MARIA INES BARRETO SILVA

• PhD
• Rio de Janeiro State University

Understanding sex differences in immunological responses in the context of obesity is important to improve health outcomes. This systematic review aimed to investigate sex differences in systemic inflammation, immune cell phenotype, and function in diet‐induced obesity (DIO) animal models. A systematic search in Medline, Embase, and CINAHL from inc...

Introduction Individuals with obesity and/or type 2 diabetes are at higher risk of infection and have worse prognoses compared to healthy individuals. Several factors may influence immune responses in this population, including high adiposity, hyperglycemia, and unhealthy dietary habits. However, there is insufficient data on the independent or clu...

Background & aims: Recent evidence suggests that moderate coffee intake is associated with multiple health benefits, including lower risk of obesity, sarcopenia and cardiovascular disease (CVD) in the general population. However, to date, no study has evaluated these associations in kidney transplant recipients (KTR). The aim of the present study...

Obesity is a complex chronic metabolic disease that impairs health and reduces lifespan. Therefore, effective strategies for the prevention and treatment of obesity are necessary. Although several studies have demonstrated that gut dysbiosis is associated with obesity it, remains controversial whether the altered gut microbiota is a risk factor for...

Background & aims The effects of calorie restriction and physical activity on autonomic regulation and cardiac vagal control in overweight and obese individuals remain inconsistent. Thus, this systematic review aimed to evaluate the weight loss effects through lifestyle changes on heart rate variability (HRV) markers in overweight and obese subject...

Purpose of review: This review summarizes literature from the last 18 months reporting on sarcopenia (or its components) in chronic kidney disease (CKD). Recent findings: The prevalence of sarcopenia in CKD is reported to be 5-62.5%, with higher rates observed later in the disease. Sarcopenic obesity rates are reported to be 2-23%. Sarcopenia in...

Objective: To achieve and maintain normal serum potassium and phosphorus levels reducing potassium and phosphorus intake is frequently recommended for adults living with chronic kidney disease (CKD). Exploring food preparation methods to reduce potassium and phosphorus content appears warranted. The study aim was to determine the impact of soaking...

Introduction Chronic kidney disease (CKD) is associated with a reduction in bone mineral density (BMD), but less is understood regarding the relation between BMD and muscle mass, especially in non-dialysis dependent-CKD (NDD-CKD). The aim of this study was to explore the prevalence and association of low BMD (osteopenia and osteoporosis) with marke...

Background & Aims Evidence suggests that gut microbiota is a potential factor in the pathophysiology of both obesity and related metabolic disorders. While individual randomized controlled trials (RCTs) have evaluated the effects of probiotics on adiposity and cardiovascular disease (CVD) risk factors in subjects with overweight and obesity, the re...

Objectives Obesity and insulin resistance (IR) are associated with systemic inflammation, lower immune function, and a higher risk of infection. We previously reported that individuals with obesity and type 2 diabetes have an impaired T cell response (i.e., lower IL-2 production, a marker of proliferation) upon T cell stimulation despite having mor...

Objectives Cardiovascular (CV) mortality is higher in male compared to female patients with chronic kidney disease (CKD), but biological mechanisms for sex-specific differences are not established. Inflammation and high body fat are both associated with the development of CKD and CV diseases. Yet, little is known about the relationship between sex,...

Objectives Abnormal bone mineral density (BMD) is common in chronic kidney disease (CKD) and related with higher risk of disease progression, cardiovascular disease, and mortality. The aim of this study was to assess BMD, its change overtime and association with body composition and biochemical parameters of mineraly metabolism. Methods This was a...

Accurate measurement of body composition is required to improve health outcomes in children and adolescents with overweight or obesity. This systematic review aimed to summarize the reliability and validity of field and laboratory body composition techniques employed in pediatric obesity studies to facilitate technique selection for research and cl...

Background & Aims Bioelectrical impedance analysis (BIA) and anthropometric predictive equations have been proposed to estimate whole-body (SMM) and appendicular skeletal muscle mass (ASM) as surrogate for dual energy X-ray absorptiometry (DXA) in distinct population groups. However, their accuracy in estimating body composition in non-dialysis dep...

The prevalence of chronic kidney disease (CKD) is increasing and dietary interventions may be a strategy to reduce this burden. In the general population, higher potassium intake is considered protective for cardiovascular health. Due to the risk of hyperkalemia in CKD, limiting potassium intake is often recommended. However, given that poor cardio...

Sarcopenia is a progressive and generalized skeletal muscle disorder, associated with adverse outcomes. Aging causes primary sarcopenia, while secondary causes include chronic kidney disease (CKD), long-term use of glucocorticoids and obesity. The aim of this study was to evaluate: the prevalence of sarcopenia using guidelines recommended by The Eu...

Obesity is associated with increased risk of cardiovascular disease (CVD). Body mass index (BMI) is the most used parameter for obesity screening. However, the evaluation of CVD risk in overweight individuals should include the assessment of body fat distribution and body composition. Renal transplant recipients (RTR) have a high CVD risk and frequ...

The aim of the present study was to evaluate the prevalence of vitamin B12 (B12) deficiency in kidney transplant recipients (KTR), and its possible association with B12 dietary intake, body adiposity, and immunosuppressive drugs. In this cross-sectional study were included 225 KTR, aged 47.50±12.11years, and 125 (56%) were men. Serum levels of B12...

Background: High body adiposity, inflammatory cytokines, insulin resistance (IR), and the endothelial markers-soluble intercellular adhesion molecule-1 (sICAM-1) and soluble vascular adhesion molecule-1 (sVCAM-1)-are among cardiovascular risk factors observed in chronic kidney disease (CKD). Synergistic interaction of inflammatory cytokines with a...

Objectives: Obstructive sleep apnea (OSA) is a risk factor for cardiovascular disease (CVD), the main cause of mortality in chronic kidney disease (CKD). Although the prevalence of OSA in patients with CKD has not been established, a few studies suggest that it is higher than in the general population, potentially increasing the risk for CVD. Obes...

Recent evidence suggests that vitamin D deficiency is associated with CVD, impaired kidney function and proteinuria. To date, no study has evaluated these associations in renal transplant recipients (RTR) adjusting for body adiposity assessed by a ‘gold standard’ method. This study aimed to evaluate the vitamin D status and its association with bod...

Objectives: The association of vitamin D status with high body adiposity is poorly investigated in the chronic kidney disease (CKD) population. The aim of the present study was to describe vitamin D status and to identify body adiposity predictors of vitamin D deficiency, in a nondialyzed CKD population inhabiting a tropical city. Methods: This...

INTRODUCTION: Vitamin D deficiency is reported to be associated with Insulin Resistance (IR) in general population. Although the impaired homeostasis of vitamin D and IR are common conditions in chronic kidney disease (CKD), the underlying mechanisms of IR remain unclear and it is not known if vitamin D status is associated with IR in nondialyzed C...

Introduction: Obesity is reported as an important contributor for vitamin D (VitD) deficiency. Nevertheless, most of the studies use body mass index (BMI) to evaluate this relationship and results are not clear. In CKD, obesity and VitD deficiency are common conditions, however the association of body adiposity and VitD in nondialyzed CKD patients...

Objective: Chronic kidney disease (CKD) is associated with metabolic disorders, including insulin resistance (IR), mainly when associated with obesity and characterized by high abdominal adiposity (AbAd). Anthropometric measures are recommended for assessing AbAd in clinical settings, but their accuracies need to be evaluated. The aim of this stud...

The aim of this study was to evaluate high body adiposity and cardiovascular disease (CVD) risk factors prevalence, in renal transplant recipients (RTR), comparing men with women. In this retrospective cross-sectional study, 102 patients (55 men) who were 49 ± 1.2 y and 114.3 ± 9 mo post-transplant (post-tx) were evaluated. Pretransplant (pre-tx) p...

High body fat (BF) is an alarming condition that also affects nondialyzed chronic kidney disease (CKD) patients. Distinct methods are used to evaluate BF; however, in CKD population it remains unclear which one is more reliable showing high accuracy. Dual-energy X-ray absorptiometry (DXA), used as reference method to estimate adiposity, is expensiv...

Objective: Low adherence is frequently observed in patients with chronic kidney disease (CKD) who are following a low-protein diet. We have evaluated whether a specific nutrition education program motivates patients with CKD who do not yet receive dialysis to reduce their protein intake and whether such a program improves adherence to a low-protei...

High body fat (BF) is an alarming condition that also affects nondialyzed chronic kidney disease (CKD) patients. Distinct methods are used to evaluate BF, however in CKD population it remains unclear which one is more reliable showing high accuracy. Dual energy X-ray absorptiometry (DXA), used as reference method to estimate adiposity, is expensive...

The aim of this study was to assess the association between body adiposity with adipokines and with insulin resistance in non-dialysed CKD patients. This is a cross-sectional study including CKD patients under regular treatment in an outpatient clinic. Glomerular filtration rate was estimated by MDRD equation (eGFR). The nutritional status was asse...

The purpose of this study was to evaluate inflammation in non-dialysed CKD patients with normal and high body adiposity level. One hundred and thirty four CKD patients (male: 56%; age=65±12 years) under treatment for 3.0±2.0 years were evaluated in a cross-sectional study. Glomerular filtration rate (eGFR) was estimated by MDRD equation. Body adipo...

Avaliação longitudinal do estado nutricional de pacientes com doença renal crônica na fase não-dialítica CERES; 2010; 5(3); 127-137 127 127 127 127 127 Avaliação longitudinal do estado nutricional de pacientes com doença renal crônica na fase não-dialítica Longitudinal assessement of nutritional status in nondialyzed chronic kidney disease patients...

In dialysis patients, cross-sectional studies show that total and abdominal body fat associate with inflammatory markers. Whether this is true in earlier disease stages is unknown. We evaluated the cross-sectional and longitudinal (12-month interval) association between body fat markers and C-reactive protein (CRP) in pre-dialysis chronic kidney di...

The method capable of best identifying protein-energy wasting (PEW) in hemodialysis (HD) patients is controversial. Thus, we assessed the nutritional status of HD patients by use of different methods and verified which one identified the highest number of patients with PEW. The study assessed the nutritional status of 15 HD patients (age: 52.7 ± 10...

We investigated reproducibility and agreement between anthropometry (ANT) and bioelectrical impedance (BIA) in nonobese and obese nondialyzed chronic kidney disease (CKD) patients, and examined the factors influencing the agreement between these two methods. One hundred and five clinically stable CKD patients, comprising stages 3 and 4 of CKD, had...

Obesity may be a risk factor for renal graft loss. The purpose of this study was to assess weight gain and its association with glomerular filtration rate after kidney transplant. This retrospective analysis of 152 adult renal transplant outpatients (77 males, 75 females; mean age, 45.6 +/- 10.1 years) with at least 6 months posttransplantation (po...

Cardiovascular disease (CVD) is the major cause of death in renal transplant recipients. The aim of this study was to assess the prevalence of CVD risk factors among Brazilian adult renal transplant recipients. This cross-sectional study included 192 cases in which the evaluated CVD risk factors were hypertension, diabetes mellitus, impaired fastin...

Few studies have focused on bone disease in patients with chronic kidney disease under conservative treatment. The objective was to evaluate bone disease in patients with chronic kidney disease. Case series, at the Nephrology Division, Hospital Universitário Pedro Ernesto. 131 patients with creatinine clearance from 10 to 60 ml/min/1.73 m(2) were f...

A substantial number of patients with end-stage chronic renal failure (CRF) on dialysis have an inflammatory state that can be detected by elevation in serum levels of C-reactive protein (CRP). Hypoalbuminemia, which occurs in this population and always has been associated with malnutrition, seems to be a consequence of this inflammatory state. Dat...

Objective: A substantial number of patients with end-stage chronic renal failure (CRF) on dialysis have an inflammatory state that can be detected by elevation in serum levels of C-reactive protein (CRP). Hypoalbuminemia, which occurs in this population and always has been associated with malnutrition, seems to be a consequence of this inflammatory...

The purpose of this study was to assess the nutritional status of low-income Brazilian mothers, who were supplemented with iron and vitamin B12 during pregnancy, in terms of iron, zinc, folate and vitamin B12, in different stages of lactation and to determine the influence of the maternal nutritional status on milk composition. The effect of folate...

The purpose of this study was to assess the concentration and binding pattern of zinc, iron, folate and vitamin B12 in milk of Brazilian women of low socioeconomic status giving birth at term or preterm, during early lactation. Protein, fat, total solids and ash concentrations were also determined. Protein and zinc concentrations decreased signific...