María Andrea Camilletti

María Andrea Camilletti
National Scientific and Technical Research Council | conicet · IQUIBICEN Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales

PhD

About

16
Publications
737
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Citations
Introduction
I'm a postdoc fellow currently working in the Faculty of Exact and Natural Sciences, at the University of Buenos Aires (FCEyN-UBA). My research focuses on the molecular mechanisms of pituitary development and the identification of the genetic cause of hormonal deficiencies
Additional affiliations
April 2014 - December 2018
National Scientific and Technical Research Council
Position
  • PhD Student
Description
  • Project: Role of progesterone and estrogen classical and non classical receptors in lactotroph function. Ph.D supervisor: Dr. Graciela Díaz-Torga

Publications

Publications (16)
Article
Gender differences in the control of prolactin secretion are well documented. Sex-related differences in intra-pituitary factors regulating lactotroph function have recently attracted attention. Gender differences in prolactinomas development are well documented in clinic, prolactinomas being more frequent in women but more aggressive in men, for p...
Article
Among pituitary adenomas, prolactinomas are the most frequently diagnosed (about 50%). Dopamine agonists are generally effective in the treatment of prolactinomas. However, a subset of about 25% of patients does not respond to these agents. The management of drug-resistant prolactinomas remains a challenge for endocrinologists and new inhibitory tr...
Article
Full-text available
Pituitary hormone deficiency or hypopituitarism is characterized by a malformed or underdeveloped pituitary gland resulting in an impaired pituitary hormone secretion. Several transcription factors have been described in its etiology, but defects in known genes account for only a small proportion of cases. We sought to identify the cause of hypopit...
Article
Full-text available
Congenital hypopituitarism (CH), septo-optic dysplasia (SOD), and holoprosencephaly (HPE) constitute an important group of structural birth defects that cause significant morbidity and life-long consequences for quality of life and care. The genetic causes are highly overlapping. As such, these disorders can be considered as a spectrum of related d...
Article
Full-text available
Purpose Congenital hypopituitarism (CH) can present in isolation or with other birth defects. Mutations in multiple genes can cause CH, and the use of a genetic screening panel could establish the prevalence of mutations in known and candidate genes for this disorder. It could also increase the proportion of patients that receive a genetic diagnosi...
Article
Full-text available
The anterior pituitary gland is comprised of specialized cell-types that produce and secrete polypeptide hormones in response to hypothalamic input and feedback from target organs. These specialized cells arise during embryonic development, from stem cells that express SOX2 and the pituitary transcription factor PROP1, which is necessary to establi...
Article
Serum prolactin levels gradually increase from birth to puberty in both male and female rats, with higher levels observed in female since the first days of life. The increase in lactotroph secretion was attributed to the maturation of prolactin-inhibiting and -releasing factors; however, those mechanisms could not fully explain the gender differenc...
Article
Among all the hormone-secreting pituitary tumours, prolactinomas are the most frequently found in the clinic. Since dopamine is the primary inhibitor of lactotroph function, dopamine agonists represent the first-line therapy. However, a subset of patients exhibits resistance to these drugs, and therefore, alternative treatments are desired. As acti...
Article
Progesterone (P4) has controversial physiological effects on the regulation of the lactotroph population. While some studies have shown a negative role for P4 in prolactin secretion and lactotroph proliferation, antagonizing estradiol effects, others demonstrated a proliferative role of P4 at the pituitary level. Usually, progesterone actions in th...
Article
Membrane progesterone receptors are known to mediate rapid nongenomic progesterone effects in different cell types. Recent evidence revealed that mPRα is highly expressed in the rat pituitary, being primarily localized in lactotrophs, acting as an intermediary of P4-inhibitory actions on prolactin secretion. The role of mPRs in prolactinoma develop...
Article
Full-text available
Ovarian steroids control a variety of physiological functions. They exert actions through classical nuclear steroid receptors, but rapid non-genomic actions through specific membrane steroid receptors have been also described. In this study, we demonstrate that the G-protein-coupled estrogen receptor (GPER) is expressed in the rat pituitary gland a...
Article
Female transgenic mice that overexpress the human chorionic gonadotrophin β subunit (hCGβ+) develop prolactinomas, while hCGβ+ males do not. The high levels of circulating hCG induces massive luteinization in the ovary of hCGβ+ females, and progesterone becomes the primary steroid hormone produced, but estradiol remains at physiological level. The...
Article
Dopamine D2 receptors (D2R) participate in a complex system of adaptive functions to improve performance, reproductive success and survival of individuals. Using combined strategies with drug, cell lines and transgenic mice, our laboratory demonstrated that D2R take part, not only in the development of prolactinomas, but also in the regulation of t...

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