María Alejandra González-González

María Alejandra González-González
University of Houston | U of H, UH · Department of Biomedical Engineering

PhD _ University of Houston
- Open to the job market.

About

20
Publications
3,595
Reads
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104
Citations
Introduction
I study the functional neurophysiology of the autonomic nervous system at central and peripheral level during health and diseases, as fundamental basis for bioelectronic medicine. I integrate the use of engineered materials such is graphene and shape memory polimers as neural interfaces to study functional, cellular and molecular mechanisms. I have special interest on the vagus nerve-related networks, splenic neural components and cerebellar implications in non-motor functions.
Additional affiliations
January 2020 - present
University of Houston
Position
  • Research Associate
Description
  • Research in bioelectronic medicine
May 2019 - present
Marine Biological Laboratory
Position
  • Fellow
November 2016 - December 2019
University of Texas at Dallas
Position
  • Research Associate
Description
  • Regenerative Neurobiology and Neuroelectronics Laboratory - Neuromodulation of peripheral nerves. - Anatomo-functional mapping of peripheral nerves. - In-vivo-characterization of intra and extraneuronal electrodes.
Education
August 2012 - August 2016
Neurobiology Institute, UNAM
Field of study
  • Biomedical Sciences (Neurosciences)
July 2009 - August 2011
Neurobiology Institute, UNAM
Field of study
  • Neurosciences
July 2002 - August 2006
Autonomous University of Queretaro
Field of study
  • Chemist Pharmaceutical Biologist

Publications

Publications (20)
Article
Full-text available
Hypertension is a main cause of death in the United States with more than 103 million adults affected. While pharmacological treatments are effective, blood pressure (BP) remains uncontrolled in 50–60% of resistant hypertensive subjects. Using a custom-wired miniature electrode, we previously reported that deep peroneal nerve stimulation (DPNS) eli...
Article
Full-text available
Electroceuticals is an emerging field that combines the technology in conductive materials with their ability to interface with biological systems. The development of highly conductive electrodes to monitor human health in real-time while simultaneously delivering stimulation promises to revolutionize medical science. Aspects to consider during dev...
Article
Full-text available
Neural interfacing nerve fascicles along the splenic neurovascular plexus (SNVP) is needed to better understand the spleen physiology, and for selective neuromodulation of this major organ. However, their small size and anatomical location have proven to be a significant challenge. Here, we use a reduced liquid crystalline graphene oxide (rGO) fibe...
Conference Paper
Hypertension affects nearly half of the US population but only 43% achieved blood pressure control with medication alone. Medical devices for hypertension include implantable lead electrodes that stimulate the carotid baroreceptors with promising results, albeit with significant adverse complications. To address these limitations, we have proposed...
Preprint
Full-text available
Neural interfacing nerve fascicles along the splenic neurovascular plexi (SNVP) is needed to better understand the spleen physiology, and for selective neuromodulation of this major organ. However, the small size and anatomical location have proven to be a significant challenge. Here, we use a reduced liquid crystalline graphene oxide (rGO) fiber c...
Article
Selective interfacing to small multifunctional nerves such as the vagus nerve (VN) which is the main multimodal autonomic nerve that provides a major communication pathway from vital peripheral organs to the brain, can have significant potential in treating and diagnosing diseases as well as enhancing our understanding of peripheral nerve circuits....
Article
Full-text available
While intracortical microelectrode arrays (MEAs) may be useful in a variety of basic and clinical scenarios, their implementation is hindered by a variety of factors, many of which are related to the stiff material composition of the device. MEAs are often fabricated from high modulus materials such as silicon, leaving devices vulnerable to brittle...
Article
Objective: Neural interfaces designed to stimulate or record electrical activity from peripheral nerves have applications ranging from the electrical modulation of nerve activity as a therapeutic option (e.g. epilepsy and untreatable depression) to the design of prosthetics. Currently, most peripheral nerve interfaces are either cuff-style devices...
Article
Full-text available
Silicone nerve cuff electrodes are commonly implanted on relatively large and accessible somatic nerves as peripheral neural interfaces. While these cuff electrodes are soft (1–50 MPa), their self-closing mechanism requires of thick walls (200–600 µm), which in turn contribute to fibrotic tissue growth around and inside the device, compromising the...
Article
Full-text available
The periventricular zone of cerebellum is a germinative niche during the embryonic development, nevertheless its structural organization and functional implications in adult have not been widely studied. Here we disclose the presence of two novel clusters of cells in that area. The first one was named the subventricular cellular cluster (SVCC) and...
Article
Full-text available
GABA-A receptors mediating synaptic or extrasynaptic transmission are molecularly and functionally distinct, and glial cells are known to express a plethora of GABA-A subunits. Here we demonstrate that GFAP+ cells of the granular layer of cerebellum express GABAρ subunits during early postnatal development, thereby conferring peculiar pharmacologic...
Article
Full-text available
The ependymal glial cells (EGCs) from the periventricular zone of the cerebellum were studied to determine their distribution and the functional properties of their γ-aminobutyric acid type A (GABA(A) ) receptors. EGCs were identified by the presence of ciliated structures on their ventricular surface and their expression of glial fibrillary acidic...
Article
Full-text available
The calyx of Held synapse (CoH) is the largest synapse in mammals. It is located in the medial nucleus of the trapezoid body (MNTB) and forms part of the auditory pathway. Modest GABAergic signaling is present in the CoH before hearing onset, when glutamatergic transmission predominates. In mice, after postnatal day 12, the absolute strength of gly...

Questions

Questions (9)
Question
Any suggestion on writing a research statement is appreciated.
Question
I need to modify the blood pressure in a monkey while is awake in the recording chamber, and I am planing on provide a drug for that in the food or water used for reward... any advise?
Thank you
Question
I have processed sciatic nerve as usual (4% PFA followed by increased gradients of sucrose and sectioned in cryostat) with very good results, however I started with vagus nerve from rat and the same procedure doesn't work, It seems that the myelin is destroyed and very poor hystological quality in general. I hope somebody has suggestions or could share your protocol.
Thanks!!!
Question
I need to assess trans-synaptic tracing, from the PNS to the CNS, I'll use PRV virus, I was planning to administrate it direct in the peripheral nerve (not in the nerve extreme) by a micro injection, but I'm not sure if it works in this way or the virus should be administrated direct in the synaptic end.   
I have found controversial info in the literature and is the first time that I'm going to do it, 
Thanks in advance
Is it possible to induce cerebellar medulloblastoma? if not in cerebellum... in other area in central nervous system? 
Question
Is it possible tu induct the formation of medulloblastome in vermis or periventricular zone in cerebellum in rodent?  if not in cerebellum .... in other area in central nervous system?
Question
I´m planning to dissect  some neuronal cells in mice, and I know that laser microdissection is a good choice. If anyone has another suggestion, let me know please. 
Question
I´m looking for a hypoosmótic model in mice, could somebody help me? 
Question
I used DiI and I traced very well some fibers, but a disadvantage is that when it's exposed to UV light in a microscope, loses fluorescence very quickly. I need a tracer in fixed tissue because it's easier to administrate the tracer in the zone that I'm studying than in stereotaxic. Thanks.

Projects

Projects (2)
Project
My current projects are focused on: - In-vivo characterization of extraneuronal and intraneuronal electrodes to interface pheriferal nerves. - Elucidate electrophisiologically the fiber composition on peripheral nerves focusing on organ-specific targets. - Characterize at cellular and anatomical levels the organ-specific fibers involved in vagus nerve innervation.
Project
My current interest is on understanding the cellular organization and functionality of new cellular populations in the subventricular zone in cerebellum, as well as the molecular and cellular characteristics of these cellular populations.