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Margriet van der Zee

Margriet van der Zee
Science Lines

PhD

About

50
Publications
16,847
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Introduction
I am a senior European Registered Toxicologist with a passion for writing. I have extensive experience in regulatory human health risk assessment of nanotechnology, chemicals and medical technology. It is my ambition to work on innovative developments that improve the quality of life. Innovative developments have always fascinated me. I am driven to help turn promising innovative ideas into successful and safe products with a positive impact on society.

Publications

Publications (50)
Article
Full-text available
Cell-based therapies have been making great advances toward clinical reality. Despite the increase in trial activity, few therapies have successfully navigated late-phase clinical trials and received market authorization. One possible explanation for this is that additional tools and technologies to enable their development have only recently becom...
Article
Full-text available
Various nanomedicinal products (NMPs) have been reported to induce an adverse immune response, which may be related to their tendency to accumulate in or target cells of the immune system. Therefore, before their market authorization, NMPs should be thoroughly evaluated for their immunotoxic potential. Nonclinical regulatory immunotoxicity testing...
Book
Full-text available
Engineered nanomaterials (ENMs) are being applied in various nanotechnology products and are used in consumer products such as cosmetics and food; fertilizers; synthetic organs or engineered microbes, or self-assembling materials that assemble into new structures in the body upon their release; and molecular devices used in genetic therapy. People...
Article
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An early dialogue between nanomedicine developers and regulatory authorities are of utmost importance to anticipate quality and safety requirements for these innovative health products. In order to stimulate interactions between the various communities involved in a translation of nanomedicines to clinical applications, the European Commission's Jo...
Article
The biodistribution of engineered inorganic nanomaterials with size characteristics of one, two, or three dimensions smaller than 100 nm is a fast‐growing analytical and toxicological research field. This article gives a detailed overview of biodistribution studies with gold (Au), silver (Ag), and titanium dioxide (TiO2) nanoparticles (NPs). Exposu...
Article
Mass is traditionally the unique measure of the administered dose in toxicity studies with conventional chemical substances. Because of the variety of specific physical properties of nanoparticles, other dose metrics such as the number of particles, their size, shape, surface area or volume may be more appropriate. Here we applied a systematic, unb...
Article
Iron oxide nanoparticles (ION) have received much attention for their utility in biomedical applications, such as magnetic resonance imaging, drug delivery and hyperthermia, but concerns regarding their potential harmful effects are also growing. Even though ION may induce different toxic effects in a wide variety of cell types and animal systems,...
Article
Within the EU FP-7 GUIDEnano project, a methodology was developed to systematically quantify the similarity between a nanomaterial (NM) that has been tested in toxicity studies and the NM for which risk needs to be evaluated, for the purpose of extrapolating toxicity data between the two materials. The methodology is a first attempt to use current...
Article
Full-text available
The European Union FP-7 project GUIDEnano developed a web-based guidance tool, which guides users to assess human and environmental risks of nanomaterial-enabled products throughout their life cycle. One of the aims in the GUIDEnano hazard assessment strategy is to derive safety limit values based on existing human toxicity and ecotoxicological stu...
Article
The terms ‘Safe innovation’ and ‘Safe(r)-by-design’ are currently popular in the field of nanotechnology. These terms are used to describe approaches that advocate the consideration of safety aspects already at an early stage of the innovation process of (nano)materials and nano-enabled products. Here, we investigate the possibilities of considerin...
Article
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Due to their specific properties and pharmacokinetics, nanomedicinal products (NMPs) may present different toxicity and side effects compared to non-nanoformulated, conventional medicines. To facilitate the safety assessment of NMPs, we aimed to gain insight into toxic effects specific for NMPs by systematically analyzing the available toxicity dat...
Article
Full-text available
Nanomaterials (NMs) are attractive for biomedical and pharmaceutical applications because of their unique physicochemical and biological properties. A major application area of NMs is drug delivery. Many nanomedicinal products (NMPs) currently on the market or in clinical trials are most often based on liposomal products or polymer conjugates. NMPs...
Article
To study the effects of nanomaterials after inhalation, a large number of in vitro lung models have been reported in literature. Although the in vitro models contribute to the reduction of animal studies, insufficient data exists to determine the predictive value of these in vitro models for the in vivo situation. The aim of this study was to deter...
Article
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This paper aimed to clarify whether maternal inhalation of engineered nanoparticles (NP) may constitute a hazard to pregnancy and fetal development, primarily based on experimental animal studies of NP and air pollution particles. Overall, it is plausible that NP may translocate from the respiratory tract to the placenta and fetus, but also that ad...
Article
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The increasing use of nanoparticles in products likely results in increased exposure of both workers and consumers. Because of their small size, there are concerns that nanoparticles unintentionally cross the barriers of the human body. Several in vivo rodent studies show that, dependent on the exposure route, time, and concentration, and their cha...
Article
A number of studies have shown that induction of pulmonary toxicity by nanoparticles of the same chemical composition depends on particle size, which is likely in part due to differences in lung deposition. Particle size mostly determines whether nanoparticles reach the alveoli, and where they might induce toxicity. For the risk assessment of nanom...
Article
Full-text available
Aim: A horizon scan of nanomedicinal product on the market or undergoing clinical investigation by analyzing the current nanomedicinal landscape. Materials & methods: The horizon scan includes a search of literature, clinical trial registries and the internet. Results: This horizon scan yielded 175 nanomedicinal products. Most products were in...
Article
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Doses of conventional chemical substances in toxicity studies are traditionally described by administered mass. For deriving toxic doses of nanomaterials, mass and chemical composition alone may not be an adequate description of the dose as particles with the same chemical composition can have completely different toxic mass doses, depending on pro...
Article
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Background Although silver nanoparticles are currently used in more than 400 consumer products, it is not clear to what extent they induce adverse effects after inhalation during production and use. In this study, we determined the lung burden, tissue distribution, and the induction and recovery of adverse effects after short-term inhalation exposu...
Article
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The successful transplantation of human materials such as organs, tissues and cells into patients does not only depend on the benefits, but also on the mitigation of risks. To gain insight into recent publications on risks associated with the process of transferring human materials from donor to recipient we performed a horizon scan by reviewing sc...
Article
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The increasing manufacture and use of products based on nanotechnology raises concerns for both workers and consumers. Various studies report induction of pulmonary inflammation after inhalation exposure to nanoparticles, which can vary in aspects such as size, shape, charge, crystallinity, chemical composition, and dissolution rate. Each of these...
Book
Full-text available
http://www.ttl.fi/en/publications/Electronic_publications/Nanosafety_in_europe_2015-2025/Documents/nanosafety_2015-2025.pdf
Article
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Because of its antibacterial activity nanosilver is one of the most commonly used nanomaterials. It is increasingly used in a variety of both medical and consumer products resulting in an increase in human exposure. However, the knowledge on the systemic toxicity of nanosilver is relatively limited. To determine the potential systemic toxicity of s...
Chapter
The biodistribution of engineered inorganic nanomaterials with size characteristics of one, two, or three dimensions smaller than 100 nm is a fast-growing analytical and toxicological research field. This review gives a detailed overview about biodistribution studies with gold (Au), silver (Ag), and titanium dioxide (TiO2) nanoparticles (NPs). Exp...
Chapter
Recent emphasis of research on engineered nanomaterials (ENM) can be justified by the fact that nowadays ENM or the use of nanotechnology can be found in a wide variety of commercial products with more than a fivefold increase in the last 5 years. The increase in ENM use is primarily due to the physicochemical properties that distinguish them from...
Article
Full-text available
The biological response to four well-characterized amorphous silica nanoparticles was investigated in RAW 264.7 macrophages in view of their potential application as drug carriers to sites of inflammation. All silica nanoparticles-induced cell membrane damage, reduced metabolic activity, generated ROS and released various cytokines, but to differen...
Article
Silver nanoparticles are of interest to be used as antimicrobial agents in wound dressings and coatings in medical devices, but potential adverse effects have been reported in the literature. The most pronounced effect of silver nanoparticles and the role of particle size in determining these effects, also in comparison to silver ions, are largely...
Article
Full-text available
We investigated the potential of four well-characterized amorphous silica nanoparticles to induce chromosomal aberrations and gene mutations using two in vitro genotoxicity assays. Transmission electron microscopy (TEM) was used to verify the manufacturer's nominal size of 10, 30, 80 and 400 nm which showed actual sizes of 11, 34, 34 and 248 nm, re...
Article
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Nanotechnology applications already on the market or in development promise great benefits for humans as well as the environment. Simultaneously, the pressure to advance the development of fast methods for evaluating the potential risks of increased human exposure to nanomaterials is augmented. One way forward would be to enhance the role of in vit...
Article
While research into the potential toxic properties of nanomaterials is now increasing, the area of developmental toxicity has remained relatively uninvestigated. The embryonic stem cell test is an in vitro screening assay used to investigate the embryotoxic potential of chemicals by determining their ability to inhibit differentiation of embryonic...
Article
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RIVM is working on the development of a new system to decrease the chance of contamination of food with so-called mycotoxins, poisonous chemicals produced by fungi. These chemicals causing various disorders can end up in human food sources via different pathways. An example of a mycotoxin is aflatoxin b1, sometimes found in nuts. On long-term expos...
Article
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This report provides guidance to the use of ConsExpo 4.0, successor to ConsExpo 3.0, a computer program that was developed to assist in the exposure assessment of compounds in non-food consumer products. The wide range of available consumer products is associated with an even wider variation in consumers and product use. Measured data on exposure t...
Article
Development of an estrogen receptor-mediated, chemical-activated luciferase reporter gene-expression (ER-CALUX) assay was attempted by stable transfection of luciferase reporter genes in a number of cell lines. Stable transfection of the chimeric Gal4 estrogen receptor and luciferase gene constructs in MCF-7 breast cancer and Hepa.1c1c7 mouse hepat...
Article
Full-text available
Exposure to compounds in consumer products can be assessed using the computer program ConsExpo (Consumer Exposure). Given the huge number of consumer products, it is not possible to calculate the exposure for each separate product, so a limited number of groups containing similar products are defined. The information for each group of products is d...
Article
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Little is known about the possible risks when consumers are exposed to fragrances. Fragrances are added to many consumer products, from detergents to toys. Passive room perfumes and spray perfumes represent two groups of products that are popular in use and may lead to high and long-lasting exposures for consumers. The degree of exposure can be est...
Article
Full-text available
ConsExpo is a suitable computer software programme with mathematical models for assessing the exposure of consumers to chemicals in consumer products. This tool can be further improved by adopting certain features from other existing consumer exposure modelling tools. In ConsExpo, different routes of exposure are taken into account, such as the rou...
Article
Full-text available
Inhalation of the fragrance chemicals, isoeugenol and cinnamal, by mice resulted in immune reactions in the respiratory tract. This was observed in experiments performed by the RIVM (National Institute for Public Health and the Enviroment) of which results indicate that inhalation of some fragrance chemicals could induce unwanted effects on the imm...

Projects

Projects (2)
Project
Screening the toxicity of microplastics on immune cells to gain indications for potential hazards to humans, and with this, to contribute to our understanding of the extent of the plastic problem on humans. https://www.zonmw.nl/nl/onderzoek-resultaten/life-sciences-health/programmas/project-detail/microplastics-health/fishh-first-immunotox-screening-of-microplastics-on-human-health/