Maria Gabriela M Oliveira

Maria Gabriela M Oliveira
Universidade Federal de São Paulo | UNIFESP · Departamento de Psicobiologia

PhD

About

99
Publications
9,251
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2,047
Citations
Citations since 2016
31 Research Items
741 Citations
2016201720182019202020212022020406080100120
2016201720182019202020212022020406080100120
2016201720182019202020212022020406080100120
2016201720182019202020212022020406080100120

Publications

Publications (99)
Article
In neuroscience research, longitudinal data are often analyzed using ANOVA and MANOVA for repeated measures (rmANOVA/rmMANOVA). However, these analyses have special requirements: the variances of the differences between all possible pairs of within-subject conditions (i.e., levels of the independent variable) must be equal. They are also limited to...
Article
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Considering the long-lasting effects of ayahuasca in the brain and emotional processing, the objective of this study was to evaluate the behavioural and neurobiological effects of repeated ayahuasca administration in an animal model of exploratory behaviour related to novel-environment anxiety. Male Wistar rats received water, 120, 240, 480 or 3,60...
Article
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Ayahuasca is a psychoactive brew from the decoction of different Amazonian plants, traditionally used in several cultures, religions, and rituals. Scientific studies with ayahuasca are rapidly increasing due to its subjective effects and therapeutic potential. Although ayahuasca is traditionally used in its liquid presentation, lyophilized (freeze-...
Article
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Introduction. The involvement of the striatal system in S-R learning is usually based on neural plasticity related to immediate early-genes (IEGs). Previous studies also have shown that the dorsal striatum plays a role in tone fear conditioning (TFC). Objectives. Given that IEg expression in dorsal striatum supports S-R learning we analyzed early m...
Article
The dorsal subiculum (DSub) has reciprocal connections with the dorsal hippocampus, and these regions play a role in spatial representation in contextual fear conditioning (CFC). Recently, we used AP5 and muscimol infusions to show that the DSub is required for CFC consolidation. The CFC component can be present in other learning tasks, such as ste...
Preprint
Full-text available
The insular cortex (IC) is notably implicated in emotional and cognitive processing; however, little is known regarding to what extent its two main subregions play functionally distinct roles on memory consolidation of conditioned fear tasks. Here we verified the effects of temporary functional inactivation of the anterior (aIC) and posterior IC (p...
Article
Sleep medications, especially benzodiazepines, are known to cause motor and cognitive impairments as side-effects from their use. However, an evaluation of the effects of sleep medications in general on prospective and retrospective memory remains to be seen. Thus, the effects of the different types of sleep medicines were assessed using the total...
Article
Introduction Use of medications to treat sleep complaints is a common practice that may incur in cognitive deficits. Evidence, beyond the well-described effects of benzodiazepines on cognition, still needs expansion. This study assessed the use of sleep aid medications of different classes and associated factors on prospective and retrospective mem...
Article
The hippocampal formation has a well-known role in contextual fear conditioning. The dorsal subiculum connects the hippocampus to the entorhinal cortex through pathways that seemingly rely on NMDA-dependent synaptic plasticity. The role of the dorsal subiculum in contextual fear conditioning retrieval, but not acquisition, has been previously repor...
Article
Although stimuli that are associated often overlap in time, previous events can also predict the occurrence of a later aversive stimulus and be associated with it to better guide future behavior. Associations of stimuli separated in time have been studied using discrete stimulus as the conditioned stimulus (CS) in trace conditioning or, more recent...
Article
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Exposure to stress may contribute to enhanced vulnerability to drug use disorders, by altering sensitivity to drug-related reward and psychomotor effects. This study aimed to characterize the psychomotor effects of nicotine administration and then investigate the consequences of two types of repeated social defeat stress (episodic and continuous) o...
Article
Full-text available
Hippocampal damage results in profound retrograde, but no anterograde amnesia in contextual fear conditioning (CFC). Although the content learned in the latter have been discussed, alternative regions supporting CFC learning were seldom proposed and never empirically addressed. Here, we employed network analysis of pCREB expression quantified from...
Data
Hub identification in the SHAM-nH network. The centrality values were ranked according to each metric (A) and each threshold. Non-grey regions indicate the upper 25% in each metric. Regions are colored according to the color code on Fig 2. The intersection of the upper 25% most central regions in each metric (B) showed the hubs in each threshold, d...
Data
Hub identification in the SHAM network. The centrality values were ranked according to each metric (A) and each threshold. Non-grey regions indicate the upper 25% in each metric. Regions are colored according to the color code on Fig 2. The intersection of the upper 25% most central regions in each metric (B) showed the hubs in each threshold, defi...
Data
Euclidian distance-based network configuration in each group. This network configuration reveals the regions that were more strongly correlated showing them closer to each other. The node sizes are proportional to the degree of each region. The edge width is proportional to its corresponding correlation coefficient. The networks are shown by group:...
Data
Detailed centrality comparison between SHAM-nH and dHPC networks. The comparison was done for each region, centrality metric and threshold. Values in each cell show the permutation test p-value for each comparison. Green round shades show significantly higher values in SHAM-nH, and blue round shades show significantly higher values in dHPC (p < 0.0...
Data
Behavioral data acquired in Experiment 2. Organized by subject, group and total freezing time. (XLSX)
Data
Hub identification in the dHPC network. The centrality values were ranked according to each metric (A) and each threshold. Non-grey regions indicate the upper 25% in each metric. Regions are colored according to the color code on Fig 2. The intersection of the upper 25% most central regions in each metric (B) showed the hubs in each threshold, defi...
Data
Connectivity change in dHPC network by threshold. Cumulative distributions of the Fisher’s Z transformed correlation coefficients from the SHAM-nH and dHPC matrices (Left). The “#” indicates that these distributions are significantly different (Kolgomorov-Smirnov test, p<0.05). Cumulative distribution showing the z-score of the correlation coeffici...
Data
Impaired behavior in the dHPC_RSC group is independent of the incidental RSGd damage. (A) Mean and bootstrapped 95% IC of the percentage of damage in the RSC and RSGd in the RSC and dHPC_RSC groups and in the strict dHPC_RSC subgroup. Dots show the sample distribution in each group. (B) Mean and bootstrapped 95% IC of the total freezing time in the...
Data
Supporting experiments. We describe two supporting experiments in which we show, in a within-subject design, a task that is impaired by dHPC damage followed by an unimpaired performance at CFC. These task were the post-training CFC and the water maze. These experiments replicate classical findings on the effect of dHPC damage on spatial/contextual...
Data
Behavioral data acquired in Experiment 1. Organized by subject, group and total freezing time. (XLSX)
Data
pCREB expression data acquired in Experiment 1. Organized by subject, group and brain region. (XLSX)
Data
Behavioral data acquired in Experiment 3. Organized by subject, group and total freezing time. (XLSX)
Data
Behavioral data acquired in S Experiment 1. Organized by subject, group, test and total freezing time. (XLSX)
Data
Behavioral data acquired in S Experiment 2. Organized by subject, group, day, phase, quadrant, latency and freezing time. (XLSX)
Article
Full-text available
Background: Sleep loss in infants may have a negative effect on the functional and structural development of the nociceptive system. We tested the hypothesis that neonatal sleep restriction induces a long-term increase of pain-related behaviors in mice and that this hypersensitivity occurs due to changes in the neuronal activity of nociceptive pat...
Article
Sleep deprivation is known to affect memory formation, but how it interacts with different memory systems is not completely understood. Adenosine, a homeostatic regulator of sleep that has an increased extracellular concentration during sleep deprivation, is one of the neuromodulators that may be involved in this interaction. The A1adenosine recept...
Preprint
Hippocampal damage results in profound retrograde, but not anterograde amnesia in contextual fear conditioning (CFC). Possible compensating regions were seldom proposed and never empirically addressed. Here, we modelled functional brain networks based on pCREB expression of various regions in rats with dorsal hippocampal lesion (dHPC) after undergo...
Article
Time plays an important role in conditioning, it is not only possible to associate stimuli with events that overlap, as in delay fear conditioning, but it is also possible to associate stimuli that are discontinuous in time, as shown in trace conditioning for a discrete stimuli. The environment itself can be a powerful conditioned stimulus (CS) and...
Article
Several studies have investigated the transition of consolidation of recent memory to remote memory in aversively motivated tasks, such as contextual fear conditioning (CFC) and inhibitory avoidance (IA). However, the mechanisms that serve the retrieval of remote memories, has not yet been fully understood. Some evidences suggest that the central c...
Article
Full-text available
Ayahuasca is a hallucinogenic beverage that combines the action of the 5-HT2A/2C agonist N,N-dimethyltryptamine (DMT) from Psychotria viridis with the monoamine oxidase inhibitors (MAOIs) induced by beta-carbonyls from Banisteriopsis caapi. Previous investigations have highlighted the involvement of ayahuasca with the activation of brain regions kn...
Article
Extensive research has shown the involvement of the central cholinergic system in the acquisition and consolidation of tasks involving conditioned fear responses, such as those observed in contextual fear conditioning (CFC), tone fear conditioning (TFC) and inhibitory avoidance (IA). However, there are few data concerning the role of this system in...
Article
Prematurely-born infants are exposed to multiple invasive procedures while in the intensive care unit. Newborn rats and humans have similar behavioral responses to noxious stimulation. Previous studies have shown that early noxious stimuli may alter dentate gyrus neurogenesis and the behavioral repertoire of adult rats. We evaluated the late effect...
Article
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Obstructive sleep apnea syndrome is mainly characterized by intermittent hypoxia (IH) during sleep, being associated with several complications. Exposure to IH is the most widely used animal model of sleep apnea, short-term IH exposure resulting in cognitive and neuronal impairment. Pigment epithelium-derived factor (PEDF) is a hypoxia-sensitive fa...
Article
Full-text available
Numerous studies show that sleep deprivation (SD) impacts negatively on cognitive processes, including learning and memory. Memory formation encompasses distinct phases of which acquisition, consolidation and retrieval are better known. Previous studies with pre-training SD induced by the platform method have shown impairment in fear conditioning t...
Article
Full-text available
Pre-training rapid eye movement sleep (REMS) deprivation affects memory acquisition and/or consolidation. It also produces major REMS rebound at the cost of waking and slow wave sleep (SWS). Given that both SWS and REMS appear to be important for memory processes, REMS rebound after training may disrupt the organization of sleep cycles, i.e., exces...
Article
In contextual fear conditioning (CFC), hippocampus is thought to process environmental stimuli into a configural representation of the context and send it to amygdala nuclei, which current evidences point to be the site of CS-US association and fear memory storage. If it's true, hippocampus should influence learning-induced plasticity in the amygda...
Article
Extensive research has shown that the hippocampus and striatum have dissociable roles in memory and are necessary for place and response learning, respectively. Additional evidence indicates that muscarinic cholinergic receptors in the hippocampus and striatum exert an important role in the modulation of these memory systems. In our experiments, we...
Conference Paper
Full-text available
Resumo: O ouvido absoluto (OA) é um traço cognitivo raro caracteriza-do pela capacidade de identificar a altura de qualquer nota musical sem re-ferência externa. Este trabalho teve como objetivo fazer um levantamento estatístico da prevalência de alunos com OA em cursos de música de sete instituições de nível superior nas cidades de São Paulo e Bra...
Article
Full-text available
It has been demonstrated that resistance exercise improves cognitive functions in humans. Thus, an animal model that mimics this phenomenon can be an important tool for studying the underlying neurophysiological mechanisms. Here, we tested if an animal model for resistance exercise was able to improve the performance in a hippocampus-dependent memo...
Article
We investigated the relationship between deficits in fear memory induced by sleep deprivation and pCREB expression in the basal and central nuclei of the amygdala. Sleep deprivation reduced pCREB expression in the central nucleus compared to control or sleep recovered groups, and in the basal nucleus only compared to sleep recovered group. Moreover...
Article
Modafinil is a non-amphetaminic psychostimulant used therapeutically for sleep and psychiatric disorders. However, some studies indicate that modafinil can have addictive properties. The present study examined whether modafinil can produce behavioral sensitization in mice, an experience and drug-dependent behavioral adaptation, and if individual di...
Article
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A growing body of scientific evidence indicates that exercise has a positive impact on human health, including neurological health. Aerobic exercise, which is supposed to enhance cardiovascular functions and metabolism, also induces neurotrophic factors that affect hippocampal neurons, thereby improving spatial learning and memory. Alternatively, l...
Article
Studies investigating factors that influence tone recognition generally use recognition tests, whereas the majority of the studies on verbal material use self-generated responses in the form of serial recall tests. In the present study we intended to investigate whether tonal and verbal materials share the same cognitive mechanisms, by presenting a...
Article
Full-text available
Few data exists about the pharmacological properties of Heteropterys aphrodisiaca O. Mach. (Malpighiaceae), which is native to the scrubland regions of Brazil. The present study investigated the effects of oral treatment with H. aphrodisiaca extract (BST0298) on the learning and memory of young (3-6 months) and aged (21-23 months) rats, and compare...
Article
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Study Objectives Evaluation of modafinil effects on the inhibitory avoidance task (IA). Design Rats were trained on a multiple trial IA task after receiving modafinil or vehicle injections. In experiment 1 they were trained with a weak protocol under baseline condition and in experiment 2, with a stronger protocol under sleep-deprivation condition...
Article
Full-text available
Evaluation of modafinil effects on the inhibitory avoidance task (IA). Rats were trained on a multiple trial IA task after receiving modafinil or vehicle injections. In experiment 1 they were trained with a weak protocol under baseline condition and in experiment 2, with a stronger protocol under sleep-deprivation condition. In experiment 1 modafin...
Conference Paper
Full-text available
Resumo Este estudo investigou, através do uso de questionários, a prevalência de ouvido absoluto entre 263 estudantes de música universitários de duas diferentes regiões brasileiras (130 da Universidade de Brasília – UnB e 133 da Universidade Estadual Paulista – UNESP). Além disso, investigou: particularidades da percepção auditiva entre aqueles qu...
Article
Full-text available
Introdução O modelo de memória operacional assume a existência de quatro componentes re-lacionados: executivo central, alça fonológica, esboço vísuo-espacial e buffer episó-dico (Baddeley, 2000). Tais componentes seriam responsáveis pelo armazenamento e manipulação da informação necessária para atividades cognitivas. A alça fonoló-gica está relacio...
Article
Increasing evidence indicates that sleep deprivation (SD) alters responses to pharmacological agents by affecting specific transmitter systems. The present work addressed deficits in passive avoidance (PA) performance that are seen after SD, and investigated whether treatment with the inverse benzodiazepine agonist beta-CCM could prevent such defic...
Article
Facilitation of extinction can be used as a therapeutic tool in treatment of both post-traumatic stress disorder and drug addiction. The present study examined whether the blockade of D2 receptors before each extinction trial would accelerate the extinction of cocaine-induced place preference. Male Wistar rats were initially conditioned and tested...
Article
NMDA receptor antagonist D-AP5 was injected into the dorsal hippocampus of Wistar rats before or immediately after the training session in fear conditioning. Training was conducted both with signaled (background context) or unsignaled (foreground context) footshocks. Contextual fear conditioning was assessed 24 h later and tone fear conditioning 48...
Article
The present study evaluated the effects of intermittent hypoxia (IH) and sleep restriction (SR) upon motor and cognitive function in rats. Also evaluated were catecholamine concentrations and tyrosine hydroxylase (TH) protein expression in different regions of the forebrain. Wistar Hannover rats were submitted to IH for 4 days or 21 days (2 min roo...
Article
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Semantic relations among words and repetition enhance free recall, but it is unknown if these facilitating factors are effective in dementia. Alzheimer's patients (MILD-Alz, MOD-Alz) were compared to healthy elderly. Fifteen-word lists were read out to the subjects. In four sets of lists the words in intermediary input positions were semantically r...
Conference Paper
Full-text available
Resumo: O ouvido absoluto é um traço cognitivo raro caracterizado pela capacidade de identificar a altura de qualquer tom isolado sem nenhuma referência externa. O objetivo deste trabalho foi realizar um levantamento estatístico da incidência de alunos com ouvido absoluto em uma instituição superior de ensino musical e, ao mesmo tempo, tentar categ...
Article
Full-text available
Nociceptin, or orphanin FQ (N/OFQ), the endogenous ligand of NOP receptors, is known to regulate learning and memory processes. To verify the role of N/OFQ in the acquisition of contextual (CFC) and tone fear conditioning (TFC), Wistar male rats received intracerebroventricular injections of N/OFQ (0.1-5.0 nmol) before training, and were tested 24...
Article
Previous studies show that early life events result in neurobehavioural alterations that may be either beneficial or detrimental to the stress response. Given the close relationship between corticosterone secretion and mnemonic processes, the purpose of the present study was to investigate the effects of brief (BMS, 15 min) and long maternal separa...
Article
The cholinergic system is important in learning processes and probably influences behavioral sensitization to drugs. This study examined the effects of scopolamine (scop), a muscarinic antagonist, on the behavioral sensitization to ethanol (EtOH) stimulant effect in mice. In experiments 1 and 2, male Swiss albino mice received saline or 1.0 mg/kg s...
Article
It has been shown that exercise is helpful against brain disorders. However, this may not be true for intense exercise (IE). Because it is easy to misadjust exercise intensity with physical condition, it is essential to know the effects of IE on cognitive process because it may have important consequences on people skills and work skills. We invest...
Article
The objective of the present study was to observe the effects of pre-training or post-training administration of dicyclomine, a M1 muscarinic antagonist, on inhibitory avoidance (IA) and contextual fear conditioning (CFC) and to investigate if the effects observed with the pre-training administration of dicyclomine are state-dependent. For each beh...