Maria Martha Bernardi

Maria Martha Bernardi
Universidade Paulista · Instituto de Ciências da Saúde (ICS)

PhD

About

302
Publications
31,133
Reads
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3,992
Citations
Citations since 2016
108 Research Items
2043 Citations
2016201720182019202020212022050100150200250300
2016201720182019202020212022050100150200250300
2016201720182019202020212022050100150200250300
2016201720182019202020212022050100150200250300
Additional affiliations
August 2011 - present
Universidade Federal do ABC (UFABC)
Position
  • Professor visitante senior
March 1993 - present
Universidade Paulista
Position
  • Full Professor and Research
January 1993 - January 2017
Universidade Paulista
Position
  • Professor (Full)

Publications

Publications (302)
Article
Full-text available
Isotherapics prepared from toxic substances have been described as attenuation factors for heavy metal intoxication in aquatic animals. Herein, Artemia salina and mercury chloride were used as a model to identify treatment-related bioresilience. The aim was to describe the effects of Mercurius corrosivus (MC) in different potencies on Artemia salin...
Article
Glyphosate is the organophosphate pesticide most widely used in the world. Recent studies correlate exposure to glyphosate and the emergence of neurodevelopmental disorders. Therefore, it was objective to propose a rat model of perinatal exposure to glyphosate‐ based herbicides (HBG) to study associated neurodevelopmental disorders. Behavioral aspe...
Article
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Objectives: The herbicide glyphosate, a pesticide used in agriculture to control weeds, both in food crops and in other agricultural areas, has been identified as an endocrine modulator through the inhibition of aromatase activity and the activation of estrogen receptors. The present study examined the effects of a glyphosate-based herbicide (Round...
Article
Full-text available
Introduction: Different environmental conditions can influence the effects of toxic agents on living beings. Recently, a series of experiments performed in Artemia salina submitted to different kinds of intoxication have shown that both, isotherapic and succussed water can change Artemia salina´s bio resilience at different levels. Moreover, it see...
Article
Full-text available
Introduction: Artemia salina, an ecotoxicity bioindicator, is a microcrustacean belonging to the order Anostraca. Glyphosate is an herbicide widely used to control weeds. However, its intoxication can cause serious damage to human health and the balance of the environment, given its effects as an endocrine disruptor. Objective: verify the possible...
Article
Several analgesics are suggested for pain management in mice. Nonsteroidal antiinflammatories (NSAIDs), such as meloxicamcan be administered for the treatment of inflammation and acute pain; however, several side effects can occur which include gastrointestinal ulceration and renal and hepatic toxicity. We previously performed a pilot study to test...
Article
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After analgesic administration, we evaluated general activity in the Open-Field and anxiety-like behavior in the Elevated Plus Maze of vasectomized mice. We divided C57BL/6J male mice into eight groups: saline, three non-operated control groups treated with 10 mg/kg meloxicam, 20 mg/kg tramadol, or both intraperitoneally, and four vasectomized mice...
Article
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Previous study of this research group revealed that water from the Billings reservoir (Brazil) intended for human use (water supply and seafood) has microbiological contamination and causes lethality and brain and behavioral impairments in zebrafish. The objective of this study was to understand what have induced these impairments in the animal mod...
Article
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Background: ZINCUM METALLICUM (ZM) is a homeopathic medicine whose materia medica is defined by diverse behavioral and mental symptoms, including depression. Moreover, as a microelement, zinc itself is involved in several functions of Central Nervous System, including development and cell maturity during the intra-uterus life. Aims: Herein, the put...
Article
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Introduction: The factors related to obesity are complex, involving biologic, environmental and neuropsychological mechanisms[1-3]. Among the factors which influence the gain of weight, we can consider the stressful factors. Aims: The aim of this experiment was to evaluate the influence of the commercial homeopathic product compound by Fucus vesicu...
Article
Introduction: Finding solutions to mitigate the impact of pollution on living systems is a matter of great interest. Homeopathic preparations of toxic substances have been described in the literature as attenuation factors for intoxication. Herein, an experimental study using Artemia salina and mercury chloride was developed as a model to identify...
Article
Background: The simulated bacterial infection is a classical experimental model, by the injection of purified gram negative bacteria wall lipopolysaccharide (LPS) which produces effects similar to real infection, but without presence of the microorganism. The LPS is a stress factor as during the pregnancy and delivery, and pilot experiments have sh...
Article
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Introduction: Clinical studies have shown that adverse events in childhood can lead to the development of psychiatric disorders, such as anxiety, in adolescence and adulthood in humans. Manipulations with laboratory animals, such as maternal deprivation (MD), are a source of stress for the offspring and can be a useful tool for the understanding ho...
Article
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Background: Depression is a hot topic for research including for the homeopathy community. Laboratory models for human diseases offer the possibility to evaluate depression-like behavior in mice by the tail suspension test (TST), such as the challenge of mothers with induced inflammation by lipopolysaccharide (LPS) during gestation. Moreover, it is...
Article
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Aging is an extremely complex and multifactorial process. Over time, the elderly begin exhibiting signs of function reduction. The aim of the present study was to assess the effects of homeopathic medicines on testicle histomorphometry in senescence/senility. The study was approved by the animal experimentation ethics committee of Santo Amaro Unive...
Article
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Background: Clinical studies have shown that adverse events in early life are quite stressful and can lead to the development of psychiatric disorders, such as anxiety, in adolescence and adulthood in humans. Experimental models of maternal deprivation (MD) in rats can be a useful tool for the understanding how these events in the early period of d...
Article
Introduction Artemia salina, a micro-crustacean of the order Anostraca, is one of the most used ecotoxicity bioindicators. Glyphosate is an herbicide widely used in the world, whose toxicity is still controversial, although many evidences point to endocrine disruption effects. Objective Since in homeopathic practice intoxications are often treated...
Article
Ethnopharmacological relevance The tea made with the fruits of Luffa operculata (L.) Cogn. (Cucurbitaceae; EBN) is popularly used as abortive. Aim of the study The present work aimed at accessing how the exposition of female Wistar rats to 1.0 mg/kg of EBN (experimental group, EG), or distilled water (control group, CG), by gavage, at gestational...
Article
The aim of this review was to present the main parameters used for the assessment of neurotoxicity during the initial period of life of rodents until puberty and to carry out a review of the most current literature on the toxic effects of pesticides, medications, licit and illicit drugs, toxins and environmental agents in rodent offspring. The bibl...
Article
Ethnopharmacological relevance Luffa operculata (L.) Cogn (Cucurbitaceae), is a traditional plant popularly used against sinusitis and as abortive. Aim of the study The verification of the effects of BNE prenatal exposure to juvenile male Wistar rats (F1 generation). Materials and methods Pregnant female rats (F0 generation) received 1.0 mg/kg BN...
Article
Despite the great number of test batteries already known to assess the behavior of genetically modified and inbred strains of mice, only a few of them focus on basic neurological parameters. The purpose of the battery test proposed is to settle a specific methodology to characterize the phenotype of neurological disease models in mutant or genetica...
Article
The tremor mutant phenotype results from an autosomal recessive spontaneous mutation arisen in a Swiss-Webster mouse colony. The mutant mice displayed normal development until three weeks of age when they began to present motor impairment comprised by whole body tremor, ataxia, and decreased exploratory behavior. These features increased in severit...
Article
Considering all mental and addictive disorders, depression is the most responsible for years of life lost due to premature mortality and disability. Antidepressant drugs have limited effectiveness. Depression can be triggered by immune/inflammatory factors. Zinc and paracetamol interfere with immune system and have demonstrated beneficial effects o...
Article
Objective: Previously we observed an attenuation of body temperature in lactating rats treated with lipopolysaccharide (LPS) compared with virgin saline-treated females. We proposed that high levels of prolactin (PRL) during lactation may induce this attenuation because PRL has a suppressive effect on inflammation. In the present study, we induced...
Article
Purpose: The influence of a challenge dose of lipopolysaccharide (LPS) on the behavioural selection between maternal (MB) and predatory behaviours (PB) of female rats prenatally treated with the same endotoxin or saline solution (F1 generation) were studied. Material and methods: Thus, in adult age, these female rats were mated and, at lactation da...
Article
Full-text available
Sickness behavior (SB) is considered part of the adaptive behavioral and neuroimmune changes that occur in response to inflammatory processes. However, SB is a motivational state modulated by the environmental context. The objective of this study was to evaluate if selenium could ameliorate symptoms of SB and if stress would affect these responses....
Conference Paper
Full-text available
Introduction: Asthma is an inflammatory disease caused by repeated immediate phase hypersensitivity and late- phase allergic reactions in the lungs. The prevalence of allergic diseases and asthma are in-creasing worldwide. Asthma is a serious health problem and eco-nomic concern through morbidity, loss of productivity, and death. RESP – AID is an i...
Article
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Forensic Science is formed by areas that perform analysis in different traces found in crime scenes and that can correlate with the fact that happened, thus being able to help in judicial procedure. One of the most important evidence found at a crime scene is blood, but to prove it, rapid tests are performed, such as the Kastle-Meyer (KM) test, whi...
Article
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We have shown that exposure of rats to lipopolysaccharide (LPS) during gestation induces autistic-like behaviors in juvenile offspring and pioglitazone post treatment corrects social and communication deficits. The first objective of the present study was to evaluate the cognition of the rats, because this is also a behavioral sphere committed in a...
Article
Grooming behaviour has different functions on many species during development and can be observed and affected during periods of stress. By selecting male mice with high (HI) and low (LI) immobility traits in the tail suspension test, a screening for antidepressant drugs, we investigate how these phenotypes associated with grooming behaviour may be...
Article
Ivermectin is a human and veterinary antiparasitic drug which is one of the most widely used in the world. Studies from our group have revealed several behavioral and neurochemical impairments induced by therapeutic doses of ivermectin in adult rats. However, the effects on juveniles remain unknown. Ivermectin has been prescribed for juvenile human...
Article
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The recessive mutant mice bate palmas (bapa) or claps in Portuguese arose from ENU (N‐ethyl‐N‐nitrosourea) mutagenesis. A single nucleotide, T>C, change in exon 13, leading to a Thr1289Ala substitution, was identified in the lysine (K)‐specific methyltransferase 2D gene (Kmt2d) located on chromosome 15. Mutations with a loss‐of‐function in the KMT2...
Article
Sickness behavior is a motivational state that can be modulated by the environmental context. We induced sickness behavior in rats using lipopolysaccharides (LPS). Rats were treated with selenium in order to verify possible changes of sickness behavior expression. We exposed these rats to a restraint stress challenge and studied the paradigms: cure...
Article
Previous study by our group showed that acute lipopolysaccharide (LPS) switches the selection of maternal behavior to predatory behavior in rats. We studied now the effects of a challenged dose of LPS on behavioral selection of F1 lactating rats prenatally exposed to LPS. Female rats prenatally exposed to LPS (on gestation day 9.5) received a LPS c...
Article
Doxorubicin (Dox), a topoisomerase interactive agent, is commonly used to treat several types of cancer. This drug is known to cause cognitive impairments in individuals submitted to long-term chemotherapy (deficits also called as chemobrain). The present study investigated whether morphological, oxidative and behavioral impairments could be induce...
Article
This study analyzed the effects of lipopolysaccharide (LPS)-induced sickness behavior on selection between maternal behavior and predatory behavior in lactating rats. We also evaluated general maternal activity and TNF-alpha levels to confirm that LPS-induced sickness behavior. Lactating rats received 100 μg/kg LPS or saline solution on day 5 or 6...
Article
The present study investigated whether a hypercaloric diet that is administered in rats during the juvenile period prevents sexual impairments that are caused by maternal food restriction and the tendency to become overweight/obese. Female rats were prenatally fed a 40% restricted diet from gestational day 2 to 18. The pups received a hypercaloric...
Article
Full-text available
Levothyroxine (LT4) is a form of thyroid hormone used to treat hypothyroidism. In the brain, T4 is converted to the active form T3 by the type 2 deiodinase (D2). Thus, it is intriguing that carriers of the Thr92Ala polymorphism in the D2 gene (DIO2) exhibit clinical improvement when liothyronine (LT3) is added to LT4 therapy. Here we report that D2...
Article
Full-text available
Objectives: Previous studies from our group showed that lipopolysaccharide (LPS) exposure induces several signs of sickness behavior, including a decrease in food consumption, body weight gain, adipsia, and a biphasic effect in tympanic temperature with a first phase of hypothermia, followed by an increased tympanic temperature. LPS can activate a...
Article
Introduction: Obesity promotes hypothalamic inflammation and local morphological changes in astrocytes, including the increased expression of the astrocytic biomarker glial fibrillary acidic protein (GFAP), which is seen as a sign of neuroinflammation. Objective: This study aimed to observe the astrocytic expression of GFAP in different brain areas...
Article
Background: Crude extract obtained from the stem of Xylopia aromatica (Annonaceae, EB149) known as pimenta-de-macaco, a traditional Brazilian medicinal and edible plant, showed cytotoxicity against leukemia cell lines. Despite the initial findings, no information regarding its influence on behavioral phenotype (BP) has been previously reported. Obj...
Article
The Billings reservoir is the largest water-storage facility in the São Paulo Metropolitan Region, with only a small part of the reservoir used for water supply. Recently, the São Paulo Metropolitan Region has experienced the greatest water collapse ever recorded. Thus, the intensification of use of the Billings reservoir should be considered. The...
Article
Full-text available
The aim of the present study was to determine the validity of behavior as an early sign of toxicity and respiratory injuries induced by acute exposure to cadmium in adult zebrafish (Danio rerio). The effects of three cadmium concentrations (35, 45, and 55 μg/L) on zebrafish behavior (i.e., general activity, exploratory/motor behavior, climbing to t...
Article
Otoconia are crucial for the correct processing of positional information and orientation. Mice lacking otoconia cannot sense the direction of the gravity vector and cannot swim properly. This study aims to characterize the behavior of mergulhador (mlh), otoconia-deficient mutant mice. Additionally, the central catecholamine levels were evaluated t...
Article
Full-text available
Autism is characterized by social deficits, communication abnormalities, and repetitive behaviors. The risk factors appear to include genetic and environmental conditions, such as prenatal infections and maternal dietary factors. Previous investigations by our group have demonstrated that prenatal exposure to lipopolysaccharide (LPS), which mimics...
Article
Ethnopharmacological relevance: Luffa operculata (L.) Cogn., Cucurbitaceae (buchinha-do-norte), aqueous extract (EBN) is popularly used to relieve symptoms of sinusitis and as abortive. Aim of the study: As neurotoxicity and toxicity studies on the male reproductive system are scarce, the present study aimed at quantitatively addressing the ques...
Article
O camundongo mutante recessivo bate-palmas (bapa) originou-se de mutagênese química induzida por ENU (N-ethyl-N-nitrosourea) e apresenta alterações posturais com movimentos anormais dos membros posteriores quando levantado pela cauda. No sequenciamento do exoma identificou-se uma mutação no gene Kmt2d, localizado no cromossomo 15, que foi confirmad...
Article
Full-text available
Obesity is associated with a chronic and low-grade inflammatory response in the hypothalamus, where astrogliosis occurs with the upregulation of the astrocyte structural protein GFAP. As propentofylline (PPF) has inhibitory effects on astrocyte and microglial activation during inflammation, this study aimed to investigate if this xanthine derivativ...