María Carmen Ovejero-Benito

María Carmen Ovejero-Benito
University Foundation San Pablo CEU | CEU · Faculty of Pharmacy

BSc Chemistry, MS Biochemistry, MS Neuroscience PhD Neuroscience

About

35
Publications
1,858
Reads
How we measure 'reads'
A 'read' is counted each time someone views a publication summary (such as the title, abstract, and list of authors), clicks on a figure, or views or downloads the full-text. Learn more
405
Citations
Additional affiliations
February 2016 - February 2016
Hospital Universitario de La Princesa
Position
  • Researcher

Publications

Publications (35)
Article
Neurons are usually regarded as postmitotic cells that undergo apoptosis in response to cell cycle reactivation. Nevertheless, recent evidence indicates the existence of a defined developmental program that induces DNA replication in specific populations of neurons, which remain in tetraploid state for the rest of their adult life. Similarly, de no...
Article
Psoriasis prevalence has been traditionally considered equal in men and women1. Nonetheless, recent studies have shown that psoriasis also presents sex differences, with a higher severity and prevalence in males2. Therefore, we hypothesized that these differences may be partially explained by sex‐specific methylation differences. To elucidate this,...
Article
Full-text available
Eslicarbazepine acetate is a third-generation anti-epileptic prodrug quickly and extensively transformed to eslicarbazepine after oral administration. Reduction in seizure frequency in patients managed with eslicarbazepine is only partial in the majority of patients and many of them suffer considerable ADRs that require a change of treatment. The P...
Article
Biological drugs targeting tumour necrosis factor are effective for psoriasis. However, 30-50% of patients do not respond to these drugs and may even develop paradoxical psoriasiform reactions. This study search-ed for DNA copy number variations that could predict anti-tumour necrotic factor drug response or the appearance of anti-tumour necrotic f...
Article
Full-text available
Donepezil and memantine are the most common drugs used for Alzheimer’s disease. Their low effectiveness could partly be explained by genetic factors. Thus, we aim to identify Single Nucleotide Polymorphisms (SNPs) associated with pharmacokinetics, pharmacodynamics, and the safety of donepezil and memantine. For this regard, 25 volunteers enrolled i...
Preprint
Epilepsy is a disabling neurological disease that affects 2% of the population. Drug-resistant epilepsy (DRE) affects 25-30% of epilepsy patients. Understanding its underlying mechanisms is key to adequately manage this condition. To analyze the main epigenetic marks of DRE an epigenome-wide association study was carried out including samples from...
Preprint
Background Epilepsy is one of the most prevalent neurological diseases, a third of patients remain drug-resistant. The exact etiology of drug-resistant epilepsy (DRE) is still unknown. Neural tetraploidy has been associated with neuropathology. The aim of this study was to assess the presence of tetraploid neurons and astrocytes in DRE. Materials...
Article
Introduction Eslicarbazepine acetate (ESL) is a sodium channel blocker indicated for partial-onset seizures with or without secondary generalization, at a single daily dose. There are very few publications on the levels of ESL metabolites in real clinical practice. Objective To describe the serum levels of licarbazepine (main metabolite of ESL) in...
Article
The P2X7 receptor (P2X7R) is a ligand-gated ion channel that is being recognized as a major player in neuropsychiatric disorders such as Major Depressive Disorder (MDD). P2X7R activation is triggered by high extracellular ATP concentrations, leading to channel opening and inducing an increase in cytosolic calcium concentration ([Ca2+]c), that activ...
Article
Full-text available
The interplay between T cells, dendritic cells and keratinocytes is crucial for the development and maintenance of inflammation in psoriasis. GADD45 proteins mediate DNA repair in different cells including keratinocytes. In the immune system, GADD45a and GADD45b regulate the function and activation of both T lymphocytes and dendritic cells and GADD...
Article
Full-text available
Aim To evaluate the effectiveness of the application of topical heat, high pressure or a combination of both on antebrachial venous cannulation. Design A cross‐over clinical trial blinded for haemolysis analysis. Methods This cross‐over clinical trial with two periods was performed in the Clinical Trial Unit of Hospital Universitario de La Prince...
Article
Epigenetics is the study of the mechanisms that regulate gene expression without modifying DNA sequences. Knowledge of and evidence about how epigenetics plays a causative role in the pathogenesis of many skin diseases is increasing. Since the epigenetic changes present in tumor diseases have been thoroughly reviewed, we believe that knowledge of t...
Article
Full-text available
Background and objectives: Psoriasis is a chronic immune-mediated skin disease caused by several complex factors, both environmental and genetic, many of which are still not fully understood. Nowadays, several groups of biological drugs are being used for psoriasis treatment. Although these therapies are very effective, they show significant variab...
Preprint
Full-text available
The interplay between T cells, dendritic cells and keratinocytes is crucial in the development and maintenance of inflammation in psoriasis. GADD45 proteins mediate DNA repair in many cells including keratinocytes. In the immune system, GADD45a and GADD45b regulate the function and activation of both T lymphocytes and dendritic cells and GADD45a li...
Article
While anti‐TNF therapies are effective against psoriasis, 30%–50% of patients do not show an adequate response to these drugs. Different candidate‐gene pharmacogenetics studies have identified single nucleotide polymorphisms that may predict anti‐TNF drugs response in psoriasis. Nevertheless, only one paper has undertaken a pharmacogenomic approach...
Article
Biological therapies are effective for moderate‐to‐severe psoriasis. However, they show inter‐individual variability in the response, are expensive and, although rarely, may cause severe side effects. Dose reduction or increase of interval of biological drug administration has become an off‐label therapeutic alternative for patients who exhibit an...
Article
Psoriatic arthritis (PsA) has been classified as an inflammatory musculoskeletal disease with a strong genetic background. Although anti‐TNF drugs are effective for PsA and moderate‐to‐severe psoriasis up to 30‐40% of patients do not respond to them. We evaluated the possible association between 13 single‐nucleotide polymorphisms (SNPs) and anti‐TN...
Article
Several polymorphisms have been identified in ABCB1, the gene encoding for the P-glycoprotein. This transporter alters the pharmacokinetics or effectiveness of drugs by excreting them from cells where it is expressed (e.g., blood–brain barrier, intestine or tumors). No consensus has been reached regarding the functional consequences of these polymo...
Article
Introduction Epigenetic factors play an important role in psoriasis onset and development. Biological drugs are used to treat moderate‐to‐severe psoriasis patients resistant to conventional systemic drugs. Although they are safe and effective, some patients do not respond to them. Therefore, it is necessary to find biomarkers that could predict res...
Poster
Introduction: The P-glycoprotein (P-gp) is an efflux pump widely expressed in the organism that exports xenobiotic compounds out of the tissue where it is expressed. It plays a central role in the Blood-Brain Barrier permeability, being responsible of Central Nervous System side-effects or ineffectiveness of many drugs. Several single-nucleotide...
Article
Aim: This study evaluated the influence of pharmacogenetics in psoriatic patients treated with adalimumab and/or infliximab. Materials & methods: Prospective observational study evaluating the association of 124 polymorphisms with the response to adalimumab or infliximab (PASI75) in patients with moderate-to-severe plaque psoriasis at 3 months (...
Article
Sertraline is a selective serotonin reuptake inhibitor (SSRI) widely metabolized in the liver by cytochrome P450 (CYP) enzymes. Besides, it is a P-glycoprotein substrate. Moreover, serotonin transporters and serotonin receptors are involved in its efficacy and safety. The aim of the present study was to evaluate the role of polymorphisms of metabol...
Article
Aim: The aim was to evaluate the effect of polymorphisms in metabolizing enzymes and transporters on the pharmacokinetics, pharmacodynamics and adverse effects of trazodone in healthy volunteers. Materials & methods: 36 healthy volunteers receiving a single 100-mg oral dose of trazodone were genotyped for 11 variants in CYP3A4, CYP3A5, CYP2D6 an...
Article
Pharmacogenetics is the study of variations in DNA sequence related to drug response. Moreover, the evolution of biotechnology and the sequencing of human DNA have allowed the creation of pharmacogenomics, a branch of genetics that analyzes human genes, the RNAs and proteins encoded by them, and the inter-and intra-individual variations in expressi...
Article
Aim: Few studies have evaluated the influence of pharmacogenetics in psoriatic patients treated with etanercept. Materials & methods: We evaluated the association between 124 polymorphisms with the response to etanercept in patients with moderate-to-severe plaque psoriasis at 3 months (n = 78) and 6 months of treatment (n = 68). Results: The r...
Article
It has recently been discovered that epigenetic modifications, specially DNA methylation, participates in the pathology of psoriasis. DNA methylation is a covalent modification dynamic and heritable that takes place in Cytosine-Phosphate-Guanine (CpG) sites and may exert transcriptional effects. Although anti-tumour necrosis factor ? (TNF) therapie...
Article
Full-text available
Nuclear DNA duplication in the absence of cell division (i.e. endoreplication) leads to somatic polyploidy in eukaryotic cells. In contrast to some invertebrate neurons, whose nuclei may contain up to 200,000-fold the normal haploid DNA amount (C), polyploid neurons in higher vertebrates show only 4C DNA content. To explore the mechanism that preve...
Chapter
Neurotoxicity, neurodegeneration, and other disorders affecting neuron survival are often related to cell cycle reentry in neurons. Traditionally, cell cycle reentry of these postmitotic cells has been thought to be associated with apoptosis. Nevertheless, cell cycle reentry and DNA synthesis in neurons could also lead to tetraploidy which may expl...
Chapter
Neurotoxicity, neurodegeneration, and other disorders affecting neuron survival are often related to cell cycle reentry in neurons. Traditionally, cell cycle reentry of these postmitotic cells has been thought to be associated with apoptosis. Nevertheless, cell cycle reentry and DNA synthesis in neurons could also lead to tetraploidy which may expl...
Article
Full-text available
Neurodegeneration is often associated with DNA synthesis in neurons, the latter usually remaining for a long time as tetraploid cells before dying by apoptosis. The molecular mechanism preventing G2/M transition in these neurons remains unknown, but it may be reminiscent of the mechanism that maintains tetraploid retinal ganglion cells (RGCs) in a...
Article
Somatic tetraploid neurons are present in different structures of the vertebrate nervous system, including cortex and retina. In this chapter, we provide evidence that these neurons can be widely detected in the chick nervous system. We also discuss mechanisms creating neuronal tetraploidy in vertebrates, concluding that the neurotrophin receptor p...
Article
A method for the accurate determination of ultratrace selenium species of relevance to cancer research, such as gamma-glutamyl-Se-methylselenocysteine (gamma-glutamyl-SeMC), using species-specific double isotope dilution analysis (IDA) with HPLC-ICP-MS is reported for the first time. The (77)Se-enriched gamma-glutamyl-SeMC spike was produced in-hou...

Network

Cited By