either an aromatic or cyclic ring on the self-association process in the series of monohydroxy alcohols (MAs), from cyclohexanemethanol to 4-cyclohexyl-1-butanol and from benzyl alcohol to 4-phenyl-1-butanol, was studied using X-Ray Diffraction (XRD), Differential Scanning Calori...

The studies of molecular dynamics in the vicinity of liquid–glass transition are an essential part of condensed matter physics. Various experimental techniques are usually applied to understand different aspects of molecular motions, i.e., nuclear magnetic resonance (NMR), photon correlation spectroscopy (PCS), mechanical shear relaxation (MR), and...

An ultimate aim of researchers is to predict the properties of matter based on the molecular structure. However, despite many efforts, this goal is still far from being achieved. Herein, using an example of two compounds differing from each other only in the type of six-carbon ring, i.e., benzene vs. cyclohexane, we show how aromaticity affects the...

Itraconazole (ITZ) is a thermotropic liquid crystal that exhibits isotropic, nematic, and smectic phases on cooling towards the glass transition upon melting. Over the years, new aspects regarding the liquid-crystalline ordering of this antifungal drug were systematically revealed. It has been shown recently that the temperature range of individual...

We examined a series of structurally related glass-forming liquids in which a phenothiazine-based tricyclic core (PTZ) was modified by attaching n -alkyl chains of different lengths ( n = 4, 8, 10). We systematically disentangled the impact of chemical structure modification on the intermolecular organization and molecular dynamics probed by broadb...

In this paper, we have studied local structure, interactions scheme, and molecular dynamics of series of aliphatic butanol (AB) isomers: n-butanol, iso-butanol, sec-butanol, and their phenyl counterparts (PhB): 4-phenyl-1-butanol, 2-methyl-3-phenyl-1-propanol, and 4-phenyl-2-butanol by means of X-ray diffraction (XRD), Fourier transform infrared (F...

In this work, we show how the structure and intermolecular interactions affect the dynamic heterogeneity of aprotic ionic liquids. Using calorimetric data for thirty ionic samples, we examine the influence of the strength of van der Waals and Coulombic interactions on dynamic heterogeneity. We show that the dynamic length scale of spatially heterog...

In this work, we compare the dielectric properties of single-crystal and pelletized perovskite-like formamidinium-templated inorganic-organic hybrid [NH2CHNH2][Mn(HCOO)3] (FAMn) at ambient pressure. Furthermore, we report pressure-dependent dielectric measurements of pelletized FAMn allowing us to determine the equation of state, as well as changes...

Herein, we investigated the molecular dynamics as well as intramolecular interactions in two primary monohydroxy alcohols (MA), 2-ethyl-1-hexanol (2EHOH) and n-butanol (nBOH), by means of broad-band dielectric (BDS) and Fourier transform infrared (FTIR) spectroscopy. The modeling data obtained from dielectric studies within the Rubinstein approach...

The Walden rule, revealing a universal conductivity-viscosity relationship, is considered as a useful tool to investigate the transport mechanism in ionic liquids (ILs). In this work, we constructed the Walden plots covering 10 orders of magnitude for two ILs: 1-butyl-2,3-dimethylimidazolium bis(trifluoromethylsulfonyl)imide [BMMIm][NTf2] and 1-but...

Fast ON/OFF switches are the basis of contemporary microelectronics. Dielectrics alternating between high and low dielectric permittivity states (ON and OFF, respectively) seem to be up-and-coming candidates for efficient switches. Currently, the change of their state is induced by a temperature gradient, which is a relatively slow process. In this...

The subject of the invention is a method of pressure polymerization of γ-butyrolactone (GBL), enabling the production of chemically pure poly(γ-butyrolactone) PGBL, consisting in mixing the monomer in the form of γ-butyrolactone with a catalyst in the form of 1,5,7-triazabicyclo[ 4.4.0]dec-5-ene, preferably dried, in a catalyst to monomer ratio ran...

The Adam–Gibbs (AG) model, linking thermodynamics with molecular dynamics of glass-forming liquids, plays a crucial role in the studies of the glass transition phenomenon. We employ this approach to investigate the relationship between ion dynamics and thermodynamics in three imidazolium-based ionic liquids in the current work. We show that the AG...

The invention relates to a method for producing poly(N-vinylpyrrolidone) through pressure-induced free-radical polymerization of N-vinylpyrrolidone (NVP) initiated by light, either in bulk or in a solvent, under favorable pressure and temperature conditions (p and T). The method involves adding a radical photoinitiator to the monomer in the form of...

In this paper, we examine the virial- and the potential-energy correlation for quasireal model systems. This correlation constitutes the framework of the theory of the isomorph in the liquid phase diagram commonly examined using simple liquids. Interestingly, our results show that for the systems characterized by structural anisotropy and flexible...

In this Letter we report significant differences in the dielectric behavior of four nonpolymeric and sizable glass-forming molecules with related chemical structures. They belong to the recently constituted class of sizable glass-formers [Jedrzejowska et al. Phys. Rev. E: Stat. Phys., Plasmas, Fluids, Relat. Interdiscip. Top. 2020, 101, 010603], fo...

Over the last decade, the volume has been envisioned as a critical variable controlling the dynamics of glass-forming systems in general, and charge transport of ionic conductors in particular. Herein, we use theoretical and experimental approaches to investigate the volume effects in a specific 1,2,3-triazolium-base poly(ionic liquid) (PIL) at bot...

The rich dielectric properties of hybrid formate frameworks are tightly related to the dipolar dynamics and phase transitions of these compounds. A complete understanding of such phenomena requires experiments performed under non-standard conditions. Herein, we report high-pressure dielectric properties of anisotropic single crystal of 1,4-diaminob...

The glassy, supercooled, and normal liquid states of the 1-alkyl-3-methylimidazolium tricyanomethanide series [CnC1im][TCM] (n = 2, 4, 6, 8, 16) were investigated using dielectric and mechanical (rheological) experiments supplemented by X-ray diffraction. The conductivity relaxation was found to be accompanied by a pronounced secondary relaxation....

In this paper, conductivity and viscosity of 1-alkyl-3-methylimidazolium tricyanomethanide series ([CnC1im][TCM], where n = 2, 4, 6, and 8) were measured and analyzed in the broad temperature range covering supercooled and normal liquid states at ambient pressure. The density at ambient pressure up to 363.15 K was also investigated. From these expe...

The density scaling behavior of dynamics and thermodynamics is investigated in ionic liquids. By comparing the scaling exponent of different dynamic quantities (dc-conductivity, viscosity, and diffusion) of a series of homologous ionic liquids, we discover that longer alkyl chain in the cation provides lower scaling value. Additionally, a systemati...

Since 1998 the primitive relaxation time τ 0(T,P) of the Coupling Model (CM) and the Johari-Goldstein (JG) β-relaxation time τJG(T,P) are shown approximately equal in many glass-formers. The CM relation between τ 0(T,P) and τα(T,P) at any T and P is exact. Additionally from the CM relation τα(T,P)/τ 0(T,P) is exactly invariant to variations of T an...

In this letter, we examine the virial and the potential energy correlation for the quasi-real model system. This correlation constitutes the framework of the theory of the isomorph in the liquid phase diagram commonly examined using simple-liquids. Interestingly, our results show that for the systems characterized by structural anisotropy and flexi...

Segmental dynamics is considered as a major factor governing ionic conductivity of polymerized ionic liquids (PILs), envisioned as potential electrolytes in fuel cells and batteries. Our dielectric studies performed in T−P thermodynamic space on ionene, composed of the positively charged polymer backbone and freely moving anions, indicate that othe...

In this article, the kinetics of shear-induced alignment changes in the nematic phase of itraconazole (ITR) has been investigated by means of rheo-dielectric experimental technique. We discovered that the nematic alignment modifications in ITR are retarded by increasing the temperature and therefore are associated with negative activation energy. I...

In this communication, the Adam–Gibbs model connecting molecular dynamics with configurational entropy is tested for the first timefor ionic liquids. For this purpose, we investigate simultaneously the shear viscosityηand configurational entropyScof an aprotic ionicliquid: 1-butyl-3-methylimidazolium bis(trifluoromethylsulfonyl)imide (BMIm TFSI). C...

The relaxation dynamics and thermodynamic properties of supercooled and glassy gambogic acid are investigated using both theory and experiment. We measure the temperature dependence of the relaxation times in three polymorphs (alpha-, beta-, and gamma-form). To gain insight into the relaxation processes, we propose a theoretical approach to quantit...

In this paper, we present facile synthetic strategies enabling production of well-defined poly(ionic liquids) PILs based on 1-vinyl-4-benzyl-3-methylimidazolium- (VBIm) and 1-vinyl-4-benzyl-3-methylpyrrolidium (VBPy) ionic liquids (IL) possessing different counterions (chloride Cl􀀀 vs. bis(trifluoromethanesulfonyl)imide NTf2 - ) (VBIm/NTf2,VBIm/Cl,...

In this paper, based on the molecular dynamics simulations of quasireal model systems, we propose a method for determination of the effective intermolecular potential for real materials. We show that in contrast to the simple liquids, the effective intermolecular potential for the studied systems depends on the thermodynamic conditions. Nevertheles...

We examine the density scaling properties of two ionic materials, a classic aprotic low molecular weight ionic liquid, 1-butyl-3-methylimidazolium bis(perfluoroethylsulfonyl)imide ([BMIm][BETI]), and a polymeric ionic liquid, poly(3-methyl-1,2,3-triazolium bis(trifluoromethylsulfonyl)imide) (TPIL). Density scaling is known to apply rigorously to si...

In this Rapid Communication we report the unusual dynamics of planar, rigid, and anisotropy glass-forming molecules of unusually large size by dielectric spectroscopy by using two examples. The size of the molecules is much larger than the dipolar moiety located at the end of the longer axis of each molecule. The observed dynamics deviates strongly...

In this paper, Broadband dielectric spectroscopy (BDS) has been applied to study molecular dynamics and crystallization kinetics of antihyperlipidemic active pharmaceutical ingredient (API) – gemfibrozil (GEM), as well as its deuterated (dGEM) and methylated (metGEM) derivatives, characterized with different type and strength of intermolecular inte...

Computer simulations of model systems play a remarkable role in the contemporary studies of structural, dynamic and thermodynamic properties of supercooled liquids. However, the commonly employed model systems, i.e., simple-liquids, do not reflect the internal features of the real molecules, e.g., structural anisotropy and spatial distribution of c...

Infrared and dielectric spectroscopy, X-ray diffraction, and density functional theory computations have been used to study hydrogen-bonding pattern, molecular dynamics, internal structure, and dipole moment distribution in 2-ethyl-1-hexanol, 2-ethyl-1-hexylamine, 2-ethyl-1-hexanethiol, and 1-phenyl-2-butanol. Dielectric investigations revealed tha...

In recent years, ionic liquids (ILs) have been developed as novel solvents, electrolytes, and functional materials for numerous applications in diverse fields. Of interest is confining ILs into various nanoporous matrices, which not only solve the drawbacks of ILs due to their fluid nature, for example, electrolyte leakage in batteries, but also en...

Theoretical approaches are formulated to investigate the molecular mobility under various cooling rates of amorphous drugs. We describe the structural relaxation of a tagged molecule as a coupled process of cage-scale dynamics and collective molecular rearrangement beyond the first coordination shell. The coupling between local and non-local dynami...

Theoretical approaches are formulated to investigate the molecular mobility under various cooling rates of amorphous drugs. We describe the structural relaxation of a tagged molecule as a coupled process of cage-scale dynamics and collective molecular rearrangement beyond the first coordination shell. The coupling between local and non-local dynami...

Broadband dielectric spectroscopy (BDS), combined with X-ray diffraction (XRD) and Fourier transform infrared (FTIR) techniques were used to study the dynamics of primary (α) relaxation process and slow mode (SM), as well as structural properties and intermolecular interactions in the methyl-, isopropyl-, hexyl-, and benzyl derivative of a well-kno...

Advance was made recently in identifying the nature of the Debye relaxation observed by dielectric spectroscopy in monohydroxy alcohols by other experimental techniques. Consistent with the experimental findings, the transient chain model give a good description of the origin of the Debye relaxation. Notwithstanding, a general property of the Debye...

In this paper, Broadband Dielectric Spectroscopy (BDS) has been applied to study the molecular dynamics of the two active pharmaceutical ingredients (APIs), probucol (PRO) and droperidol (DRO), above and below the glass transition temperature, at varying thermodynamic conditions. We found that the structural (α)-relaxation process in both compounds...

The article describes the preparation and characterization of 3D-printed tablets with bicalutamide obtained using two-material co-extrusion-based fused deposition modeling (FDM). This method is a modification of typical two-material FDM where separate nozzles are used to print from two filaments. In this work we used a ZMorph® 3D printer with DualP...

One of the greatest problems of pre-clinical development of new chemical entities is their poor aqueous solubility. Herein, we focus our attention on MD20 – a novel calcium channel blocker that selectively blocks T-type calcium channel (Cav3.2) over L-type calcium channel (Cav1.2). To avoid future problems with limited solubility of this compound,...

In this paper, catalyzed and non-catalyzed water-initiated Ring-Opening Polymerization (ROP) of ε-caprolactone (ε-CL) at varying thermodynamic conditions (T=293-393 K and p=0.1-500 MPa) was carried out. As organocatalysts, two non-nucleophilic bases characterized by a different mode of action, i.e. 1,8-Diazabicyclo(5.4.0)undec-7-ene (DBU) and 1,5,7...

Currently, a great effort is put on the understanding of the effect of the nanometrical constraint on the dynamics of the soft materials. Recent studies by Alexandris et al. [Macromolecules, 2016, 49, 7400–7414] and some of us [J. Phys. Chem. C, 2019, 123, 5549–5556] revealed that the enhancement of the molecular mobility and depression in the glas...

In this paper, we studied the impact of saccharides having a similar backbone but differing in the degree of freedom, local molecular mobility, flexibility of the ring and intermolecular interactions on the glass-forming ability (GFA) of naproxen (NAP) in binary mixtures. For this purpose, a series of methyl and acetyl derivatives of glucose (GLS)...

This Letter addresses a fundamental issue of condensed-matter physics, which is the validity of the density-scaling concept. For this purpose, the ambient and high-pressure conductivity measurements of two selected ionic liquids (ILs), with the different contribution of H-bonding interactions, were performed in the dynamic range of 13 orders of mag...

In glass-forming liquids, there is a secondary β-relaxation that bears a strong connection to structural α-relaxation and is of fundamental importance. It is natural to inquire whether ionic conductivity relaxation in ionic conductors possesses the same property. This question has not been answered before because β-relaxation had not been found or...

The vitrification process is usually preceded by the significant change (around 6-8 decades) in the viscosity, structural relaxation times, or diffusion that occurs in a relatively small range of temperatures in fragile liquids. Along with this phenomenon, also conformations of the molecules vary as well. In fact, this process is studied in bulk po...

The subject of the invention is a method of pressure polymerization of 1-vinyl-2-pyrrolidone (VP), enabling the production of chemically pure poly(1-vinyl-2-pyrrolidone) PVP, consisting in the monomer in the form of 1-vinyl-2-pyrrolidone (VP ) with a purity preferably above 99%, is mixed with a thermoinitiator in the form of azobis(isobutyronitrile...

In this paper, we employed Broadband Dielectric Spectroscopy (BDS) in order to determine the effect of the high pressure on the solubility limits of the amorphous flutamide within Kollidon VA64 matrix. In order to achieve this goal, drug-polymer systems have been examined: (i) at ambient pressure and both isothermal and nonisothermal conditions by...

In this paper, we examine the transport properties of a 1,2,3-triazolium9 based poly(ionic liquid) (PIL) at ambient and elevated pressure up to 475 MPa. We show that the isothermal and isobaric conductivity measurements analyzed in the 3D plane give a unique possibility to estimate the thermodynamic (isothermal compressibility and thermal expansion...

The article describes the preparation and characterization of binary mixtures of two antiandrogens used in prostate cancer treatment, i.e. flutamide (FL) and bicalutamide (BIC), as well as their ternary mixtures with either poly(methyl methacrylate-co-ethyl acrylate) (MMA/EA) or polyvinylpyrrolidone (PVP). The samples were converted into amorphous...

The uniform thin films with variable thicknesses (d = 49, 120, 220 nm) of active pharmaceutical ingredient (API) glibenclamide (GCM) was spin-coated and investigated using broadband dielectric, grazing incident FTIR spectroscopies, atomic force microscopy, and ellipsometry. Data analysis revealed that nanoconfined systems consist of a mixture of am...

Broadband Dielectric Spectroscopy (BDS) at elevated pressures and Positron Annihilation Lifetime Spectroscopy (PALS) are employed to elucidate the importance of the ratio of activation and free volumes during vitrification. We...

We propose a simple approach to investigate the structural relaxation time and glass transition of amorphous drugs. Amorphous materials are modeled as a set of equal sized hard spheres. The structural relaxation time over many decades in hard sphere fluids is theoretically calculated using the Elastically Collective Nonlinear Langevin Equation theo...

We propose a simple approach to investigate the structural relaxation time and glass transition of amorphous drugs. Amorphous materials are modeled as a set of equal sized hard spheres. The structural relaxation time over many decades in hard sphere fluids is theoretically calculated using the Elastically Collective Nonlinear Langevin Equation theo...

Using dielectric spectroscopy, we demonstrate that confinement-induced changes in the glass transition dynamics, as observed for polymethylphenylsiloxane in alumina nanopores, reveal a pronounced nonequilibrium nature. Our results indicate that glass formers confined to nanopores are able to recover their bulklike mobility. We found that the charac...

We report, for the first time, the metal-free green synthesis of linear poly(vinyl pyrrolidone) (PVP) homopolymers of molecular weight higher than 100 kg/mol and narrow dispersities via thermal and photo-induced...

In this paper, we explored the influence of both the variation in the molecular weight (M n = 400, 2000, 4000 g/mol) and the terminal groups (hydroxyl, amino, and methoxy) on the molecular dynamics of poly(propylene glycols) confined within anodic aluminum oxide membranes of different pore diameters. All confined samples revealed the presence of tw...

This work focuses on the influence of non-polar side-chain length on the glass transition dynamics and crystallization behavior of a family of non-aromatic pyrrolidinium-based ionic liquids bearing bis(trifluoromethanesulfonyl)imide counterion, [CnMPyrr]+[Tf2N]−, where n varies from 4-8. A combination of different experimental techniques, including...

In this paper, comprehensive calorimetric, structural, inter- and intramolecular dynamics measurements with the use of Differential Scanning Calorimetry (DSC), X-ray diffraction (XRD), Broadband Dielectric and Fourier Transform Infrared (FTIR) spectroscopies have been applied to investigate properties of itraconazole (ITZ) glasses obtained via slow...

Different experimental techniques were applied to study thermal and structural properties, strength of H-bonds, possible keto-enol tautomerism and molecular dynamics at various thermodynamic conditions in the H-bonded active substance, curcumin (CRM). Dielectric measurements revealed dynamical features of examined compound that are uncharacteristic...

In this paper, the high-pressure calorimetry was used to monitor the heat of the polymerization of bisphenol-A diglycidyl ether (DGEBA) mixed with a stoichiometric amount of aniline over a wide range of pressure (p = 0.1–350 MPa at T = 298.15 K). To the best of our knowledge, this is the first high-pressure calorimetric study of the reaction kineti...

In this paper, we investigate the temperature-dependent relaxation dynamics in the glassy and supercooled liquid state of dipolar and ionic eutectic mixtures made of two anesthetic agents (lidocaine and prilocaine) and their hydrochloride salts, respectively. In addition to eutectic phases containing 1:1 and 4:1 mol/mol of LD/PRL and LD-HCl/PRL-HCl...

The self-assembly phenomenon of amphiphiles has attracted particular attention in recent years due to its wide range of applications. The formation of nanoassemblies able to solubilize sparingly water-soluble drugs was found to be a strategy to solve the problem of poor solubility of active pharmaceutical ingredients. Binary and ternary solid dispe...

The purpose of this paper is to examine the physical stability as well as viscoelastic properties of the binary amorphous ezetimibe–simvastatin system. According to our knowledge, this is the first time that such an amorphous composition is prepared and investigated. The tendency toward re-crystallization of the amorphous ezetimibe–simvastatin syst...

The series of N-alkylpyridinium bis(trifluoromethylsulfonyl)imide, [Cnpy][NTf2], where n = 2, 3, 4, 6, and 8 have been synthesized and the effect of alkyl chain length in cation on their thermophysical properties have been studied and compared with those observed in analogous imidazolium-based ILs. To drive this comparison, the speed of sound, dens...

In this article, we investigated aripiprazole + Kollidon® VA64 (ARP/KVA) and aripprazole + Soluplus® (ARP/SOP) amorphous solid dispersions. Thermal properties of all prepared systems have been examined by means of Differential Scanning Calorimetry (DSC). Compositions revealing the recrystallization tendency were subsequently investigated by means o...

Under confinement, the properties of polymers can be much different from the bulk. Because of the potential applications in technology and hope to reveal fundamental problems related to the glass-transition, it is important to realize whether the nanoscale and macroscopic behavior of polymer glass-formers are related to each other in any simple way...

In this paper we determined the solubility limits of the amorphous flutamide within the two different polymeric matrixes – poly vinylpyrrolidone and poly vinylacetate. In order to achieve this goal, series of broadband dielectric spectroscopy measurements were performed. As a result we found that the maximal amount of the drug that can be successfu...

The effect of hard confinement and high pressure on the progress of free-radical and reversible addition-fragmentation chain transfer polymerizations of sterically hindered 1-octyl-3-vinylimidazolium bis(trifluoromethanesulfonyl)imide ([OVIM][NTf2]) has been investigated.

The behavior of the low and high molecular weight glass formers confined in nanoporous templates remains an unsolved puzzle despite the intensive long-term studies in this matter. The special effort is put to understand the enhancement of the segmental or structural dynamics and the depression of the glass transition temperatures in materials infil...

Influence of different factors on nematic alignment and relaxation dynamics in supercooled mixture of liquid crystals E7 was investigated by means of dielectric and rheo-dielectric spectroscopy. Results show that elevated pressure or application of strong oscillatory shear aligned the nematic director parallel to the electrodes. On the other hand,...

Proton conducting materials play an important role in a variety of electrochemical devices. Especially, the class of protic ionic glass-formers with fast water-independent proton transport within the Grotthuss mechanism has been envisioned as promising fuel cell electrolytes. Nevertheless, despite a number of reports on protic ionic glasses the des...

Herein, we tested the validity of the thermodynamic scaling of two (α and δ) relaxation processes observed in the isotropic and nematic phases of itraconazole, that is classified as a liquid crystal (LC). As illustrated, relaxation times of both processes obtained at various thermodynamic conditions can be successfully superposed over 1/TV^γ with d...

The aim of this work is to analyze in detail the effect of the alkyl chain length on the dynamics of glass-forming propylene carbonate (PC) derivatives. Examined samples are low-molecular weight derivatives of the PC structure, i.e., the 4-alkyl-1,3-dioxolan-2-one series, modified by changing the alkyl substituent from methyl to hexyl. The molecula...

Theoretical concepts in condensed matter physics are typically verified and also developed by exploiting computer simulations mostly in simple models. Predictions based on these usually isotropic models are often at odds with measurement results obtained for real materials. One of the examples is an intriguing problem within the density scaling ide...

We present investigations of the charge transport in an ionic glass-former carvedilol dihydrogen phosphate (CP) at various T-P-V thermodynamic conditions in terms of density scaling concept. The studied material was found to reveal superprotonic properties both at ambient end elevated pressure as proved by Walden rule. Surprisingly, from isobaric c...

In this paper, the crystal growth of three active pharmaceutical ingredients (APIs): griseofulvin, nifedipine and naproxen from the single component systems and the solid dispersions composed of APIs and acetylated maltose, has been investigated in a wide temperature range using optical microscopy. Additionally, complementary calorimetric and diele...

Method of pressure polymerization of ε-caprolactone The subject of the invention is a method of pressure polymerization of ε-caprolactone (ε-CL), enabling the production of linear polycaprolactone (PCL), in which an initiator in the form of water is added to the ε-caprolactone (ε-CL) monomer with a purity preferably above 90%. or anhydrous alcohol...

We report a striking anomaly in the pressure dependent Debye-relaxation time of the branched monohydroxy alcohol 2-butyl-1-octanol. Evidence of a crossover from slower to faster than exponential pressure dependency was obtained at different temperatures via high pressure broadband dielectric spectroscopy. At the same time, viscosity easurements rev...

Broadband dielectric and Raman spectroscopies combined with calorimetric measurements and DFT calculations have been used to investigate the molecular dynamics of the benzyl derivative of ibuprofen (Ben-IBU) incorporated into aluminum oxide (AAO) templates of various pore diameters (d=20 nm and d=80 nm). Time-dependent experiments on the material c...

In this paper, we have investigated the molecular dynamics above and below the glass-transition temperature of bisphenol-A diglycidyl ether (known as DGEBA, Mn = 340 g/mol) infiltrated in nanoporous alumina (AAO) templates of various pore sizes by means of dielectric and Raman spectroscopies. It was found that the temperature dependence of the stru...

Coupling-Model-based theoretical explanation of the minor change of JG β-relaxation achieved by ultrastability in contrast to the dramatic change in α-relaxation.

The study focused on the pharmacological action of sumatriptan, in particular its antiallodynic and antihyperalgesic properties, as an effect of cyclodextrinic inclusion of sumatriptan, resulting in changes of its physicochemical qualities such as dissolution and permeability through artificial biological membranes, which had previously been examin...