Margarethus M Paulides

Margarethus M Paulides
Eindhoven University of Technology | TUE · Department of Electrical Engineering

PhD
Building the www.tue.nl/EM4C&C research lab

About

143
Publications
29,729
Reads
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3,170
Citations
Citations since 2017
63 Research Items
2190 Citations
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Introduction
My ambition is to improve the efficacy and sustainability of healthcare through electromagnetic technologies. Specifically, I develop novel electromagnetic treatment and MR imaging technology for application in oncology and neurostimulation. Experimental, pre-clinical and clincal validation of these technologies is a key aim. This work has resulted e.g. in novels applicators, simulation-controlled hyperthermia technology and pioneering data for improving EMF exposure guidelines.
Additional affiliations
July 2021 - December 2021
Eindhoven University of Technology
Position
  • Professor (Full)
Description
  • Professor of Biomedical Electromagnetics and Chair of the Electromagnetics for Care & Cure research lab (www.tue.nl/EM4C&C). Focus topics: MR guided thermotherapy, Phased array microwave hyperthermia, Translational clinical studies. Side topics: EM neuronal and muscle stimulation, MRI coil design, In/on body communication, MR guided therapies (RT, FUS). Also Scientific Director of the Center for Care & Cure Technology Eindhoven (www.tue.nl/C3Te)
November 2019 - present
Erasmus MC
Position
  • Professor (Associate)
Description
  • Continuing the research on MRI-Guided Thermotherapy/Hyperthermia and leading/supporting clinical evaluations on head and neck hyperthermia
September 2018 - June 2021
Eindhoven University of Technology
Position
  • Professor (Associate)
Description
  • Biomedical Electromagnetics and Scientific Director of the EM4C&C research lab focus: MR guided thermal therapy, Head and neck hyperthermia, EM neuronal and muscle stimulation.
Education
February 2003 - October 2007
Erasmus University Rotterdam
Field of study
  • Health and Medical Physics
September 1997 - October 2002
Eindhoven University of Technology
Field of study
  • Electrical Engineering

Publications

Publications (143)
Article
Full-text available
Purpose: In current clinical practice, head and neck (H&N) hyperthermia treatment planning (HTP) is solely based on computed tomography (CT) images. Magnetic resonance imaging (MRI) provides superior soft-tissue contrast over CT. The purpose of the authors' study is to investigate the relevance of using MRI in addition to CT for patient modeling i...
Article
Full-text available
Magnetic resonance thermometry (MRT) offers non-invasive temperature imaging and can greatly contribute to the effectiveness of head and neck hyperthermia. We therefore wish to redesign the HYPERcollar head and neck hyperthermia applicator for simultaneous radio frequency (RF) heating and magnetic resonance thermometry. In this work we tested the f...
Article
Full-text available
Clinical studies have established a strong benefit from adjuvant mild hyperthermia (HT) to radio- and chemotherapy for many tumor sites, including the head and neck (H&N). The recently developed HYPERcollar allows the application of local radiofrequency HT to tumors in the entire H&N. Treatment quality is optimized using electromagnetic and thermal...
Article
Full-text available
Abstract Clinical trials have shown that hyperthermia (HT), i.e. an increase of tissue temperature to 39-44 °C, significantly enhance radiotherapy and chemotherapy effectiveness [1]. Driven by the developments in computational techniques and computing power, personalised hyperthermia treatment planning (HTP) has matured and has become a powerful to...
Article
Full-text available
Purpose: Hyperthermia treatments are successful adjuvants to conventional cancer therapies in which the tumor is sensitized by heating. To monitor and guide the hyperthermia treatment, measuring the tumor and healthy tissue temperature is important. The typical clinical practice heavily relies on intraluminal probe measurements that are uncomforta...
Article
Purpose We studied the differences between planning and treatment position, their impact on the accuracy of hyperthermia treatment planning (HTP) predictions, and the relevance of including true treatment anatomy and position in HTP based on magnetic resonance (MR) images. Materials and methods All volunteers were scanned with an MR-compatible hyp...
Article
Full-text available
Purpose Hyperthermia is a cancer treatment in which the target region is heated to temperatures of 40–44 °C usually applying external electromagnetic field sources. The behavior of the hyperthermia applicators (antennas) in clinical practice should be periodically checked with phantom experiments to verify the applicator’s performance over time. Th...
Article
Full-text available
Background: During resonance frequency (RF) hyperthermia treatment, the temperature of the tumor tissue is elevated to the range of 39-44°C. Accurate temperature monitoring is essential to guide treatments and ensure precise heat delivery and treatment quality. Magnetic resonance (MR) thermometry is currently the only clinical method to measure te...
Chapter
Hyperthermia therapy involves mild heating (40–44°C) that has been shown to be a potent enhancer of radiation and chemotherapy. Microwave (MW) and radiofrequency (RF) hyperthermia devices provide a variety of heating approaches that can treat most cancers regardless of their size and depth. This review introduces the physics of MW/RF hyperthermia,...
Article
Full-text available
(1) Background: Head and neck cancer (HNC) patients with recurrent or second primary (SP) tumors in previously irradiated areas represent a clinical challenge. Definitive or postoperative reirradiation with or without sensitizing therapy, like chemotherapy, should be considered. As an alternative to chemotherapy, hyperthermia has shown to be a pote...
Article
Full-text available
During hyperthermia cancer treatments, especially in semi-deep hyperthermia in the head and neck (H&N) region, the induced temperature pattern is the result of a complex interplay between energy delivery and tissue cooling. The purpose of this study was to establish a water bolus temperature guide for the HYPERcollar3D H&N applicator. First, we mea...
Article
Objective: Computational modeling is increasingly used to design charging systems for implanted medical devices. The design of these systems must often satisfy conflicting requirements, such as charging speed, specific absorption rate (SAR) and coil size. Fast electromagnetic solvers are pivotal for enabling multi-criteria optimization. In this pa...
Article
Full-text available
Clinical effectiveness of hyperthermia treatments, in which tumor tissue is artificially heated to 40–44 °C for 60–90 min, can be hampered by a lack of accurate temperature monitoring. The need for noninvasive temperature monitoring in the head and neck region (H&N) and the potential of MR thermometry prompt us to design an MR compatible hypertherm...
Article
Full-text available
Background: The success of cancer hyperthermia (HT) treatments is strongly dependent on the temperatures achieved in the tumor and healthy tissues as it correlates with treatment efficacy and safety, respectively. Hyperthermia treatment planning (HTP) simulations have become pivotal for treatment optimization due to the possibility for pretreatment...
Article
Full-text available
The efficacy of a hyperthermia treatment depends on the delivery of well-controlled heating; hence, accurate temperature monitoring is essential for ensuring effective treatment. For deep pelvic hyperthermia, there are no comprehensive and systematic reports on MR thermometry. Moreover, data inclusion generally lacks objective selection criteria le...
Article
Full-text available
Purpose To develop a head and neck hyperthermia phased array system compatible with a 1.5 T magnetic resonance (MR) scanner for noninvasive thermometry. Methods We designed a dielectric-parabolic-reflector antenna (DiPRA) based on a printed reflector backed dipole antenna and studied its predicted and measured performance in a flat configuration (...
Article
Model Predictive Control (MPC) is a successful control methodology, which is applied to increasingly complex systems. However, real-time feasibility of MPC can be challenging for complex systems, certainly when an (extremely) large number of constraints have to be adhered to. For such scenarios with a large number of state constraints, this paper p...
Article
Full-text available
Hyperthermia treatments in the clinic rely on accurate temperature measurements to guide treatments and evaluate clinical outcome. Currently, magnetic resonance thermometry (MRT) is the only clinical option to non-invasively measure 3D temperature distributions. In this review, we evaluate the status quo and emerging approaches in this evolving tec...
Article
Full-text available
In hyperthermia, the general opinion is that pre-treatment optimization of treatment settings requires a patient-specific model. For deep pelvic hyperthermia treatment planning (HTP), tissue models comprising four tissue categories are currently discriminated. For head and neck HTP, we found that more tissues are required for increasing accuracy. I...
Article
Full-text available
Temperature monitoring plays a central role in improving clinical effectiveness of adjuvant hyperthermia. The potential of magnetic resonance thermometry for treatment monitoring purposes led to several MR-guided hyperthermia approaches. However, the proposed solutions were sub-optimal due to technological and intrinsic limitations. These hamper ac...
Article
Full-text available
Purpose: Thermal dose-effect relations have demonstrated that clinical effectiveness of hyperthermia would benefit from more controlled heating of the tumor. Hyperthermia treatment planning (HTP) is a potent tool to study strategies enabling target conformal heating, but its accuracy is affected by patient modeling approximations. Homogeneous phant...
Article
Microwave hyperthermia is a promising cancer treatment used in combination with radio- and chemotherapy. Typically, hyperthermia systems involve several antennas that transfer electromagnetic energy into the tissue. The principal need in hyperthermia treatment is to optimally focus the heating into the target while minimising heating in the surroun...
Article
Full-text available
The potential of MR thermometry (MRT) fostered the development of MRI compatible radiofrequency (RF) hyperthermia devices. Such device integration creates major technological challenges and a crucial point for image quality is the water bolus (WB). The WB is located between the patient body and external sources to both couple electromagnetic energy...
Experiment Findings
Full-text available
Article
Full-text available
Hyperthermia therapy is a potent enhancer of chemotherapy and radiotherapy. In particular, microwave (MW) and radiofrequency (RF) hyperthermia devices provide a variety of heating approaches that can treat most cancers regardless the size. This review introduces the physics of MW/RF hyperthermia, the current state-of-the-art systems for both locali...
Article
Full-text available
Clinical trials have demonstrated the therapeutic benefits of adding radiofrequency (RF) hyperthermia (HT) as an adjuvant to radio-and chemotherapy. However, maximum utilization of these benefits is hampered by the current inability to maintain the temperature within the desired range. RF HT treatment quality is usually monitored by invasive temper...
Article
Full-text available
Introduction: Within the hyperthermia community, consensus exists that clinical outcome of the treatment radiotherapy and/or chemotherapy plus hyperthermia (i.e. elevating tumor temperature to 40 - 44 °C) is related to the applied thermal dose; hence, treatment quality is crucial for the success of prospective multi-institution clinical trials. Cu...
Article
Full-text available
Clinical outcome of hyperthermia depends on the achieved target temperature, therefore target conformal heating is essential. Currently, invasive temperature probe measurements are the gold standard for temperature monitoring, however, they only provide limited sparse data. In contrast, magnetic resonance thermometry (MRT) provides unique capabilit...
Article
Background: Addition of deep hyperthermia results in improved local control (LC) and overall survival (OS) compared to radiotherapy alone in patients with cervical carcinoma. Previously, we showed that the thermal dose of hyperthermia significantly correlates with LC and disease specific survival (DSS). Over the last decade, new radiation techniqu...
Article
Full-text available
Purpose: To investigate the effect of patient specific vessel cooling on head and neck hyperthermia treatment planning (HTP). Methods and materials: Twelve patients undergoing radiotherapy were scanned using computed tomography (CT), magnetic resonance imaging (MRI) and contrast enhanced MR angiography (CEMRA). 3D patient models were constructed u...
Article
Full-text available
Purpose: Hyperthermia treatment quality determines treatment effectiveness as shown by the clinically derived thermal-dose effect relations. SAR based optimization factors are used as possible surro-gate for temperature, since they are not affected by thermal tissue properties uncertainty and variations. Previously, target coverage (TC) at the 25%...
Article
Full-text available
Hyperthermia treatment planning is a deeply patient-specific task which includes the optimal determination of the excitations of an array applicator. To enhance flexibility, various solutions exploiting different frequencies, antenna element, number and applicator geometries have been proposed in the literature. Among them, increasing the frequency...
Data
KM analysis of low and high time interval per time period. KM-curves for low and high time interval for LC were compared using log-rank test.
Data
Development of the time interval in time. Shown are the different time periods used in subsequent KM-analysis.
Data
KM analysis of low and high CEM43T90 groups. KM-curves for low and high CEM43T90 for LC (A) and DFS (B) were compared using log-rank test.
Article
Full-text available
Background: Addition of deep hyperthermia to radiotherapy results in improved local control (LC) and overall survival compared to radiotherapy alone in cervical carcinoma patients. Based on preclinical data, the time interval between radiotherapy, and hyperthermia is expected to influence treatment outcome. Clinical studies addressing the effect of...
Article
Objective Mild hyperthermia (HT) treatments are generally monitored by phase-referenced proton resonance frequency shift calculations. A novel phase and thus temperature-sensitive fast spin echo (TFSE) sequence is introduced and compared to the double echo gradient echo (DEGRE) sequence. Theory and methods For a proton resonance frequency shift (P...
Article
Full-text available
Clinical trials have shown that hyperthermia is a potent adjuvant to conventional cancer treatments, but the temperatures currently achieved in the clinic are still suboptimal. Hyperthermia treatment planning simulations have potential to improve the heating profile of phased-array applicators. An important open challenge is the development of an e...
Article
Full-text available
Background: Radiofrequency (RF) mild hyperthermia (40 °C–44 °C for 60 minutes) is an effective adjuvant treatment for several types of cancer. To ensure treatment efficacy, quality assurance (QA) is necessary. This study presents the first systematic 3D characterisation of the heating performance of the commonly used Pyrexar BSD2000-3D MR-compatibl...
Conference Paper
Full-text available
Treatment planning for deep pelvic hyperthermia is currently based on tissue models comprising four tissue categories. For head and neck hyperthermia, we earlier found that more tissues are required for an accurate representation. Hence, we studied the accuracy of the clinical tissue segmentation (4 tissues) using a full detailed tissue list segmen...
Article
Multi-channel image registration is an important challenge in medical image analysis. Multi-channel images result from modalities such as dual-energy CT or multispectral microscopy. Besides, multi-channel feature images can be derived from acquired images, for instance, by applying multi-scale feature banks to the original images to register. Multi...
Article
Clinical studies have shown that hyperthermia sensitizes tumor cells for conventional therapies. During phased-array microwave hyperthermia, an array of antennas is used to focus the electromagnetic waves at the target region. Selective heating, while preserving the healthy tissue, is a demanding challenge and currently patient specific pre-treatme...
Article
Full-text available
Purpose: Radiotherapy (RT) treatment of locally-advanced and recurrent head and neck carcinoma (HNC) results in disappointing outcomes. Combination of RT with cisplatin or cetuximab improves survival but the increased toxicity and patient's comorbidity warrant the need for a less-toxic radiosensitizer. Stimulated by several randomized studies demon...
Article
Full-text available
Image registration is an important task in medical image analysis. Whereas most methods are designed for the registration of two images (pairwise registration), there is an increasing interest in simultaneously aligning more than two images using groupwise registration. Multimodal registration in a groupwise setting remains difficult, due to the la...
Article
Full-text available
Background and purpose: To protect against any potential adverse effects to human health from localised exposure to radio frequency (100 kHz–3 GHz) electromagnetic fields (RF EMF), international health organisations have defined basic restrictions on specific absorption rate (SAR) in tissues. These exposure restrictions incorporate safety factors w...
Article
Full-text available
Purpose: In this study, we investigated the differences in hyperthermia treatment (HT) quality between treatments applied with different hyperthermia systems for sub-superficial tumors in the head and neck (H&N) region. Materials and methods: In 24 patients, with a clinical target volume (CTV) extending up to 6cm from the surface, we retrospectivel...