Maria-Cristina Navas

Maria-Cristina Navas
University of Antioquia | UdeA · Departamento de Microbiología y Parasitología, Facultad de Medicina

MSc, PhD

About

108
Publications
14,745
Reads
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812
Citations
Additional affiliations
April 2001 - present
University of Antioquia
Position
  • Profesora Asociada
April 2001 - present
University of Antioquia
Position
  • Research Director
April 2001 - present
University of Antioquia
Position
  • Professor (Associate)
Education
October 1996 - March 2001
University of Strasbourg
Field of study
  • Virology
February 1988 - April 1991
Universidad del Valle (Colombia)
Field of study
  • Virology

Publications

Publications (108)
Article
Hepatitis C Virus (HCV) infection is one of the leading risk factors for end-stage liver disease development worldwide. This RNA virus displays high genetic diversity with 8 genotypes and 96 subgenotypes with heterogeneous geographical distribution around the world. In this study, we carried out an active case finding of individuals with a history...
Article
Objetivo. Describir la epidemiología de la infección por el virus de la hepatitis C (VHC) en Colombia. Métodos. Revisión crítica de los estudios de epidemiología de la infección por VHC en Colombia mediante búsqueda de artículos originales y revisiones de tema publicados en el período 1989 a 2020 en las bases de datos PubMed, SciELO y ScienceDirect...
Poster
Full-text available
The frequency of antibodies anti-VHC described in the study population (2,69%) is lower than the expected one (10%). The preliminary results of viral genotype distribution are similar to the data described previously in Colombian population (1b). This is the first report the circulation of subgenotype 4d in Colombia. The identification of mutations...
Article
El Virus de la Hepatitis C (VHC) codifica la proteína Core. Core, además de ser la subunidad de la cápside, participa en diferentes mecanismos de patogénesis de la infección por VHC. Dado que el sistema de replicación in vitrodel VHC presenta limitaciones, el uso de vectores virales podría ser una herramienta útil para estudiar las propiedades de l...
Article
Full-text available
El virus de la hepatitis delta (VHD) es un virus satélite del virus de la hepatitis B (VHB), dado que requiere el antígeno de superficie del VHB (HBsAg) para la producción de partículas virales infecciosas. Se han caracterizado ocho genotipos del VHD, con una distribución geográfica relacionada con la prevalencia de la infección por VHB. Se estima...
Article
Full-text available
Hepatitis C virus (HCV) infection is accompanied by increased oxidative stress and endoplasmic reticulum stress as a consequence of viral replication, production of viral proteins, and pro-inflammatory signals. To overcome the cellular stress, hepatocytes have developed several adaptive mechanisms like anti-oxidant response, activation of Unfolded...
Article
Full-text available
Objectives: The occurrence of oxidative stress and endoplasmic reticulum (ER) stress in hepatitis C virus (HCV) infection has been demonstrated and play an important role in liver injury. During viral infection, hepatocytes must handle not only the replication of the virus, but also inflammatory signals generating oxidative stress and damage. Alth...
Article
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Hepatitis C Virus belongs to the Flaviviridae family. One proposed mechanism of HCV persistence in the ability to infect hematopoietic cells, including Dendritic cells (DCs). HCV infection of DCs could impair their functions that represent one of the mechanisms, thus hampering viral clearance by the host immune system. Among HCV-encoded proteins, t...
Article
Full-text available
Hepatitis C virus (HCV) infection is a global public health problem because it is a main cause of liver cirrhosis and hepatocellular carcinoma. This human oncogenic virus is also associated with the development of non-Hodgkin lymphoma and cholangiocarcinoma (CCA). The association between HCV infection and CCA has been examined in a number of epidem...
Article
Full-text available
Introducción: la exposición dietaria a la aflatoxina es un factor de riesgo para carcinoma hepatocelular, el cáncer primario de hígado más frecuente. Esta asociación se estableció gracias a la evidencia in vitro e in vivo de la relación entre la exposición a la aflatoxina B1 y la transversión G→T en el codón 249 del gen TP53, así como evidencia de...
Article
Oxidative- and endoplasmic reticulum (ER)-stress are common events during hepatitis C virus (HCV) infection and both regulate cell survival and determine clinical outcome. In response to intrinsic and extrinsic cellular stress, different adaptive mechanisms have evolved in hepatocytes to restore cellular homeostasis like the anti-oxidant response,...
Article
Full-text available
El consumo de alcohol es un conocido factor de riesgo para muerte prematura, morbilidad y discapacidad a nivel mundial. Los registros de la mortalidad que se asocian con el consumo de alcohol están fraccionados. El objetivo de este estudio fue escribir la mortalidad relacionada con la ingesta de alcohol en pacientes con cirrosis atendidos en un hos...
Article
Full-text available
Introduction: Type III glycogen storage disease (GSD III) is an autosomal recessive disorder in which a mutation in the AGL gene causes deficiency of the glycogen debranching enzyme. The disease is characterized by fasting hypoglycemia, hepatomegaly and progressive myopathy. Molecular analyses of AGL have indicated heterogeneity depending on ethni...
Article
Full-text available
Abstract INTRODUCTION: Type III glycogen storage disease (GSD III) is an autosomal recessive disorder in which a mutation in the AGL gene causes deficiency of the glycogen debranching enzyme. The disease is characterized by fasting hypoglycemia, hepatomegaly and progressive myopathy. Molecular analyses of AGL have indicated heterogeneity depending...
Article
Full-text available
El virus de la hepatitis E es un patógeno hepatotrópico transmitido por agua y alimentos contaminados, y uno de los principales agentes etiológicos de hepatitis viral aguda de transmisión enteral en el mundo.La infección por el virus de la hepatitis E usualmente es autolimitada; sin embargo, se han descrito casos de infección crónica en pacientes i...
Article
Full-text available
The human pegivirus (HPgV), classified in the Flaviviridae family - Pegivirus genus, is an RNA virus identified in 1995. HPgV is a lymphotrophic virus, with replication sites in bone marrow and lymphoid tissue, as well as in peripheral blood mononuclear cells (PBMCs). Transmission is through sexual and parenteral routes, and recent estimations sugg...
Article
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INTRODUCTION One of the most important risk factors for hepatocellular carcinoma (HCC) is alcohol consumption: Studies in different populations suggest that the risk of liver disease could be associated with genetic variants of the enzymes involved in alcohol metabolism, such as alcohol dehydrogenase (ADH) and cytochrome P450 CYP2E1. OBJECTIVE To...
Article
Background: Hepatitis B virus (HBV) infection is highly endemic in the Colombian Amazon basin. In Colombia, the universal hepatitis B vaccination in that area has been active since 1993. The program targets children aged under five years. Newborns receive at least three doses, and in 2001, HBV vaccine birth dose was included. This study aimed to e...
Article
Full-text available
The human pegivirus (HPgV), classified in the Flaviviridae family - Pegivirus genus, is an RNA virus identified in 1995. HPgV is a lymphotrophic virus, with replication sites in bone marrow and lymphoid tissue, as well as in peripheral blood mononuclear cells (PBMCs). Transmission is through sexual and parenteral routes, and recent estimations sugg...
Article
Full-text available
Background Hepatitis B Virus (HBV) infection is a worldwide public health problem. In the 1980’s a highly effective and safe vaccine against HBV was developed, although breakthrough infection still occasionally occurs because of the emergence of escape mutants. The aim of this study was to identify HBV genotypes and escape mutants in children and t...
Data
Database of a cross-sectional survey designed to evaluate the prevalence of HBV in mothers of rural communities in the Amazonas State, Colombia. Database variables of the study carried out from June 2010 and June 2011 on 572 mothers belonging to 37 amerindian communities setllted on the banks of the Putumayo and Amazonas rivers and theirs tributari...
Data
Database of a cross-sectional survey designed to evaluate the prevalence of HBV and vaccine coverage in children population of rural communities in the Amazonas State, Colombia. Database variables of the study carried out from June 2010 and June 2011 on 1275 children belonging to 37 amerindian communities settled on the banks of the Putumayo and Am...
Article
Full-text available
Background Hepatitis B virus (HBV) occult infection (OBI) is a risk factor to be taken into account in transfusion, hemodialysis and organ transplantation. The aim of this study was to identify and characterize at the molecular level OBI cases in patients with end-stage liver disease. Methods Sixty-six liver samples were obtained from patients with...
Data
Complete genome sequencing strategies. Overlapping primers of four PCR strategies were used to amplify the complete genome of HBV. (DOCX)
Data
List of sequences used for phylogenetic analysis. (DOCX)
Data
Primers used for HBV genome detection and sequencing. (DOCX)
Data
List of sequences used for pairwise mutation analysis. (DOCX)
Data
HBV DNA detection by southern blot. Total DNA from OBI identified samples was tested for HBV detection using DIG-labeled probe of 319bp targeting S gene was used to detect viral DNA. Line 1: pJET-TH24-1,5, 2: TH3, 3: TH6, 4: TH28, 5: TH78, 6: TH75. Plasmid pJET-TH24-1,5 (10μg) and total DNA (40–50μg) were used. (DOCX)
Article
Cholangiocarcinoma represents 10% of primary liver malignancies and accounts for less than 3% of all gastrointestinal malignant tumors, with an enormous geographical variation. This neoplasia can arise from the biliary tract epithelium or hepatic progenitor cells. Depending on the anatomic localization, it is classified into three subtypes: intrahe...
Article
Full-text available
Hepatitis E virus (HEV) is one of the main causes of acute viral hepatitis of enteric transmission. HEV has been detected in environmental samples in several countries from Europe and Asia, constituting a risk factor for waterborne infection. In Colombia, HEV has been identified in samples obtained from patients as well as from swine, but no enviro...
Article
Worldwide, chronic hepatitis B virus (HBV) infection is a major health problem and no cure exists. Importantly, hepatocyte intrusion by HBV particles results in a complex deregulation of both viral and host cellular genetic and epigenetic processes. Among the attempts to develop novel therapeutic approaches against HBV infection, several options ta...
Article
Full-text available
Introducción: la infección oculta por el virus de la hepatitis B (VHB) se caracteriza por la presencia del genoma viral en suero y/o tejido hepático de individuos negativos para el antígeno de superficie HBsAg. La infección oculta se ha asociado con el desarrollo de cirrosis y carcinoma hepatocelular. Objetivo: identificar casos de infección oculta...
Article
Full-text available
Introducción: el virus de la Hepatitis E (VHE), transmitido por la ruta fecal-oral, causa enfermedad hepática aguda. En Colombia se han realizado algunos estudios en pacientes con diagnóstico de hepatitis viral, en trabajadores de fincas porcícolas, en población porcina y en muestras ambientales. Objetivo: evaluar la presencia de anticuerpos anti-V...
Article
Introduction: Occult hepatitis B virus infection is characterized by the presence of the viral genome in serum and/or liver tissue from individuals who test negative for the HBsAg surface antigen. Occult infection has been associated with the development of cirrhosis and hepatocellular carcinoma. Objective: The objective of this study was to identi...
Article
Full-text available
Occult hepatitis B virus infection is characterized by the presence of the viral genome in serum and/or liver tissue from individuals who test negative for the HBsAg surface antigen. Occult infection has been associated with the development of cirrhosis and hepatocellular carcinoma. Objective: The objective of this study was to identify cases of oc...
Article
Introduction: The hepatitis E virus (HEV) is transmitted via the fecal-oral route and causes acute liver disease. In Colombia there have been some studies of patients who have been diagnosed with viral hepatitis, of swine farm workers and in environmental samples. Objective: The objective of this study was evaluate samples from blood donors in the...
Article
Full-text available
Introduction: Ten viral genotypes (A-J) distributed in all continents have been described for hepatitis B virus (HBV). One of the methodologies for determining the viral genotype is the restriction fragment length polymorphism (RFLP) technique, a simple and relatively inexpensive method, albeit with some limitations. Objective: The initial objec...
Article
Full-text available
Introduction: The hepatitis E virus (HEV) is transmitted via the fecal-oral route and causes acute liver disease. In Colombia there have been some studies of patients who have been diagnosed with viral hepatitis, of swine farm workers and in environmental samples. Objective: The objective of this study was evaluate samples from blood donors in the...
Article
Full-text available
Introduction: Hepatitis A virus (HAV) is an important pathogen, typically transmitted via the faecal-oral route. The epidemiology of the infection is directly related to drinking water access and adequate disposal of sewage water. Objective: To determine the presence and identify the genotype of HAV in environmental samples from eight municipaliti...
Article
Full-text available
La cirrosis hepática es la tercera causa de muerte alrededor del mundo que es atribuible al consumo de alcohol. Más del 80% de los consumidores crónicos de alcohol desarrollan esteatosis y entre el 20% al 40% presentan otras complicaciones como fibrosis, hepatitis alcohólica y cirrosis; sin embargo, no todos los individuos con consumo crónico de al...
Article
Full-text available
Background: Hepatitis E virus is a major cause of outbreaks as well as sporadic hepatitis cases worldwide. The epidemiology of this enterically transmitted infection differs between developing and developed countries. The aims of this study were to describe HEV infection in Colombian patients and to characterize the genotype. Methods: A prospect...
Article
Liver cirrhosis is the third most common cause of death attributable to alcohol consumption throughout the world. More than 80% of chronic drinkers develop steatosis, and 20% to 40% develop other complications such as fibrosis, alcoholic hepatitis and cirrhosis. However, not everyone who chronically consumes alcohol develops cirrhosis. This is part...
Article
Full-text available
Background: In Colombia, cases of Hepatitis D virus (HDV) infection have been officially described since 1985 mainly in Amerindian population from Sierra Nevada de Santa Marta (North Caribbean Coast), Uraba (North West), and Amazon (South East). The last official report of a clinical case of HDV infection in Colombia was registered in 2005. Objecti...
Article
La alteración de las vías de señalización es un mecanismo común en la oncogénesis de diferentes tipos de tumor. La modificación de una de las proteínas de la vía por mutaciones o por modificaciones genéticas o epigenéticas en el promotor del gen correspondiente podría generar una alteración en la vía, y por tanto condiciones para el crecimiento des...
Article
Full-text available
The modification of signaling pathways is a common mechanism in the oncogénesis process of different types of tumor. An alteration in any protein of the pathway by genetic mutations or by epigenetic changes in its gene promoter could cause misregulation of the pathway and therefore lead to uncontrolled cell proliferation. The Wnt/β-catenin signalin...
Chapter
Esta es la obra más completa que sobre las enfermedades infecciosas del hombre haya sido escrita originalmente en español. Cuenta con 215 capítulos divididos en 4 unidades (respuesta inmune, terapia antimicrobiana, enfoque clínico de las enfermedades infecciosas, y agentesetiológicos), los que han sido preparados por 260 autores provenientes de 4 c...
Article
Full-text available
Hepatitis A virus infection is a global public health problem. The virus has a wide range of distribution and it is the main cause of acute hepatitis transmitted by the enteric route in Latin America. The viral particle is stable under environmental conditions and conserves its infectivity for several weeks, enabling its transmission by contaminate...
Article
Full-text available
The hepatitis B virus (HBV) infection is a public health problem worldwide. Considering HBV morbidity and mortality and the economic consequences .of this infection, policies and strategies to control it have been implemented, especially in regions where HBV infection is endemic, with high rates of vertical and horizontal infection. One of these st...
Article
Full-text available
Introduction: Colombia has a varied geographical pattern of prevalence of hepatitis B virus (HBV) infections with regions of high, moderate and low prevalences. Objective: The objective of this study was to identify cases of HBV infection and characterize viral genotypes in population with factors of exposure in the cities of Quibdo and Apartado, C...
Article
Full-text available
Introduction: Colombia has a heterogeneous prevalence pattern of Hepatitis B virus (HBV) infection, including regions of high, moderate and low prevalence. Aim: To identify cases of HBV infection and to characterize the viral genotypes in population with exposition factors in Quibdo and Apartado cities, Colombia. Materials and methods: The study po...
Article
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Background and aim: Hepatocellular carcinoma (HCC) is the most common primary liver cancer diagnosed worldwide. Deregulation of Wnt/beta-catenin pathway has been associated with the development of HCC in a substantial number of cases in Europe and far less in Asia. Nothing is known about this pathway in HCC cases from South America. This study aim...
Article
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Introduction: Infection with the hepatitis C virus is a public health problem. According to the World Health Organization there are an estimated 184 million cases of HCV infection around the world. The main risk factor in developing countries is transfusion of blood components. In 1993, Colombian regulations began requiring serological screening by...
Article
Full-text available
Introduction: Infection with the hepatitis C virus is a public health problem. According to the World Health Organization there are an estimated 184 million cases of HCV infection around the world. The main risk factor in developing countries is transfusion of blood components. In 1993, Colombian regulations began requiring serological screening by...
Article
Full-text available
Background Hepatitis B virus (HBV) surface antigen (HBsAg) screening in blood banks reduced the risk of HBV transmission through transfusion. However, the detection of occult HBV infection among blood donors is imperative for improving blood safety. The aim of this study was to determine the frequency of occult hepatitis B virus infection among blo...
Article
Full-text available
Introducción. El virus de la hepatitis E (HEV), agente etiológico de casos esporádicos y epidemias de hepatitis, es un virus emergente de importancia global. En Colombia se desconoce la epidemiología de la infección causada por este virus. Objetivo. Determinar la seropositividad para el virus de la hepatitis E en muestras de suero de pacientes con...
Article
Aflatoxin, a mycotoxin produced by pollutant molds, is a potent hepatotoxic and carcinogenic agent. Dietary exposition to it is of particular importance in certain regions of Southeast Asia and sub-Saharan Africa. Populations in these regions suffer from high incidence of hepatocellular carcinoma, and have high frequency of the mutation in the codo...
Article
Full-text available
Aflatoxin, a mycotoxin produced by pollutant molds, is a potent hepatotoxic and carcinogenic agent. Dietary exposition to it is of particular importance in certain regions of Southeast Asia and sub-Saharan Africa. Populations in these regions suffer from high incidence of hepatocellular carcinoma, and have high frequency of the mutation in the codo...
Article
Full-text available
Objective: occult hepatitis B virus infection is characterized by the presence of the viral genome in serum and / or liver tissue samples but without surface antigen detection. The mechanisms of pathogenesis are not fully known. The purpose of this article is to discuss and describe the most important clinical, epidemiological and molecular aspects...
Article
Full-text available
The human immunodeficiency virus (HIV) infection is one of the most important problems in public health. It is estimated that 3 3 million people are infected around the world. HIV and GBV-C share the same transmission route, being frequent the co-infection. Since both viruses replicate in CD4+ lymphocytes, recent studies have described an interacti...