Maria Livia Ognean

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Maria Livia verified their affiliation via an institutional email.

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• Assoc. Prof., Senior Neonatologist, MD PhD
• Head of Neonatology Department at Lucian Blaga University of Sibiu

Background/Objectives: Preterm infants represent a population group at increased risk for vitamin D deficiency (VDD) and for its negative impact on various outcomes like metabolic bone disease or rickets, respiratory complications like respiratory distress syndrome and the development of bronchopulmonary dysplasia, necrotizing enterocolitis, or ret...

Background and Objective: The effects of neonatal hypoglycemia on the developing brain are well known, resulting in poor neurological outcomes. We aimed to perform an updated meta-analysis on neonatal hypoglycemia, the severity of hypoglycemia, and the associated neurodevelopmental outcomes from infancy to adulthood. Methods: A systematic literatur...

Surfactant therapy in preterm and term born infants has been a huge success story. In the meantime, we have very detailed answers to the five essential questions of each medical therapy: which infant should be treated, when, with which drug, in/at what dose, and via which route of administration. The answers to these questions depend on the gestati...

Background: Respiratory distress syndrome (RDS) is the primary cause of respiratory failure in preterm infants, but it also affects 5–7% of term infants. Dysfunctions in pulmonary surfactant metabolism, resulting from mutations of the lung surfactant genes, are rare diseases, ranging from fatal neonatal RDS to interstitial lung disease, associated...

Candida spp. is rarely found in neonatal early-onset sepsis (EOS) etiology. However, candidemia is associated with increased mortality and morbidity, as in late-onset sepsis. Congenital candidiasis may present as a mucocutaneous infection or, more rarely, as a systemic infection in term and preterm infants. This paper presents case reports of two c...

Dextro-transposition of the great arteries (D-TGA) is a critical congenital heart defect that can impact neurodevelopment due to cerebral perfusion and oxygenation disorders followed by alterations in synaptogenesis, gyrification, sulcation, and the microstructure. Brain injuries can occur both pre-operatively and postoperatively, especially white...

Background. Respiratory distress syndrome (RDS) is the primary cause of respiratory failure in preterm infants, but it also affects 5-7% of term infants. Dysfunctions in pulmonary surfactant metabolism, resulting from mutations of the lung surfactant genes, are rare diseases, ranging from fatal neonatal RDS to interstitial lung disease, associated...

Dextro-transposition of the great arteries (D-TGA) is a critical congenital heart defect that can impact neurodevelopment due to cerebral perfusion and oxygenation disorders. Materials and Methods: In a retrospective study conducted at a tertiary center between 2016 and 2023, we investigated the early effects of Prostaglandin E1 (PGE1) administrati...

Gastric cancer stands as the fourth leading cause of cancer-related deaths globally, primarily comprising adenocarcinomas, categorized by anatomic location and histologic type. Often diagnosed at advanced stages, gastric cancer prognosis remains poor. To address the critical need for accurate tumoral markers for gastric cancer diagnosis, we conduct...

Candida spp. is rarely found in the etiology of neonatal early-onset sepsis (EOS). However, candidemia is associated with increased mortality and morbidity, as in late-onset sepsis. Congenital candidiasis may present as mucocutaneous infection or, more rarely, as a systemic infection in term and preterm infants. Material and methods: Case reports o...

Nasal high-frequency oscillatory ventilation (nHFOV) has emerged as an effective initial and rescue noninvasive respiratory support mode for preterm infants with respiratory distress syndrome (RDS); however, little is known about nHFOV use in Romanian neonatal intensive care units (NICUs). Objectives: We aimed to identify the usage extent and clini...

Despite all the advances in diagnosis and treatment, early-onset neonatal sepsis remains a serious and potentially life-threatening condition, with increased morbidity and mortality. The authors review the persistent controversies and challenges surrounding the definitions of neonatal sepsis, neonatal early- and late-onset sepsis, clinical signs an...

Background and objective. Renal agenesis is a rare condition with complex causes, often involving genetic and environmental factors, though the exact triggers remain elusive. Studies have suggested an increased prevalence of renal agenesis. This study aims to evaluate the prevalence of renal agenesis and types of associated anomalies in newborns. M...

Nasal high-frequency oscillatory ventilation (nHFOV) has emerged as an effective initial and rescue noninvasive respiratory support mode for preterm infants with respiratory distress syndrome (RDS). Multiple noninvasive respiratory support modes are currently available in Romania, but little is known about nHFOV use in Romanian neonatal intensive c...

Background and Objectives: The purpose of this study was to investigate whether early surfactant administration affects the status of ductus arteriosus (DA) in preterm infants ≤ 32 weeks of gestational age (GA) within 24 h of birth. Materials and Methods: It is a prospective study conducted from 1 March 2022 to 31 December 2023 in a tertiary academ...

Persistent pulmonary hypertension of the newborn (PPHN) is a common neonatal condition in newborns admitted to the neonatal intensive care units (NICUs). PPHN has still a high mortality and morbidity. Inhaled nitric oxide (iNO) is the first line vasodilator therapy for PPHN in high income countries. In low-to-middle income countries (LMICs), availa...

D-bifunctional protein deficiency (D-BPD) is a rare, autosomal recessive peroxisomal disorder that affects the breakdown of long-chain fatty acids. Patients with D-BPD typically present during the neonatal period with hypotonia, seizures, and facial dysmorphism, followed by severe developmental delay and early mortality. While some patients have su...

Background and Objectives: The purpose of this study was to investigate whether early surfactant administration affects the status of ductus arteriosus (DA) in preterm infants ≤32 weeks of gestational age (GA) within 24 hours of birth. Materials and Methods: It is a prospective study conducted from March 15, 2022, to November 15, 2023, in a tertiar...

Background. Diaphragmatic hernia is a complex congenital anomaly, often associated with other structural defects with lethal potential. Congenital diaphragmatic hernia (CHD) often causes a chain of multiple complications since intrauterine development, the most frequent of which is pulmonary hypoplasia complicated, in turn, by the installation of p...

Background and Objectives: The purpose of this study to investigate if the early variations in the hematological profile could be a useful tool in the prediction and evaluation of intraventricular hemorrhage. Materials and Methods: It is a retrospective study conducted between 1 January 2017 and 31 December 2022, in a tertiary academic center. In-b...

Background: Adequate perinatal management is essential in caring for extremely preterm (EP) infants. We aimed to evaluate and compare the impact of different protocols on short-term outcomes. Methods: A retrospective study was conducted on EP infants in a Romanian perinatal tertiary center during 2008-2012 and 2018-2022. Results: Data on 270 EP inf...

Background: Survival and outcome of extremely preterm (EP) infants have improved due to changes in the management of stabilization at birth and respiratory distress syndrome. Methods: In a retrospective study conducted at an academic perinatal level III center in Romania, we compared the effects of different protocols on the early outcomes of EP in...

Introduction This study is part of a European survey on delivery room practices endorsed by the Union of European Neonatal and Perinatal Societies (UENPS) and the Romanian Association of Neonatology (ANR). The aim of our study was to evaluate the current neonatal resuscitation practices in Romanian maternity hospitals and to compare the results bet...

Vitamin D has been long time recognized as an important vitamin for bone mineralization but recent studies have revealed multiple and complex implications of vitamin D for health, starting with reproduction success, embryogenesis, fetal development and growth, protection against multiple complications during pregnancy and prevention of neonatal mor...

Background: Transportation of sick newborns is a major predictor of outcome. Prompt identification of the sickest newborns allows adequate intervention and outcome optimization. An optimal scoring system has not yet been identified. Aim: To identify a rapid, accurate, and easy-to-perform score predictive for neonatal mortality in outborn neonates....

Background: Neonatal transportation of sick newborns is a major predictor of outcome. Prompt identification of the sickest newborns allows immediate corrective intervention and outcome optimization. Multiple severity scores were developed, however an optimal score has not yet been identified. Aim: To identify a rapid, accurate, and easy to perform...

Background: As the COVID-19 pandemic evolved, concerns grew about its impact on pregnant women. This study aimed to determine how SARS-CoV-2 affects pregnancy, birth, and newborns, in order to identify vulnerable individuals and provide proper care. Methods: This is a retrospective case-control study of 398 pregnant women who delivered at the Em...

Background and objectives. Multiple reports, available while the pandemic progressed, raised concerns that COVID-19 poses higher risks to pregnant women and their newborns. Still, limited evidence exists on the impact of the COVID-19 pandemic during pregnancy and perinatal period. This study aimed to evaluate the rate of early-onset neonatal COVID...

Background and objectives. The authors are shortly reviewing the national and international recommendations for umbilical cord clamping at birth and the most important evidence supporting these recommendations. Also, based on the recommendations discussed, a clinical protocol for delayed umbilical cord clamping (DCC) is proposed.

Prematurity is a major health problem and it is an important life-threatening pathology for the children in their perinatal, new-born and infantile period. We have evaluated the epidemiologic factors for prematurity in Obstetrics Clinic of Sibiu city. We have analysed the epidemiology of 649 preterm babies between 2012 and 2019 in a III grade Mater...

de 5 ani în cadrul epidemiilor anuale [1-3]. Majoritatea deceselor asociate infecției cu VSR au loc în țările în curs de dezvoltare [1,4]. De asemenea, se estimează că VSR este cea mai frecventă cauză virală de deces la copiii mai mici de 2 ani [5]. Infecțiile severe cu VSR reprezintă circa 50-80% din to-talul bronșiolitelor și apar mai ales la cop...

Proiectul European Standards of Care for Newborn Health (ESCNH)-Standardele Europene de Îngrijire a Sănătății Nou-născuților-este o colaborare interdisciplinară inițiată de European Foundation for the Care of Newborn Infants (EFCNI)-Fundația Europeană pentru Îngrijirea Nou-născuților-, prima organizație și rețea pan-europeană constituită în interes...

Citation: Neamt , B.M.; Visa, G.; Maniu, I.; Ognean, M.L.; Pérez-Elvira, R.; Dragomir, A.; Agudo, M.; S , Ofariu, C.R.; Gheonea, M.; Pitic, A.; et al. A Decision-Tree Approach to Assist in Forecasting the Outcomes of the Neonatal Brain Injury. Int. J. Environ.

Until 1989, Romania was one of the countries of the communist bloc in Europe and its healthcare system was characterized by centralized planning and severe underfunding, with low performance and low quality healthcare. Since 1998, Romania replaced the Semashko model with a social health insurance system, highly centralized under the management of t...

1. Scop Scopul oricărui protocol este de a standardiza actul medical într-o situație clinică dată, în scopul eficientizării acestuia, evitării erorilor și obținerii celor mai bune pro-gnosticuri clinice. Reanimarea nou-născutului este o procedură în trepte, care se aplică tuturor nou-născuților la naștere pentru a asigura supraviețuirea în cele mai...

1. Scop Scopul oricărui protocol este de a standardiza actul medical într-o situație clinică dată, având ca obiectiv eficientizarea acestuia, evitarea erorilor și obținerea celor mai bune prognosticuri clinice. În ciuda progreselor realizate în perinatologie, infecțiile neonatale continuă să repre-zinte o cauză semnificativă de morbiditate și morta...

1. Scop Scopul oricărui protocol este de a standardiza actul medical într-o situație clinică dată, cu rolul eficientizării acestuia, al evitării erorilor și al obținerii celor mai bune prognosticuri clinice. Ventilația mecanică, deși salvatoare de viață, prezintă însă numeroase riscuri pentru pacient. Infecţiile nosocomiale (IN) reprezintă o cauză...

Scop Scopul oricărui protocol este de a standardiza actul medical într-o situație clinică dată în scopul eficientizării acestuia, evitării erorilor și obținerii celor mai bune prognostice clinice. Afecțiunile respiratorii neonatale reprezintă cele mai frecvente afecțiuni ale nou-născuților prematuri și la termen internați în terapia intensivă neona...

Aspecte generale-certitudini și incertitudini Clostridium difficile (CD) a fost decris initial, în studiile vechi, ca și germen comensal în cazul sugarilor cu vârsta mai mică de un an. În ultimii ani CD este tot mai mult identificat ca germen patogen enteric la vârsta pediatrică, chiar și în cazul copiilor la care nu sunt identificați factori tradi...

Clostridium difficile (CD), described initially as a commensal germ in infants under 1 year of age, is more and more often recognized as enteric pathogen in newborns and children, even in those without risk factors. Aim: The paper is shortly reviewing available data regarding CD colonization and infection in neonates and presents a case report. Ma...

Aim:To identify risk factors for BPD in preterm infants ≤ 32 weeks of gestation managed on non-invasive respiratory support. Material and methods: • Information prospectively collected from the National Register of RDS between 01.01.2010-31.12.2015 • All surviving preterm infants with GA ≤ 32 weeks were included • Analysis was done using IBM SPSS S...

Aim: To evaluate the impact of maternal diabetes on neonatal short term outcome. Material and methods : • All newborns delivered by mothers with diabetes between 2015 and 2017 in our regional level III unit • For each infant of a diabetic mother two other infants with gestational age ± 1 week and birth weight ± 100g were selected • Anthropometric d...

Acute neonatal respiratory failure may have different etiology and evolves with hypoxia, persistent pulmonary hypertension, and often with cardiac failure. Ultrasonography, including cardiac and pulmonary ultrasound, have acquired, in recent years, an extremely important role in the diagnosis and management of neonatal respiratory distress. Objecti...

The impact of maternal thrombophilia, both for the mother and the fetus, is controversial. Early during pregnancy thrombophilia may cause abortions while placental vascular abnormalities may induce problems towards the end of the pregnancy (fetal loss, preeclampsia, placental abruption, intrauterine fetal retardation). Perinatal intraventricular he...

Myelomeningocele is the most common congenital abnormality of the central nervous system, characterized by impaired neuromuscular function, Statistically, this malformation occurs one in 1000 births and the neural tube defect can be located anywhere along the spine. The paper presents two cases evaluated by prenatal ultrasound and MRI. In both case...

The widespread use of fetal morphology ultrasound in the 2nd trimester of pregnancy has increased the fetal anomaly detection rate. Fetal hydronephrosis is the most common antepartum detected anomaly. Fetal hydronephrosis is defined as dilation of the kidney pelvis and calycels. When hydronephrosis is observed, the antenatal ultrasound should docum...

Purpose Methods Conclusions References To evaluate differences in neonatal outcomes between pregnancy induced maternal hypertension and preexistent maternal hypertension.

Aim: to identify risk factors for HIVS and the impact of HIVS during early neonatal period Material and methods: • Retrospective study between 2015-2017 on newborns delivered by diabetic mothers evaluated by echocardiography • Analysis was done using IBM SPSS Statistics 19, p considered significant when <0.050, CI of 95%. Results: • The study group...

Aim:To evaluate the incidence and impact of neonatal hypoglycemia in IDM during the neonatal period Material and methods: • retrospective study , • IDM born between 2015-2017 in the Maternity Hospital Sibiu • Analysis was done using IBM SPSS Statistics 19, p considered significant when <0.050, CI of 95%. Results: • The study group comprised 108 IDM...

Acute neonatal respiratory failure may have different etiology and evolves with hypoxia, persistent pulmonary hypertension, and often with cardiac failure. Ultrasonography, including cardiac and pulmonary ultrasound, have acquired, in recent years, an extremely important role in the diagnosis and management of neonatal respiratory distress. Objecti...

A case report of neonataly diagnosed Apert syndrome