• Home
  • Margaret Chesney
Margaret Chesney

Margaret Chesney
UCSF · Medicine

PhD

About

433
Publications
97,254
Reads
How we measure 'reads'
A 'read' is counted each time someone views a publication summary (such as the title, abstract, and list of authors), clicks on a figure, or views or downloads the full-text. Learn more
34,999
Citations
Citations since 2017
51 Research Items
7474 Citations
201720182019202020212022202302004006008001,0001,200
201720182019202020212022202302004006008001,0001,200
201720182019202020212022202302004006008001,0001,200
201720182019202020212022202302004006008001,0001,200

Publications

Publications (433)
Article
Full-text available
This study used Human Centered Design methods to develop a digital platform tailored for PLWD and test an online version of PLIÉ, called Moving Together. We assessed feasibility and satisfaction of a 12-week online program using completion rates, attendance, and evaluation surveys. 39 people (18 PLWD, 7 MCI, 14 CP) attended 75% classes; 96% rated c...
Article
Full-text available
PLIÉ was initially developed and tested in the adult day setting. Caregivers reported qualitative improvements in PLWD in psychological, physical, cognitive, and social domains that were supported by class video-recordings. Paired PLIÉ was adapted for the community setting and expanded to include dyads of PLWD and care partners (CPs) who participat...
Article
Preventing Loss of Independence through Exercise (PLIÉ) is a gentle, in‐person, mind‐body, group movement program for people with dementia (PWD) or mild cognitive impairment (MCI); Paired PLIÉ includes dyads of PWD and care partners (CPs). We previously found that PLIÉ and Paired PLIÉ improve physical, cognitive, social, and emotional well‐being. T...
Article
Full-text available
In this study, we collected formative data from key stakeholders (nursing home staff and leadership, dementia care experts), developed, pilot tested, and refined a 10-week remote training program at 2 VA nursing homes with 15 interprofessional staff (e.g., recreation therapists, social workers, registered nurses). Training components included weekl...
Article
This brief report describes the rapid conversion of a randomized trial of a Hatha-based yoga program for older women with urinary incontinence to a telehealth videoconference platform during the coronavirus disease 2019 (COVID-19) pandemic. Interim results demonstrate the feasibility of recruiting and retaining participants across a wide range of a...
Article
Background: Non-pharmacologic programs can improve function and quality of life in people with memory loss (PWML), but in-person programs are not available in many communities. We previously developed the interactive, livestreaming, group-based, Moving TogetherTM program for PWML and their caregivers (CGs). This study assesses feasibility, satisfa...
Article
Full-text available
Background: High normal resting pCO2 is a risk factor for salt sensitivity of blood pressure (BP) in normotensive humans and has been associated with higher resting systolic BP in postmenopausal women. To date, however, no known studies have investigated the effects of regular practice of voluntary mild hypocapnic breathing on BP in hypertensive p...
Article
Full-text available
Background: Preventing Loss of Independence through Exercise (PLIÉ) is a group movement program initially developed for people with mild-to-moderate dementia that integrates principles from several well-established traditions to specifically addresses the needs of people with cognitive impairment. Objective: To investigate whether PLIÉ would ben...
Article
Dr. Kristina Orth-Gomér passed away on May 14, 2020. With her passing, we lost a major pioneer and scientific contributor at the nexus of basic medical science, public health science, preventive medicine, and psychosomatic/behavioralmedicine. Kristina was convinced that in the psychosomatic/behavioral field we should work as clinicians for the indi...
Article
Full-text available
MOVING TOGETHER classes deliver an online live-streaming version of the evidence-based Paired PLIÉ (Preventing Loss of Independence through Exercise) group movement program for people living with dementia (PLWD) and caregivers (CGs) that targets physical movements, mindful body awareness, and social engagement. Paired PLIÉ has been found to be asso...
Article
Preventing Loss of Independence through Exercise (PLIÉ) is an integrative group movement program for people living with dementia that combines exercises to maintain daily function with mindful body awareness and social engagement. We performed a randomized, controlled trial to examine PLIÉ’s effects on physical, cognitive, and social/emotional outc...
Article
Paired PLIÉ (Preventing Loss of Independence through Exercise) is an in‐person, group movement program for people living with dementia (PLWD) and caregivers (CGs) that targets physical movements, mindful body awareness, and social engagement. We have previously found Paired PLIÉ to be associated with CG‐reported improvements in physical, cognitive,...
Article
Preventing Loss of Independence through Exercise (PLIÉ) is an integrative group movement program developed to improve quality of life and daily function in people with mild‐to‐moderate dementia. We performed a single‐arm pre‐post pilot trial to examine the impact of PLIÉ in people with mild cognitive impairment (MCI) on behavioral and neuroimaging...
Article
Objectives: To evaluate for differences in demographic and clinical characteristics, as well as subjective and objective measures of chemotherapy-induced peripheral neuropathy (CIPN), among different exercise groups. Sample & setting: Cancer survivors (N = 290) were recruited from throughout the San Francisco Bay Area. Methods & variables: Bas...
Article
Full-text available
Background/Aims Subjective tinnitus is a common impairment throughout the world and typically cannot be cured. Coping strategies are cognitive, affective, and behavioural approaches for managing stressors like tinnitus. The aim of this study was to investigate the effects of two brief interventions on coping and tinnitus-related distress. Methods...
Article
Full-text available
Background: Most clinical investigations involving yoga lack adequate description of the specific yoga elements, including physical postures. Few studies have measured self-efficacy regarding the performance of yoga postures or assessed observed success in performing postures. Methods: We developed and piloted several tools to evaluate self-effi...
Article
Full-text available
Purpose While older adults with cancer are more likely to develop chemotherapy-induced peripheral neuropathy (CIPN), the study aimed to determine if patient-reported and objective measures of CIPN differ by age among cancer survivors. Methods Cancer survivors with persistent CIPN after completion of platinum and/or taxane chemotherapy completed CI...
Article
Full-text available
Background: Although multiple co-occurring symptoms are a significant problem for cancer survivors, to the authors' knowledge little is known regarding the phenotypic characteristics associated with a higher symptom burden. The objectives of the current study were to evaluate the occurrence, severity, and distress associated with 32 symptoms and e...
Article
Paclitaxel is a common chemotherapy drug associated with the development of chronic paclitaxel-induced peripheral neuropathy (PIPN). PIPN is associated with neuroinflammatory mechanisms in pre-clinical studies. Here, we evaluated for differential gene expression (DGE) in peripheral blood between breast cancer survivors with and without PIPN and for...
Article
Context: Recent, albeit, limited evidence suggests that body mass index (BMI) may be a modifiable risk factor to reduce the deleterious effects of chemotherapy-induced peripheral neuropathy (CIPN) in cancer survivors. Objectives: To evaluate for differences in demographic, clinical, pain, sensation, and balance characteristics among three BMI gr...
Article
Full-text available
Background Paclitaxel is one of the most commonly used drugs to treat breast cancer. Its major dose-limiting toxicity is paclitaxel-induced peripheral neuropathy (PIPN). PIPN persists into survivorship and has a negative impact on patient’s mood, functional status, and quality of life. No interventions are available to treat PIPN. A critical barrie...
Data
Supplemental material for Expression of mitochondrial dysfunction-related genes and pathways in paclitaxel-induced peripheral neuropathy in breast cancer survivors
Article
Full-text available
Preventing Loss of Independence through Exercise (PLIÉ) and Paired PLIÉ are unique integrative group movement programs that target abilities and neural mechanisms that are relatively well-preserved in people with dementia. PLIÉ includes 1-hour daycare center-based classes with up to 10 individuals with dementia, 3 days/week for 18 weeks + 4 monthly...
Article
Background: Because of the limitations of existing clinical treatments for urinary incontinence, many women with incontinence are interested in complementary strategies for managing their symptoms. Yoga has been recommended as a behavioral self-management strategy for incontinence, but evidence of its feasibility, tolerability, and efficacy is lac...
Article
Objectives: Numbness associated with neuropathic pain suggests the loss of function in myelinated, large diameter sensory neurons. The purpose of this study was to examine the relationships between pain severity and subjective (ie, severity of numbness) and objective (ie, loss of light touch sensations, vibration thresholds) measures of loss of la...
Article
Context: While paclitaxel is one of the most commonly used drugs to treat breast, ovarian, and lung cancers, little is known about the impact of paclitaxel-induced peripheral neuropathy (PIPN) on cancer survivors. Objectives: The purposes of this study were to evaluate for differences in demographic and clinical characteristics, as well as measu...
Article
Full-text available
Background Tinnitus (ie, ear or head noises not caused by external sounds) is common among the general population and is the most prevalent service-connected disability in the United States’ Department of Veterans Affairs system. While numerous clinical interventions have been created to systematically address the range of issues caused by tinnitus...
Article
Introduction/Background There is a high incidence of hyperlipidemia, increased body fat, decreased aerobic performance, function and psychological distress in long-term survivors of cancer. This study compares the efficacy of Tai Chi (TC) vs. aerobic exercise (AE) in impacting some of these factors in adult survivors of solid tumors. Material and...
Article
Context: The most common adverse effects from neurotoxic chemotherapy are chemotherapy-induced neuropathy (CIPN), hearing loss, and tinnitus. While associations between perceived stress and persistent pain, hearing loss, and tinnitus are documented, no studies have examined these associations in cancer survivors who received neurotoxic chemotherap...
Article
Purpose: The purpose of this study was to evaluate for differences in demographic, clinical, and pain characteristics, as well as measures of sensation, balance, perceived stress, symptom burden, and quality of life (QOL) among survivors who received neurotoxic chemotherapy (CTX) and who reported only chemotherapy-induced neuropathy (CIN, n = 217)...
Article
Background: Assays that detect HIV antigen (Ag) and antibody (Ab) can be used to screen for HIV infection. Objectives: To compare the performance of the BioPlex 2200 HIV Ag-Ab assay and two other Ag/Ab combination assays for detection of acute HIV infection. Study design: Samples were obtained from 24 individuals (18 from the US, 6 from South...
Article
Full-text available
Background: Posttraumatic stress disorder (PTSD) is prevalent among military veterans and is associated with significant negative health outcomes. However, stigma and other barriers to care prevent many veterans from pursuing traditional mental health treatment. We developed a group-based Integrative Exercise (IE) program combining aerobic and res...
Article
Full-text available
Objective: Innovative approaches to the treatment of war-related posttraumatic stress disorder (PTSD) are needed. We report on secondary psychological outcomes of a randomized controlled trial of integrative exercise (IE) using aerobic and resistance exercise with mindfulness-based principles and yoga. We expected-in parallel to observed improveme...
Article
Full-text available
Objectives: To assess the feasibility, safety, and initial estimates of efficacy of a yoga program in postoperative care for women at high risk for breast cancer-related lymphedema (BCRL). Design: Single-group pretest-post-test design. Settings/location: Patients were recruited from the University of California, San Francisco Carol Franc Buck...
Article
We have recently developed a novel, multi-modal, group movement program for people with dementia called Preventing Loss of Independence through Exercise (PLIÉ) that is grounded in neuroscience and focuses on abilities that are relatively well-maintained (procedural memory, mindful body awareness, social connection). This randomized, controlled tria...
Article
151Background: CIN is the most prevalent neurologic complication of cancer treatment. Inter-individual variability exists in survivors’ reports of the factors that aggravate CIN in their feet. The purpose of this study was to identify groups of survivors with CIN in their feet based on distinct aggravating factors and evaluate for differences in de...
Article
157 Background: CIN is the most prevalent neurologic complication of cancer treatment. Inter-individual variability exists in survivors’ reports of the factors that aggravate CIN in their hands. The purpose of this study was to identify groups of survivors with CIN in their hands based on distinct aggravating factors and evaluate for differences in...
Article
Full-text available
Background The novel group treatment program Training for Awareness, Resilience, and Action (TARA) was developed to target specific mechanisms based on neuroscience findings in adolescent depression and framed within the National Institute of Mental Health Research Domain Criteria. TARA contains training of autonomic and emotional self-regulation,...
Article
Context: Evidence suggests that chemotherapy-induced neuropathy (CIN) is a significant problem for cancer survivors. However, a detailed phenotypic characterization of CIN in cancer survivors is not available. Objectives: To evaluate between group differences in demographic and clinical characteristics, as well as in measures of sensation, funct...
Article
Full-text available
Objectives: This study examines gradients in depressive symptoms by socioeconomic position (SEP) (i.e., income, education, employment) in a large, multi-site sample of MSM. Methods: Baseline data were used from EXPLORE, a randomized controlled behavioral HIV prevention trial for HIV-uninfected MSM in 6 U.S. cities (n = 4,277). Depressive symptom...
Book
Full-text available
This book represents a collective effort to summarize the findings of decades of research on psycho social aspects of women´s cardiovascular disease. ”Women of your age simply do not get heart disease” was the comment from the nurse at the emergency room of a large Stockholm University Hospital , to the woman patient who came to the acute cardiolo...
Article
Full-text available
Psychology, Health & Medicine ISSN: 1354-8506 (Print) 1465-3966 (Online) Journal homepage: http://www.tandfonline.com/loi/cphm20 The role of self-regulation in health and illness Gerdi Weidner, Monika Sieverding & Margaret A. Chesney To cite this article: Gerdi Weidner, Monika Sieverding & Margaret A. Chesney (2015): The role of self-regulation in...
Article
Full-text available
Psychosocial and dietary factors can contribute to the development of primary hypertension, but the physiological mechanism mediating this most common cardiovascular disorder remains elusive. It is often assumed that the effects of stress are mediated by the sympathetic nervous system, and an interaction between high sodium intake and behavioral st...
Article
Full-text available
Background: Current dementia medications have small effect sizes, many adverse effects and do not change the disease course. Therefore, it is critically important to study alternative treatment strategies. The goal of this study was to pilot-test a novel, integrative group exercise program for individuals with mild-to-moderate dementia called Preve...
Article
We conducted a secondary data analysis of 11 AIDS Clinical Trials Group (ACTG) studies to examine longitudinal associations between 14 self-reported antiretroviral therapy (ART) adherence barriers (at 12 weeks) and plasma HIV RNA (at 24 weeks) and to discern the relative importance of these barriers in explaining virologic detectability. Studies en...
Article
Full-text available
Cross-sectional studies have suggested that co-occurring epidemics or "syndemics" of psychosocial health problems may accelerate HIV transmission among men who have sex with men (MSM) in the United States. We aimed to assess how five syndemic conditions (depressive symptoms, heavy alcohol use, stimulant use, polydrug use, and childhood sexual abuse...
Article
Objective The present study reports on the long-term effects of a mindfulness-based stress reduction (MBSR) program for adult survivors of childhood sexual abuse.Method Of the study participants, 73% returned to the clinic for a single-session follow-up assessment of depression, posttraumatic stress disorder (PTSD), anxiety, and mindfulness at 2.5...
Article
Full-text available
Major depressive disorder (MDD) is one of the current leading causes of disability worldwide. Adolescence is a vulnerable period for the onset of depression, with MDD affecting 8–20% of all youth. Traditional treatment methods have not been sufficiently effective to slow the increasing prevalence of adolescent depression. We therefore propose a new...
Article
Full-text available
Objectives: Preventing Loss of Independence through Exercise (PLIÉ) is a novel, integrative exercise program for individuals with dementia that combines elements of different conventional and complementary exercise modalities (e.g. tai-chi, yoga, Feldenkrais, and dance movement therapy) and focuses on training procedural memory for basic functiona...
Article
Full-text available
Objectives Having effective ways to cope helps HIV-infected individuals maintain good psychological and physical well-being. This study investigated the relationship between coping self-efficacy levels, as determined by the Coping Self-Efficacy Scale (CSE), HIV status disclosure, and depression in a Danish cohort. Methods In 2008, the CSE was admi...
Article
Full-text available
The aim of this study is to examine the feasibility, efficacy, and safety of a group-based yoga therapy intervention for middle-aged and older women with urinary incontinence. We conducted a pilot randomized trial of ambulatory women aged 40 years and older with stress, urgency, or mixed-type incontinence. Women were randomized to a 6-week yoga the...
Article
Full-text available
Hyperventilation has been linked to emotional distress in adults. This study investigates end-tidal carbon dioxide (ETCO2 ), respiratory rate (RR), and heart rate variability (HRV) in adolescent girls with emotional disorders and healthy controls. ETCO2 , RR, HRV, and ratings of emotional symptom severity were collected in adolescent female psychia...
Article
The subgenual anterior cingulate cortex (sgACC) and its connected circuitry have been heavily implicated in emotional functioning in adolescent-onset major depressive disorder (MDD). While several recent studies have examined sgACC functional connectivity (FC) in depressed youth at rest, no studies to date have investigated sgACC FC in adolescent d...
Article
Background: Effective and easy to implement interventions to improve adherence to antiretroviral therapy are needed. Objective: To compare site nurse-initiated adherence and symptom support telephone calls for HIV-positive individuals starting antiretroviral therapy to the study site's standard of care. Methods: A randomized controlled trial o...
Article
Objective To explore whether primary school entry is associated with changes in immune system parameters in HIV-affected children. HIV-affected children are vulnerable to psychosocial stressors, regardless of their own HIV serological status.Methods Data from 38 HIV-positive and 29 HIV-negative children born to seropositive women were obtained. Mea...
Article
Full-text available
Background. Complementary and alternative medicine (CAM) and integrative medicine (IM) modalities are widely used by patients, including those with infectious diseases (ID). Methods. One thousand randomly selected ID practitioners were surveyed. The survey was divided into domains related to familiarity and recommendation, beliefs and attitudes, an...
Article
Full-text available
The increasing burden of chronic diseases presents not only challenges to the knowledge and expertise of the professional medical community, but also highlights the need to improve the quality and relevance of clinical research in this domain. Many patients now turn to complementary and integrative medicine (CIM) to treat their chronic illnesses; h...