María-Elena Cazar- Ph. D.
- Professor (Full) at University of Cuenca
María-Elena Cazar
- Ph. D.
- Professor (Full) at University of Cuenca
About
28
Publications
17,156
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544
Citations
Introduction
Biotechnology and Natural Products Research
Current institution
Additional affiliations
September 2013 - present
September 2013 - May 2016
Position
- Research Director
Description
- Bioactivity of plants and microorganisms with potential as biologic control agents
March 2005 - July 2013
Position
- Professor (Associate)
Description
- Environmental Chemistry, Biostatistics, Experimental Design
Education
March 2009 - July 2013
Publications
Publications (28)
Introducción:
Los fármacos antiinflamatorios no esteroideos (AINEs) son ampliamente utilizados para la terapia del dolor, a pesar de sus efectos secundarios que ocurren a nivel renal, estomacal y coagulatorio. Las fosfolipasas A2 (PLA2) presentes en los venenos de serpientes, abejas e incluso en el organismo humano, son responsables de varios proce...
Biotechnology is an important and rapidly growing field that has the potential to unlock many of the hidden secrets of orchids. To meet the demands of orchids in the future and to conserve their biodiversity, the development of new technologies is significant to improve breeding, conservation, and cultivation of orchids and discover their use in me...
The loss of biodiversity is a problem that particularly affects biodiversity hotspots. Children play a crucial role in the conservation of endangered species. One important prerequisite for conservation behavior is the willingness to protect endangered animal species. The present study investigated the influence of several variables on Ecuadorian c...
Der fortschreitende Biodiversitätsverlust ist ein schwerwiegendes, durch den Menschen verursachtes Problem, das insbesondere Biodiversity Hotspots betrifft. Durch Ecuador verlaufen gleich zwei Biodiversity Hotspots: die Tropischen Anden und der Tumbes-Chocó-Magdalena-Hotspot. Ohne geeignete Schutzmaßnahmen wird die biologische Vielfalt dieser Regio...
The main etiological agents in dermatophytosis of human skin and nails are Trichophyton, in particular Trichophyton rubrum (T. rubrum) and Trichophyton mentagrophytes (T. mentagrophytes). A new series of twenty‐three 3‐ and 4‐arylcoumarins was synthesized and the antifungal activities against clinical isolates of T. rubrum and T. mentagrophytes wer...
The native flora of Chile has unique characteristics due to the geographical situation of the country, with the vast desert in the North, Patagonia in the South, the Andean Mountains on the east and the Pacific Ocean on the west. This exclusivity is reflected in high concentrations of phytochemicals in the fruits and leaves of its native plants. So...
Never before has the biosphere, the thin layer of life we call home, been under such intensive and urgent threat. Deforestation rates have soared as we have cleared land to feed ever-more people, global emissions are disrupting the climate system, new pathogens threaten our crops and our health, illegal trade has eradicated entire plant populations...
Societal Impact Statement
Plants and fungi have provided, or inspired, key pharmaceuticals for global health challenges, including cancer, heart disease, dementia, and malaria, and are valued as traditional medicines worldwide. Global demand for medicinal plants and fungi has threatened certain species, contributing to biodiversity loss and depleti...
Kew’s State of the World’s Plants and Fungi project provides assessments of our current knowledge of the diversity of plants and fungi on Earth, the global threats that they face, and the policies to safeguard them. Produced in conjunction with an international scientific symposium, Kew’s State of the World’s Plants and Fungi sets an important inte...
La sobreproducción de melanina está relacionada con desórdenes en la melanogénesis y con ciertos tipos de cáncer de piel debido a la acción de la tirosinasa, enzima reguladora de esta vía bioquímica que se asocia también con el pardeamiento enzimático en alimentos. Por tal motivo, en el presente trabajo se desarrolló un modelo in silico basado en u...
The interaction between seeds and mycorrhizal fungi in germination and developmental processes is complex and far from being understood. The efficiency assessment of mycorrhizal fungi at “in vitro” seed germination of orchids will improve protocols for conservation and horticultural purposes. Applying a culture-dependent approach, we isolated 45 en...
Species of the genus Azorella have been widely studied for the presence of secondary metabolites with biological activities. Azorella pedunculata is the most common species of Azorella genus in Ecuadorian moors.
The present study evaluated the oxidative stress-protective and antioxidant effects of methanolic extract from
A. pedunculata on A549 cell...
Azorella spinosa is a species belonging to the genus Azorella of the Apiaceae Family, and is widely it is distributed in the Andean-Patagonian region from Costa Rica to southern Chile and Argentina, and a potential source of bioactive compounds with various diterpenoids structures of type azorellane, yaretane and mulinanes, exhibiting a wide range...
The objective of this study was to investigate the inhibition of antibacterial and antioxidant activity by extracts of the aerial parts of Azorella multifida collected in Cuenca, Ecuador. Azorella multifida presented poor antioxidant activity in dichloromethane and petroleum ether extracts (DPPH) with IC 50 values >300 ug/mL, while it showed modera...
Five essential oils obtained from common plants from the Ecuadorian Highlands were tested as inhibitors of Listeria monocytogenes. Mixture design was used as an strategy to enhance the antibacterial activity displayed by the bioactive essential oils.
Phytochemical investigation of Azorella madreporica led to the isolation of four known compounds and an unknown chalcone. The structure of the new compound was identified by spectroscopy, including two-dimensional NMR techniques and comparison with published spectral data. The antioxidant activity of chalcone (compound 1) was measured using the 1,2...
The inhibitory effect of ethanolic extracts against Alternaria sp. in greenhouse cabbage cultivation (Oleracea brassica) and in-situ potato growing (Solanum tuberosum) was tested. Ethanolic extracts
were prepared from Eucalyptus leaves (Eucalyptus globulus) with a Soxhlet extractor. Phytochemical analysis revealed the presence of considerable amoun...
INTRODUCCION: La quimioterapia altamente emetogenica puede limitar el tratamiento oncologico al punto de exponer al paciente al abandono terapeutico. El antagonista de la sustancia P de los receptores de neuroquinina (NK1) Aprepitant es de reciente uso en nuestro pais por lo que el objetivo del presente estudio fue comparar su efectividad en un gru...
The inhibitory effect of ethanolic extracts against Alternaria sp. in greenhouse cabbage cultivation (Oleracea brassica) and in-situ potato growing (Solanum tuberosum) was tested. Ethanolic extracts were prepared from Eucalyptus leaves (Eucalyptus globulus) with a Soxhlet extractor. Phytochemical analysis revealed the presence of considerable amoun...
Medicinal plants are organisms that are naturally endowed with chemical compounds (secondary metabolites) with properties of high therapeutic value, yielding advances in the development of synthetic drugs with physiological action beneficial to humans (ref). The use of these plants has an ancient origin in different cultures around the world and th...
The fungus Aspergillus terreus Thorn var. terreus isolated from an Ecuador soil sample was cultured in liquid and solid media and yielded three main metabolites identified
as terreic acid (1), butyrolactone I (2) and lovastatin (3). The natural products as well as three synthetic butyrolactone I derivatives were assessed for antimicrobial activity...
Diverse N-(heteroarylmethyl)anilines were easily prepared from corresponding aldimines derived from commercially available aromatic aldehydes and anilines. New series of substituted NH-tetrahydroquinolines were also prepared using imino-Diels-Alder reaction between aldimines and N-vinylpyrrolidin-2-one in the presence of BF3. OEt2 and the multi-com...
