Maria Del Carmen Garcia Molina Wolgien

Universidade Federal de São Paulo | UNIFESP · Senology Division of Gynaecology Department

Breast cancer is the most common cancer among women. Angiotensin-(1-7) [Ang-(1-7)] has been correlated with cancer antiproliferative and apoptotic effects, similar properties of the human Chorionic Gonadotrofin (hCG). The aims of this work are to evaluate the role of Ang-(1-7) and of hCG in modulating the expression of Nuclear Receptors and Coregul...

Renin-Angiotensin System (RAS) is involved with hypertension and other cardiovascular diseases. However, the association of RAS components to cancer still causes suspicion. To try to clarify this, here we aimed to show this association for three important components: Angiotensin Converting Enzyme 1 (ACE1), Angiotensin Type 1 Receptor (AGTR1) and An...

Background: Many types of cancer are associated with polymorphisms of the renin-angiotensin system. Our aim was to assess possible association between single-nucleotide polymorphisms (SNPs) of the angiotensin II receptor types 1 (A168G), and 2 (T1247G and A5235G) with breast cancer. Patients and methods: 242 participating subjects were genotyped...

Breast cancer ist the most common type of cancer among women diagnosed and treated timely, patients may have good prognostics. In Brazil, in 2012, the estimate of new cases was 52.680 and the number of registered deaths in 2012 was 12,852. The Renin-Angiotensin System (RAS) is known for its roll in arterial hypertension and in other cardiovascular...

Introduction: The importance of epigenetic in the onset and progression of breast cancer has led many researchers to incorporate this new and exciting theme in the development of anti-cancer drugs. Breast cancer is the most common cancer among women. Human chorionic gonadotropin (hCG) has been correlated to antitumoral actions in the breast epithel...

Abstract: Mesenchymal stem cells (MSCs) are progenitor cells that can be isolated from all connective tissues such as bone, adipose, cartilage, blood and muscle. MSCs have recently been described to localize within breast carcinomas where the stem cells integrate into tumor-associated stromal tissues whereby the MSCs promote breast cancer cell inva...

Background Emerging evidence has shown that miRNAs are involved in human carcinogenesis as tumor suppressors or oncogenes. Single nucleotide polymorphisms (SNPs) located in pre-miRNAs may affect the processing and therefore, influence the expression of mature miRNAs. Previous studies generated conflicting results when reporting association between...

Resumen: A heterogeneidade tumoral do carcinoma mamário continua sendo um grande desafio.Mutações, instabilidades genômicas, dano celular, etc, interferem nos mecanismos reguladores da diferenciação e proliferação celular.Novos biomarcadores preditivos e prognósticos são testados em amostras tumorais, por meio do método imunohistoquímico, com a det...

Resumen: Avanços da medicina, dos métodos diagnósticos de imagem, o maior grau de conscientização das mulheres, a detecção precoce e o tratamento precoce do carcinoma mamário, vem contribuindo para tratamentos cada vez mais conservadores na abordagem do tumor primário e na abordagem axilar. Devem, no entanto, ser obedecidos critérios precisos na in...

Resumen O tratamento do carcinoma mamário vem evoluindo cada vez mais, com melhores resultados estéticos e com segurança oncológica significativa. A Oncoplastia Mamária tem se mostrado como marco de mudança na abordagem do tratamento cirúrgico juntamente com a abordagem multidisciplinar terapeutica do carcinoma mamário. Avaliação das técnicas cirú...

Resumen Apresentação de Caso de Fibroadenoma Juvenil volumoso numa paciente jovem de 16 anos de idade, com a finalidade de discutir os aspectos clínicos e o tratamento. MÉTODOS: Avaliação de um caso de paciente jovem, do sexo feminino, com 16 anos de idade, com volumosa tumoração mamária à direita medindo cerca de 20 cm de diâmetro, ocupando mais...

Diabetic mastopathy affects premenopausal women with longstanding type 1 diabetes mellitus. The diagnosis is based on clinical findings (uni or bilateral hardened, palpable mass) associated with radiological (increase in breast density), sonographic (marked posterior acoustic shadowing), and histopathological (fibrosis and perivascular and periduct...

Our purpose was to identify tamoxifen (TAM) responsive genes after 30 days of TAM treatment in tumor tissues obtained from women with breast cancer using microarray expression analysis. In our study, we identified 12 candidates to be considered as tamoxifen-modulated genes. Among them, we selected two candidates the TEGT BI-1 (testis enhanced gene...