Marga Lopez-Viota

Marga Lopez-Viota
University of Granada | UGR · Department of Pharmacy and Pharmaceutical Technology

Bachelor of Pharmacy

About

22
Publications
1,421
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509
Citations
Citations since 2016
2 Research Items
246 Citations
2016201720182019202020212022010203040
2016201720182019202020212022010203040
2016201720182019202020212022010203040
2016201720182019202020212022010203040
Introduction
Skills and Expertise

Publications

Publications (22)
Article
A great attention is presently paid to the design of drug delivery vehicles based on surface-modified magnetic nanoparticles. They can, in principle, be directed to a desired target area for releasing their drug payload, a process triggered by pH, temperature, radiation, or even magnetic field. To this, the possibility of forming part of diagnostic...
Article
It is described the reproducible formulation and complete physicochemical characterization of nanohybrids based on magnetite (Fe3O4) cores embedded within a polyethylenimine (PEI) matrix. Particle size, surface electrical charge, X-ray diffraction and Fourier transform infrared spectroscopy (FTIR) analyses, and magnetic field-responsive behaviour c...
Article
The introduction of magnetic nanocarriers in chemotherapy aims to enhance the anticancer activity of antitumor molecules whereas keeping their toxicity to a very minimum. Magnetite/poly(hexylcyanoacrylate) (core/shell) nanoplatforms were synthesized by an emulsion/polymerization procedure. An exhaustive physicochemical characterization (including i...
Article
Combination of cyclodextrins (CDs) and agar may render hydrogels that interact with drugs by forming inclusion complexes and/or ionic bonds. Hydroxypropyl-β-cyclodextrin and methyl-β-cyclodextrin (20%) in alkaline solutions containing or not agar (up to 1.5%) were cross-linked with ethyleneglycol diglycidylether at 50°C. Agar increases hardness, co...
Article
The efficacy and safety of chemotherapy is conditioned by the very high drug doses needed to obtain an efficient therapeutic activity, the poor pharmacokinetics of anticancer drugs, and the frequent multi-drug resistance of cancer cells. The application of nanotechnology strategies in oncology has revolutionized the transport of drugs to cancer, al...
Article
Despite the very efficient antitumor activity of conventional chemotherapy, generally high doses of anticancer molecules must be administered to obtain the required therapeutic action, simultaneously leading to severe side effects. This is frequently a consequence of the development of multidrug resistance by cancer cells and of the poor pharmacoki...
Article
In this work an investigation is described on the use of organically modified montmorillonite clay particles as stabilizers of bioplastic films based on xylan. With the aim of facilitating the incorporation of the nanoparticles to the films, the former were treated with a non-ionic surfactant, inulin. In order to evaluate the possible role of elect...
Article
Conventional chemotherapy of intracellular infections often fails due to the low uptake of commonly used antibiotics or to their reduced activity at the acidic pH of lysosomes. With the aim of improving the therapeutic action of metronidazole against intracellular infections along with an overcome of their important drawbacks, we investigated its i...
Article
Even though 5-fluorouracil has been demonstrated to display antitumor activity against a wide variety of cancers, high doses are needed to bring out the required therapeutic activity that could simultaneously lead to severe side effects. We hypothesized that the efficient delivery of 5-fluorouracil to tumors using a magnetic nanoplatform could redu...
Article
Even though 5-fluorouracil has been demonstrated to display antitumor activity against a wide variety of cancers, it is needed to be administered at high doses to elicit the required therapeutic activity, simultaneously leading to severe side effects. We hypothesized that the efficient delivery of 5-fluorouracil to tumors using a magnetic colloid c...
Article
Diclofenac sodium is a non-steroidal anti-inflammatory drug of choice to treat arthritis because of its potential anti-inflammatory and analgesic activity. Because of its shorter biological half-life, it is needed to be given frequently and at high doses to elicit the required therapeutic activity, simultaneously leading to severe side effects. We...
Article
Even though conventional pharmacotherapy has been demonstrated to display very efficient activity against a wide variety of diseases, several active agents (e.g., anti-tumor drugs and non-steroidal anti-inflammatory drugs) are generally needed to be administered at high doses to elicit the required therapeutic action, simultaneously leading to seve...
Article
The purpose of this study was to determine the stability of the pH sensitive drug, omeprazole, within different solid oral pharmaceutical formulations and to determine whether the addition of antacid and surfactant agents, at varying concentrations, influenced drug stability and release. Spectrophotometric and chromatographic techniques were used f...
Article
Ondansetron is a carbazol with antiemetic properties that acts as a competitive and selective antagonist for the 5 HT3 serotonin receptors. It is used primarily to control nausea and vomiting caused by cytotoxic chemotherapy and radiotherapy, as well as in postoperative vomiting in gynecological surgery. The main aim of this work was to obtain a st...
Article
Our objective has been the development and study of the stability of transdermal methimazole formulae as alternative to oral administration. Preparation of F-127 and PLO Pluronic gel (Pluronic lecitin organogel) are described, as well as their characteristics from transmission electron microscopy. The possible structural and rheological changes to...
Article
In this paper we have carried out a detailed investigation of the stability and redispersibility characteristics of fenbendazole aqueous suspensions, through a thermodynamic and electrokinetic characterization, considering the effect of both pH and ionic strength. The hydrophobic character of the drug, and the surface charge and electrical double-l...
Article
In this paper we have carried out a detailed investigation of the stability and redispersibility characteristics of fenbendazole aqueous suspensions, through a thermodynamic and electrokinetic characterization, considering the effect of both pH and ionic strength. The hydrophobic character of the drug, and the surface charge and electrical double-l...
Article
"In vitro" Solar Protection Factor (SPF) is determined by measuring the intensity of radiation penetration through a layer of photoprotector formulations prepared with different solar filters (Eusolex® 232, Eusolex® 6300 and Neo Heliopan" AV) of a different chemical nature, hydrosoluble and liposoluble, solid and liquid, with a common silicon vehic...
Article
Because of the fundamental importance of new therapeutic routes for cancer treatment, a number of systems based on colloidal particles as vehicles for the delivery of chemotherapeutic agents have been devised. The target is always to provide the proper dose of the antitumour agent only at the desired locus of action, thus reducing the unwanted side...
Article
A reproducible method for the preparation of mixed colloidal nanoparticles, consisting of a magnetic carbonyl iron nucleus and a biocompatible ethylcellulose latex shell, is described in this article. The heterogeneous structure of the particles can confer them both the possibility of being used as drug delivery systems and the responsiveness to ex...
Article
Ultrasmall superparamagnetic iron oxide (USPIO) particles are iron oxide nanoparticles currently used for Biomedical applications: contrast agents in magnetic resonance imaging, drug delivery systems, etc. The coatings surrounding the USPIO inorganic core may control the in vitro stability and the in vivo fate. Different physicochemical properties...

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