María Del Rayo Camacho Corona

Autonomous University of Nuevo León | UANL · Facultad de Ciencias Químicas

There is an urgent need to develop new therapies for cancer treatment due to high rates of resistance and tumor relapse. Moreover, chemotherapy and radiation weaken the immune system and leave patients susceptible to sudden death from infections and organ failure since antineoplastic drugs lack specificity. Hence, scientists worldwide continue the...

Objective: The stems from plants of the genus Cissus are used in traditional medicine worldwide. In Mexico Cissus trifoliata is employed for the management of several diseases, however little is known about the active compounds. The present investigation focuses on the extraction, isolation, and characterization of the lipid contents from the stems...

Técnicas biofísicas y bioinformáticas aplicadas al análisis de la actividad antibacteriana de ceramidas aisladas de Cissus incisa

Obesity causes systemic inflammation, hepatic and renal damage, as well as gut microbiota dysbiosis. Alternative vegetable sources rich in polyphenols are known to prevent or delay the progression of metabolic abnormalities during obesity. Vachellia farnesiana (VF) is a potent source of polyphenols with antioxidant and anti-inflammatory activities...

The synthesis of 19 compounds derived from L-serine and analogs of p-substituted cinnamic acid is reported. Oxazolines 9 and oxazoles 10 have high antitubercular activity with Minimum Inhibitory Concentration (MIC) of 0.7812-25.0 µg/mL (3.21-100.3 µM), against two strains of Mycobacterium tuberculosis sensitive to first-line drugs Isoniazid (INH),...

Cissus trifoliata (L.) L belongs to the Vitaceae family and is an important medicinal plant used in Mexico for the management of infectious diseases and tumors. The present study aimed to evaluate the metabolic profile of the stems of C. trifoliata and to correlate the results with their antibacterial and cytotoxic activities. The hexane extract wa...

SUMMARY The human being since ancient times has sought in plants to cure their various diseases. The plants used for traditional medicine contain a wide range of substances that can be used to treat chronic and infectious diseases. Phytochemical researchers have great interest in the selection of medicinal plants for new therapies. In the present s...

Background: Acacia farnesiana (AF) pods have been traditionally used to treat dyspepsia, diarrhea and topically for dermal inflammation. Main objectives: (1) investigate the antioxidant activity and protection against oxidative-induced damage of six extracts from AF pods and (2) their capacity to curb the inflammation process as well as to down-reg...

Bioassay guided fractionation of an antimycobacterial extract of Foeniculum vulgare var dulce (Apiaceae) led to the isolation and characterization of 5-hydroxyfurano-coumarin. The chemical structure of this compound was elucidated by 1 H and 13 C (1D and 2D) Nuclear Magnetic Resonance (NMR) spectroscopy. In addition, the active fractions were analy...

The results on the bioevaluation of thirty five plant-derived secondary metabolites against one sensitive and three multidrug-resistant clinical isolates of Mycobacterium tuberculosis are reported. Results toward the sensitive strain showed that five products gave MIC values of 12.5 µg/mL: the alkaloids 6-methoxydihydrochelerytrine (2) and 6-methox...

Twenty-six pure plant-derived compounds including alkaloids, quinones, flavonoids, and coumarins, obtained from five species of Central American plants associated with traditional uses, were tested in vitro for antiprotozoal and cytotoxic activities. The quinone, 1-acetyl-benzoisochromanquinone displayed significant antiprotozoal activity against L...

Methanolic and aqueous extracts derived from 43 plant species, selected either from ethnobotanical or chemotaxonomical data, were screened for their antiprotozoal activity against Leishmania donovani and Trypanosoma brucei brucei. The cytotoxic activity against KB cells was also determined. Eight extracts had IC50 values of less than 10 microg/ml a...

Four new terpenoids, comprising three nor-secofriedelanes (1-3) and one nor-friedelane (4), were isolated from Galphimia glauca, together with the known flavonol quercetin and the sterols stigmasterol and sitosterol 3-O-beta-D-glucoside. The structure elucidation of the new isolates was conducted by 1D and 2D NMR techniques. Compounds 1-4 were give...

In the search for antiprotozoal compounds from natural sources, Triclisia patens displayed activity against L. donovani promastigotes (IC(50) = 1.5 microg/mL) and T. b. brucei blood stream trypomastigote forms (IC(50) = 31.25 microg/mL). In addition, a total of 20 bisbenzylisoquinoline alkaloids were screened for antileishmanial and antitrypanosoma...

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Four new terpenes including, two sandaracopimaradiene diterpenoids, ent-8(14),15-sandaracopimaradiene-2alpha,18-diol, and ent8(14),15-sandaracopimaradiene-2beta,18-diol, and two lanostane triterpenoids, 23-hydroxy-5alpha-lanosta 7,9(11),24-triene-3-one, and 5alpha-lanosta-7,9(11),24-triene-3alpha,23-diol, were isolated from the methanolic extract p...

Bioactivity-directed fractionation of the CHCl3-MeOH extract of the leaves of Celaenodendron mexicanum by means of the brine shrimp lethality test and chromatographic techniques led to the isolation of three carboxylic acid triterpenes, the new tirucalla-type triterpene, 3 alpha-hydroxytirucalla-7,24Z-dien-26-oic acid, 3-oxotirucalla-7,24Z-dien-26-...

Bioactivity-guided fractionation of Stephania dinklagei yielded six compounds including, two zwitterionic oxoaporphine alkaloids, N-methylliriodendronine, and 2-O,N-dimethylliriodendronine, two oxoaporphine alkaloids, liriodenine, and dicentrinone, one aporphine alkaloid, corydine, and one anthraquinone, aloe-emodin. Apart from corydine, the isolat...

Bioactivity-guided fractionation of Stephania dinklagei yielded six compounds including, two zwitterionic oxoaporphine alkaloids, N-methylliriodendronine, and 2-O,N-dimethylliriodendronine, two oxoaporphine alkaloids, liriodenine, and dicentrinone, one aporphine alkaloid, corydine, and one anthraquinone, aloe-emodin. Apart from corydine, the isolat...

A diversity of compounds with antiprotozoal activity (eg, alkaloids, terpenes, quinones, flavonoids, aurones, xanthones, cyclic tetrapeptides) have been reported in the literature between January 1990 and November 1999. The majority of these compounds have been tested for in vitro activity, some of them have been evaluated in vivo and their mode of...

C22H22O11.3H2O, M(r) = 516.4, orthorhombic, P2(1)2(1)2(1), a = 10.977 (2), b = 12.894 (2), c = 31.135 (6) angstrom, V = 4407 (1) angstrom3, Z = 8, D(x) = 1.557 Mg m-3, lambda(Cu Kalpha) = 1.54178 angstrom, mu = 1.084 mm-1, F(000) = 2176, T = 293 K, R = 0.048 for 2779 observed reflections. The X-ray study confirms that the structure of the title com...

A novel phenylstyrene, 6-O-β-d-glucopyranosyl-2,3′,4′-trihydroxy-4-methoxy-α-phenylstyrene, and a new 4-phenylcoumarin, 5-O-(6″-acetyl-β-d-glucopyranosyl)-7,3′,4′-trihydroxy-4-phenylcoumarin, were isolated from the stem bark of Hintonia latiflora. The proposed structures are based on spectroscopic and chemical grounds.

Bioactivity directed fractionation of the acetone extract of Teloxys graveolens (Willd.) Weber (Chenopodiaceae), using the brine shrimp lethality test, led to the isolation of 5,7-dihydroxyflavanone (pinocembrine) (LC50 = 4.25 micrograms/ml) as the only active compound. Pinocembrine also exhibited fasciolicide, ovicide and larvicide activities on n...

Two new glycosides and several known compounds were isolated fron the stem bark Hintonia latiflora. The new metabolites wre characterized by chemical and spectroscopic methods as 3-O-β-d-glucopyranosyl-23,24-dihydrocucurbitacin F and 5-O-β-d-galactopyranosyl-4′-hydroxy-7-methoxy-4-phenylcoumarin.

The new cucurbitacin glucoside 2-O-beta-D-glucopyranosylcucurbitacin F 25-acetate and arvenin I were isolated from the more polar fractions of the MeOH extract of Cigarrilla mexicana.