Margherita A.G. Matarrese- PhD Biomedical Engineering
- Adjunct Professor at Campus Bio-Medico University
Margherita A.G. Matarrese
- PhD Biomedical Engineering
- Adjunct Professor at Campus Bio-Medico University
About
20
Publications
1,750
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Introduction
I am a biomedical engineer who aims to apply engineering methods translationally to clinical practice. My goal is identifying robust biomarkers to delineate the epileptogenic zone in pediatric patients with drug refractory epilepsy. I am currently working on electromagnetic source imaging and in-silico modeling of epilepsy, using multimodal image fusion, signal and image processing techniques and in-house developed solutions.
Current institution
Additional affiliations
October 2021 - present
March 2020 - present
Education
November 2017 - February 2020
October 2014 - October 2017
Publications
Publications (20)
High frequency oscillations have been extensively investigated as interictal biomarkers of epilepsy. Yet, their value is largely debated due to the presence of physiological oscillations, which complicate distinguishing between normal versus abnormal events. So far, this debate has been addressed using intracranial EEG data from patients with drug-...
Artificial intelligence is increasingly showing potential in assisting physicians with disease diagnosis due to its improved predicting performance. In addition to achieving high performance, these systems must also be efficient and explainable. In this study, we propose a novel Feature Distillation method to transfer knowledge and explainability b...
Spikes are the most established interictal epilepsy biomarkers. Yet, they suffer from low specificity since they are partially concordant with the epileptogenic zone and often found in non-epileptogenic areas. High frequency oscillations, classified as ripples and fast ripples, are considered more specific biomarkers compared to spikes. Ripples occ...
Living systems rely on coordinated molecular interactions, especially those related to gene expression and protein activity. The Unfolded Protein Response is a crucial mechanism in eukaryotic cells, activated when unfolded proteins exceed a critical threshold. It maintains cell homeostasis by enhancing protein folding, initiating quality control, a...
Objective
Interictal biomarkers are critical for identifying the epileptogenic focus. However, spikes and ripples lack specificity while fast ripples lack sensitivity. These biomarkers propagate from more epileptogenic onset to areas of spread. The pathophysiological mechanism of these propagations is elusive. Here, we examine zones where spikes an...
This manuscript presents a parallel among important EU legal frameworks, such as the Medical Device Regulations and General Data Protection Regulation and economic-historical challenges faced by European citizens. This parallel offers a prospective for understanding the direction taken by policymakers for forthcoming regulations, such as the Europe...
Neurosurgical intervention is the best available treatment for selected patients with drug resistant epilepsy. For these patients, surgical planning requires biomarkers that delineate the epileptogenic zone, the brain area that is indispensable for the generation of seizures. Interictal spikes recorded with electrophysiological techniques are consi...
The Unfolded Protein Response is the cell mechanism for maintaining the balance of properly folded proteins in the endoplasmic reticulum , the specialized cellular compartment. Although it is largely studied from a biological point of view, much of the literature lacks a quantitative analysis of such a central signaling pathway. In this work, we ai...
The study of RNA structure is fundamental to clarify the RNA molecular functioning. The flexible RNA nature, the huge number of expressed RNAs, and the variety of functions make it challenging to obtain a quantity of structural information comparable to what is already available for proteins. The in silico prediction of RNA 3D structures is of part...
Objective
Delineation of the seizure onset zone (SOZ) is required in children with drug resistant epilepsy (DRE) undergoing neurosurgery. Intracranial EEG (icEEG) serves as gold standard but has limitations. Here, we examine the utility of virtual implantation with electrical source imaging (ESI) on ictal scalp EEG for mapping the SOZ and predict s...
Interictal epileptiform discharges (IEDs) serve as sensitive but not specific biomarkers of epilepsy that can delineate the epileptogenic zone (EZ) in patients with drug resistant epilepsy (DRE) undergoing surgery. Intracranial EEG (icEEG) studies have shown that IEDs propagate in time across large ar-
eas of the brain. The onset of this propagatio...
Studies on intracranial electroencephalography (icEEG) recordings of patients with drug resistant epilepsy (DRE) show that epilepsy biomarkers propagate in time across brain areas. Here, we propose a novel method that estimates critical features of these propagations for different epilepsy biomarkers (spikes, ripples, and fast ripples), and assess...
Objective
Intracranial electroencephalographic (icEEG) studies show that interictal ripples propagate across the brain of children with medically refractory epilepsy (MRE), and the onset of this propagation (ripple onset zone [ROZ]) estimates the epileptogenic zone. It is still unknown whether we can map this propagation noninvasively. The goal of...
