Maria Eugenia Castellanos

Maria Eugenia Castellanos
James Cook University · School of Public Health, Tropical Medicine and Rehabilitation Sciences

Doctor of Philosophy

About

52
Publications
3,116
Reads
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292
Citations
Citations since 2017
28 Research Items
269 Citations
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20172018201920202021202220230204060
20172018201920202021202220230204060
20172018201920202021202220230204060
Additional affiliations
November 2008 - present
University of the Valley of Guatemala
Position
  • Research Assistant

Publications

Publications (52)
Article
Full-text available
Several neglected infectious pathogens, such as the monkeypox virus (MPXV), have re-emerged in the last few decades, becoming a global health burden. Despite the incipient vaccine against MPXV infection, the global incidence of travel-related outbreaks continues to rise. About 472 confirmed cases have been reported in 27 countries as of 31 May 2022...
Article
There is little information about the amount of recent tuberculosis transmission in low-income settings. Genetic clustering can help identify ongoing transmission events. A retrospective observational study was performed on Mycobacterium tuberculosis isolates from persons living with HIV (PLHIV) and HIV-seronegative participants who submitted sampl...
Article
Background: There is an absence of clinically relevant epidemiological data in regional Australia pertaining to haematological malignancies. Aim: To determine the incidence and geographical variation of haematological malignancies in North Queensland using a clinically appropriate disease classification. Methods: Retrospective, observational s...
Article
Full-text available
Background Insecticide-treated bed nets (ITNs) are widely used for the prevention and control of malaria. In Guatemala, since 2006, ITNs have been distributed free of charge in the highest risk malaria-endemic areas and constitute one of the primary vector control measures in the country. Despite relying on ITNs for almost 15 years, there is a lack...
Article
Full-text available
One principle of tuberculosis control is to prevent the development of tuberculosis disease by treating individuals with latent tuberculosis infection. The diagnosis of latent infection using the tuberculin skin test is not straightforward because of concerns about immunologic cross reactivity with the Bacille Calmette-Guerin (BCG) vaccine and envi...
Preprint
Full-text available
Background. Exposure to an individual with tuberculosis is necessary for transmission to occur. Previously, we developed a score that measures contact between tuberculosis cases and their social networks in an African urban context. This score was built using exploratory factor analysis and identified contact as the conjunction of two domains – set...
Article
Full-text available
Rationale Although households of tuberculosis cases represent a setting for intense transmission of M. tuberculosis, household exposure accounts for less than 20% of transmission within a community. Objectives To estimate excess risk of M. tuberculosis infection among household and extra-household contacts of index cases. Methods We performed a c...
Article
Background: There are large knowledge gaps on the transmission dynamics of Mycobacterium tuberculosis in settings where both tuberculosis and HIV are endemic. We aimed to assess the infectiousness of tuberculosis patients coinfected with HIV. Methods: We systematically searched for studies of contacts of both HIV-positive and negative tuberculos...
Preprint
Full-text available
Background. Insecticide-treated bednets (ITNs) are widely used for the prevention and control of malaria. In Guatemala, since 2006, ITNs have been distributed free of charge in the highest risk malaria-endemic areas and constitute one of the primary vector control measures in the country. Despite relying on ITNs for almost 15 years, there is a lack...
Preprint
Full-text available
Background. Insecticide-treated bednets (ITNs) are widely used for the prevention and control of malaria. In Guatemala, since 2006, ITNs have been distributed free of charge in the highest risk malaria-endemic areas and constitute one of the primary vector control measures in the country. Despite relying on ITNs for almost 15 years, there is a lack...
Article
Full-text available
Background: The risk of infection from respiratory pathogens increases according to the contact rate between the infectious case and susceptible contact, but the definition of adequate contact for transmission is not standard. In this study we aimed to identify factors that can explain the level of contact between tuberculosis cases and their soci...
Article
Full-text available
Plasmodium vivax malaria is a neglected disease, particularly during pregnancy. Severe vivax malaria is associated with inflammatory responses but in pregnancy immune alterations make it uncertain as to what cytokine signatures predominate, and how the type and quantity of blood immune mediators influence delivery outcomes. We measured the plasma c...
Preprint
Full-text available
Background. There is little information about the proportion of clustering of tuberculosis cases from low-income settings, which can represent ongoing transmission events. Objectives. We investigated the proportion of clustered tuberculosis cases based on genotypic matching in Guatemala and potential factors associated with clustering in HIV-infect...
Preprint
Background. The risk of infection from respiratory pathogens increases according to the contact rate between the infectious case and susceptible contact, but the definition of adequate contact for transmission is not standard. In this study we aimed to identify factors that can explain the level of contact between tuberculosis cases and their socia...
Article
The immune status of women changes during and after pregnancy, differs between blood compartments at delivery and is affected by environmental factors particularly in tropical areas endemic for multiple infections. We quantified the plasma concentration of a set of thirty-one TH1, TH2, TH17 and regulatory cytokines, pro-inflammatory and anti-inflam...
Article
Full-text available
Directly observed therapy (DOT) is almost universally used for the treatment of TB. Several meta-analyses using different methods have assessed the effectiveness of DOT compared to self-administered therapy (SAT). The results of these meta-analyses often conflict with some concluding DOT is superior and others that there is little or no difference....
Article
Full-text available
Objective: To investigate diagnostic agreement of the QuantiFERON®-TB Gold In-Tube (QFT-GIT) test in adult tuberculin skin test (TST) converters in a high tuberculosis (TB) burden setting. Setting and design: We performed a case-cohort study from 2014 to 2016 in Uganda among residents who were not infected with Mycobacterium tuberculosis. Partic...
Article
Background: Several cohort studies demonstrate that diabetics are at increased risk for active tuberculosis, and poor glycemic control may exacerbate this risk. A higher prevalence of tuberculosis infection at baseline among diabetics may partially explain these results; however, no population-based studies have investigated this association. Furt...
Article
Background: Safety climate involves worker perception about the relative importance where they work and safety climate and has been shown to be a reliable predictor of safety-related outcomes. Methods: The primary objective of this study is to investigate ethnic differences in perceived safety climate among construction workers. Surveys (n = 179...
Article
Full-text available
Background: Despite that over 90 million pregnancies are at risk of Plasmodium vivax infection annually, little is known about the epidemiology and impact of the infection in pregnancy. Methodology and principal findings: We undertook a health facility-based prospective observational study in pregnant women from Guatemala (GT), Colombia (CO), Br...
Data
Incidence of malaria detected through passive case detection (PCD) and through active detection of infection (ADI), overall and by species and country. (PDF)
Data
Further details of the methods used in the histological evaluation of placentas. (PDF)
Data
Comparison of baseline characteristics between lost to follow-up women and women with complete follow-up. (PDF)
Article
Full-text available
A vaccine to eliminate malaria would need a multi-stage and multi-species composition to achieve robust protection, but the lack of knowledge about antigen targets and mechanisms of protection precludes the development of fully efficacious malaria vaccines, especially for Plasmodium vivax (Pv). Pregnant women constitute a risk population who would...
Article
Full-text available
P. vivax infection during pregnancy has been associated with poor outcomes such as anemia, low birth weight and congenital malaria, thus representing an important global health problem. However, no vaccine is currently available for its prevention. Vir genes were the first putative virulent factors associated with P. vivax infections, yet very few...
Data
Gating strategy. After exclusion of debris and doublets, lymphocytes were displayed according to CD3 expression and a dump channel containing a viability marker, CD14 and CD19. Live CD3+ T cells were then gated for CD4+ and CD8+ and intracytoplasmic expression of IFN-γ and CD69 was assessed in each of the populations. (JPG)
Data
Baseline characteristics of study population. (DOCX)
Data
Peptide sequences of the long peptides (PvLP). P. vivax long synthetic peptides (PvLP) representing conserved central core (PvLP1) and C-terminal (PvLP2) VIR motifs. Derivatized diethylene glycol (DEG,Merck Chemicals,Nottingham, UK) was inserted in between the different individual segments. (DOCX)
Data
Number of samples for which anti-VIR antibody responses were analyzed by country, timepoint and antigen. (DOCX)
Data
Correlation of anti-VIR responses with other anti-Plasmodium responses. (DOCX)
Data
Effect of time of bleeding on antibody levels. (DOCX)
Data
Characteristics of the one-exon vir genes and proteins selected for cloning and expression, and primer sequences used for gDNA amplification. (DOCX)
Data
Characteristics of the var2csa-like vir genes and proteins selected for cloning and expression, and primer sequences used for gDNA amplification. (DOCX)
Data
STROBE checklist for cohort studies. (DOC)
Data
Human IgG antibodies against GST were detected by Luminex in peripheral plasma at recruitment. Antibody levels are represented as median fluorescence intensity (MFI). Median (white line), and 25th and 75th percentiles (lower and upper hinge respectively) are represented in the box. Outside values are not displayed in the graph. (GIF)
Article
Rationale: Policy recommendations on contact investigation of HIV seropositive tuberculosis patients have changed several times. Current epidemiological evidence informing these recommendations is considered low quality and few large studies investigating the infectiousness of HIV seropositive and seronegative index cases have been performed in su...
Article
Full-text available
Plasmodium vivax is the most widely distributed human parasite and the main cause of human malaria outside the African continent. However, the knowledge about the genetic variability of P. vivax is limited when compared to the information available for P. falciparum. We present the results of a study aimed at characterizing the genetic structure of...
Data
Baseline characteristics of patients analyzed in our study. (TIF)
Data
Molecular markes and PCR conditions used in the present study. (TIF)
Data
Complete results for all P. vivax and P. falciparum MS analyzed loci. (XLSX)
Data
Genetic diversity, allelic richness, linkage disequilibrium and genetic distance of Brazilian P. vivax subpopulations. (TIF)
Data
Number of infected pregnant women with available data for each compartment. (TIF)
Research
Full-text available
Abstract Background: Anopheles albimanus is a key malaria vector in the northern neotropics. Current vector control measures in the region are based on mass distributions of long-lasting insecticidal nets (LLINs) and focal indoor residual spraying (IRS) with pyrethroids. Resistance to pyrethroid insecticides can be mediated by increased esterase an...
Article
Full-text available
The Mesoamerican Ministers of Health have set 2020 as the target for malaria elimination to be achieved in the region. Imported malaria cases are a potential threat to countries attempting elimination or working to prevent resurgence. We report the first imported Plasmodium ovale infection with molecular confirmation in Central America, which occur...
Article
Full-text available
Anopheles albimanus is a key malaria vector in the northern neotropics. Current vector control measures in the region are based on mass distributions of long-lasting insecticidal nets (LLINs) and focal indoor residual spraying (IRS) with pyrethroids. Resistance to pyrethroid insecticides can be mediated by increased esterase and/or multi-function o...
Article
Full-text available
This is a report of the first Plasmodium vivax congenital malaria case in Guatemala and the first case in Latin America with genotypical, histological and clinical characterization. The findings show that maternal P. vivax infection still occurs in areas that are in the pathway towards malaria elimination, and can be associated with detrimental hea...

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Projects

Projects (2)
Project
About this Research Topic: In recent years, the effect of environmental events on human health has been receiving global attention. Biological, physical, and chemical environmental risk factors from various sources of exposure (air, water, land, and organisms) influence people's health. These environmental stressors increase the risk of many chronic diseases, including cancer, cardiovascular and respiratory diseases. In addition, the World Health Organization reports that 99% of the world’s population is exposed to poor air quality, and about 7 million deaths are attributed to air pollution yearly. To further complicate this scenario, climate change is resulting in an alteration on the degree of human exposure to these environmental stressors and in their impact on population health. For example, climate change has already led to extreme heatwaves, bushfires, and rising sea levels, causing coastal flooding and tropical cyclones. The 6th assessment report of the United Nations’ Intergovernmental Panel on Climate Change concluded that global temperature over the next 20 years is expected to reach or exceed 1.5°C of warming, increasing heat-related morbidity and mortality. Understanding the environmental risks to health is essential for disease and injury prevention. The magnitude and the impact of environmental stressors on human health in different contexts, populations, and geographical regions are not fully understood. Evidence suggests that the frequency, duration, and intensity of extreme weather events such as bushfires, flooding, storms, cyclones, and heat waves will increase. These adverse events and other environmental risk factors pose threats to human health. Therefore, this Research Topic is timely and will provide critical information and understanding of the degree to which environmental stressors affect human health. The general scope of this Research Topic will cover all aspects related to physical and chemical environmental stressors, including, but not limited to, the quantitative health impact assessment of extreme weather events, air pollution, floods, bushfires (bushfire smoke, dust-storms), temperature (heatwaves), and environmental noise on human health (mortality, incidence of infectious and non-infectious diseases). In addition, studies from regions that have been affected by environmental risk factors due to recent climate-driven changes are welcome. Other studies on statistical/mathematical methodological approaches (e.g. time series regression) to environmental epidemiology are also desirable. The Research Topic could be original research, systematic reviews, meta-analysis, methods, review, perspective, data report, policy brief, brief research report, and general commentary on these thematic areas. We would like to acknowledge Dr. Anton Pak, The University of Queensland, who will act as a coordinator for the Research Topic. Keywords: planetary health, temperature, air pollution, earthquakes, bushfires, floods, noise pollution, hail, tropical storms, tornadoes Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review. Click here to submit: https://www.frontiersin.org/research-topics/27818/environmental-stressors-multi-hazards-and-their-impact-on-health
Project
To characterize the proportion of clustered tuberculosis cases based on genotypic matching in Guatemala City between 2013 and 2014 and to identify risk factors associated with these clustered cases in HIV-infected subjects.