Margarita A. Goldberg

• PhD
• Senior Researcher at A. A. Baikov Institute of Metallurgy and Materials Science of Russian Academy of Sciences (IMET)

Calcium phosphate cements are of great interest for researchers and their applications in medical practice expanded. Nevertheless, they have a number of drawbacks including the insufficient level of mechanical properties and low degradation rate. Struvite (MgNH4PO4) -based cements, which grew in popularity in recent years, despite their neutral pH...

Mesoporous hydroxyapatite (HA) and iron(III)-doped HA (Fe-HA) are attractive materials for biomedical, catalytic, and environmental applications. In the present study, the nanopowders of HA and Fe-HA with a specific surface area up to 194.5 m2/g were synthesized by a simple precipitation route using iron oxalate as a source of Fe3+ cations. The inf...

Space exploration is perhaps one of the most difficult tasks ever undertaken since the emergence of humankind. The International Space Station is a unique platform for advanced technology research that is not possible anywhere else. Tissue engineering in outer space, where state of the gravity can be 'turned off' or 'turned on' in the case of appli...

Zirconia-toughened alumina (ZTA) powders with 20.0 wt.% of ZrO2 were synthesized using the coprecipitation method. Transmission electron microscopy indicated that the powders contained needle-like particles 15–30 nm long and 50–70 nm flake-like particles with a uniform component distribution. Effects of different Y2O3 concentrations (3.0, 4.0, or 5...

The creation of injectable bone cements (BC) remains a pressing issue in modern biomaterial science due to the prospects for their use in minimally invasive surgical interventions in onco-orthopedics for replacing bone defects in patients that occur after removal of primary or metastatic spinal tumors.

Mesoporous hydroxyapatite (HA) is widely used in various applications, such as the biomedical field, as a catalytic, as a sensor, and many others. The aim of this work was to obtain HA powders by means of chemical precipitation in a medium containing a polymer—polyvinyl alcohol or polyvinylpyrrolidone (PVP)—with concentrations ranging from 0 to 10%...

Calcium sulfate powder materials containing terbium ions at 0, 1.0, or 2.0 mol.% were obtained. They are characterized by the presence of a CaSO4 × 0.5H2O phase, while Tb3+ is incorporated into the lattice at ≤1.0 mol.%. Specific surface area enlarged from 2.1 to 22.5 m2/g as crystallite size decreased from 68 to 31 nm. Thermal analysis showed that...

Hydroxyapatite (HA) remains one of the most popular materials for various biomedical applications and its fields of application have been expanding. Lithium (Li⁺) is a promising candidate for modifying the biological behavior of HA. Li⁺ is present in trace amounts in the human body as an alkaline and bioelectric material. At the same time, the intr...

Calcium sulfate (CS) materials containing terbium ions at 0, 1.0, or 2.0 mol.% were obtained by mechanochemical synthesis. According to X-ray diffraction data, the powder materials are characterized by the presence of a CaSO4×0.5H2O phase, while Tb3+ is incorporated into the lattice at ≤1.0 mol.%. Specific surface area enlarged from 2.1 to 22.5 m2/...

The development of magnesium calcium phosphate bone cements (MCPCs) has garnered substantial attention. MCPCs are bioactive and biodegradable and have appropriate mechanical and antimicrobial properties for use in reconstructive surgery. In this study, the cement powders based on a (Ca + Mg)/P = 2 system doped with Zn2+ at 0.5 and 1.0 wt.% were obt...

The development of magnesium calcium phosphate bone cements (MCPCs) have garnered big attention. MCPCs are bioactive and biodegradable and have appropriate mechanical and antimicrobial properties for use in reconstructive surgery. In this study, the cement powders based on a (Ca + Mg)/P = 2 system doped with Zn2+ at 0.5 and 1.0 wt.% were obtained a...

Space exploration is perhaps one of the most difficult tasks ever undertaken since the existence of mankind. International Space Station (ISS) is a unique instrument for advanced technology research that is not possible anywhere else. Tissue engineering in a space environment where “turnoff” gravity can be done is the most emerging field with high-...

Powders based on β-tricalcium phosphate (β-TCP) containing sulphate groups at up to 12.0 mol.% were synthesised by chemical precipitation from aqueous solutions. The obtained materials were characterised by X-ray phase analysis, Fourier transform infrared spectroscopy, measurement of specific surface area, scanning electron microscopy, energy dispe...

Mesoporous hydroxyapatite (HA) materials demonstrate advantages as catalysts and as support systems for catalysis, as adsorbent materials for removing contamination from soil and water, and as nanocarriers of functional agents for bone-related therapies. The present research demonstrates the possibility of the enlargement of the Brunauer–Emmett–Tel...

In this work, the effect of a complex additives based on Na2Si2O5 and Mn2+ on the properties and sintering temperature of ZrO2 ceramic material stabilized with 3 mol. % Y2O3 — 2.5 wt. % Al2O3 (Z–A) was studied. It has been found that the introduction of complex additives increases the strength in three-point bending and the microhardness of ceramic...

Hydroxyapatite (HA) with a stoichiometry composition of Ca10(PO4)6(OH)2 is widely applied for various biomedical issues, first of all for bone defect substitution, as a catalyst, and as an adsorbent for soil and water purification. The incorporation of foreign ions changes the acid–base relation, microstructure, porosity, and other properties of th...

The paper demonstrated the increase of the surface area and meso- and microporosity volume with the low concentration Mg-substitution introduction during the hydroxyapatite (HA) wet method synthesis, as well as samples phase and structure evolution during the heat treatment up to 1200 °C. The incorporation of 0.1 and 1.0 mol.% Mg²⁺ were studied by...

Cement materials based on calcium sulfate into which up to 20 mol % of phosphate groups were introduced were obtained in order to improve their cytocompatibility and solubility. It was found that, during exposure of cement materials on the basis of calcium sulfate containing 0, 5, 10, and 20 mol% phosphate groups in model Kokubo solution (simulated...

In the recent years, a magnesium-calcium phosphate materials are considered as an alternative to materials based on the calcium phosphates in the reconstructive surgery. The injectable bone cements have been particular interest for the minimally invasive surgical approaches. The aim of this work is considered to the creating and studying of the str...

In this work, we studied the effect of complex additives containing Na2Si2O5 and Ni, Zn oxides on the properties and sintering temperature of a ceramic material 3Y-TZP- Al2O3 with an aluminum oxide (Al2O3) content of 5 wt %. It was shown that the introduction of complex additives promoted an increase in the flexural strength of ceramic materials. T...

The article presents the results of 3D printing with ceramic suspensions by DLP method using inorganic dyes.

Substituted calcium phosphates (CaPs) are vital materials for the treatment of bone diseases and repairing and replacement of defects in human hard tissues. In this paper, we present some applications of the rarely used pulsed electron paramagnetic resonance (EPR) and hyperfine interaction spectroscopy approaches [namely, electron spin-echo envelop...

For bone replacement materials, osteoconductive, osteoinductive, and osteogenic properties are desired. The bacterial resistance and the need for new antibacterial strategies stand among the most challenging tasks of the modern medicine. In this work, brushite cements based on powders of Zinc (Zn) (1.4 wt%) substituted tricalcium phosphate (β-TCP)...

This article presents the results of a study of radiation-induced defects in various synthetic calcium phosphate (CP) powder materials (hydroxyapatite—HA and octacalcium phosphate—OCP) by electron paramagnetic resonance (EPR) spectroscopy at the X, Q, and W-bands (9, 34, 95 GHz for the microwave frequencies, respectively). Currently, CP materials a...

The effect of complex additives based on cobalt, iron, and manganese oxides and sodium silicate on the phase composition, microstructure, mechanical properties, and sintering of tetragonal zirconia ceramics stabilized with 3 mol % yttria and containing 10 wt % alumina (3Y–TZP–10Al2O3) was studied. The introduction of complex additives significantly...

Data obtained by the authors upon creating composite materials based on biopolymers and calcium phosphates adapted to the prototyping technology are presented. Results concerning the creation and investigation of the properties of three-dimensional structures for the replacement of bone defects, as well as novel studies of the functionalization of...

An overview of the results in the field of creating bone cements based on calcium and magnesium phosphates with antimicrobial properties intended to replace bone tissue defects is presented. It was noted that the modification of cements based on calcium phosphates with magnesium made it possible to provide high strength, optimal setting time, absen...

Cement materials have based on calcium sulfate were obtained, which have introduced up to 20 mol. % of phosphate groups to improve their cytocompatibility and solubility. It was found that during exposure of cement materials based on calcium sulfate, containing of 0, 5, 10 and 20 mol. % phosphate - groups, in model solutions SBF (Kokubo solution, s...

Using atomic-emission analysis with inductively coupled plasma (AES – ICP) and atomic absorption spectroscopy (AAS) were developed methods, which allow rapidly, with good metrological characteristics without prior separation of the matrix and without the use of standard composition samples to determine impurity elements (Ag, Cu, Fe, Zn) of concentr...

The main highlights in this paper are about investigation of cation-dopped cements based on the calcium phosphate —magnesium phosphate system with a ratio of (Ca + Mg) / P = 2 containing 40 mol. % Mg for application in the reconstructive surgery. The powders were synthesized by the method of deposition from a salt solution, the powders were certifi...

Composite cements based on the tricalcium phosphate (TCP) —calcium sulfate (CS) system were synthesized and investigated. The second component which were introduced into the cement paste (TCP) in the form of modified carbonate anion granules is the calcium sulfate. As a result, new composite cement materials based on the tricalcium phosphate —carbo...

We studied the effect of complex additives containing Na2Si2O5and Co, Fe oxides on the properties and sintering temperature of a ceramic material zirconium dioxide (ZrO2) with an aluminum oxide (Al2O3) content of 10 wt %. It was shown that the introduction of complex additives contributed to the intensification process and a significant increase in...

Radiation-induced impurity nitrogen centers in nanosized powders of synthetic hydroxyapatite are studied by pulse EPR and pulse double-frequency EPR (NMR detected by electron-electron double resonance - ELDOR detected NMR, EDNMR) method. The EPR signals caused by the interaction of the electron of with the environmental nuclei (1H, 14N, and 31P) ar...

Calcium sulfate-based powders with contents of phosphate groups of 5, 10, and 20 mol % were synthesized by chemical precipitation from aqueous solutions. The products were studied by powder X-ray dif-fraction and IR spectroscopy. The synthesized powders were used to prepare cement pastes with distilled water as a cement fluid. The phase composition...

The effect of the introduction of Co2+ to ZrO2–10 wt % Al2O3 ceramic materials on their phase composition, porosity, microstructure, strength, microhardness, cytotoxicity, and cytocompatibility was studied. It was shown that the addition of Co2+ stabilizes the tetragonal form of ZrO2, which is the only form in sintering at 1400°С. An increase in th...

Исследованы радиационно-наведенные примесные азотные центры NO32- в наноразмерных порошках синтетического гидроксиапатита (ГА) методами импульсного электронного парамагнитного резонанса (ЭПР) и импульсного двухчастотного ЭПР – ядерного магнитного резонанса (ЯМР), детектируемого по двойному электрон-электронному резонансу (ДДЯМР). Идентифицированы с...

Nanocrystalline 3 mol% yttria-tetragonal zirconia polycrystal (3Y-TZP) ceramic powder containing 5 wt.% Al2O3 with 64 m2/g specific area was synthesized through precipitation method. Different amounts of Co (0–3 mol%) were introduced into synthesized powders, and ceramic materials were obtained by heat treatment in the air for 2 h at 1350–1550 °C....

We have synthesized powders and produced ceramic materials in the tricalcium phosphate–trimagnesium phosphate system with a degree of Mg2+ substitution for Ca2+ up to 40 wt %. It has been shown that increasing the percentage of magnesium in the materials reduces their sintering temperature from 1300 to 1100°C. We have determined the phase compositi...

We have prepared powders and ceramic composite materials in the ZrO2–Al2O3 system containing 10 and 20 wt % Al2O3 and examined the effect of ferric oxide additions on the linear shrinkage, phase composition, porosity, microstructure, and mechanical properties of the ZrO2–Al2O3 ceramic materials. The results demonstrate that the addition of ferric o...

The new bone cements were obtained in the calcium phosphate – magnesium phosphate system. The cement powders were synthesized by precipitation method and calcium-magnesium phosphates and magnesium oxide were obtained. The cement liquids based on Na 2 HPO 4 and NaH 2 PO 4 characterized by pH 3.5-5.5 were used and cements phase composition, microstru...

This work is focused on the development of «Magnesium (Mg) – Hydroxyapatite (HA)” composite for bioresorbable implant obtained by spark plasma sintering method (SPS). The structural-phase state of the samples was studied using the X-ray phase analysis method and scanning microscopy (SEM). It is essential to understand the mechanical behaviour of th...

The paper presents the results of the investigation of the transition metals oxides – cobalt and iron additives influence on the sintering and properties of the ceramic material based on ZrO 2 - Al 2 O 3 system with 10 wt.% Al 2 O 3 . It is shown that the addition of the oxides resulted in the significant increase of the sintered ceramic materials...

Calcium sulphate-based materials were synthesized and investigated, in which Ca2+ cations were substituted for Na+ or K+ cations in an amount of 5, 10 and 20 mol.%. With the introduction of Na+, materials with the structure semi-aqueous and two-water calcium sulfate were obtained, with the introduction of potassium, a mixture of calcium sulfates wi...

Materials based on calcium sulfate in which Na⁺ or K⁺ cations were substituted to a concentration of 5, 10, or 20 mol % for Ca²⁺ cations were synthesized and studied. The introduction of Na⁺ produced materials with the structure of calcium sulfate hemihydrate and dihydrate, and the incorporation of potassium yielded a mixture of calcium sulfates wi...

Al-substituted hydroxyapatite (Al-HA) powders with apatite structure and particle size of 30-70 nm were obtained via precipitation method. The effect of Al content on specific surface area and morphology of powders was studied, and a formation of highly anisotropic phase due to Al doping was observed. The influence of heat treatment in 300-1400 • C...

Nanopowders of aluminum substituted (0 – 20 mol.%) hydroxyapatite (HA) with the average size of 40-60 nm were synthesized by the precipitation method from the nitrate solutions. The series of the samples was studied by various analytical tools to elucidate the peculiarities of Al introduction. Electron paramagnetic resonance and pulsed electron-nuc...

The dependences of the formation of the microstructure and the phase composition of ceramics based on partially stabilized zirconium dioxide on the sintering temperature and the content of the sintering additive are established. It is shown that the introduction of an additive, which forms a low-temperature melt based on sodium silicate - Na2SiO3,...

Dependences of the formation of the microstructure and phase composition of partially stabilized zirconia ceramics on the sintering temperature and the content of the sintering additive have been studied. It has been shown that introduction of an additive forming a low-temperature melt based on sodium silicate Na2SiO3 reduces the sintering temperat...

Nanocrystalline triple-doped ceria based solid electrolyte materials (CuxMn0.1-xZr0.1Ce0.8O2, where x = 0, 0.02, 0.04, 0.06, 0.08 and 0.1, as well as Cu0.08Mn0.02ZryCe0.9-yO2, where y = 0 and 0.1) for intermediate temperature solid oxide fuel cells were successfully synthesized by co-precipitation method with sonication and sintered at 1150 °C for...

Nano- and micro-dimensional surface layers of titanium on flat and wire NiTi substrates were obtained. The structure and composition of the samples was determined using SEM, AES, Auger spectroscopy and X-ray diffraction. With increasing deposition time, the thickness of the surface layer increases nonlinearly. The transition layer provides high adh...

The results of investigation of sintering, microstructure and phase composition of the system ZrO2-Al2O3-SiO2 with MnO admixture are shown. It was approved that the usage of MnO admixture promoted sintering temperature decrease up to 1250-1350 °C. The product obtained is characterized by a high content of tetragonal phase as well as high strength w...

The sintering, microstructure, and phase composition of the eutectic ceramics of the ZrO2–Al2O3–SiO2 system with an MnO additive have been studied. It has been shown that the additive contributes to the decrease in the sintering temperature to 1250–1350°С. The synthesized materials have a high content of the tetragonal phase, a fine crystalline str...

New materials based on calcium sulphate with the replacement of calcium cations to magnesium cations – 10, 20 and 40 mol.% were obtained. The synthesis of substituted forms of calcium sulphate, the study of the phase composition, and the strength of the obtained materials were carried out in the work. It is shown that the solubility of the synthesi...

The study of sintering, microstructure and phase composition of zirconia ceramics containing the additive - sodium niobate. It is shown that the use of an additive helps to reduce the sintering temperature to 1,400 ° C. The obtained materials are characterized by a high content of the tetragonal phase, a fine-crystalline structure and high strength...

The sintering, microstructure, and phase composition of zirconia ceramics containing a sodium niobate addition have been studied. It has been shown that the addition leads to a decrease in the sintering temperature to 1400°С. The resulting materials are characterized by a high content of the tetragonal phase, a fine-crystalline structure, and a hig...

Calcium sulfate-based powders with magnesium substituting for calcium cations in amounts of 10, 20, and 40 mol % were synthesized by the mechanochemical method. The phase composition of the products, the solubility, and the compressive strength of the obtained cement materials mixed with water were studied. It was shown that the solubility in the p...

Composite materials based on α-tricalcium phosphate and reinforced with calcium sulfate dihydrate (gypsum) granules were studied. In these materials, pores can form in vivo in the medium of the human body because of selective gypsum dissolution. Such materials can be promising for cell technologies of bone tissue regeneration. Such characteristics...

Based on tricalcium phosphate, new high-strength composite materials were synthesized, in which the strengthening phase was ZrO2. To reduce the sintering temperature and obtain a fine crystalline structure, a special additive based on sodium silicate was developed, which favored the formation of low-temperature melts. It was studied how the ratio b...

Electromechanical treatment (EMT) is a technology with great potential for post-processing of plasma sprayed coatings. In recent years it has been reported that the EMT can improve structure, mechanical and tribological properties of the coatings. In past studies the effect of process speed and current density during the EMT on the properties of th...

The review of results obtained by the authors in the design of bioresorbable calcium phosphate ceramic materials intended for bond tissue defect regeneration is presented. The development of composite materials and new data in the fabrication of octacalcium phosphate bioresorbable ceramic are elucidated as well.

It was studied how gamma irradiation affects the formation of the phase composition and the properties of ZrO2-based ceramics containing various contents of Y2O3, which stabilizes the tetragonal ZrO2 phase. Gamma irradiation favored sintering and a decrease in the content of the monoclinic ZrO2 modification. At a sintering temperature of 1250°C, Zr...

The influence of lithium substitution for calcium over a broad concentration range (0–20 mol %) on the crystal lattice parameters, coherent scattering regions, and phase composition was studied for hydroxyapatite synthesized by precipitation from solutions and heat treatment at 900, 1200, and 1400°C. The lithium substitution in a more than 10 mol %...

Powders of synthetic hydroxyapatite doped with aluminium (Al) ions in concentrations 0 and 20 mol. % were synthesized by the precipitation method from the nitrate solutions and investigated by atomic emission spectrometry with inductively coupled plasma (AES-ICP), X-ray diffraction (XRD), scanning electron microscopy (SEM), gas absorption and conve...

New magnesium-substituted bone cements containing MgO as a separate phase have been developed and demonstrated enhanced mechanical properties and cytological compatibility.