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María Concepción Serrano

María Concepción Serrano
Instituto de Ciencia de Materiales de Madrid, Consejo Superior de Investigaciones Científicas · Energy, Environment and Health

PhD

About

87
Publications
6,086
Reads
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3,241
Citations
Additional affiliations
January 2014 - present
Hospital Nacional de Paraplejicos
Position
  • Postdoctoral Associate (Miguel Servet I)
December 2010 - December 2013
Instituto de Ciencia de Materiales de Madrid
Position
  • Postdoctoral Associate (Juan de la Cierva)
December 2010 - December 2013
Spanish National Research Council
Position
  • PostDoc Position

Publications

Publications (87)
Article
Along with the development of the next generation of biomedical platforms, the inclusion of graphene-based materials (GBMs) into therapeutics for spinal cord injury (SCI) has potential to nourish topmost neuroprotective and neuroregenerative strategies for enhancing neural structural and physiological recovery. In the context of SCI, contemplated a...
Article
Full-text available
Along with the development of the next generation of biomedical platforms, the inclusion of graphene-based materials (GBMs) into therapeutics for spinal cord injury (SCI) has potential to nourish topmost neuroprotective and neuroregenerative strategies for enhancing neural structural and physiological recovery. In the context of SCI, contemplated a...
Chapter
As living organisms, we have the ability to detect and respond to environmental stimuli for adaptation and survival purposes. The nervous system, responsible for orchestrating these functions, is a complex set of specialized structures functioning in a coordinated manner. Such system can be disrupted by external and/or internal conditions leading t...
Chapter
Spinal cord injury (SCI), with either traumatic or non-traumatic aetiology, brings lifetime health, economic and social consequences to thousands of people worldwide. Tragically, there are no available therapies capable of reversing the condition of SCI patients, who experience their daily routines becoming nearly impossible tasks due to the abrupt...
Article
Full-text available
Progress in the clinical application of recording and stimulation devices for neural diseases is still limited, mainly because of suboptimal material engineering and unfavorable interactions with biological entities. Nanotechnology is providing upgraded designs of materials to better mimic the native extracellular environment and attain more intima...
Article
Full-text available
Due to their specific mesoporous structure and large surface area, mesoporous bioactive glasses (MBGs) possess both drug-delivery ability and effective ionic release to promote bone regeneration by stimulating osteogenesis and angiogenesis. Macrophages secrete mediators that can affect both processes, depending on their phenotype. In this work, the...
Article
Full-text available
Angiogenic biomaterials are designed to promote vascularization and tissue regeneration. Nanoparticles of bioactive materials loaded with drugs represent an interesting strategy to stimulate osteogenesis and angiogenesis and to inhibit bone resorption. In this work, porcine endothelial progenitor cells (EPCs), essential for blood vessel formation,...
Preprint
Full-text available
Silicon-substituted hydroxyapatite (SiHA) macroporous scaffolds have been prepared by robocasting. In order to optimize their bone regeneration properties, we have manufactured these scaffolds presenting different microstructures: nanocrystalline and crystalline. Moreover, their surfaces have been decorated with vascular endothelial growth factor (...
Preprint
Full-text available
The osteogenic and angiogenic responses to metal macroporous scaffolds coated with silicon substituted hydroxyapatite (SiHA) and decorated with vascular endothelial growth factor (VEGF) have been evaluated in vitro and in vivo. Ti6Al4V-ELI scaffolds were prepared by electron beam melting and subsequently coated with Ca10(PO4)5.6(SiO4)0.4(OH)1.6 fol...
Article
Graphene oxide (GO) assists a diverse set of promising routes to build bioactive neural microenvironments by easily interacting with other biomaterials to enhance their bulk features or, alternatively, self-assembling towards the construction of biocompatible systems with specific 3D geometries. Herein, we firstly modulate both size and available o...
Article
Full-text available
Understanding neural physiopathology requires advances in nanotechnology‐based interfaces, engineered to monitor the functional state of mammalian nervous cells. Such interfaces typically contain nanometer‐size features for stimulation and recording as in cell‐non‐invasive extracellular microelectrode arrays. In such devices, it turns crucial to un...
Article
Spinal cord injury (SCI) characterizes by the disruption of neuronal axons and the creation of an inhibitory environment for spinal tissue regeneration. For decades, researchers and clinicians have been devoting a great effort to develop novel therapeutic approaches which include the fabrication of biocompatible implants that could guide neural tis...
Article
We have developed a reproducible and facile one step strategy for the synthesis of doxorubicin loaded magnetoliposomes by using a thin-layer evaporation method. Liposomes of around 200 nm were made of 1,2-Dipalmitoyl-sn-glycero-3-phosphocholine (DPPC) and iron oxide nanoparticles (NP) with negative, positive and hydrophobic surfaces that were incor...
Article
Silicon-substituted hydroxyapatite (SiHA) macroporous scaffolds have been prepared by robocasting. In order to optimize their bone regeneration properties, we have manufactured these scaffolds presenting different microstructures: nanocrystalline and crystalline. Moreover, their surfaces have been decorated with vascular endothelial growth factor (...
Article
The osteogenic and angiogenic responses to metal macroporous scaffolds coated with silicon substituted hydroxyapatite (SiHA) and decorated with vascular endothelial growth factor (VEGF) have been evaluated in vitro and in vivo. Ti6Al4V-ELI scaffolds were prepared by electron beam melting and subsequently coated with Ca10(PO4)5.6(SiO4)0.4(OH)1.6 fol...
Article
Neural diseases at the central nervous system including spinal cord injury (SCI) remain therapeutic challenges. Graphene materials are being delineated as alternative tools for neural repair. Herein, the regenerative ability of reduced graphene oxide (rGO) scaffolds to support pivotal features of neural repair at 4 months after SCI is assessed by a...
Article
Graphene-based materials are revealing a great promise for biomedical applications and demonstrating attractiveness for neural repair. Nanostructured reduced graphene oxide (rGO) microfibers regulate the neural stem cell differentiation into neurons, eventually serving as a potential artificial tissue engineering scaffold for neural regeneration. W...
Article
Electron beam lithography (EBL) was used for preparing nanostructured reduced patterns on the GO paper surface, while preserving its mechanical resistance and flexibility. Different EBL parameters, like dose and time of exposure for patterning were tested. SEM analysis showed the consequent increase of contrast of the reduced stripes on the pattern...
Article
Full-text available
Neural tissue engineering approaches show increasing promise for the treatment of neural diseases including spinal cord injury, for which an efficient therapy is still missing. Encouraged by both positive findings on the interaction of carbon nanomaterials such as graphene with neural components and the necessity of more efficient guidance structur...
Article
Full-text available
The attractiveness of graphene-derived materials (GDMs) for neural applications has fueled their exploration as components of biomaterial interfaces contacting the brain and the spinal cord. In the last years, an increasing body of work has been published on the ability of these materials to create biocompatible and biofunctional substrates able to...
Article
Full-text available
The incorporation of multi-walled carbon nanotubes (MWCNTs) into chondroitin sulphate-based scaffolds and the effect on the structural, mechanical, conductive, and thermal properties of the resulting scaffolds is investigated. Three-dimensional hierarchical materials are prepared upon the application of the ice segregation-induced self-assembly (IS...
Chapter
The use and interest of graphene-based materials for neural repair is still in its infancy. In the last years, a more and more solid body of work is being published on the ability of these materials to create biocompatible and biofunctional substrates able to promote the in vitro growth of neural cells, often supporting enhanced neural differentiat...
Article
Attractive physic-chemical features of graphene oxide (GO) and promising results in vitro with neural cells encourage its exploration for biomedical applications including neural regeneration. Fueled by previous findings at the subacute state, we herein investigate for the first time chronic tissue responses (at 30 days) to 3D scaffolds composed of...
Article
Vascular endothelial growth factor (VEGF) plays an essential role in angiogenesis and vascular homeostasis. Endothelial progenitor cells (EPCs) are primitive bone marrow cells participating in neovascularization and revascularization processes, which also promote bone regeneration. Synthetic hydroxyapatite (HA) has been widely used in bone repair a...
Article
Ordering neural cells is of interest for the development of neural interfaces. The aim of this work is to demonstrate an easy-to-use, versatile, and cost/time effective laser-based approach for producing platforms that promote oriented neural growth. We use laser interferometry to generate fringed channels with topography on partially reduced graph...
Article
Shape-memory composites may be used as advanced photonic white paints to manipulate the transport of light. On page 1080, M. C. Serrano, A. Blanco, and co-workers show how they can perform as shape-configurable active media when doped with an organic dye, able to sustain non-resonant feedback random lasing. Photoluminescence may be used to monitor...
Article
Spinal cord injury remains a challenge for both clinicians and scientists. Novel materials such as graphene oxide have arisen as attractive alternatives for the design of more efficient reparative platforms. On page 1861 Maria C. Serrano and co-workers investigate the sub-acute response of the rat injured spinal cord to 3D graphene oxide scaffolds...
Article
The increasing prevalence and high sanitary costs of lesions affecting the central nervous system (CNS) at the spinal cord are encouraging experts in different fields to explore new avenues for neural repair. In this context, graphene and its derivatives are attracting significant attention, although their toxicity and performance in the CNS in viv...
Article
Full-text available
We have investigated the ring-opening polymerization (ROP) of ε-caprolactone using mixtures of methanesulfonic acid and the guanidine 1,5,7-triazabicyclo[4.4.0]dec-5-ene as the catalyst. Our interest in these mixtures is based on the capability of both acids and bases to behave as bifunctional catalysts; the former by the combined action of acidic...
Article
Although enormous advances are accomplished using shape memory polymers (SMPs) and their derived composites, the application of these media in optics and photonics is still restricted to a few systems. The present work addresses the fabrication and characterization of novel composites based on polydiolcitrates doped with titania nanoparticles, aimi...
Article
Liquid marbles (LM) are non-sticky droplets covered by micro- or nanometrically scaled particles and obtained by simply rolling small amounts of a liquid in a very hydrophobic powder. Since pioneer work by Aussillous and Quéré, a wide palette of hydrophobic materials for the preparation of LM, as well as potential applications, has been reported. D...
Article
This chapter discusses the use of deep eutectic solvent-assisted syntheses which allow the preparation of both chemically and structurally modified carbon monoliths suitable as electrodes in supercapacitor cells. Either carbons or carbon-carbon nanocomposites exhibiting a hierarchical structure and a tailored composition (either nitrogen or phospho...
Article
Since pioneer works by Iijima in 1991, carbon nanotubes (CNTs) have received a great deal of attention as confirmed by the increasing number of papers in the topic. Their unique and attractive properties have made them extensively demanded materials for a wide variety of technological applications, including their promising use as scaffolds in tiss...
Article
The absence of efficient therapies for the treatment of lesions affecting the central nervous system encourages scientists to explore new material avenues in an attempt to enhance neural tissue regeneration while preventing inhibitory fibroglial scars. In the recent years, the superlative properties of graphene-based materials are strongly impellin...
Article
The use of deep eutectic solvents (DESs) that act as all-in-one solvent-template-reactant systems offers an interesting green alternative to conventional syntheses in materials science. This Review aims to provide a comprehensive overview to emphasize the similarities and discrepancies between DES-assisted and conventional syntheses and rationalize...
Article
Novel photonic nanostructures with thermoresponsive shape-memory properties are presented. These materials, synthesized by imprinting a surface nanopattern on shape-memory polydiolcitrate elastomers, incorporate programmable optical properties that can be modulated or temporary erased by external stimuli. The multifunctional nature of these materia...
Conference Paper
Photonic systems with the capability to respond to different stimuli are more and more desirable for achieving multifunctionality and higher levels of performance. They demand materials with responsivity that may eventually be used for integrating sensing and actuating functions, a feature highly pursued in technological applications. A notable pro...
Article
Nervous tissue lesions are an important social concern due to their increasing prevalence and their high sanitary costs. Their treatment still remains a challenge because of the reduced ability of nervous tissue to regenerate, its intrinsic structural and functional complexity and the rapid formation of fibroglial scars inhibiting neural repair. He...
Article
Full-text available
Recent advances in nanotechnology have permitted the development of a wide repertoire of inorganic magnetic nanoparticles (NPs) with extensive promise for biomedical applications. Despite this remarkable potential, many questions still arise concerning the biocompatible nature of NPs when in contact with biological systems. Herein, we have investig...
Article
Bacterial infection related to the implantation of medical devices still represents a serious clinical complication, with dramatic consequences for many patients. In the past decades, numerous attempts have been performed to develop materials with antibacterial and/or antifouling properties by the incorporation of antibiotic and/or antiseptic compo...
Article
Carbon nanotubes (CNTs) have lately attracted significant attention in the field of biomedicine. Although a wide repertoire of CNT-based composites has been explored as substrates for cell growth, the fabrication of 3D scaffolds has been more rarely accomplished. Additionally, concerns referred to CNT biocompatibility make their use in biomaterials...
Article
The treatment of bone lesions, including fractures, tumor resection and osteoporosis, is a common clinical practice where bone healing and repair are pursued. It is widely accepted that calcium phosphate-based materials improve integration of biomaterials with surrounding bone tissue and further serve as a template for proper function of bone-formi...
Article
The immobilization of more than one single substance within the structure of a biocompatible polymer provides multifunctional biomaterials with attractive and enhanced properties. In the context of bone tissue engineering, it could be of great interest to synthesize a biomaterial that simultaneously contains amorphous calcium phosphate (ACP), to fa...
Article
Shape-memory polymers (SMP) are versatile stimuli-responsive materials that can switch, upon stimulation, from a temporary to a permanent shape. This advanced functionality makes SMP suitable and promising materials for diverse technological applications, including the fabrication of smart biomedical devices. In this paper, advances in the design o...
Article
The aim of this review is to provide an exposition of some of the most recent applications of deep-eutectic solvents (DESs) in the synthesis of polymers and related materials. We consider that there is plenty of room for the development of fundamental research in the field of DESs because their compositional flexibility makes the number of DESs sus...
Article
Si-doped hydroxyapatite (Si-HA) is a suitable ceramic for the controlled release of agents to improve bone repair. We recently showed that parathyroid hormone-related protein (PTHrP) (107-111) (osteostatin) has remarkable osteogenic features in various in vitro and in vivo systems. Fibroblast growth factor (FGF)-2 modulates osteoblastic function an...
Article
Since the discovery of nitric oxide (NO) in the 1980s, this cellular messenger has been shown to participate in diverse biological processes such as cardiovascular homeostasis, immune response, wound healing, bone metabolism, and neurotransmission. Its beneficial effects have prompted increased research in the past two decades, with a focus on the...
Article
Poly(octanediol-co-citrate) elastomers containing high loading of lidocaine were synthesized at temperatures below 100 °C by means of using deep eutectic mixtures of 1,8-octanediol and lidocaine. The preservation of lidocaine integrity resulted in high-capacity drug-eluting elastomers.
Article
Novel polydiolcitrate elastomers with thermally induced shape-memory properties are synthesized. These thermoresponsive polymers can be prepared as films or porous 3D sponges. Above their transition temperature, these materials display an elastomeric behavior, but below their transition temperature they have a glassy state. This thermally induced t...
Article
The synthesis of poly(diol-co-citrate) elastomers that are biocompatible with vascular cells and can modulate the kinetics of the NO release based on the diol of selection is reported. NO-mediated cytostatic or cytotoxic effects can be controlled depending on the NO dose and the exposure time. When implanted in vivo in a rat carotid artery injury m...
Article
The haemocompatibility of NaOH-treated poly(ε-caprolactone) (PCL) has been evaluated in vitro by analysing several parameters, including plasma recalcification time, whole blood clotting time and platelet adhesion/activation. NaOH-treated PCL films showed a significant decrease in the clot formation speed and a reduced number of adhered platelets,...
Article
Three dimensional interconnected macroporous (pore diameter: 600-800 μm) hydroxyapatite/agarose disks have been evaluated in this study as potential bone regeneration scaffolds. With this purpose, the adhesion and proliferation of human Saos-2 osteoblasts on this biomaterial were analyzed. As an index of cell function, the following parameters were...
Article
When elastomers were first proposed as useful materials for regenerative medicine a few decades ago, their high versatility and suitability for a diverse and wide range of in vivo applications could not have been predicted. Due to their ability to recover after deformation, these materials were first introduced in tissue engineering in an attempt t...
Conference Paper
Neointimal hyperplasia and thrombogenicity continue to be significant problems for the long-term function of vascular grafts. A promising strategy to address these problems is the use of nitric oxide, which has been shown to have positive effects on both processes. Nitric oxide (NO) is a small signalling molecule with critical roles in the cardiova...
Article
Biphasic calcium phosphate, a mixture of hydroxyapatite (HA) and beta-tricalcium phosphate (beta-TCP), has been successfully used as an excellent bone graft substitute because of the HA capacity for direct interaction with bone and the beta-TCP resorption properties. Agarose has been recently mixtured with ceramics as natural biodegradable binder t...
Article
Poly(epsilon-caprolactone) (PCL) is a biodegradable polyester whose biocompatibility has been widely demonstrated both in vivo and in vitro. In the last few years, our group has confirmed that NaOH-treated PCL films can serve as a suitable biomaterial for vascular tissue engineering by supporting the culture of primary vascular cells and, more rece...
Article
We have developed novel poly(diol citrate) elastomers, which are capable of providing localized and sustained release of nitric oxide (NO). The elastomer prepolymer was obtained by condensation of citric acid, 1,8-octanediol, and N,N'-bis(2-hydroxyethyl)ethylenediamine at 130 degrees C for 40 min. Films were prepared by solvent casting followed by...
Article
Biomaterials have been widely used to prepare synthetic vascular grafts over the past thirty years, but the inherent thrombogenicity of their surface can lead to graft failure. Endothelial progenitor cells (EPC) are circulating premature cells able to differentiate in either myocardial or endothelial cells (EC). The therapeutic potential of these c...
Article
Biphasic calcium phosphate (BCP), a mixture of hydroxyapatite (HA) and beta-tricalcium phosphate (beta-TCP), has attracted attention as an excellent bone graft substitute. Mixtures of ceramics with agarose, as natural biodegradable binder, have been recently performed in order to increase the flexibility of the ceramic component and to facilitate t...
Article
A new kind of magnetic thermoseed for bone tissue engineering has been synthesized. The materials used are specially designed to restore bone tissue after tumor extirpation, because they exhibit bioactive behavior and the ability to act as thermoseeds for cancer treatment using hyperthermia. The L929 cell line of mouse fibroblasts has been used in...