Maria Vasileiou

• National and Kapodistrian University of Athens

Pioglitazone (ACTOS) is a thiazolidinedione for peroxisome proliferator-activated receptor γ (PPAR-γ) that has been well established for the second or third line treatment of type 2 diabetes mellitus. Beyond the effects on glucose metabolism, pioglitazone displays positive effects on lipid metabolism, blood pressure, endothelial function, bone dens...

Pioglitazone (ACTOS) is a thiazolidinedione for peroxisome proliferator–activated receptor γ (PPARγ) that has been well established for the second or third line treatment of type 2 diabetes mellitus. Beyond the effects on glucose metabolism, pioglitazone displays positive effects on lipid metabolism, blood pressure, endothelial function, bone densi...

Skin cancer remains a significant public health concern, with rising incidence rates worldwide. Our literature review examines current knowledge on skin cancer prevention, focusing on key areas such as epidemiology, risk factors, ultraviolet (UV) radiation exposure, pathophysiological and genetic mechanisms, and prevention strategies. A comprehensi...

The Warburg effect is one of the most studied mechanisms involved in cancer progression. It refers to the increased glucose uptake by cancer cells through aerobic glycolysis, instead of the Krebs cycle that takes place under normal conditions, followed by lactic acid fermentation. This mechanism is regulated by hypoxia-inducible factor-1 (HIF-1), a...

Breast cancer is the most commonly diagnosed cancer in women and is a leading cause of cancer death in women worldwide. Despite the implementation of multiple treatment options, including immunotherapy, breast cancer treatment remains a challenge. In this review, we aim to summarize present challenges in breast cancer immunotherapy and recent advan...

Prostate cancer (PCa) is the most commonly diagnosed cancer in men and the second leading cause of cancer death among men worldwide. While the exact etiology of PCa remains unclear, various factors contribute to the onset of the disease. These factors include modifiable risk factors such as physical activity, diet, obesity, smoking, alcohol consump...

The standard of care for locally advanced rectal cancer is total neoadjuvant therapy followed by surgical resection. Current evidence suggests that selected patients may be able to delay or avoid surgery without affecting survival rates if they achieve a complete clinical response (CCR). However, for older cancer patients who are too frail for surg...

Epidemiological trends in cancer research show that lung cancer can affect up to 1 in 15 men and 1 in 17 women. With incidence rates as high as these and significant associated mortality and morbidity, it is no wonder that lung cancer is one of the main areas of research focused on cancer. Advances in targeted treatments and specialized irradiation...

Cancer stem cells (CSCs) are a rare cancer cell population, responsible for the facilitation, progression, and resistance of tumors to therapeutic interventions. This subset of cancer cells with stemness and tumorigenic properties is organized in niches within the tumor microenvironment (TME) and presents altered regulation in a variety of metaboli...

Simple Summary Older patients are at risk of skin cancer. Head and neck cutaneous squamous-cell carcinoma is due to prolonged sun exposure. When the disease is advanced, it requires a combination of an operation to remove the cancer, followed by radiotherapy for possible cure. However, older patients may not tolerate surgery. Recent studies show th...

Simple Summary Accelerated clinical development of anticancer drugs is crucial to ensure patients’ access to the most safe and effective treatments. At the same time, the development process should be designed to ensure that the optimal dose and schedule are administrated. Therefore, pharmacological methods such as pharmacogenomics, pharmacokinetic...

Breast cancer is the most commonly diagnosed cancer in women and is a leading cause of cancer death in women worldwide. Despite the available treatment options, such as surgery, chemotherapy, radiotherapy, endocrine therapy and molecular targeted therapy, breast cancer treatment remains a challenge. The advent of immunotherapy has revolutionized th...

Simple Summary Oligometastases carries a better prognosis. Even though standard treatment for distant metastases is systemic therapy, those with oligometastases have a better survival rate if they receive surgery or stereotactic body radiotherapy (SBRT). The advantage of SBRT over surgery is its minimal toxicity and the induction of program death l...

Efstratios Athanasiou, Konstantinos Evgenikos, Nikolaos Biagkis, Dioni - Pinelopi Petsiou, Christina Karaoulani, Vasiliki Ioannidou, Themistoklis Aivaliotis, Vasiliki Kouveloglou, Theodora Tatsiou, Sylvia Raftopoulou, Maria Vasileiou, Eleni Pavlidou, Ismini Tsakiri, Alkistis Photiou, Georgios-Ioannis Verras, Christos Tsagkaris. The correlation betw...

According to the latest epidemiological data, breast cancer has recently been acknowledged as the most frequently diagnosed malignancy. To date, a body of evidence has established the involvement of multiple – and frequently interrelated - genetic and environmental factors in the pathogenesis of the disease. Emerging research on cancer prevention h...

Background: Coronavirus disease 19 carry a high mortality rate among older patients and minorities such as ethnic Africans and Latinos through the induction of a cytokines storm. Many pharmacologic interventions were proposed to improve the mortality rate from normal organ damage such as pneumonia. Low dose whole lung radiotherapy has been used in...

Background and objective: The standard of care for locally advanced non-small cell lung cancer (NSCLC) is either surgery followed by adjuvant chemotherapy with or without radiotherapy or concurrent chemotherapy and radiotherapy. However, older patients (70 years old or above) with multiple co-morbidities may not be able to tolerate the combined tr...