Maria Flaviana Bezerra Morais Braga

Maria Flaviana Bezerra Morais Braga
Universidade Regional do Cariri · Department of Biological Sciences

Doutora em Etnobiologia e Conservação da Natureza; Mestre em Bioprospecção Molecular

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165
Publications
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1,611
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March 2016 - present
Universidade Regional do Cariri
Position
  • Professor

Publications

Publications (165)
Article
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The number of arbovirus cases has increased in recent years, demonstrating a need for investing in effective control actions. Among these actions, are strategies using biological control vectors, a field where Wolbachia pipientis has shown itself as useful. Wolbachia pipientis, an obligatory intracellular Gram-negative bacteria, which parasites art...
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Species of the genus Miconia are used in traditional medicine for the treatment of diseases, such as pain, throat infections, fever, and cold, and they used as depuratives, diuretics, and sedatives. This work reviewed studies carried out with Miconia species, highlighting its ethnomedicinal uses and pharmacological and phytochemical potential. This...
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Caryocar coriaceum is an endemic tree of Brazil, occurring mainly in the northeast region in the Cerrado environment. The species, popularly known as "pequi", produces fruits that are used in the manufacture of oil for food and medicinal purposes. This work reviewed studies conducted with the species, highlighting its ethnomedicinal use, its pharma...
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Lectins participate in the defense against microorganisms and in signaling the damage caused by pathogens to the cell surface and/or intracellular in plants. This study aims to analyze the antifungal potential of lectins extracted from seeds of Canavalia ensiformis (L.) DC and Canavalia rosea (Sw.) DC, against Candida albicans and Candida tropicali...
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One of the main global problems that affect human health is the development of bacterial resistance to different drugs. As a result, the growing number of multidrug-resistant pathogens has contributed to an increase in resistant infections and represents a public health problem. The present work seeks to investigate the chemical composition and ant...
Article
Lectins are biologically versatile biomolecules with remarkable antimicrobial effects, notably against bacteria, fungi and protozoa, in addition to modulating host inununity. For this, the lectins bind to carbohydrates on the surface of the pathogen, which can cause dan1age to the cell wall and preveni the attachment of microorganisms to host cells...
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There is a recurring concern about the increase in infections caused by fungi and bacteria in the hospital environment. Considering the increase in resistant microorganisms and with that the need for more aggressive treatments for the treatment of these infections, research with natural products has been an effective alternative in the search for n...
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Weeds are an important source of natural products; with promising biological activity. This study investigated the anti-kinetoplastida potential (in vitro) to evaluate the cytotoxicity (in vitro) and antioxidant capacity of the essential oil of Rhaphiodon echinus (EORe), which is an infesting plant species. The essential oil was analyzed by GC/MS....
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(1) Background: Candida is a genus of yeasts with notable pathogenicity and significant ability to develop antimicrobial resistance. Gossypium hirsutum L., a medicinal plant that is traditionally used due to its antimicrobial properties, has demonstrated significant antifungal activity. Therefore, this study investigated the chemical composition an...
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Mesosphaerum suaveolens (L.) Kuntze is a species widely used traditionally in the treatment of ailments, such as stomach pain, hemorrhoids, cough, verminosis, ulcer, liver disease, fever, influenza, nasal congestion, and inflammation. is review aims to provide a survey of available information on seven international electronic databases (Google Sch...
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Spondias mombin is used in the folk medicine for the treatment of diarrhea and dysentery, indicating that extracts obtained from this species may present pharmacological activities against pathogenic microorganisms. The purpose of this work was to investigate the chemical composition and evaluate the antimicrobial activity of extracts obtained from...
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Antimicrobial resistance has emerged as a health public concern as the combat of resistant microorganisms has become increasingly challenging. Thus, considering the urgent need of developing new therapeutic alternatives, the present study aimed to investigate the chemical composition and evaluate the antimicrobial and drug enhancing potential of th...
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Due to the increase in fungal resistance to existing drugs, a need exists to search for new antifungals. This study aimed to evaluate the antifungal activity of α, β, and δ-damascone and inclusion complexes with β-cyclodextrin against different Candida spp. The inclusion complex of β-damascone was prepared by the co-evaporation method using three m...
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Sida L. is one of the most diverse genera within Malvaceae, with species popularly used in different countries for the treatment of diseases. Scientific support for the ethnopharmacological potential of some of these species has been provided by bio-assays. In this work, leaf extracts of S. galheirensis, one of the least chemically and pharmacologi...
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The chemical composition of the Cynophalla flexuosa hydroethanolic extract (CFHEE) was identified and its antioxidant, antifungal and antipleomorphic activities against C. albicans and C. tropicalis strains were evaluated. Phytochemical prospecting evidenced polyphenolic and triterpenoid compounds while UPLC-MS analysis revealed the presence of Iso...
Article
Chagas Disease and Leishmaniasis are neglected parasitic diseases that constitute a major public health problem. In the search for new therapeutic alternatives for such pathologies, the essential oil of the leaves of Psidium brownianum Mart ex DC was investigated regarding its chemical composition, antiparasitic, and cytotoxic effects. The chemical...
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Popularly, the fixed oil from the fruits of Caryocar coriaceum Wittm. extracted by extractivists from Chapada of Araripe, it is used for the treatment of various diseases, especially for the treatment of infectious and parasitic diseases. Due to this popular use, it was hypothesized that this product had an effect against pathogenic microorganisms....
Article
Candida species are considered opportunistic microorganisms present in the normal microbiota of the oral cavity and gastrointestinal and urogenital tracts of human beings. These infections are more common in individuals with compromised immune systems and their frequency has increased over the years. Regarding bioproducts, recent research from natu...
Article
Lectins are biologically versatile biomolecules with remarkable antimicrobial effects, notably against bacteria, fungi and protozoa, in addition to modulating host immunity. For this, the lectins bind to carbohydrates on the surface of the pathogen, which can cause damage to the cell wall and prevent the attachment of microorganisms to host cells....
Article
Full-text available
The Chapada of Araripe, located in the Northeast of Brazil, presents a great vegetal diversity. The region presents a great cultural plurality, which is reflected in several popular knowledge, such as medicinal plants in the region. The study aimed to carry out an ethnopharmacological bibliographic survey of angiosperms present in the region. The s...
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The barks of Anacardium occidentale (cashew tree) been used for centuries in the popular pharma-copoeia of South America and West Africa for the treatment of infections and neurodegenerative diseases. Thus, this work aimed to evaluate the biological effect of the ethanolic extract of the barks against strains of Candida spp. and cancer cell lines,...
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Croton heliotropiifolius Kunth (Euphorbiaceae), whose occurrence has already been registered in the most varied Brazilian biomes, is commonly found in the Chapada do Araripe, Ceará. The species is traditionally used to treat fungal, parasitic, and degenerative diseases. This study investigated the chemical composition and pharmacological potential...
Article
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Croton heliotropiifolius Kunth (Euphorbiaceae), whose occurrence has already been registered in the most varied Brazilian biomes, is commonly found in the Chapada do Araripe, Ceará. The species is traditionally used to treat fungal, parasitic, and degenerative diseases. This study investigated the chemical composition and pharmacological potential...
Article
Plant-derived essential oils are volatile hydrophobic compounds with significant antimicrobial activities. Considering the rise of antimicrobial resistance, these natural products have been highlighted as efficient weapons against multidrug-resistant microorganisms. This work aimed to investigate the phytochemical composition and antimicrobial acti...
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This study aimed to investigate the chemical composition and antifungal potential of the essential oil of Baccharis trimera (Less.) DC. against Candida strains. The half maximal inhibitory concentration (IC50) was assessed by the microdilution method using the essential oil at a concentration range of 8192 to 8 μg/mL. The minimum fungicide concentr...
Article
In recent decades, fungal infections have been increasing, as well as the indiscriminate use of large-scale antifungal. The objective of the present study was to characterize the chemical components of L. montevidensis leaf essential oil (EOLm) and evaluate its antifungal potential and fluconazole modulating activity against Candida strains. The es...
Article
Concerns regarding environmental contamination by heavy metals extends worldwide with some studies showing promising alternatives for soil recovery using plants. This research aimed to evaluate the ability of rutin flavonoid to reduce the toxicity of mercury dichloride (HgCl2) in microbiological and vegetable models, by antioxidant tests (DPPH) and...
Article
Ethnopharmacological relevance: The Malvaceae family, an important group of plants that have the Gossypium (cotton) genus has been used in folk medicine to treat microbial diseases and symptoms. Aims of the study: This article aims to understand its ethnobotany expression in communities and scientific elucidation of antimicrobial activities of t...
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Fungal pathologies caused by the genus Candida have increased in recent years due to the involvement of immunosuppressed people and the advance of resistance mechanisms acquired by these microorganisms. Liposomes are nanovesicles with lipid bilayers in which they store compounds. α-Bisabolol is a sesquiterpene with proven biological activities, and...
Article
Neglected tropical diseases such as leishmaniasis and Chagas disease have difficult management, as their causative agents demonstrate resistance to the currently available drugs. Therefore, the development of novel antiparasitic compounds is urgent. This study investigated the chemical composition, cytotoxicity and antiparasitic activities of the e...
Article
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Antimicrobial resistance and the consequent inefficiency of antibiotics are the main problems faced by medicine. In view of this, numerous researches have been aimed at looking for new agents with antibacterial activity, among them natural products. Thus, this study aims to evaluate the antioxidant activity of aqueous and hydroalcoholic extracts of...
Article
Candida infections represent a threat to human health. Candida albicans is the main causative agent of invasive candidiasis, especially in immunosuppressed patients. The emergence of resistant strains has required the development of new therapeutic strategies. In this context, the use of liposomes as drug carrier systems is a promising alternative...
Article
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The objective of this work was to evaluate the antiparasitic potential and cytotoxic effect of extracts by the leaves and roots of S. tuberosa. The results show that the extracts of S. tuberosa have low antipromastigote activity against strains of L. braziliensis, since there was no action at concentrations ≤ 500 µg/mL. While for L. infantum there...
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(1) Background: Infections by Candida species represent a serious threat to the health of immunocompromised individuals. Evidence has indicated that nerolidol has significant antifungal properties. Nonetheless, its use is restricted due to a low water solubility and high photosensitivity. The incorporation into liposomes may represent an efficient...
Article
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The aim of this study was to evaluate the antifungal and modulatory potential of the Ziziphus joazeiro bark and leaf extracts, both in isolation and in association with fluconazole, against resistant species from the Candida genus. Antifungal assays were used to determine the half maximal inhibitory concentration (IC 50) of the extract in isolation...
Article
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The use in folk medicine of leaves of Mesosphaerum suaveolens for the treatment of diseases of the digestive system and respiratory system, raised the hypothesis that its volatile oil has biological properties against pathogenic microorganisms. To evaluate this hypothesis, the antibacterial, antifungal activity against Candida yeast strains, which...
Article
Background/Purpose The fractions were tested to investigate their chemical composition and antifungal potential in vitro. Methods/Results The results obtained through the chromatographic analysis allowed the identification of 28 compounds. Microbiological assays were carried out in order to determine the IC50, cell viability curve and inhibitory e...
Article
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The emergence of fungal resistance to commercial drugs has been a major problem for the WHO. In this context, research with natural products is promising in the discovery of new active substances. Thus, this work evaluated the antifungal effect of a medicinal plant (i.e., Mesosphaerum suaveolens) against strains of the genus Candida, tested the com...
Article
Infections by multiresistant microorganisms have led to a continuous investigation of substances acting as modifiers of this resistance. By following this approach, the chemical composition of the essential oil from Piper caldense leaf and its antimicrobial potential were investigated. The antimicrobial activity was determined by broth microdilutio...
Article
Full-text available
Infections by multiresistant microorganisms have led to a continuous investigation of substances acting as modifiers of this resistance. By following this approach, the chemical composition of the essential oil from Piper caldense leaf and its antimicrobial potential were investigated. The antimicrobial activity was determined by broth microdilutio...
Article
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Efflux pumps are proteins present in the plasma membrane of bacteria, which transport antibiotics and other compounds into the extracellular medium, conferring resistance. The discovery of natural efflux pump inhibitors is a promising alternative. α-Bisabolol is a sesquiterpene isolated from several plants such as Matricaria chamomilla L. and has i...
Article
The present study aimed to investigate the influence of seasonality from different collection periods on the chemical composition and antifungal activity of the Psidium myrtoides O. Berg essential oil (OEFPm). The OEFPm chemical composition was evaluated through gas chromatography coupled to mass spectrometry (GC/MS). The oil's antifungal activity...
Article
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Candida sp. treatment has become a challenge due to the formation of biofilms which favor resistance to conventional antifungals, making the search for new compounds necessary. The objective of this study was to identify the composition of the Licania rigida Benth. leaf ethanolic extract and to verify its antifungal activity against Candida sp. and...
Article
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The aim of this study was to identify and evaluate the chemical compositions and effects of the S. tuberosa leaf and root hydroalcoholic extracts (HELST and HERST) against different strains of Candida. Chemical analysis was performed by Ultra-Performance Liquid Chromatography Coupled to Quadrupole/Time of Flight System (UPLC-MS-ESI-QTOF). The Inhib...
Article
The Piper mikanianum species were investigated by the antimicrobial potential and chemical composition. Chemical analysis was performed by gas chromatography coupled to mass spectrometry (GC/MS). The Minimum Inhibitory Concentration (MIC) as well as the 50% Inhibitory Concentration against Candida strains were determined by microdilution. The effec...
Article
The search for natural substances such as plant extracts with antimicrobial properties has considerably increased, given that biofilms constitute a barrier against antifungal therapy, where these can be formed on any surface, such as acrylic resin prosthesis. The objective of this study was to identify the chemical composition of the Persea america...
Article
In this study, the Piper cernuum Essential Oil (EOPC) was tested against bacterial and fungal strains using the microdilution method to evaluate its minimum inhibitory concentration (MIC) and minimum fungicidal concentration (MFC), as well as its antibiotic modifying effect, in addition to observing the oils ability to cause fungal dimorphism and t...
Article
Active principles found in plants may aid in antiparasitic treatments, however it is important to evaluate if they do not have cytotoxicity. The leishmanicidal and trypanocidal activities of Tarenaya spinosa were evaluated, as well as the cytotoxic potential of their extracts, as well as the phytochemical and antioxidant profile. The phyto-chemical...
Article
Plant extracts are defined as complex heterogeneous mixtures composed of diverse active ingredient categories which characterize their bioactivities. Ziziphus joazeiro Mart., belonging to the Rhamnaceae family, is an endemic caatinga species with a wide economic potential and application in medicine. In the search for new antibacterial drugs, due t...
Article
Background: This is the first report demonstrating the antibiotic-modifying activity of cholecalciferol. Aim: In this study, cholecalciferol was evaluated against multiresistant strains of Staphylococcus aureus, Pseudomonas aeruginosa, and Escherichia coli. Methods: The antibacterial and modulatory effects of cholecalciferol, ergosterol, and ch...
Article
The oil presented the α-Terpinene as the major compound with 54.09% presence. Antibacterial activity demonstrated significant MIC against Staphylococcus aureus (256 μg/mL) and moderate against Pseudomonas aeruginosa (512 μg/mL). The modulating effect of antibiotics was significant against P. aeruginosa potentiating the effect of all the antibiotics...
Article
Phytochemical prospecting was performed by HPLC-DAD. The Inhibitory Concentration of 50% of mortality the microorganisms (IC 50 ) was determined and a cell viability curve was obtained. Minimum Fungicidal Concentration (MFC) was determined by subculture in Sabourad Dextrose Agar. The effect of the combination extract/fluconazole was verified by mic...
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Objective: To compare the in vitro antiparasitic activity of aqueous extracts from Ziziphus joazeiro leaves and stem bark against Trypanosoma cruzi, Leishmania braziliensis, and Leishmania infantum, as well as to evaluate its cytotoxicity in mammalian cells, in addition to identifying the chemical composition of the extracts. Methods: Ziziphus joaz...
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Resumo: Fungos do gênero Candida fazem parte da microbiota natural do ser humano, mas podem produzir infecções quando há alterações no sistema imunológico do hospedeiro. Ultimamente tem sido observado o aumento da resistência desses micro-organismos aos medicamentos. Em vista disso, pesquisas na busca por novos agentes terapêuticos, inclusive produ...
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The genus Berberis includes about 500 different species and commonly grown in Europe, the United States, South Asia, and some northern areas of Iran and Pakistan. Leaves and fruits can be prepared as food flavorings, juices, and teas. Phytochemical analysis of these species has reported alkaloids, tannins, phenolic compounds and oleanolic acid, amo...
Article
Medicinal plants play a crucial role in the search for components that are capable of neutralizing the multiple mechanisms of fungal resistance. Psidium salutare (Kunth) O. Berg is a plant native to Brazil used as both food and traditional medicine to treat diseases and symptoms such as stomach ache and diarrhea, whose symptoms could be related to...