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16
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338
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Introduction
Additional affiliations
February 2009 - February 2013
Publications
Publications (16)
Context:
The loss of progesterone during menopause is linked to sleep complaints of the affected women. Previously we demonstrated sleep promoting effects of oral progesterone replacement in postmenopausal women. The oral administration of progesterone, however, is compromised by individual differences in bioavailability and metabolism of the ster...
A single nucleotide polymorphism substitution from glutamine (Gln, Q) to arginine (Arg, R) at codon 460 of the purinergic P2X7 receptor (P2X7R) has repeatedly been associated with mood disorders. The P2X7R-Gln460Arg variant per se is not compromised in its function. However, heterologous expression of P2X7R-Gln460Arg together with wild-type P2X7R h...
Objectives:
The relevance of rapid eye movement (REM) sleep in affective disorders originates from its well-known abnormalities in depressed patients, who display disinhibition of REM sleep reflected by increased frequency of rapid eye movements (REM density). In this study we examined whether heart rate variability (HRV) and prefrontal theta cord...
Mounting evidence for the role of sleep spindles in neuroplasticity has led to an increased interest in these non-rapid eye movement (NREM) sleep oscillations. It has been hypothesized that fast and slow spindles might play a different role in memory processing. Here, we present a new sleep spindle detection algorithm utilizing a continuous wavelet...
The trait-like nature of electroencephalogram (EEG) is well established. Furthermore, EEG of wake and non-rapid eye movement (non-REM) sleep has been shown to be highly heritable. However, the genetic effects on REM sleep EEG microstructure are as yet unknown. REM sleep is of special interest since animal and human data suggest a connection between...
Many young females take exogenous hormones as oral contraceptive (OC), a condition rarely controlled for in studies on sleep and memory consolidation even though sex hormones influence consolidation. This study investigated the effects of OCs on sleep-related consolidation of a motor and declarative task, utilizing a daytime nap protocol. Fifteen h...
To evaluate whether prefrontal cordance in theta frequency band derived from REM sleep EEG after the first week of antidepressant medication could characterize the treatment response after 4 weeks of therapy in depressed patients.
20 in-patients (15 females, 5 males) with a depressive episode and 20 healthy matched controls were recruited into 4-we...
Background
Overnight memory consolidation is disturbed in both depression and schizophrenia, creating an ideal situation to investigate the mechanisms underlying sleep-related consolidation and to distinguish disease specific processes from common elements in their pathophysiology.
Methods
We investigated patients with depression and schizophrenia...
The loss of progesterone during menopause is linked to common sleep complaints of the affected women. Consequently, a previous study of our laboratory could demonstrate sleep promoting effects of progesterone replacement in postmenopausal women [1]. The oral of administration of progesterone, however, is compromised by individual differences in bio...
Cordance is a new quantitative EEG-method with at least 19 electrodes, which has shown usability as a biomarker for depression within the waking-state. We tested whether differences in cordance derived from sleep EEG exist between responders and non-responders after antidepressant medication. Additionally, we compared these with healthy subjects. 2...