Maria Bicalho

Maria Bicalho
Federal University of Minas Gerais | UFMG · Departamento de Clínica Médica

PhD

About

97
Publications
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739
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Publications

Publications (97)
Article
Full-text available
Introduction Neurological manifestations have been associated with a poorer prognosis in COVID-19. However, data regarding their incidence according to sex and age groups is still lacking. Methods This retrospective multicentric cohort collected data from 39 Brazilian hospitals from 17 cities, from adult COVID-19 admitted from March 2020 to Januar...
Article
Objective To evaluate the feasibility of implementing an adaptation of the Hospital Elder Life Program (HELP) with the participation of family caregivers in a public university hospital. Method Descriptive exploratory pilot study developed with 30 hospitalized patients and their caregivers. Registration Forms were applied to identify risk factors f...
Article
Full-text available
Objective: To evaluate the ability of the Clinical Frailty Scale (CFS) to predict 90-day mortality and other poor outcomes in older adults admitted at a Hospital Emergency Department (ED). Method: This is a prospective cohort study including older adults admitted at ED of a Public Hospital who spent at least one night in it. The degree of baseline...
Article
Resumo Objetivo Avaliar a viabilidade da implementação de uma adaptação do Hospital Elder Life Program (HELP) com a participação de cuidadores familiares em hospital público universitário. Método Estudo piloto descritivo exploratório desenvolvido com 30 pacientes internados e seus cuidadores. Os Formulários de Registro foram aplicados para identifi...
Article
Studies on brain networks indicate that the functional integration between brain networks decreases progressively with Alzheimer`s disease (AD). The intermittent Theta Burst Stimulation (ITBS) has been shown to modulate the connectivity of DMN administered to parietal (PPC) and dorsolateral prefrontal (DLPFC) cortex. We selected 9 patients with AD,...
Article
Background: Elderly population is rising significantly in Brazil. It may reach 25.5% of the population by 2060. Cognitive and functional declines may happen during pathological aging process. Low and medium-income countries tend to present higher dementia growth rate than high-income countries. The aim of this study was to assess whether socio-dem...
Article
Comparison between functionality and cognition in elderly patients with Alzheimer’s dementia (AD) and without cognitive impairment with positive and negative Aβ‐42 and p‐Tau biomarkers evaluated using the Luminex technique. Patients with Alzheimer’s dementia and normal cognition (control) were recruited. They were divided in two groups according to...
Article
Background: Individuals with mild cognitive impairment (MCI) have increased risk to convert to Alzheimer's dementia (AD). Our aim was to evaluate the role of auditory evoked potential N200 and P300 and serum level of BDNF in predicting conversion from MCI patients to AD, considering APOE and BDNF genetic background. Method: 32 MCI patients were...
Article
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Objectives: to evaluate two instruments for screening frailty in the elderly in Primary Health Care. Methods: this is an observational, cross-sectional study, with a quantitative approach, with 396 elderly people. SPSS software helped to perform the statistical analyses. The study used the kappa coefficient and Spearman's correlation. Results:...
Article
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Background: Alzheimer's disease (AD) biomarkers are of great relevance in clinical research, especially after the AT(N) framework. They enable early diagnosis, disease staging and research with new promising drugs, monitoring therapeutic response. However, the high cost and low availability of the most well-known methods limits their use in low and...
Article
Background: Obesity has reached epidemic proportions worldwide, affecting life quality and span. Susceptibility to obesity is partly mediated by genetic differences. Indeed, several genes from the clock gene family have already been shown to be intimately associated with obesity in diverse ethnic groups. In the present study, an association betwee...
Article
Although randomized controlled trials have not confirmed cognitive impairing effects of statins, continuing evidence suggests statins have the ability to cause reversible cognitive impairment in some patients. Paradoxically, statins have also been shown to decrease risk of dementia, Alzheimer’s disease, and to improve cognitive impairment in some c...
Article
Indication for alternative feeding route (enteral nutrition ‐ EN) in elderly patients with advanced dementia remains controversial, especially when considering caregiver burden. The objective of this work was to evaluate caregiver burden of patients with advanced dementia with moderate to severe oropharyngeal dysphagia. A cohort of 67 patients with...
Article
Resilience is a concept related to individual diferences between functionality/cognition and clinical situations associated to aging. In Brazil, elderlies commonly have low educational level and, years of schooling , is not necessarily associated to learning. In this context, we hypothesize that inteligency could be a potencial proxy of cognitive r...
Poster
Psychiatric disorders are among etiologies for Mild Cognitive Impairment (MCI), one of the main one is depression. The relationship between depression and Alzheimer's disease (AD) is not yet fully understood and it is considered both, isolated risk factor and prodrome stage of AD. The aim of this work is to investigate if older adults with MCI asso...
Poster
Full-text available
Depression and diabetes mellitus (DM) are associated with an increased risk for dementia and mild cognitive impairment (MCI). Subcortical anatomical changes associated with processing speed impairment are shared by both DM subtypes. This profile is similar for depression, a condition in which processing speed and executive functions mediate deficit...
Article
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Purpose Parathyroid cancer is a rare tumor associated with poor prognosis particularly when disseminated. While chemotherapy and/or radiotherapy are of no clinical value in disseminated disease, immunotherapy should be considered. Subject and results A patient with CDC73-associated metastatic parathyroid carcinoma was treated with combined anti-hP...
Article
Purpose The presence of deleterious variants of dihydropyrimidine-dehydrogenase gene (DPYD) is associated with 5-Fluorouracil toxicity. Most of the data are based on findings in Caucasian populations. The variant Y186C (rs115232898) is found almost exclusively in African populations and is related to low DPD function. Its prevalence may vary among...
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Objective: To review systematically the influence of admission criteria on the mortality of elderly patients under intensive therapy. Methods: We performed a search on the PUBMED and BIREME databases by using the MeSH and DeCS terms "intensive care units", "patient admission", and "aged" in Portuguese, English, and Spanish. Only prospective and...
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Objective: Aging studies regularly assume that years of education are a protective factor for baseline cognition. In developing countries with specific sociocultural issues, this relationship may not work as expected, and an unmet need remains for alternative resilience factors. This study aimed to analyze different moderators for the relationship...
Article
We investigated through measurements in serum, the occurrence of oxidative stress in patients with Alzheimer's disease (AD), mild cognitive impairment (MCI) and healthy elderly controls. Possible correlations between a genetic risk factor for AD, the allele ε4 of the apolipoprotein E (APOE) gene, and oxidative stress were also investigated. Through...
Article
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Objective: Elderly people are at a high risk of developing vitamin D (VitD) deficiency due to both decreased intake and cutaneous synthesis. Most of the biological actions of VitD are mediated by the vitamin D receptor (VDR), which is present in neurons and glial cells of the hippocampus, and in the cortex and subcortical nuclei, essential areas f...
Article
Cognitive impairment, including mild cognitive impairment (MCI) and dementia, compromises the patients' cognitive abilities and, to different extents, to carry out daily activities, accompanied by personality and behavioral changes. Studies suggest that leptin, an adipokine, has a neuroprotective role against Alzheimer's disease (AD) and that cytok...
Article
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Objective: The objective of this study was to characterize the conventional lipid profile, oxLDL levels and ApoE polymorphism in patients with Alzheimer's disease (AD) and in elderly individuals without cognitive impairment. Methods: Eighty elderly individuals were selected and the levels of oxLDL were determined using the ELISA kit, and ApoE ge...
Article
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Objective: To compare the results of neuropsychological tests, evoked potentials N200 and P300 and polymorphisms of ApoE and BDNF rs6265 between patients with normal cognition and those with mild cognitive impairment (MCI) and Alzheimer's dementia (AD). Methods: This is a cross-sectional study of elderly individuals with normal cognition and tho...
Article
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Objective: Translate, transcultural adaptation and application to Brazilian Portuguese of the Alzheimer’s Disease Cooperative Study - Activities of Daily Living (ADCS-ADL) scale as a cognitive screening instrument. Method: We applied the back translation added with pretest and bilingual methods. The sample was composed by 95 elderly individuals an...
Article
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Objective:: Cognitive impairment is a hallmark of mild cognitive impairment (MCI) and Alzheimer's disease dementia (AD). Although the cognitive profile of these patients and its association with activities of daily living (ADLs) is well documented, few studies have assessed deficits in fine motor dexterity and their association with ADL performanc...
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Objectives: This study aims to evaluate the association between polymorphisms in circadian genes and Alzheimer's disease (AD) and/or late-onset depression (LOD). AD pathology leads to circadian disturbances, with clear negative influence on quality of life. In addition, there is an increasing evidence that regulators of circadian system have effec...
Article
Microparticles (MPs) are small membrane fragments that are released during cellular activation and apoptosis. An increase in platelet MPs (PMPs) has been observed in patients with higher platelet activation, such as Alzheimer's disease (AD) patients. This study has evaluated the levels of PMPs in patients with AD. It has also evaluated whether the...
Article
Full-text available
Ageing is closely associated with increasing frailty, and it continues to be defined in various different ways, complicating its practical application in the clinical context. Frailty is commonly used to predict the risk of functional decline, institutionalization or even death. Current models of frailty display significant limitations, because the...
Article
Objectives: In 2012, Kamboh and colleagues published a genome-wide association study that identified the DCHS2 gene (rs1466662 T/A) influencing the age at onset of Alzheimer's disease (AD). We aimed to investigate if there is association between the DCHS2 gene and amnestic mild cognitive impairment (aMCI) and AD in a sample of the Brazilian popula...
Article
Higher risk of dementia is expected for patients with late onset depression (LOD) history. The IL-10 polymor-phisms are associated with Alzheimer disease (AD). On the other hand, there is no study associating IL-10 poly-morphisms to LOD. This study aimed to investigate the −1082G/A polymorphism association in LOD, AD patients and controls and also...
Article
Full-text available
Depressive symptoms are associated with cognitive-functional impairment in normal aging older adults (NA). However, less is known about this effect on people with mild Cognitive Impairment (MCI) and mild Alzheimer’s disease dementia (AD). We investigated this relationship along with the NA-MCI-AD continuum by reanalyzing a previously published data...
Article
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Introduction: Lung cancer is the leading global cause of cancer-related mortality and is associated with poor prognosis. To improve survival rates of lung cancer patients, better understanding of tumorigenic mechanisms is necessary, which may lead to development of new therapeutic strategies. The hOGG1 and NTH1 genes act in the DNA BER repair path...
Article
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Cognitive functioning influences activities of daily living (ADL). However, studies reporting the association between ADL and neuropsychological performance show inconsistent results regarding what specific cognitive domains are related to each specific functional domains. Additionally, whether depressive symptoms are associated with a worse functi...
Article
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Previous studies suggest that executive functions influence the performance on visuoconstructional tasks. This study aims to investigate whether the relationship between planning ability and the copy of complex figures is mediated by distinct components of executive functions (i.e., working memory, inhibitory control and cognitive flexibility). We...
Article
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Evidences suggest that GAB2 and BDNF genes may be associated with Alzheimer's disease (AD). We aimed to investigate the GAB2 rs2373115 and BDNF rs6265 polymorphisms and the risk of AD in a Brazilian sample. 269 AD patients and 114 controls were genotyped with Real-time PCR. Multifactor dimensionality reduction (MDR) was employed to explore the effe...
Article
The objectives of this study were to assess demographic trends of a long-term care institution (LTCI) for the aged throughout 24 years and to discuss the results considering regulations and demographic, socioeconomic, and epidemiological changes in Brazil during this period. We assessed administrative data of 394 residents of a Brazilian LTCI betwe...
Poster
18F-FDG PET/CT on the differential diagnosis between Mild Cognitive Impairment and mild Alzheimer’s disease Background The pathophysiological process of Alzheimer’s disease (AD) is thought to begin many years before the diagnosis of dementia. The Mild Cognitive Impairment (MCI) is a prodromol state. It is critical to better define the biomarker tha...
Article
Examine the association between polymorphisms in the AKT1 and AKTIP genes and late-onset depression (LOD). Major depressive disorder is one of the most prevalent neuropsychiatric diseases. LOD is a disorder that starts after 65 years old. AKT1 is a downstream enzyme that has been implicated in the pathogenesis of neurotransmitter-related disorders,...
Article
Summary Lung cancer is the leading global cause of cancer-related mortality. Inter-individual variability in treatment response and prognosis has been associated with genetic polymorphisms in specific genes: EGFR, KRAS, BRAF, PTEN and TTF-1. Somatic mutations in EGFR and KRAS genes are reported at rates of 15-40% in non-small cell lung cancer (NSCL...
Article
Objective Depression might be a prodromal stage of dementia. Many factors contribute to the etiology of depression and dementia, being inflammation one of those. The present work measured and analyzed immune molecules involved in the innate immunity on cluster of differentiation 14 (CD14+) monocytes trying to investigate any relationship among late...
Article
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Objective: To propose and evaluate the psychometric properties of a multidimensional measure of activities of daily living (ADLs) based on the Katz and Lawton indices for Alzheimer's disease (AD) and mild cognitive impairment (MCI). Methods: In this study, 85 patients with MCI and 93 with AD, stratified by age (≤ 74 years, > 74 years), completed...
Article
Full-text available
The neuropsychological exam plays a central role in the assessment of elderly patients with cognitive complaints. It is particularly relevant to differentiate patients with mild dementia from those subjects with mild cognitive impairment. Formal education is a critical factor in neuropsychological performance; however, there are few studies that ev...
Article
Full-text available
Objective: Depressive pseudodementia (DPD) is a clinical condition characterized by depressive symptoms followed by cognitive and functional impairment characteristics of dementia. Memory complaints are one of the most related cognitive symptoms in DPD. The present study aims to assess the verbal learning profile of elderly patients with DPD. Met...