Maria Teresa Garcia-Romero

Health‐related quality of life (HRQoL) in pediatric patients with vascular malformations (VaM) remains challenging to measure due to an absence of disease‐specific tools and limited correlation with clinical measures. In this cross‐sectional study of 50 children with VaM we evaluated self and parental‐reported physical and psychosocial HRQoL using...

Importance Individuals with atopic dermatitis are frequently colonized and infected with Staphylococcus aureus . Empirical antibiotic therapy for individuals with atopic dermatitis is common, but data about the antimicrobial susceptibility profiles of S aureus strains isolated from these individuals are scarce for those living in particular geograp...

We present two pediatric patients who exhibited an unusual clinical presentation of cutaneous acute graft‐versus‐host disease (GVHD), characterized by livedo‐like appearance. Such manifestations of cutaneous acute GVHD have not been previously documented.

Importance Detecting activity of morphea can be complex but is crucial for adequate treatment and outcome assessment. The Morphea Activity Measure (MAM) was recently validated, but its responsiveness to change in disease activity has not been studied. Objective To evaluate the internal and external responsiveness of MAM to changes in disease activ...

The opportunistic pathogen Staphylococcus aureus frequently colonizes the inflamed skin of people with atopic dermatitis (AD) and worsens disease severity by promoting skin damage. Here, we show, by longitudinally tracking 23 children treated for AD, that S. aureus adapts via de novo mutations during colonization. Each patient's S. aureus populatio...

Importance: Morphea is an insidious inflammatory disorder of the skin and deeper tissues. Determining disease activity is challenging yet important to medical decision-making and patient outcomes. Objective: To develop and validate a scoring tool, the Morphea Activity Measure (MAM), to evaluate morphea disease activity of any type or severity th...

A 7-year-old girl presented with a 2-year history of recurrent blisters on the skin and oral mucosa. The patient was otherwise healthy, and her family history was unremarkable for any dermatologic or other medical disease. Examination revealed multiple tense vesicles, milia, and atrophic scars present over the extensor surface of the extremities an...

Background: Bleach bathing is frequently recommended to treat atopic dermatitis (AD), but its efficacy and safety is uncertain. Objective: Systematically synthesize randomized controlled trials (RCTs) addressing bleach baths for AD. Methods: We searched MEDLINE, EMBASE, CENTRAL, GREAT from inception to December 29, 2021, for RCTs assigning patients...

Juvenile dermatomyositis (JDM) is an uncommon disease in children younger than 3 years of age. The clinical manifestations may be different than in older children, often delaying the diagnosis. We present two patients with early-onset JDM and review the literature describing the unique clinical characteristics in this age group.

The prognosis of IgA vasculitis (also known as Henoch-Schönlein purpura) is determined by renal or other organ involvement. We conducted a retrospective study to identify the initial features of 106 children with IgA vasculitis and their association with unfavorable outcomes. Location of purpura above the waist and an altered urinalysis at diagnosi...

The genus Helicobacter is classified into two main groups according to its habitat: gastric and enterohepatic. Patients with X-linked agammaglobulinemia (XLA) appear to be associated with invasive infection with enterohepatic non-Helicobacter pylori species (NHPH), mainly H. cinaedi and H. bilis. Such infections are difficult to control and have a...

Menkes disease (MD) is a rare X-linked recessive neurodegenerative disorder caused by mutations in the ATP7A gene, with a high mortality rate within the first 3 years of life. It typically affects males and is characterized by impaired copper distribution and malfunction of several copper-dependent enzymes. Patients develop progressive muscle hypot...

Autoimmune diseases reflect a continuum of a proinflammatory state and depend on the target tissues affected; isolated clinical manifestations or systemic involvement may also occur. Recognition of subtle cutaneous changes in the early stages of the disease, such as erythema/edema of the morphea plaques, photosensitivity in some types of cutaneous...

Introduction: Atopic dermatitis (ad) is a very frequent, chronic, multifactorial inflammatory skin disease. Therapeutic patient education (tpe) is a patient-centered process that im�plies the transfer of necessary information and skills to manage disease effectively Objetives: Should be included in tpe interventions for pa�tients with AD. Mater...

Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare and aggressive malignancy of the skin and hematopoietic system. There are few pediatric cases reported in the literature. Management of primary cutaneous BPDCN is challenging because, despite an apparently indolent clinical presentation, rapid dissemination with high mortality can occur...

Purpose of Review Children are usually affected by superficial mycoses; however, subcutaneous mycoses are rarer and difficult to diagnose since their presentation, risk factors, epidemiology, and probably pathophysiology sometimes differ from adults. This article provides an updated overview of skin fungal infections affecting children, their clini...

The skin is considered as the largest organ in the body, functioning as a barrier providing protection from the outside environment, but also performing essential immune functions through a complex network of epidermal and dermal cells that interact with each other. The basic principle of the vaccines is to induce protection against pathogens by si...

Background and Objectives Skin diseases are a common reason for emergency department (ED) consultations; however, few studies have focused on pediatric patients. Diagnostic consistency between ED physicians and dermatologists varies from 43% to 58%, meaning many patients seeking emergency care may receive incorrect diagnoses and treatments. We aime...

Purpose of Review Coccidioidomycosis is a systemic fungal infection endemic in Southwestern United States, Northern Mexico, Central and South America. Coccidioidal infection is not well characterized in pediatric population; but due to an increasing incidence in this age group, a special interest had surged to further describe clinical findings, tr...

Background/Objectives Acute graft‐versus‐host disease (aGVHD) is a serious condition after allogeneic hematopoietic stem cell transplantation (HSCT), frequently involving skin, gut, and liver. It can be difficult to diagnose early, yet this is vital for adequate management. We sought to identify initial clinical and histopathological features in ch...

Las anomalías vasculares son un grupo heterogéneo de alteraciones en los vasos sanguíneos y linfáticos. La International Society for the Study of Vascular Anomalies (ISSVA) las clasifica en: tumores y malformaciones vasculares. En este artículo (primera parte de dos) se revisan los principales tumores vasculares en pacientes pediátricos, su fisiopa...

Deep fungal infections are uncommon in children and are divided into subcutaneous and systemic mycoses. Subcutaneous mycoses mainly occur in tropical climates and the causal fungi are usually acquired from the environment. Systemic mycoses are divided into those that occur in specific endemic areas and those that primarily occur in immunocompromise...

Background: Autoinflammation and phospholipase Cγ2-associated antibody deficiency and immune dysregulation (APLAID) is an exceedingly rare monogenic autoinflammatory disease. To date, only five cases have been reported with four distinct pathogenic mutations. Objectives: We present a novel case of APLAID, corroborated by molecular analysis, with...

El cruzar en nuestra existencia con un ser humano como el Dr. Ramón Ruiz Maldonado, hombre culto, sensato, ingenioso y maestro en toda la extensión de la palabra, ilumina y deja huella. Cuando llega el momento de su partida, por una enfermedad prolongada que minó su cuerpo y terminó por encarcelar su mente, la sensación de vacío y nostalgia es inev...

Background: Neurofibromatosis type 1 (NF1) is a neurocutaneous disorder caused by loss-of-function mutation in the NF1 gene. Segmental or mosaic NF1 (MNF) is an uncommon presentation of the NF1 result of postzygotic mutations that present with subtle localised clinical findings. Objectives: Our study's objectives were to describe the clinical ch...

Langerhans cell histiocitosis is a neoplasm of myeloid origin characterized by a clonal proliferation of cd1a+/cd207+ cells. This proliferation and accumulation may present in any organ; therefore, the disease varies in clinical presentation, ranging from localized involvement to a widely-disseminated life-threating disease. Since cutaneous manifes...

Tropical skin diseases are infectious conditions influenced by factors such as nutrition, housing, and the environment. Migration patterns have caused these conditions to be seen all around the world, not only in developing countries. Many of these diseases have a different presentation in childhood, which changes the diagnostic approach and manage...

Because of travel and migration patterns, tropical skin diseases are now seen all around the world, not just in tropical or developing countries. Nutrition, housing, and environmental factors play an important role in these infectious diseases, so when they appear out of their normal environments, their classic presentation may vary. Tropical disea...

Los exantemas de la infancia son erupciones cutáneas localizadas o generalizadas que pueden ser causados por virus, bacterias, medicamentos o estar asociados con enfermedades sistémicas. La mayoría de los exantemas en la infancia son diagnosticados y tratados por el médico de atención primaria y por el pediatra, por lo que es deseable que ambos est...

Childhood exanthems are cutaneous eruptions localized or generalized that can be caused by virus, bacteria, drugs, or be associated to systemic diseases. Most exanthems are initially diagnosed and treated by pediatricians, therefore it's important that they know these diseases in both, classic and atypical forms.

Skin cancer represents an important public health problem, and it is associated with ultraviolet radiation exposure, particularly at early ages. Unhealthy sun exposure and intentional tanning continue to be the trend among young people. Multiple interventions to raise awareness of the risks of sun exposure have been implemented, without necessarily...

Confusion is widespread regarding segmental or mosaic neurofibromatosis type 1 (MNF1). Physicians should use the same terms and be aware of its comorbidities and risks. The objective of the current study was to identify and synthesize data for cases of MNF1 published from 1977 to 2012 to better understand its significance and associations. After a...

Recent discussions have focused on using health information technology (HIT) to support goals related to universal healthcare delivery. These discussions have generally not reflected on the experience of countries with a large amount of experience using HIT to support universal healthcare on a national level. HIT was compared globally by using data...

The detection of disease activity in patients with localised scleroderma (LS) or morphea remains a difficult challenge, both for evaluating the need for treatment and assessment of therapeutic efficacy. Neither clinical examination nor laboratory evaluations have been consistently found to be reliable indicators of disease activity. Several methods...

Fungal infections in humans are among the most prevalent diseases globally. Superficial invasion by dermatophytes leads to skin, hair, and nail infection. Even though they have usually been associated with extrinsic conditions such as immunosuppression, environmental factors, and contaminated individuals, objects, or surfaces; people are not equall...

Sweet syndrome (SS) is a relatively rare pediatric diagnosis, with fewer than 80 pediatric cases reported in the literature, characterized by tender erythematous plaques and nodules associated with systemic inflammation. We retrospectively reviewed the charts of pediatric patients diagnosed with SS both clinically and histologically at our referenc...

Background: Rapidly involuting congenital hemangiomas (RICHs) are rare vascular tumors that have a proliferative phase in utero, present fully grown at birth, and have a fast involution phase after birth. Even rarer cases have completed involution in utero and present at birth as an atrophic plaque with redundant skin. Case report: We present on...

We present two young patients with morphea or localized scleroderma undergoing systemic treatment, who developed papular lesions on pre-existing sclerotic plaques. Histology was compatible with a papular presentation of morphea and other entities in the differential diagnosis were ruled out. We believe this is a very uncommon presentation of activi...

Objective: To characterize the atypical cutaneous presentations in the coxsackievirus A6 (CVA6)-associated North American enterovirus outbreak of 2011-2012. Methods: We performed a retrospective case series of pediatric patients who presented with atypical cases of hand, foot, and mouth disease (HFMD) from July 2011 to June 2012 at 7 academic pe...

Onychomycosis is known to have predisposing factors and a high prevalence within families that cannot be explained by within-family transmission. We determined the frequency of HLA-B and HLA-DR haplotypes in 25 families of Mexican patients with onychomycosis in order to define the role of the class II major histocompatibility complex (MHC) in genet...

Commentary on: Interventions for Bullous Pemphigoid Kirtschig G, Middleton P, Bennett C, Murrell DF, Wojnarowska F, Khumalo NP Cochrane Database Syst Rev. 2010 Oct 6;(10):CD002292Background: Bullous pemphigoid (BP) is the most common autoimmune blistering disease in the West. Oral steroids are the standard treatment. This is an update of the review...

Onychomycosis is known to have predisposing factors and a high prevalence within families that cannot be explained by within-family transmission. We determined the frequency of HLA-B and HLA-DR haplotypes in 25 families of Mexican patients with onychomycosis in order to define the role of the class II major histocompatibility complex (MHC) in genet...

Teledermatology via a free public social networking Web site is a practical tool to provide attention to patients who do not have access to dermatologic care. In this pilot study, a general practitioner sent consults to a dermatology department at a general hospital via Facebook(®). Forty-four patients were seen and treatment was installed. We iden...

Aplasia cutis congenita is a rare condition characterized by the absence of skin and sometimes other underlying structures such as bone or dura. It can be a part of various syndromes and can be associated with multiple genetic diseases, malformation patterns, or a combination of all. It is even considered as a form frustre of a neural tube defect i...

Zygomycosis are invasive mould infections, rarely diagnosed in hematologic patients. Most of the cases published are in patients with prolonged neutropenia, along with other risk factors such as the use of prior broad-spectrum antibiotics (including new antifungal agents, such as voriconazole), diabetes mellitus (with or without ketoacidosis), maln...

Folliculitis, as a manifestation of immune reconstitution inflammatory syndrome (IRIS) during antiretroviral therapy, has only been described in its aseptic form. Here, we describe folliculitis associated with Malassezia spp. as a distinct manifestation of IRIS. The distinction between these two types of IRIS folliculitis is relevant for treatment.