Margarita Jimenez-Palomares

Universidad de Cádiz | UCA · Department of Biomedicine, Biotechnology and Public Health

Aging continues to be the main cause of the development of Alzheimer’s, although it has been described that certain chronic inflammatory pathologies can negatively influence the progress of dementia, including obesity and hyperlipidemia. In this sense, previous studies have shown a relationship between low-density lipoprotein receptor (LDLR) and th...

Critical limb ischemia (CLI), the most severe form of peripheral artery disease, results from the blockade of peripheral vessels, usually correlated to atherosclerosis. Currently, endovas-cular and surgical revascularization strategies cannot be applied to all patients due to related comor-bidities, and even so, most patients require re-interventio...

Organoids have arisen as promising model systems in biomedical research and regenerative medicine due to their potential to reproduce the original tissue architecture and function. In the research field of cell–cell interactions, organoids mimic interactions taking place during organogenesis, including the processes that conduct to multi-lineage di...

Background: Bone Marrow Mononuclear Cells (BM-MNC) constitute a promising alternative for the treatment of Chronic Limb-Threatening ischemia (CLTI), a disease characterized by extensive blockade of peripheral arteries, clinically presenting as excruciating pain at rest and ischemic ulcers which may lead to gangrene and amputation. BM-MNC implantati...

In atherosclerosis, circulating angiogenic cells (CAC), also known as early endothelial progenitor cells (eEPC), are thought to participate mainly in a paracrine fashion by promoting the recruitment of other cell populations such as late EPC, or endothelial colony-forming cells (ECFC), to the injured areas. There, ECFC replace the damaged endotheli...

Atherosclerosis remains the leading cause of ischemic syndromes such as myocardial infarction or brain stroke, mainly promoted by plaque rupture and subsequent arterial blockade. Identification of vulnerable or high-risk plaques constitutes a major challenge, being necessary to identify patients at risk of occlusive events in order to provide them...

Background: Critical limb ischemia (CLI) constitutes the most aggressive form of peripheral arterial occlusive disease, characterized by the blockade of arteries supplying blood to the lower extremities, significantly diminishing oxygen and nutrient supply. CLI patients usually undergo amputation of fingers, feet, or extremities, with a high risk...

Deregulation of mTOR complex 1 (mTORC1) signalling increases the risk for metabolic diseases, including type 2 diabetes. Here we show that beta-cell-specific loss of mTORC1 causes diabetes and beta-cell failure due to defects in proliferation, autophagy, apoptosis and insulin secretion by using mice with conditional (betaraKO) and inducible (MIP-be...

The mammalian target of rapamycin complex 1 (mTORC1) regulates several biological processes, although the key downstream mechanisms responsible for these effects are poorly defined. Using mice with deletion of eukaryotic translation initiation factor 4E-binding protein 2 (4E-BP2), we determine that this downstream target is a major regulator of glu...

Aging remains the main risk factor to suffer Alzheimer's disease (AD), though epidemiological studies also support that type 2 diabetes (T2D) is a major contributor. In order to explore the close relationship between both pathologies we have developed an animal model presenting both AD and T2D, by crossing APP/PS1 mice (AD model) with db/db mice (T...

Activation of pancreatic beta-cell proliferation has been proposed as an approach to replace reduced functional beta-cell mass in diabetes. Quiescent fibroblasts exit from G0 (quiescence) to G1 through pRb phosphorylation mediated by cyclin C/cdk3 complexes. Overexpression of cyclin D1, D2, D3 or cyclin E induces pancreatic beta-cell proliferation....

Type 2 diabetes (T2D) is an important risk factor to suffer dementia, including Alzheimer's disease (AD), and some neuropathological features observed in dementia could be mediated by T2D metabolic alterations. Since brain atrophy and impaired neurogenesis have been observed both T2D and AD we analyzed central nervous system (CNS) morphological alt...

Alzheimer’s disease (AD) and vascular dementia (VaD) are the most common causes of dementia, and have no successful treatment. On the other hand, type 2 diabetes (T2D) seems to be a relevant risk factor to suffer dementia and epidemiological studies support a close relationship between T2D and AD-VaD, leading to the description of a complex syndrom...

[This corrects the article on p. e52862 in vol. 8.].

There is an urgency to find new treatments for the devastating epidemic of diabetes. Pancreatic β-cells viability and function are impaired in the two most common forms of diabetes, type 1 and type 2. Regeneration of pancreatic β-cells has been proposed as a potential therapy for diabetes. In a preliminary study, we screened a collection of marine...

Alzheimer’s disease (AD) and vascular dementia (VD) are the most common causes of dementia although the ultimate neurotoxic mechanisms have not been completely elucidated. Previous clinical and epidemiological studies suggest that insulin resistance and type 2 diabetes mellitus (T2D) are relevant risks factors to suffer both AD and VD. On the other...

Whereas Alzheimer’s disease (AD) is the most common cause of dementia the ultimate neurotoxic mechanisms are not known. Epidemiological studies reveal that type 2 diabetes mellitus (T2D) is a risk factor to suffer AD, although establishing whether there is a direct relationship between T2DM and AD remains elusive. In this study we have focused on e...

Alzheimer’s disease (AD) and vascular dementia (VD) are the most common causes of dementia although the ultimate neurotoxic mechanisms have not been completely elucidated. Multiple epidemiological studies reveal that type 2 diabetes mellitus (T2D) is a risk factor to suffer AD and VD. However to our knowledge only a handful of studies have intended...

Type 2 diabetes (T2D) mellitus and Alzheimer's disease (AD) are two prevalent diseases with comparable pathophysiological features and genetic predisposition. Patients with AD are more susceptible to develop T2D. However, the molecular mechanism linking AD and T2D remains elusive. In this study, we have generated a new mouse model to test the hypot...

Type 2 Diabetes Mellitus (DM2) is a well known risk factor of the Alzheimer disease. Alzheimer is the most common cause of dementia among elderly people, At present many clinical studies have shown a relationship between both illnesses, however it remains unclear whether there is a cause-effect association between both of them and how diabetes migh...

Alzheimer’s disease and vascular dementia are the two most common causes of dementia. The ultimate cause has not been elucidated; however type 2 Diabetes Mellitus (DM2) may play a role in the onset and development of the illness. Following this idea recent clinical studies strongly relate DM2 with dementia, although the underlying mechanisms remain...

Diabetes is a well known risk factor for dementia and Alzheimer’s disease. At present many clinical studies have shown a relationship between both illnesses, however it remains unclear whether there is a cause-effect association between both of them and how diabetes might be implicated in the onset and development of Alzheimer’s disease. This study...

Apolipoprotein D (ApoD) is an atypical apolipoprotein with an incompletely understood function in the regulation of triglyceride and glucose metabolism. We have demonstrated that elevated ApoD production in mice results in improved postprandial triglyceride clearance. This work studies the role of ApoD deficiency in the regulation of triglyceride a...