Maria Victoria Sanchez

Maria Victoria Sanchez
  • PhD
  • Research Associate at National Scientific and Technical Research Council

About

21
Publications
2,736
Reads
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166
Citations
Current institution
National Scientific and Technical Research Council
Current position
  • Research Associate
Additional affiliations
July 2016 - February 2017
Helmholtz Centre for Infection Research
Position
  • Posdoc fellow
April 2015 - May 2019
National Scientific and Technical Research Council
Position
  • Posdoc
National Scientific and Technical Research Council
Position
  • Researcher

Publications

Publications (21)
Article
Full-text available
Novel adjuvants are highly desired to improve immune responses of SARS-CoV-2 vaccines. This work reports the potential of the stimulator of interferon genes (STING) agonist adjuvant, the cyclic di-adenosine monophosphate (c-di-AMP), in a SARS-CoV-2 vaccine based on the receptor binding domain (RBD). Here, mice immunized with two doses of monomeric...
Article
Full-text available
Leishmaniasis is a neglected tropical disease (NTD) caused by parasites belonging to the Leishmania genus for which there is no vaccine available for human use. Thus, the aims of this study are to evaluate the immunoprotective effect of a first-generation vaccine against L. amazonensis and to identify its immunodominant antigens. BALB/c mice were i...
Article
Full-text available
The receptor binding domain (RBD) of the Spike protein from SARS-CoV-2 is a promising candidate to develop effective COVID-19 vaccines since it can induce potent neutralizing antibodies. We have previously reported the highly efficient production of RBD in Pichia pastoris , which is structurally similar to the same protein produced in mammalian HEK...
Article
Full-text available
Background Mathematical modelling of infectious diseases is a powerful tool for the design of management policies and a fundamental part of the arsenal currently deployed to deal with the COVID-19 pandemic. Methods We present a compartmental model for the disease where symptomatic and asymptomatic individuals move separately. We introduced healthc...
Article
Rationale American tegumentary leishmaniasis comprises cutaneous and mucocutaneous manifestations caused by parasitic infections by various Leishmania species. This report details the clinical interventions for a patient with American tegumentary leishmaniasis in Mendoza, Argentina, a non-endemic region. Patient concerns A 43-year-old male was adm...
Article
Full-text available
Current influenza vaccines target highly variable surface glycoproteins; thus, mismatches between vaccine strains and circulating strains often diminish vaccine protection. For this reason, there is still a critical need to develop effective influenza vaccines able to protect also against the drift and shift of different variants of influenza virus...
Preprint
Full-text available
We covalently coupled the RBD domain of SARS-CoV-2 produced in Pichia pastoris to a decameric carrier to produce a potent immunogen
Preprint
Full-text available
Since the discovery of SARS-CoV-2, several antigens have been proposed to be part of COVID-19 vaccines. The receptor binding domain (RBD) of Spike protein is one of the promising candidates to develop effective vaccines since it can induce potent neutralizing antibodies. We previously reported the production of RBD in Pichia pastoris and showed it...
Preprint
Full-text available
Background: With the lack of an effective SARS-CoV-2 vaccine, mathematical modeling has stepped up in the COVID-19 management to guide non-pharmaceutical intervention (NPI) policies. Complete lockdown has been characterized as the most powerful strategy for the epidemic; anyhow, it is associated with undeniable negative consequences. Not aware that...
Preprint
Full-text available
Background: Mathematical modelling of infectious diseases is a powerful tool for the design of management policies and a fundamental part of the arsenal currently deployed to deal with the COVID-19 pandemic. Methods: We present a compartmental model for the disease where symptomatic and asymptomatic individuals move separately. We introduced health...
Preprint
Full-text available
Background: Mathematical modelling of infectious diseases is a powerful tool for the design of management policies and a fundamental part of the arsenal currently deployed to deal with the COVID-19 pandemic. Methods: We present a compartmental model for the disease where symptomatic and asymptomatic individuals move separately. We introduced health...
Preprint
Full-text available
Background: Mathematical modelling of infectious diseases is a powerful tool for the design of management policies and a fundamental part of the arsenal currently deployed to deal with the COVID-19 pandemic. Methods: We present a compartmental model for the disease where symptomatic and asymptomatic individuals move separately. We introduced health...
Preprint
Full-text available
Mathematical modeling of infectious diseases is a powerful tool for the design of management policies and a fundamental part of the arsenal currently deployed to deal with the COVID-19 pandemic. Here we present a compartmental model for the disease that can provide healthcare burden parameters allowing to infer possible containment and suppression...
Article
Full-text available
BACKGROUND Unfortunately, no any vaccine against leishmaniasis has been developed for human use. Therefore, a vaccine based on total Leishmania antigens could be a good and economic approach; and there are different methodologies to obtain these antigens. However, it is unknown whether the method to obtain the antigens affects the integrity and imm...
Article
Full-text available
There is a critical need for new influenza vaccines able to protect against constantly emerging divergent virus strains. This will be sustained by the induction of vigorous cellular responses and humoral immunity capable of acting at the portal of entry of this pathogen. In this study we evaluate the protective efficacy of intranasal vaccination wi...
Article
Full-text available
A broad coverage influenza vaccine against multiple viral strains based on the viral nucleoprotein (NP) is a goal pursued by many laboratories. If the goal is to formulate the vaccine with recombinant NP it is essential to count on adjuvants capable of inducing cellular immunity. This work have studied the effect of the monophosphoryl lipid A and t...
Article
Full-text available
In pursuit of better influenza vaccines, many strategies are being studied worldwide. An attractive alternative is the generation of a broadly cross-reactive vaccine based on the induction of cytotoxic T-lymphocytes (CTL) directed against conserved internal antigens of influenza A virus. The feasibility of this approach using recombinant viral vect...
Article
Full-text available
Current influenza vaccines elicit antibodies effective against homologous strains, but new strategies are urgently needed for protection against emerging epidemic or pandemic strains. Although influenza vaccine candidates based on the viral nucleoprotein (NP) or matrix protein do not elicit sterilizing immunity, they have the advantage of inducing...

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