Maria Sofia Cotelli- Bachelor of Medicine
- Medical Doctor at Spedali Civili di Brescia
Maria Sofia Cotelli
- Bachelor of Medicine
- Medical Doctor at Spedali Civili di Brescia
Neurologist
About
209
Publications
25,789
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5,093
Citations
Introduction
Neurologist
Cognitive and Behavioral Neurology ASST Spedali Civili, Brescia
Skills and Expertise
Current institution
Additional affiliations
October 2024 - present
March 2013 - February 2024
ASST VALCAMONICA-ESINE
Position
- Medical Doctor
October 2022 - September 2023
Position
- Master
Description
- Pharmacoepidemiology and assessment of integrated treatment
Education
September 2000 - March 2007
Publications
Publications (209)
Background: There is an unmet need for high-quality data from prospective studies on the safety and effectiveness of direct oral anticoagulants (DOACs) for the treatment of cerebral venous thrombosis (CVT). We aimed to compare the safety and effectiveness of DOACs versus vitamin K antagonists (VKAs) for the treatment of CVT in a setting that reflec...
Decidere in medicina 2025, 1
INTRODUCTION
Modeling the survival rate in syndromes associated with frontotemporal lobar degeneration (FTLD) is essential to assess disease trajectories.
METHODS
In 262 patients with FTLD, we considered plasma neurofilament light chain (NfL), glial fibrillary acidic protein, brain‐derived tau, phosphorylated tau217 and amyloid beta (Aβ42/Aβ40). T...
Background
Considering the increasing evidence that disease-modifying treatments for Alzheimer’s disease (AD) must be administered early in the disease course, the development of diagnostic tools capable of accurately identifying AD at early disease stages has become a crucial target. In this view, transcranial magnetic stimulation (TMS) has become...
INTRODUCTION
Plasma‐based biomarkers have shown promise for clinical implementation, but their accuracy in differentiating Alzheimer's disease (AD) from syndromes associated with frontotemporal lobar degeneration (FTLD) has yet to be fully investigated. This study assessed the potential of plasma biomarkers for differential diagnosis.
METHODS
This...
L’intelligenza artificiale (IA) è una delle tecnologie più promettenti e trasformative del nostro tempo, con applicazioni sempre più diffuse in vari settori, tra cui la medicina. Il termine “intelligenza artificiale” è stato coniato da John McCarthy nel 1955 e definito come “la scienza e l’ingegneria che permettono di realizzare macchine intelligen...
Our purpose was to evaluate the approach of two different chatbots (ChatGPT and Gemini) to a list of questions about emergency department as a border area between hospital and territory. This study was performed in a single day, on 3 March 2024. Two different questions were sequentially type in Italian language, the same for each chatbot: definitio...
INTRODUCTION
Heterozygous mutations in the progranulin gene (GRN) leading to decreased progranulin levels are one of the most frequent causes of inherited frontotemporal dementia (FTD). We evaluated progranulin levels in dried blood spots from capillary finger‐stick collection (DBScapillary).
METHODS
Paired venous Ethylenediaminetetraacetic acid (...
Neuropsychiatric symptoms, such as apathy, disinhibition and irritability, are common in Progressive Supranuclear Palsy (PSP). The Frontal Behaviour Inventory (FBI) is a useful instrument for the evaluation of behavioural disorders in neurodegenerative diseases. The main goal of the present study was to explore the psychometric properties of the FB...
Decidere In Medicina 2024/5
Decidere in Medicina 2024/5
Aim
Empirical research investigating hyperorality in syndromes associated with frontotemporal lobar degeneration (FTLD) is limited. The present study aims to assess and describe hyperorality and its clinical and imaging correlates in patients with FTLD‐associated syndromes.
Methods
This retrospective longitudinal study included consecutive patient...
Background
Dementia with Lewy bodies (DLB) is characterized by a marked shift of electroencephalographic (EEG) power and dominant rhythm, from the α toward the θ frequency range. Transcranial alternate current stimulation (tACS) is a non‐invasive brain stimulation technique that allows entrainment of cerebral oscillations at desired frequencies.
O...
Argomento dell’anno - Dal Pronto Soccorso alla Medicina di Emergenza e Urgenza
Decidere in Medicina 2024 Volume 3
Decidere in Medicina 2024/2
Introduction
Previous reports and meta-analyses derived from small case series reported a mortality rate of up to 40% in patients with coronavirus disease 2019 associated cerebral venous thrombosis (COVID-CVT). We assessed the clinical characteristics and outcomes in an international cohort of patients with COVID-CVT.
Patients and methods
This was...
Several neurological manifestations are part of the post-COVID condition. We aimed to: (1) evaluate the 6-month outcome in the cohort of patients with neurological manifestations during the COVID-19 acute phase and surviving the infection, and find outcome predictors; (2) define the prevalence and type of neurological symptoms persistent at six mon...
Background
Several earlier studies showed a female predominance in idiopathic adult-onset dystonia (IAOD) affecting the craniocervical area and a male preponderance in limb dystonia. However, sex-related differences may result from bias inherent to study design. Moreover, information is lacking on whether sex-related differences exist in expressing...
INTRODUCTION
The goal of the present work was to assess the incidence of dementia with onset before the age of 65 years (i.e., young‐onset dementia [YOD]) and define the frequencies of young‐onset Alzheimer's disease (AD), frontotemporal lobar degeneration (FTLD), and dementia with Lewy bodies (DLB) in the general population.
METHODS
The study was...
A few earlier observations and recent controlled studies pointed to the possible contribution of thyroid diseases in idiopathic adult-onset dystonia (IAOD). The aim of this study was to investigate the association between thyroid status and clinical characteristics of IAOD, focusing on dystonia localization, spread, and associated features such as...
Decidere in Medicina 2024/1
Riportiamo il caso di un giovane 22enne caucasico ricoverato per prima crisi epilettica caratterizzata da formicolio all’arto superiore destro propagatosi con “marcia” e seguito da perdita di coscienza e morsus linguale, in assenza di rilascio sfinteriale. L’anamnesi epilettologica risultava muta, così come la patologic...
Decidere in Medicina 2024/1
La storia del Pronto Soccorso (PS) in Italia deriva da un lungo e complicato percorso che ha avuto inizio verso gli anni ’30. In effetti, fino ad allora non esisteva alcuna tipologia di legislazione organizzativa. Grazie a Petragnani fu deliberato il Regio Decreto (RD) del 25/10/38, riguardante l’ordinamento dei servizi...
Decidere in Medicina 2023/6
Objectives
To determine whether blood group influences development of cerebral venous thrombosis (CVT) after administration of the coronavirus disease 2019 (COVID-19) AstraZeneca ChAdOx1-S vaccine.
Design
A case–control study. Univariate and multivariate logistic regression was used to determine the association between blood type and COVID-19 vacc...
Background
Amyotrophic lateral sclerosis (ALS) is a progressive disease for which no curative treatment is currently available.
Objective
This study aimed to investigate whether cortico-spinal transcranial direct current stimulation (tDCS) could mitigate symptoms in ALS patients via a randomized, double-blind, sham-controlled trial, followed by a...
Una lesione del basicranio rivela un quadro ben più grave
Decidere in Medicina 2023
Da una semplice “indigestione” a un complesso quadro malformativo cerebrale
Introduction:
Cerebral venous sinus thrombosis associated with vaccine-induced immune thrombotic thrombocytopenia (CVST-VITT) is a severe disease with high mortality. There are few data on sex differences in CVST-VITT. The aim of our study was to investigate the differences in presentation, treatment, clinical course, complications, and outcome of...
Background and Objective
A variety of neurological disorders has been reported as presentations or complications of COVID-19 infection. The objective of this study was to determine their incidence dynamics and long-term functional outcome.
Methods
The Neuro-COVID Italy study was a multicentre, observational, cohort study with ambispective recruitm...
Background:
To date, a few studies have systematically investigated differences in the clinical spectrum between acquired and idiopathic dystonias.
Objectives:
To compare demographic data and clinical features in patients with adult-onset acquired and idiopathic dystonias.
Methods:
Patients were identified from among those included in the Ital...
DECIDERE IN MEDICINA 2023, 1
The spectrum of acute and chronic neurological complications of coronavirus disease 2019 (COVID-19) has been illustrated in an increasing number of reports and summarized in several systematic reviews [1-3]. Cognitive impairment, stroke, headache, and sleep disorders are likely the most common findings, although other manifestations have been frequ...
Importance
Diagnostic incidence data for syndromes associated with frontotemporal lobar degeneration (FTLD) in multinational studies are urgent in light of upcoming therapeutic approaches.
Objective
To assess the incidence of FTLD across Europe.
Design, Setting, and Participants
The Frontotemporal Dementia Incidence European Research Study (FRONT...
Background:
Alzheimer's disease (AD) and frontotemporal dementia (FTD) show network dysfunctions linked with cognitive deficits. Within this framework, network abnormalities between AD and FTD show both convergent and divergent patterns. However, these functional patterns are far from being established and their relevance to cognitive processes re...
Decidere in Medicina n°6 pagg 70-75
Argomento dell’anno: Le malattie rare
Decidere in Medicina 2022/6
Decidere in Medicina 2022
Decidere in Medicina 2022
Background and purpose: The aim of this study was to assess the neurological complications of SARS-CoV-2 infection and compare phenotypes and outcomes in infected patients with and without selected neurological manifestations. Methods: The data source was a registry established by the European Academy of Neurology during the first wave of the COVID...
Objective:
To assess neurological complications of SARS-CoV-2 infection and compare phenotypes and outcome in infected patients with and without selected neurological manifestations.
Methods:
Data source was a registry established by the European Academy of Neurology during the first wave of COVID-19 pandemic. Neurologists collected data on pati...
Network neuroscience is a promising approach to explore cognitive processes in neurological disorders. Alzheimer's disease (AD) and frontotemporal dementia (FTD) show network dysfunctions linked with cognitive deficits. Within this framework, network abnormalities between AD and FTD show both convergent and divergent patterns. However, these functi...
Sarcouncil Journal of Biomedical Sciences Vol-1 issue-2
Sarcouncil Journal of Biomedical Sciences Vol-1 issue-2
Background:
Many single cases and small series of Guillain-Barré syndrome (GBS) associated with SARS-CoV-2 infection were reported during the COVID-19 outbreak worldwide. However, the debate regarding the possible role of infection in causing GBS is still ongoing. This multicenter study aimed to evaluate epidemiological and clinical findings of GB...
Diplopia, or double vision, is a symptom resulting from the perception of two images of a single object. We report a case of a possible silodosin-induced diplopia never reported before in the literature. We suggest that binocular diplopia should be considered in people assuming silodosin even if further studies should be conducted to explore possib...
PAKISTAN'S MULTI DISCIPLINARY JOURNAL FOR ARTS & SCIENCE
Objective:
To assess whether non-invasive brain stimulation with transcranial alternating current stimulation at gamma-frequency (γ-tACS) applied over the precuneus can improve episodic memory and modulate cholinergic transmission by modulating cerebral rhythms in early Alzheimer's disease (AD).
Methods:
In this randomized, double-blind, sham co...
Objective: To present a case of relapsed spinal cord infarction (SCI) as an acute spinal emergency in an in-patient elderly male patient.
Methods: This report presents a case of an in-patient 84 years-old man who was admitted due to acute paraparesis with urge incontinence and sudden worsening after initial improvement. To assess his condition, s...
DECIDERE IN MEDICINA 2022-2
DECIDERE IN MEDICINA 2022-2
Background:
Delirium is thought to be common across various settings of care; however, still little research has been conducted in rehabilitation.
Aim:
We investigated the prevalence of delirium, its features and motor subtypes in older patients admitted to rehabilitation facilities during the three editions of the "Delirium Day project".
Metho...
https://sarcouncil.com/category/scientific-research-journal-medical-series-volume-1-issue-1/
https://sarcouncil.com/category/scientific-research-journal-medical-series-volume-1-issue-1/
Epidemiology of Stroke at Department of Emergency in Valcamonica
Background:
The assessment of human and diagnostic resources is a prerequisite to improving the management of emergency neurology.
Objective:
To provide a landscape on the organization of the Lombardy Region hospitals for emergency neurological care management.
Methods:
We designed an anonymized questionnaire including 6 sections with 21 quest...
https://sarcouncil.com/2022/03/transient-global-amnesia-at-the-emergency-department/
https://sarcouncil.com/2022/03/symptomatic-retropharyngeal-lipoma-case-report/
Introduction
Dementia with Lewy bodies (DLB) may represent a diagnostic challenge, since its clinical picture overlaps with other dementia. Two toolkits have been developed to aid the clinician to diagnose DLB: the Lewy Body Composite Risk Score (LBCRS) and the Assessment Toolkit for DLB (AT-DLB). We aim to evaluate the reliability of these two que...
Background:
Despite the increasing number of reports on the spectrum of neurological manifestations of COVID-19 (neuro-COVID), few studies have assessed short and long-term outcome of the disease.
Methods:
This is a cohort study enrolling adult patients with neuro-COVID seen in neurological consultation. Data were collected prospectively or retr...
decidere in medicina 2022-1
Decidere in medicina 2022-n°1
Introduction
Delirium and sarcopenia are common, although underdiagnosed, geriatric syndromes. Several pathological mechanisms can link delirium and low skeletal muscle mass, but few studies have investigated their association. We aimed to investigate (1) the association between delirium and low skeletal muscle mass and (2) the possible role of cal...
Decidere in Medicina volume 6, 20-23
Decidere in Medicina 2021 vol 6 pagg 74-76
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease with a lifetime risk of one in 350 people and an unmet need for disease-modifying therapies. We conducted a cross-ancestry genome-wide association study (GWAS) including 29,612 patients with ALS and 122,656 controls, which identified 15 risk loci. When combined with 8,953 indi...
The default mode (DMN) and the salience (SN) networks show functional hypo-connectivity in Alzheimer's disease (AD) and the behavioral variant of frontotemporal dementia (bvFTD), respectively, along with patterns of hyper-connectivity. We tested the clinical and neurobiological effects of non-invasive stimulation over these networks in 45 patients...
Decidere in Medicina
Importance: Thrombosis with thrombocytopenia syndrome (TTS) has been reported after vaccination with the SARS-CoV-2 vaccines ChAdOx1 nCov-19 (Oxford-AstraZeneca) and Ad26.COV2.S (Janssen/Johnson & Johnson).
Objective: To describe the clinical characteristics and outcome of patients with cerebral venous sinus thrombosis (CVST) after SARS-CoV-2 vacc...
Decidere in medicina 2021; 4: 9-14
Decidere in medicina 2021; 4: 77
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