Marek Jankowski

Nicolaus Copernicus University | umk · Department of Dermatology Sexually Transmitted Infections and Immunodermatology

Oxidative stress plays an important role in the development of vitiligo. The aim of our study was to assess the effect of oral vitamin supplementation with antioxidant activity on the effectiveness of the vitiligo treatment. The study group consisted of 46 patients suffering from nonsegmental vitiligo for over a year. Before and after the therapy,...

Equal importance is given to every skin lesion in treatment guidelines and severity grading systems for facial lesions. Face recognition studies suggest differentially perceived areas of the human face. The aims of this study were to quantify the visual attention given to facial skin lesions and to explore their hierarchy. Eye movements were tracke...

Background: Allergic reaction to seminal plasma was described decades ago. In USA only tens of thousands women are estimated to be affected. Not only seminal plasma, but also cervico-vaginal fluid contains sex-restricted antigens, yet allergy to cervicovaginal fluid has never been reported in medical literature. We came to a suspicion that because...

Environmental conditions for swimming facilities may support fungal growth and also may represent a biological risk for users. However, since previously published studies both cleaning procedures and sanitary regulations are likely to have been improved. The aim of the study was to examine whether attendance to public swimming pools was still a ris...

Low-level laser (light) therapy (LLLT) has been applied recently to body contouring. However the mechanism of LLLT-induced reduction of subcutaneous adipose tissue thickness has not been elucidated and proposed hypotheses are highly controversial. Non-obese volunteers were subject to 650nm LLLT therapy. Each patient received 6 treatments 2-3 days a...

Interleukin 27 (IL-27) is a novel cytokine secreted by stimulated antigen-presenting cells. Initial studies on the biology of IL-27 provided evidence for its role in the initiation of Th1 responses; however, subsequent work has indicated that IL-27 has broad stimulatory as well as inhibitory effects on Th1, Th2, Th17, Treg, and Tr1 subsets of T cel...

Interleukin-27 plays an important role in the regulation of immune response. IL-27 signaling mediated by its heterodimeric IL-27Rα/gp130 receptor activates multiple signaling cascades, including STAT1 and STAT3, Akt/mTOR, ERK, and p38 MAPK pathways. Up- and downregulation of both receptor subunits and cross talk between immune cell populations regu...

Interleukin-27 plays an important role in the regulation of immune response. IL-27 activates multiple signaling cascades, including the JAK-STAT, Akt/mTOR, ERK, and p38 MAPK pathways. Multiple studies have revealed that IL-27 regulates Th1, Th2, Th17, Treg, Tr1, Tfh T cell population, as well as B cells, DCs, and macrophages. Due to its broad inhib...

This volume focuses on various aspects of interleukin-27 (IL-27), especially its potential for clinical applications. The authors discuss the downstream signaling from the IL-27 receptor and its molecular targets in immune cells including Th1, Th2, Th17, Treg, Tr1, Tfh, B cells, DCs and macrophages. The inhibition of Th17 cells by IL-27 is vital fo...

Background: The efficacy of anti-EGF pathway therapies, using small molecule inhibitors, as erlotinib, is limited in lung cancer by selection of secondary resistant clones. Actually, the experimental gene therapy blocking all EGFR transcripts may be an attractive alternative. Moreover, some data indicate immunostimulating effect of EGFR inhibition,...

Introduction: Previous reports have strongly suggested that HGF inhibits lung fibrosis as an antagonist of TGFβ (transforming growth factor β). Objectives: To assess HGF expression in the lower airways of patients with interstitial lung diseases (ILDs). Patients and methods: HGF levels were examined by ELISA in bronchoalveolar lavage (BAL) supernat...

Introduction: Previous studies have suggested that hepatocyte growth factor (HGF) inhibits lung fibrosis as an antagonist of transforming growth factor β (TGF‑β). Objectives: We assessed HGF expression levels in the lower airways of patients with selected interstitial lung diseases. Patients and methods: HGF levels were examined by an enzyme‑l...

Recent years have brought an enhanced understanding of Merkel cell carcinoma (MCC) biology, especially with regards to the Merkel cell polyoma virus as a causative agent. Differences between Merkel cell polyomavirus-positive and -negative MCC in morphology,, gene expression, miRNA profiles and prognosis have been reported.Origin of MCC is controver...

About 75% of cases of epidermolysis bullosa simplex result from mutations in KRT5 and KRT14 genes. Here, we report a family with a novel heterozygous missense mutation p.Leu418Gln in the KRT14 gene causing EBS of phenotype varying from EBS-loc to EBS-gen intermed. To the best of our knowledge, the family reported by us is the largest one in whom tw...

Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are rare mucocutaneous, unpredictable, life-threatening drug side reactions. A very rare case of norfloxacin-induced SJS/TEN overlap with uncommon clinical presentation in a patient with a suspected urinary tract infection is reported. The SJS/TEN management with possible treatment...

INTRODUCTION Erosive pustular dermatosis of the scalp (EPD) is a seldom reported skin disease characterized by sterile pustules, chronic crusted erosions, and skin atrophy following physical or chemical trauma. EPD is seen mostly in elderly patients with long-term sun damage to the skin. We report on a case of a middle-aged man with androgenic alop...

The exact role of FasL, and particularly its soluble and membrane-bound forms, in the development of chronic ILDs and lung fibrosis has not been extensively explored. We aimed at analyzing membrane-bound FasL expression on alveolar macrophages (AM) and lymphocytes (AL) as well as soluble FasL (sFasL) levels in bronchoalveolar lavage (BAL) from ILDs...

The exact role of FasL, and particularly its soluble and membrane-bound forms, in the development of chronic ILDs and lung fibrosis has not been extensively explored. We aimed at analyzing membrane-bound FasL expression on alveolar macrophages (AM) and lymphocytes (AL) as well as soluble FasL (sFasL) levels in bronchoalveolar lavage (BAL) from ILDs...

Interleukin (IL)-27 is a novel cytokine secreted by stimulated antigen-presenting cells. Initial studies on the biology of IL-27 provided evidence for its role in the initiation of T(H)1 responses; however, subsequent work has indicated that IL-27 has broad inhibitory effects on T(H)1, T(H)2, and T(H)17 subsets of T cells as well as the expansion o...

Ba c k g r o u n d . Development of new research methods, including molecular biology, results in new perspectives of lung cancer treatment and prognosis. Up to date small interfering RNA (siRNA) molecules have been used in several studies to silence oncogenes in the respiratory system. One of them, epidermal growth factor (EGF) receptor gene plays...

IFN-gamma a potent antifibrotic activity in interstitial lung diseases (ILD). T cells, both Th1 and Tc1, are considered to be the main local source of IFN-gamma. BAL fluids of 98 patients with ILD, incl. idiopathic pulmonary fibrosis (IPF/UIP), sarcoidosis, extrinsic allergic alveolitis (EAA), asbestosis and silicosis (n=16, 49, 7, 10, 16 resp.) we...

Parkinson's disease is a neurodegenerative disorder characterized by a dramatic loss of dopaminergic neurons in the substantia nigra. Among the many pathogenic mechanisms thought to contribute to the demise of these cells in sporadic cases of PD, oxidative stress has taken center stage due to extensive experimental evidence showing that dopamine- o...

Cigarette smoking enhances apoptosis rate of alveolar macrophages. However, little is known about the appearance and extension of apoptosis in bronchoalveolar lavage (BAL) lymphocytes originating from smoker individuals, both in pulmonary sarcoidosis (the disease characterized by lymphocytic alveolitis) and in controls. BAL was carried out in 60 no...