Maria lidia Gerra

Maria lidia Gerra
Università di Parma | UNIPR · Department of Neurosciences

MD

About

32
Publications
4,960
Reads
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483
Citations
Additional affiliations
November 2016 - November 2019
Università di Parma
Position
  • PhD Student
June 2011 - present
Università di Parma
Position
  • Medical Doctor
June 2011 - June 2017
Università di Parma
Position
  • Resident in Psychiatry

Publications

Publications (32)
Article
Malignant catatonia is a life-threatening syndrome that could be observed in various psychiatric and neurological conditions. We describe the challenging case of a young woman with relapsing-remitting malignant catatonia, which finally resolve after electroconvulsive therapy (ECT). Details regarding her psychiatric symptoms, dynamics, and EEG featu...
Article
This review aims to elucidate environmental and genetic factors, as well as their epigenetic and neuroendocrine moderators, that may underlie the association between early childhood experiences and Substance Use Disorders (SUD), through the lens of parental attachment. Here we review those attachment-related studies that examined the monoaminergic...
Article
Full-text available
Background Autism spectrum disorders (ASDs) and schizophrenia spectrum disorders (SSDs), although conceptualized as separate entities, may share some clinical and neurobiological features. ASD symptoms may have a relevant role in determining a more severe clinical presentation of schizophrenic disorder but their relationships with cognitive aspects...
Article
Both genetic and early environmental factors contribute to the pathogenesis of Alcohol Use Disorder (AUD). Gender and psychopathology symptoms might further moderate this association, resulting in an impairment of both the dopaminergic and serotoninergic pathways that sustain the binge, withdrawal and craving cycle. In a sample of of adult children...
Article
Full-text available
Improving real‐life functioning is the main goal of the most advanced integrated treatment programs in people with schizophrenia. The Italian Network for Research on Psychoses previously explored, by using network analysis, the interplay among illness‐related variables, personal resources, context‐related factors and real‐life functioning in a larg...
Article
Background This cohort study was aimed to verify whether subjects at their first acute coronary syndrome (ACS) were more alexithymic than healthy controls (HC) and whether alexithymia can predispose patients with coronary artery disease to new major adverse cardiac events (MACE) during a 24-month follow-up period. Methods The sample included 100 H...
Article
Background: Even though most of the systematic reviews suggest that depression and anxiety are related to poor neonatal outcomes, it is not yet clear whether a dose–response effect exists. Aim: The aim of the present study is to evaluate the amount of depressive and anxiety symptoms in a cohort of pregnant women and its effect on their newborns. Me...
Article
Objectives: Incident depression, occurring after an acute coronary syndrome (ACS) in never depressed patients, exerts a negative effect on the cardiac prognosis. Nonetheless only a few studies have evaluated the risk factor for incident depression and, particularly, no study have investigated the role of personality disorders. Therefore, the aim of...
Article
Few studies assess the role of personality styles in predicting the onset of depression among cardiac patients. This study evaluates whether temperament and character can represent a risk factor for the development of incident first-ever depressive episodes in patients at their first acute coronary syndrome (ACS). Two hundred sixty-seven (72.1%) su...
Article
Objective: Depression is an established risk factor for acute coronary syndrome (ACS), with an impact on cardiac prognosis; nonetheless, the literature disagrees on the role played by anxiety. No study has evaluated this relationship in a cardiac population with no history of depression and after their first diagnosis of ACS. The aim of this study...
Article
Objective The study aimed to explore premorbid academic and social functioning in patients with schizophrenia, and its associations with the severity of negative symptoms and neurocognitive impairment. Method Premorbid adjustment (PA) in patients with schizophrenia was compared to early adjustment in unaffected first‐degree relatives and healthy c...
Article
Background: A general consensus has not yet been reached regarding the role of disorganization symptoms in real-world functioning in schizophrenia. Methods: We used structural equations modeling (SEM) to analyze the direct and indirect associations between disorganization and real-world functioning assessed through the Specific Levels of Functio...
Conference Paper
Background. Bipolar Disorder is characterised by opposite fluctuations of mood and goal-directed behaviours (i.e. manic and depressive episodes) interspersed with period of stability (i.e. euthymia). Deficit in executive control have been observed both in the prodromal phases of the disorder and in euthymia, suggesting a trait feature. Recent model...
Conference Paper
INTRODUCTION Multiple lines of evidences suggest that the diagnosis of Major Depressive Disorder (MDD) encompass a heterogeneous group of disorders with various genetic patterns, neurobiological mechanisms, symptoms profiles, course-trajectories and ultimately differential treatment responses. We hypothesized that age-related neurobiological differ...
Article
A disruption of the oxytocin system seems to affect a variety of brain functions including emotions, mood and social behavior possibly underlying severe social deficits and susceptibility for substance use and mental health disorders. Early life adversity, such as insecure attachment in childhood, has been suggested to influence oxytocin tone contr...
Article
Objective: This work tested the hypothesis that patients with high negative affectivity (NA) would have a better response to a serotonergic agent (escitalopram) than to one not thought to act directly on serotonin (bupropion). Method: Data from a study conducted between August 2007 and July 2011 were reanalyzed retrospectively. Patients (N = 245...
Article
Full-text available
The goals of this study were to investigate differences in neurocognitive performance between groups of patients with unipolar major depressive disorder (MDD) or bipolar I disorder (BD-I) in a euthymic state, and to analyze associations among cognitive performance, sociodemographic and clinical variables, and global functioning. The study evaluated...
Article
Aim of this paper is to investigate the psychobiological reactions to experimentally induced negative emotional states in active marijuana-dependent smokers and whether changes in emotional reactivity were reversed by prolonged abstinence. Twenty-eight patients were randomly included into group A (fourteen active marijuana-dependent smokers) or gro...
Conference Paper
Introduction: Contradictory findings have been reported in relation to neurocognitive abilities and functioning of Bipolar Disorder (BD) and Recurrent Major Depressive Disorder (rMDD). Our aims were to compare the cognitive profile of BD and rMDD patients, in euthymic state, with healthy controls and to discern whether cognitive performance is rela...
Article
Full-text available
Cocaine dependence is characterized by compulsive drug seeking and high vulnerability to relapse. Overall, cocaine remains one of the most used illicit drugs in the world. Given the difficulty of achieving sustained recovery, pharmacotherapy of cocaine addiction remains one of the most important clinical challenges. Recent advances in neurobiology,...
Conference Paper
Background: la persistenza di sintomi depressivi subsindromici nel disturbo bipolare si correla con bassi livelli di funzionamento psicosociale. obiettivi: individuare le correlazioni tra depressione subsindromica e livelli di funzionamento interepisodici nei pazienti con disturbo bipolare e disturbo depressivo maggiore ricorrente. Materiali e meto...
Article
Full-text available
Epidemiological and clinical data show frequent associations between adverse childhood experiences (ACEs) and substance abuse susceptibility particularly in adolescents. A large body of evidences suggests that the possible dysregulation of neuroendocrine responses as well as neurotransmitters function induced by childhood traumatic experiences and...
Article
Methadone maintenance therapy (MMT) has been found effective in treating heroin addiction. Serious consideration should be given to the modality of methadone distribution, as it influences not only treatment outcome but the attitudes of policy makers and the community, too. On one hand, the choice of take-home methadone removes the need for daily a...
Article
Full-text available
For centuries Cannabis sativa and cannabis extracts have been used in natural medicine. Δ9- tetrahydrocannabinol (THC) is the main active ingredient of Cannabis. THC seems to be responsible for most of the pharmacological and therapeutic actions of cannabis. In a few countries THC extracts (i.e. Sativex®) or THC derivatives such as nabilone, and dr...
Article
Full-text available
The diagnosis of PTSD dates back to the 80s and is characterized by the observation that as a consequence of a series of traumatic events, it is possible to develop a psychiatric syndrome. Recent epidemiological data show a correlation between stress-related disorders, as in the case of PTSD, and substance abuse disorders. A large majority of drug...
Article
The hypotheses of (1) gene x environment interaction in the susceptibility to experiment with drugs and (2) hypothalamus-pituitary-adrenal (HPA) axis involvement in mediating the effects of early adverse experiences and gene variants affecting serotonin function on substance abuse vulnerability were tested by investigating in 187 healthy adolescent...
Article
Full-text available
For centuries Cannabis sativa and cannabis extracts have been used in natural medicine. Delta(9)-tetrahydrocannabinol (THC) is the main active ingredient of Cannabis. THC seems to be responsible for most of the pharmacological and therapeutic actions of cannabis. In a few countries THC extracts (i.e. Sativex) or THC derivatives such as nabilone, an...

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Projects

Projects (2)
Project
Evaluate the intercation between impairment in abstract reasoning and psychopathology in defining the levels of subjective anhedonia as a transdiagnostic symptom
Project
Indentify possible the risk factors for anxiety and depression during pregnancy and explore their relationship with birth outcomes in a cohort of unmedicated pregnant women.