Maria Pia Villa

Maria Pia Villa
Sapienza University of Rome | la sapienza · Department of Neuroscience, Mental Health and Sense Organs NESMOS

Prof.and Chair of Pediatrics

About

308
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Publications

Publications (308)
Article
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Sleep plays a fundamental role in maintaining good psycho-physical health, it can influence hormone levels, mood, and weight. Recent studies, focused on the interconnection between intestinal microbiome and sleep disorders, have shown the growing importance of a healthy and balanced intestinal microbiome for the hosts health. Normally, gut microbio...
Article
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PurposeLocal and systemic inflammatory markers and pro-inflammatory cytokines are increased in children with obstructive sleep apnea syndrome (OSAS). Therefore, systemic or topical anti-inflammatory agents are used to treat this syndrome. We evaluated the treatment with systemic corticosteroids in children with severe OSAS and adenotonsillar hypert...
Chapter
Children with sleep-disordered breathing (SDB) present alterations in posture and mobility of the stomatognathic system components. Orofacial myofunctional therapy is a modality of treatment for children with obstructive sleep apnea syndrome (OSAS) to promote changes in the orofacial musculature of the upper airways. Orofacial myofunctional therapy...
Article
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Objective To examine the impact of home confinement during the COVID-19 pandemic on the sleep patterns and sleep disturbances in Italian children and adolescents. Methods Participants completed an anonymous online survey, shared via social media and targeting children and adolescents aged 1 to 18 years, subdivided into age groups: 1-3, 4-5, 6-12,...
Chapter
Photosensitivity or “visual sensitivity” is in the literature used in different ways: (1) the focal or generalized epileptiform EEG reaction to Intermittent Photic Stimulation (IPS) or other visual stimuli, so called photoparoxysmal response or PPR; (2) visual stimuli that provoke seizures in everyday life, such as flickering sunlight, TV, videogam...
Article
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Background: Colorectal polyps are reported in 6,1% of paediatric colonoscopies and in 12% of those performed forlower gastrointestinal bleeding. Although colonoscopy is widely used in paediatric patients, it requires bowelpreparation and general anaesthesia or deep sedation, and in rare cases, it can cause complications. Non-invasivescreening techn...
Article
Background Obstructive Sleep Apnoea syndrome (OSAS) is considered a systemic inflammatory disease and is characterized by intermittent hypoxia that can damage the integrity of intestinal barrier and alter gut microbiota composition in adults and animal models. To date there is only one study on snoring children and microbiota but no studies are pre...
Article
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Introduction The quality of information on websites about tonsillectomy regarding the knowledge level may be low. Tonsillectomy is a surgical procedure to hypertrophy of the palatine and pharyngeal tonsils. So, it is an invasive procedure with possible complications, which creates insecurity in parents. Significantly, Internet searches have been in...
Article
Objectives: Paediatric studies on the role of antibiotic prophylaxis in the prevention of postoperative infections in children undergoing percutaneous endoscopic gastrostomy (PEG) are lacking. The aim of this study was to assess if a single dose of co-amoxiclav before PEG can decrease the rate of peristomal wound and systemic infection in children...
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Cyclic Vomiting Syndrome (CVS) is an underdiagnosed episodic syndrome characterized by frequent hospitalizations, multiple comorbidities, and poor quality of life. It is often misdiagnosed due to the unappreciated pattern of recurrence and lack of confirmatory testing. CVS mainly occurs in pre-school or early school-age, but infants and elderly ons...
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Inflammatory bowel disease (IBD) includes Crohn's disease (CD), ulcerative colitis and unclassified entities. CD commonly involves the terminal ileum and colon but at the time of diagnosis it can be confined to the small bowel (SB) in about 30% of the patients, especially in the young ones. Management of isolated SB-CD can be challenging and object...
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Food protein-induced allergic proctocolitis (FPIAP) is a condition characterized by inflammatory changes in the distal colon in response to one or more foreign food proteins because of immune-mediated reactions. FPIAP prevalence estimates range widely from 0.16% in healthy children and 64% in patients with blood in stools. In clinical practice, FPI...
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Cannabis extracts in oil are becoming increasingly available, and, during the last years, there has been growing public and scientific interest about therapeutic properties of these compounds for the treatment of several neurologic diseases, not just epilepsy. The discovered role of the endocannabinoid system in epileptogenesis has provided the bas...
Article
Objective: To evaluate the prevalence of omental infarction (OI) in children with suspected appendicitis, the role of ultrasonography (US) in its diagnosis and management and the efficacy of conservative management. Methods: Consecutive children with suspected acute appendicitis were prospectively enrolled. Ultrasonography was performed at baselin...
Article
Introduction Multiple anatomic and functional risk factors contribute to Obstructive Sleep Apnea (OSA) in children, most of the screening tools only evaluate clinical symptoms. The aim was to describe the evaluation of the short orofacial myofunctional protocol (ShOM) in OSA children, and to analyze if the inclusion of orofacial myofunctional aspec...
Article
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L'epidemia Sars-CoV-2 coinvolge solo marginalmente la popolazione pediatrica, che però può svolgere un ruolo importante nella trasmissione dell'infezione nella comunità. La Società Italiana di Otorinolaringoiatria Pediatrica ha redatto le seguenti raccomandazioni per la gestione della visita, dell'intervento chirurgico e della gestione delle emerge...
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Introduction: Some neurologic conditions that can quickly and with low costs be recognized, classified and treated thanks to the availability of an EEG recording in an emergency setting. However, although considered a cheap, not invasive, highly accurate diagnostic investigation, still today, an EEG recording in emergency, in real time during the e...
Article
Objective: To assess cardiac function in infants with bronchiolitis and the association with disease severity and outcomes. Working hypothesis: Cardiac function may be impaired in bronchiolitis and represent an early predictor of disease severity. Study design: A prospective cohort study. Patient selection: Infants with suspected bronchiolit...
Article
Objectives: Despite the efforts to reduce the exposure to corrosive household products, caustic ingestion in children is currently a significant medical problem. The aims of the present study were to evaluate the clinical consequences of caustic ingestion and to identify prognostic factors that could concur in driving both diagnostic and therapeut...
Article
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Objectives: We aimed to detect obstructive sleep apnea (OSA) among school-age children presented with nocturnal enuresis (NE) and to identify the possible risk factors for OSA in them. Methods: Sixty-six children aged > 5-16 years presented with NE were enrolled in the study. Children with urinary tract anatomical abnormalities or infection, int...
Article
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Background Migraine is one of the most prevalent chronic pain manifestations of childhood. Despite the multitude of available treatments, parents are often concerned about chronic therapies and pediatricians have insufficient confidence in prescribing prophylactic drugs. Therefore, there is now growing interest for natural supplements used to contr...
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Pediatric chronic intestinal pseudo-obstruction is a rare disorder characterized by a severe impairment of gastrointestinal motility leading to intestinal obstruction symptoms in the absence of mechanical causes. The diagnosis is usually clinical and diagnostic work is usually aimed to rule out mechanical obstruction and to identify any underlying...
Article
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Eosinophilic esophagitis (EoE) is an emerging chronic immune and antigen-mediated clinicopathologic disease. During the last 2 decades, the incidence of this condition in children has increased significantly, thanks to practitioners for creating the awareness and higher use of diagnostic endoscopy. We have analysed paediatric literature on EoE focu...
Article
Background: Recent evidence has emphasized the role of a short lingual frenulum in the pathogenesis of sleep-disordered breathing (SDB) in childhood. The oral dysfunction induced by a short frenulum may promote oral-facial dysmorphism, decreasing the size of upper airway lumen and increasing the risk of upper airway collapsibility during sleep. Th...
Article
Celiac disease (CD) is a systemic, chronic immune-mediated disorder elicited by gluten and related prolamines in genetically susceptible subjects. Main manifestations of CD involve the digestive tract; however, a growing body of evidence supports the theory that symptoms may occur in every part of the body. It is known that some patients with CD ca...
Article
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Headache is the third cause of visits to pediatric emergency departments (ED). According to a systematic review, headaches in children evaluated in the ED are primarily due to benign conditions that tend to be self-limiting or resolve with appropriate pharmacological treatment. The more frequent causes of non-traumatic headache in the ED include pr...
Article
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Objective To apply the Sleep Clinical Record (SCR) to a sample of Brazilian children with sleep complaints, to compare the results with Italian children, and to identify variables that influence phenotype. Methods Brazilian and Italian children, 4–11 years of age and matched for age, gender, obesity, and apnea−hypopnea index and who presented with...
Article
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The relationship between headache and epilepsy is complex and despite the nature of this association is not yet clear. In the last few years, it has been progressively introduced the concept of the “ictal epileptic headache” that was included in the recently revised International Classification of Headaches Disorders 3rd edition (ICHD-3-revised). T...
Article
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Background: A strictly gluten-free diet (GFD) is the basis for managing celiac disease (CD). Numerous studies have reported nutritional deficiencies/imbalances ascribable to a GFD. The aim of this review is to describe nutritional deficiencies observed in children with celiac disease on a GFD, to discuss the clinical consequences related to these...
Article
Background: Exercise-induced bronchoconstriction (EIB) reflects poor asthma control. Assessing noninvasive biomarkers associated with EIB could help to monitor patients in the pediatric age. Aims: To test exhaled and urinary biomarkers for assessing EIB in atopic asthmatic children. Methods: In 45 atopic patients (11.1 ± 1.8 years, 25 males) w...
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Purpose of Review We reviewed and discussed studies on the role of oropharyngeal exercises in the treatment of children with obstructive sleep-disordered breathing (SDB). Recent Findings There has been increasing recent evidence on the role of oropharyngeal exercises in the stepwise therapeutic approach in children with SDB. An oropharyngeal evalu...
Article
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It is important to distinguish children with different levels of severity of OSAS, using the patient's clinical history and physical examination, to identify children who need polysomnography http://ow.ly/gYHj30oc0Zb.
Article
Objective: We aimed to describe characteristics, etiology and health care use in children with low back pain (LBP) presenting to pediatric emergency department (ED) and to develop an algorithm to design a diagnostic approach. Methods: We conducted a 7-year cohort study of children admitted to ED with a primary complaint of LBP. They were classif...
Article
Objective Airway oxidative stress and inflammation are likely to be involved in sleep disordered breathing (SDB) in children. We aimed to measure concentrations of 8-isoprostane (8-IsoP) in the exhaled breath condensate (EBC) and exhaled nitric oxide (FENO) in patients with SBD and healthy children, in order to assess the relationship between these...
Article
Objective: To test the hypothesis that allergic proctocolitis, a cause of self-limiting rectal bleeding in infants, can predispose to the development of functional gastrointestinal disorders (FGIDs) later in childhood. Study design: We studied a cohort of 80 consecutive patients diagnosed with allergic proctocolitis. Their sibling or matched chi...
Article
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PurposeData in the literature suggest that myofunctional therapy (MT) may be able to play a role in the treatment of children with sleep-disordered breathing (SDB). Our study investigated the effectiveness of MT in reducing respiratory symptoms in children with SDB by modifying tongue tone. Methods Polysomnographic recordings were performed at base...
Article
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This study aims at determining serum levels of tryptophan and other metabolites of the kynurenine pathway in children with attention deficit hyperactivity disorder (ADHD) compared to healthy controls. Such metabolites interact with glutamate receptors in the central nervous system, potentially modulating mechanisms that are pivotal in ADHD and thus...
Article
The present statement was produced by a European Respiratory Society Task Force to summarise the evidence and current practice on the diagnosis and management of obstructive sleep disordered breathing (SDB) in children aged 1-23 months. A systematic literature search was completed and 159 articles were summarised to answer clinically relevant quest...
Article
Study objectives: In children, the effect of the common phenotype of obstructive sleep apnea (OSA) on sleep architecture is not adequately documented. The aim of this study was to evaluate sleep architecture in a pediatric population with the common phenotype of OSA. Methods: The prospective cross-sectional study included 116 children in the age...
Article
Benign epilepsy with centrotemporal spikes (BECTS) epilepsy, also known as rolandic epilepsy, is the most common childhood type of epilepsy. There is debate on its "benign" definition given the numerous literature data on its correlation to cognitive morbidity. Although its prognosis is often favorable, BECTS can present or evolve however to an aty...
Article
Background: In this study we sought to evaluate the association between viral bronchiolitis, weather conditions, and air pollution in an urban area in Italy. Methods: We included infants hospitalized for acute bronchiolitis from 2004 to 2014. All infants underwent a nasal washing for virus detection. A regional agency network collected meteorolo...
Article
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Background Acute diplopia (AD) is an uncommon and distressing symptom of numerous ocular and neurological conditions, with potentially serious sequelaes. No data are present in pediatrics on the presentation and management of AD. Aim This study investigated characteristics, etiology and health care utilization of the pediatric population with AD a...
Article
Background: Inflammation may represent a common underlying mechanism in a wide range of diseases, including neuropsychiatric disorders. Cytokine involvement has been investigated in some studies on patients with childhood neuropsychiatric diseases. The aim of this study was to determine whether cytokines are involved in ADHD to provide a rationale...
Article
Although adenotonsillectomy is the first line treatment for children with obstructive sleep apnea syndrome (0SAS),(1) improvement in objectively documented outcomes is often inadequate and a substantial number of children have residual disease. Early recognition and treatment of children with persistent OSAS is required to prevent long-term morbidi...
Article
Background: Vernal keratoconjunctivitis (VKC) is a chronic and often severe bilateral conjunctivitis. VKC etiology remains still unclear although endocrine, genetic, neurogenic and environmental factors have been implied. Vitamin D is a fat-soluble prohormone whose main function is the regulation of calcium and phosphate metabolism. The aim of thi...
Article
Background: Obesity is an important risk factor for obstructive sleep apnea syndrome (OSAS), and obese children with OSAS have frequently shown oxygen desaturations when compared with normal-weight children. The aim of our study was to investigate the oximetry characteristics in children with obesity and sleep-disordered breathing (SDB). Methods:...
Article
Objectives: To detect and raise the attention to the problem of obstructive sleep apnea (OSA) among the school-age children presented with nocturnal enuresis (NE). Methods: Sixty-three children >5 years presented with NE were enrolled in the study (35 Egyptian and 28 Italian). Children with evidence of urinary tract infection or anatomical abnormal...
Conference Paper
BACKGROUND Systemic inflammation is important in pathophysiology of obstructive sleep apnea syndrome (OSAS). Several different morbidity biomarkers have been proposed for OSAS over the last years. OBJECTIVES In this study, we aimed to evaluate the role of blood neutrophil to lymphocyte (N/L) ratio, an easily accessible marker of subclinical inflamm...
Article
Introduction: Polysomnographic recordings of children with an apparent life-threatening event (ALTE) have often displayed signs of partial or complete obstruction during sleep. Various studies have focused on facial dysmorphia in infants with ALTE and tried to establish a correlation between ALTE and obstructive sleep apnoea. Our study evaluates t...
Article
To the Editor We read with great interest the article titled “The Role of Sleep Studies in Children Who Snore” by Ishman.1 In this article the author reaffirmed the importance of performing polysomnography in children with suspected sleep disordered breathing (SDB) before and especially after treatment because the risk of persistent obstructive sle...
Article
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Objective: We investigated whether ADHD children who are positive to Purkinje cell antibodies display pro-inflammatory activity associated with high cytokine serum levels. Method: Fifty-eight ADHD outpatients were compared with 36 healthy, age- and sex-matched children. Forty-five of the ADHD children were positive to anti-Yo antibodies, whereas...
Article
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Purpose: The aim of our study was to evaluate the utility of the sleep clinical record (SCR) in the follow-up of children with obstructive sleep apnea (OSA) after treatment. Methods: SCR was completed and overnight polysomnography (PSG) was performed in all enrolled children (T0), with SCR considered positive for scores ≥6.5, as previously valid...
Article
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The sleep clinical record (SCR) may be a valid method for detecting children with obstructive sleep apnoea (OSA). This study aimed to evaluate whether there were differences in SCR depending on age and to identify the possible risk factors for OSA development. We enrolled children with sleep disordered breathing between 2013 and 2015, and divided t...
Article
Introduction: The aim of this study was to evaluate the typical clinical symptoms of obstructive sleep apnea in preschool and younger school age children using a questionnaire method and also to evaluate risk factors of upper airway obstruction. Patients: The study included 122 children (73 boys; 59.8 %) in age of 3-8 years (mean age 5.25 ± 1.56 ye...