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María Inés Isla

María Inés Isla
CONICET-CCT Tucumán · Instituto de Bioprospección y Fisiologia Vegetal

Professor

About

180
Publications
28,709
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5,063
Citations
Additional affiliations
January 2017 - January 2021
CONICET-CCT Tucumán
Position
  • Research Director
March 1989 - present
National University of Tucuman
Position
  • Professor (Full)
Description
  • -

Publications

Publications (180)
Article
Background: Collagenase, hyaluronidase, elastase and tyrosinase enzymes are overexpressed and overactive in the skin aging process and hydrolyze the components of the dermal extracellular matrix (ECM) of the skin; these enzymes produce the clinical framework of aging, which includes skin dryness, hyperpigmentation, wrinkles, and inelasticity. Aim...
Chapter
The study of the bioactive compounds of fruits of native plant species from Argentina has been of great interest in recent years. In this context, fruits of Prosopis alba, Prosopis nigra, Geoffroea decorticans, Ziziphus mistol, and Solanum betaceum that grow in different ecoregions from Argentine Northwestern have been investigated. This chapter ha...
Chapter
Prosopis alba seeds constitute an excellent source of gluten-free protein (62.09% in cotyledon or germ) that can represent a valuable nutritional complement by its amino acid composition. Proteins and protein hydrolysates from cotyledons or germ from Prosopis alba seeds showed antioxidant capacity and inhibitory activity of proinflammatory enzymes...
Chapter
Flours obtained from P. alba mature mesocarp showed a high level of polyphenolic compounds. The bound polyphenols (BPs) content (320–1700 mg GAE/100 g flour) was higher than free polyphenols (FPs) content (198–350 mg GAE/100 g flour). BPs were considered to have more health benefits since they may escape from upper gastrointestinal digestion condit...
Chapter
Dairy and vegetable-based foods both represent pillars of human nutrition, and their consumption is particularly warranted based on the multiples functional properties they carry on and the health benefits they confer. Scientific research supports the consumption of both dairy and vegetable products to sustain metabolic health. This is supported by...
Article
Background and Aims Fruit traits and their interrelations can affect foraging choices by frugivores, and hence, the probability of mutualistic interactions. Certain combinations of fruit traits that determine the interaction with specific seed dispersers are known as dispersal syndromes. The dispersal syndrome hypothesis (DSH) states that seed disp...
Article
Ethnopharmacological relevance Herbal beverages have been used as a natural part of the medicinal and food culture in northwestern Argentina. The flower beverages (infusion or decoction) of Acacia caven, Geoffroea decorticans and Larrea divaricata, three native species from arid and semiarid regions of Argentina are widely used as anti-inflammatory...
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Several hypotheses explain how sensory, anatomical and physiological constraints drive fruit preference in frugivores. Optimal diet theory (ODT) states that frugivores make decisions based on the energy contained in food. In contrast, geometry of nutrition (GN) states that animals balance their macronutrient intake instead, opting for rough energy....
Chapter
The genus Baccharis, with approximately 500 species, is one of the largest genera of the family Asteraceae. Species of this genus are distributed mainly in the warm temperate and tropical regions of Brazil, Argentina, Colombia, Chile and Mexico. In Argentina, 96 species have been described. Baccharis tola and Baccharis boliviensis are used in tradi...
Chapter
Zuccagnia punctata Cav. (Fabaceae, Caesalpiniaceae) is an argentine medicinal plant species, belonging to a monotypic genus representatives of which grow in the arid and semiarid Argentine regions, in the biogeographic Province of Monte. The taxonomic characteristics, traditional use, phytochemistry and pharmacological activity of Z. punctata aeria...
Chapter
Parastrephia lucida, known as “romero”, “tola” o “t’hola”, “chachakoa”, “tola de río”, “tola de agua”, is a medicinal plant found in large areas in the semi-arid Puna of Argentina, Chile, Bolivia and Peru. It is part of the landscape called “tolar”, with other species of Parastrephia, Baccharis, and Fabiana. The “tolares” have been a very important...
Chapter
Fabiana Ruiz & Pav. (Solanaceae) is a South American genus, growing especially in arid mountainous areas. In Argentina, 10 species are present in the High Andean, Pre-Puna, Puna, and Monte biogeographical regions, in addition to Patagonia. In this chapter reference is made to four Fabiana species, F. punensis, F. patagonica, F. bryoides and F. dens...
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The aim of this review is to provide overall information on Argentine propolis and to shed light on its potential, especially the one from the Monte region so as to support future research in the field. Around 1999, the Argentine propolis began to be chemically and functionally characterized to give it greater added value. Because Argentina has a w...
Article
The frozen fruit pulp market has shown suitable growth due to the current technology available, having broad market potential. This study aimed to evaluate the physicochemical, microbiological, functional, and sensorial characteristics of Solanum betaceum pulp (chilto pulp) with different skin colors (orange and orange-red) under storage at −18 °C...
Chapter
The Monte region from Argentina represents one of the extreme environments for the growth of numerous plant species due to its aridity, intense ultraviolet radiation, low temperatures, and marked thermal amplitude. Bioprospecting of plant species that inhabit these environments has been carried out in order to identify phytochemicals of medicinal v...
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Parastrephia lucida (Meyen) Cabrera is an endemic species from the Argentinean Puna used in traditional medicine to relieve inflammation. To give scientific support to the ethnopharmacological claim, a bio-guided fractionation of a P. lucida extract was carried out according to its antioxidant activity (in vitro by different primary and secondary m...
Article
Background: The overexposure to sun ultraviolet (UV) radiation produce photoaging by effect of free radicals on lipid, protein, and nucleic acid or by direct activation of responsible enzymes of cleavage of extracellular matrix components (EMC). Aims: To develop new anti-photoaging agents, the anti-aging activity of four "jarillas" standardized...
Article
A b s t r a c t The aim of this work was to develop bio-based packaging materials based on black carob extracts (BCE) and κ-carrageenan (κ-c) blends, and to study their impact for cheese preservation. Firstly, black carob extracts were obtained with and without alcohol pre-treatment (BCE-a and BCE-b), respectively, and its chemical composition and...
Article
Ethnopharmacological relevance Jarilla is the common name of an appreciated group of native plants from the semi-arid region in Argentina (Larrea cuneifolia Cav., Larrea divaricata Cav. and Zuccagnia punctata Cav.) that have been historically consumed to heal respiratory, musculoskeletal and skin ailments, as well as recommended for weakness/tiredn...
Article
Ethnopharmacological relevance Flourensia fiebrigii is a plant used in traditional medicine in the Argentine Calchaquí Valley as purgative, expectorant, anti-rheumatic and anti-inflammatory. Aim of the study The aim of this study was to analyze the macroscopic and microscopic characteristics of F. fiebrigii leaf and stem, the phytochemical composi...
Article
Propolis has been used in ethnobotany and traditional practices and is currently considered a source of phytotherapeutics. The aim of this study was to develop an antibiotic and antioxidant hydrogel containing Argentine propolis extract and evaluate its stability for one year in different conditions. A fingerprint by HPLC-DAD of propolis extract sh...
Article
The effect of Argentine propolis extracts against enzymes related to metabolic syndrome and oxidative stress, as well as the botanical origin of raw propolis, were studied. Histological and chemical analyses of propolis samples revealed that the botanical origin is Zuccagnia punctata , an Argentine medicinal plant. The melissopalynological analysis...
Article
Prosopis nigra fruits are consumed in Argentina principally as fine flour. The plant material with the highest granulometry is considered a waste. Metabolites such as phenolics compounds, fibers, and proteins obtained from vegetable by-products or waste can be used as ingredients for new functional foods. The present study describes the characteriz...
Article
Edible coatings based on gelatin containing an ethanolic extract of Propolis (PEE) collected of hives from Monte region in Argentina were developed and applied to raspberries (Rubus idaeus L.) with the aim of prolonging their shelf life. Initially, the antifungal activity of PEE was evaluated against the major fungal pathogens of fruit and vegetabl...
Chapter
The disposal of a large number of waste materials results in high costs for the food industry and can have a negative environmental impact. Metabolites, such as phenolic compounds, fibers, and proteins obtained from vegetable by-products or waste biomass could be used as ingredients in the formulation of new functional foods. Argentine native fruit...
Article
Ethnopharmacological relevance: The Argentinean medicinal plants Larrea divaricata Cav., Larrea cuneifolia Cav., Larrea nitida Cav., Zuccagnia punctata Cav. and Tetraglochin andina Ciald are used alone and in combined in traditional medicine by inhabitants from Argentinean northwestern to solve mycosis, vaginal infections, gastrointestinal, respir...
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The "red chilto" (Solanum betaceum Cav) is a native fruit from the Yungas forest of Argentina. Red chilto is a neglected and underutilized native species (NUS). The objective of this work was to evaluate the potentiality of pulp, seed and skin from "red chilto" as a functional food ingredient to add value to a native resource of Argentine Yungas to...
Article
Aloja is a beverage obtained using natural fermentation, and añapa an unfermented beverage from Prosopis alba pods. This study aimed to determine phytochemical composition and functional properties of añapa and aloja, as well as, their toxicity and sensorial evaluation. In these two beverages, sugars and polyphenols were found to be the main compon...
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Fermented plant-based foods and beverages constitute foods of high nutritional and functional value with appreciated health beneficial effects. They represent a natural and sustainable alternative to counteract the large wastage of vegetables and fruits due to their short shelf life. Usually, the use of controlled fermentation process using autocht...
Article
Ethnopharmacological relevance: B. boliviensis and B. tola are used in traditional medicine in the Argentine Puna to treat skin and soft tissue infections and inflammatory processes in humans and animals. Aim of the study: To assess the potential of phytotherapeutic preparations of Baccharis species as antifungal agents against clinically releva...
Article
The aim of this work was to develop active edible coatings based on marine polysaccharide matrices and polyphenols-enriched native plant extracts from arid and semiarid regions of Argentina. Initially, five plant extracts were characterized in terms of antioxidant, antibacterial and antiviral activity and the one with better biological properties a...
Article
Parastrephia lucida (Compositae), Tessaria absinthioides (Compositae), and Ephedra multiflora (Ephedraceae), three plant species from the Argentinean Puna (3600 m.a.s.l.) were selected for their anti‐inflammatory and antioxidant properties to prepare mixtures to evaluate their use as nutraceuticals. Seven binary and ternary herbal mixtures made of...
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Here, 2′,4′-dihydroxychalcone (DHC) has been isolated from Zuccagnia punctata Cav. (Fabaceae) medicinal plant and, after that, the FT-IR, UV–Visible, ¹H and ¹³C NMR spectroscopies were combined with the hybrid B3LYP/6–311++G** method to characterize this species. Structural, electronic, topological and vibrational properties of two conformers of DH...
Article
Ethnopharmacological relevance: In northwestern Argentina inhabit several ancient indigenous communities with diverse cultural and historical background. Geographical isolation has contributed to the prevalence of a native plant-based folk medicine; "jarilla" species are medicinal plants widely used in local communities for the treatment of mycosi...
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Full-text available
The typical generalist diet of most seed dispersers opens a window of opportunity to the invasion of alien plants. Fleshy-fruits show a diverse combination of traits that allow them to interact with seed dispersers. The outcome of the new relationships established between alien plant species and native fruit-eating animals depends both on attribute...
Article
Zuccagnia punctata Cav. (Zp), Larrea cuneifolia Cav. (Lc) and Larrea divaricata Cav. (Ld), are shrubs commonly called “Jarillas” and used in Argentinian local communities as medicinal plants. In this work, phytochemical profile and antioxidant activity of infusions prepared from aerial parts and mixtures in different proportions, before and after a...
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Aims: Prosopis alba flour is a natural source of nutrient and phytochemicals with potential effects on cardiovascular risk factors. The aim of this work was to examine the effects of dietary supplementation with Prosopis alba seed flour (Pr-Feed) on a high fat diet (FD)-induced rabbit model of metabolic syndrome. Main methods: Rabbits were separ...
Article
In this work, zein fibers loaded with phenolic-enriched extracts from pulp, seed and skin of orange chilto were collected on polyhydroxyalkanoate (PHA)films through the electrospinning technique, for their potential use as bioactive internal coatings for food packaging applications. The zein fibers were characterized by scanning electron microscopy...
Article
The aim of this work was to compare the anti-inflammatory activity of compounds prepared from terpenes and the synthetic drugs ibuprofen and naproxen. The anti-inflammatory activity of the hybrid compounds was compared with the activity of the parent compounds. This was accomplished using in vitro inhibition of lipoxygenases (LOX) and COX-2, and in...
Article
The present study aimed at investigating the lactic fermentation of cactus pear (Opuntia ficus-indica) fruit juice with the autochthonous and potentially probiotic strain Lactobacillus plantarum S-811. L. plantarum S-811 was able to quickly acidify the juice with a decrease in the pH from 5.5 to 3.7 and a production of 5.06 g l-1 of lactic acid. Fe...
Article
Prosopis alba (algarrobo) flours are traditional food resources from Argentina. The aim of this work was to determine the effect of particle sizes of Prosopis flour on its chemical composition and functional properties. Flours were obtained by mechanical methods (F1 to F4, >840, 840 to 500, 500 to 149 and <149 µm, respectively). F1 and F2 contain 4...
Article
Bees collect vegetal resins that they mix with their wax and mechanical impurities to elaborate propolis, whose chemical composition is complex and variable depending on botanical/geographical origin, type of bee, time of year when it was produced and function in the hive. The presence of compounds that absorb UV radiation, such as those of the phe...
Article
The design of novel delivery systems to treat vaginal fungal infections is a topic of high interest. Chitosan, being itself antimicrobial and having good mucoadhesive properties, is an excellent candidate as a delivery matrix for active compounds. In this work, chitosan microcapsules containing dry extracts of Argentinean medicinal plants with prov...
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In this work, we intended to inhibit the biofilm synthesis and the metabolism of Gram-positive and Gram-negative bacteria using two highly available wastes (stem and marc) obtained after the manufacturing of Torrontes wine at Cafayate, Argentina. Wine wastes contain a significant amount of bioactive compounds, mainly phenolic compounds, which makes...
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Larrea divaricata Cav., L. cuneifolia Cav. and L. nitida Cav., Zygophyllaceae, are evergreen xerophytic shrubs occurring in Northwestern Argentina used in traditional medicine. The aim of this work was to characterize the morphology, anatomy and histochemistry of the vegetative organs of three Larrea species by light and scanning electron microscop...
Article
Background: The consumption of flavonoids has been shown to prevent cardiovascular diseases including atherosclerosis. In this sense, in a recent in vitro study we demonstrated that a rich in flavonoids extract from Zuccagnia punctata has beneficial effects on vascular function in aorta from hypercholesterolemic rabbits. Purpose: The aim of this...
Article
Larrea divaricata (Ld), Larrea cuneifolia (Lc) and Larrea nitida (Ln) are shrubs occurring in Northwestern Argentina used in traditional medicine to treat fungal and bacterial infections and as anti-inflammatory. Antibacterial and antifungal activity of several Larrea species has been reported. However, their potential use in vaginal infections has...
Article
Propolis with a botanic origin in Zuccagnia punctata Cav. (Fabaceae), a plant species widely distributed in the Argentinean Monte region, was used to produce a standardized propolis extract by biological activity and chemical composition. In this paper the effect on microorganisms isolated from otitis was determined. The extract was active against...
Article
Ethnopharmacological relevance: The Argentinean medicinal plant Tetraglochin cristatum (Britton) Rothm is used in traditional medicine by inhabitants from Argentinean northwestern highlands (Puna) to treat candidiasis and as anti-inflammatory. Aim of the study: To assess the potential of the crude drug as an anti-Candida agent with anti-inflamma...
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Full-text available
This study evaluated the effects of a Zuccagnia punctata standardized hydroalcoholic extract (ZpE) and three of its major flavonoids [2′,4′-dihydroxychalcone (DHC), 7-hydroxyflavanone (HF) and 3,7-dihydroxyflavone (DHF)] on the vascular reactivity of aortic rings with endothelial dysfunction induced by feeding rabbits on a high cholesterol diet. Ra...
Article
In this work, a Geoffroea decorticans (chañar) extract very rich in polyphenols and with antioxidant and inhibitory activity against pro-inflammatory enzymes, was microencapsulated in a zein matrix using electrospraying to improve its stability and facilitate its handling as food ingredient. The electrosprayed microcapsules were characterized in te...
Article
Practical application: Pods of P. nigra are traditional food resources in South America. The non-conventional flour obtained from them is a food that inhibits enzymes linked to carbohydrates metabolism and lipids metabolism, show antioxidant activity and anti-inflamatory activity, principally on COX-2. This natural product is a promising resource...
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The native tree Geoffroea decorticans (cha ar) grows in the arid lands of northern Chile. It has been used as a food plant since prehistoric times. Phenolic-enriched extracts (PEEs) of Chilean cha ar fruits were assessed for their chemical composition, antioxidant properties and inhibition of pro-inflammatory and metabolic syndrome-associated enzym...
Presentation
La introducción de especies nativas en los agroecosistemas contribuye al aumento de su estabilidad. La murta (Ugni molinae Turcz.) es una especie nativa de la Patagonia argentino-chilena que produce bayas rojizas de intenso aroma. Los objetivos del presente trabajo fueron (i) analizar el comportamiento de la murta bajo distintas condiciones de irra...
Article
The mistol (Ziziphus mistol) is a native food tree occurring in dry areas of Northwestern and Central Argentina. Studies on its functional properties and bioactive compounds are scarce so far. In this work we assess the nutritional and functional components of lyophilized powder of mistol skin, pulp and seed. The powder from the different fruit par...
Article
UV-B radiation (UVBR) treatment, previously standardized in our laboratory, contributes to prevent green mold caused by Penicillium digitatum on postharvest lemons. Here, antifungal activity of flavedo extracts from irradiated and non-irradiated lemons was assayed against P. digitatum; also, compounds that could be responsible for this action were...
Article
Lactic acid fermentation of cactus fruit (Opuntia ficus-indica) juice constitutes an important biotechnology process for its preservation. The present study shows the isolation and selection of potential probiotic autochthonous strains for the preparation of a fermented cactus fruit juice. 17 strains of lactic acid bacteria were isolated from O. fi...
Article
Ethnopharmacological relevance: Human groups in the Argentinean Andes highlands (Puna) selected native plants as anti-inflammatory agents. The indications of use are mainly to relieve pain, as infusions, ethanolic extracts or plasters. Aim of the study: The objective of the study was to assess the effect of hydroalcoholic extracts from native hi...
Article
The objective of this work was to study the effect of interactions between four extracts of climbers belonging to the Bignoniaceae family and commercial antibiotics against multi-resistant pathogenic bacteria and to identify the main antibacterial compounds in the most active extract. The plant species tested were Adenocalymma marginatum, Amphiloph...
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An extracellular polygalacturonase [EC 3.2.1.15], named PG-543, was purified from the culture of Geotrichum candidum IEV 543, a phytopathogenic fungi isolated from infected lemon. The molecular mass of the enzyme was estimated to be 26 kDa by SDS-PAGE. The pH optimum determined was 5.5; the enzyme showed high stability in the pH range between 4.0 a...
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Zuccagnia punctata Cav. (Fabaceae, Caesalpiniaceae) is a plant with a long history of use in Argentine traditional medicines; it belongs to a monotypic genus, and is an endemic species of Argentina. This review provides a comprehensive overview of the traditional uses, phytochemistry, pharmacological activity and toxicology of Z. punctata. A wide r...
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The Jarilla species are commonly used in Argentinean local communities to heal different ailments and are frequently used as infusions or decoctions. Herbal mixture infusions composed of Zuccagnia punctata Cav. (Zp), Larrea cuneifolia Cav. (Lc), Larrea divaricata Cav. (Ld), also incorporating an exotic plant species Hovenia dulcis Thunb. (H), were...
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Zuccagnia punctata Cav. (Fabaceae), a native plant from Argentina has been used traditionally as medicinal species. The aim of the study was validate the antibiotic and anti-inflammatory potential of Z. punctata organic extract (ZpE) and the major compounds; 2’,4’-dihydroxy-3’-methoxychalcone (DHMC), 2’,4’-dihydroxychalcone (DHC), 7-hydroxyflavanon...
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Propolis is one of the most fascinating honey bee (Apis mellifera L.) products. It is a plant derived product that bees produce from resins that they collect from different plant organs and with which they mix beeswax. Propolis is a building material and a protective agent in the bee hive. It also plays an important role in honey bee social immunit...
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Frankenia triandra (Frankeniaceae) is a poorly studied halophyte subshrub species that grows on saline soils in the Bolivian, Argentinean and Chilean Puna, and is used by Puna inhabitants as forage and antiseptic in their folk medicine. The aim of this work is to first evaluate the antioxidant and anti-inflammatory potential (inhibitory effect on p...
Article
Propolis production by honey bees is the result of a selective harvest of exudates from plants in the neighborhood of the hive. This product is used in Argentina as a food supplement and alternative medicine. The aim of this study was to determine the botanical origin of propolis from the arid regions of Monte of Argentina using rapid histochemical...