Mareike Ludwig

Otto-von-Guericke-Universität Magdeburg | OvGU · Institute for Cognitive Neurology and Dementia Research

Transcutaneous auricular vagus nerve stimulation (taVNS), as a non-invasive brain stimulation technique may influence the locus coeruleus-norepinephrine system (LC-NE system) via modulation of the Vagus Nerve (VN) which projects to the LC. Few human studies exist examining the effects of taVNS on the LC-NE system and studies to date assessing the a...

The locus coeruleus‐norepinephrine system (LC‐NE system) supports the process of encoding of emotionally salient events. LC integrity varies in healthy elderly and is associated with altered cognitive functions in aging. Post‐mortem as well as structural indicators suggest that the modulation of the LC‐NE system is reduced in elderly. This reductio...

Postmortem studies show that the locus coeruleus (LC), the major source of cortical noradrenergic projections, exhibits evidence of neurodegeneration early in Alzheimer’s disease (AD). Indeed, the noradrenergic system is more affected than the dopaminergic or cholinergic ones. Albeit to a smaller extent, neuronal loss in the LC is also seen in cogn...

Cognitive inhibition has been suggested to deteriorate in Alzheimer’s disease. While numerous studies with different experimental paradigms found evidence on impaired inhibition in attention and memory, evidence in favour of intact memory inhibition has been reported with regard to the phenomenon of retrieval-induced forgetting (Moulin et al., 2002...

Given its non-invasive nature, there is increasing interest in the use of transcutaneous vagus nerve stimulation (tVNS) across basic, translational and clinical research. Contemporaneously, tVNS can be achieved by stimulating either the auricular branch or the cervical bundle of the vagus nerve, referred to as transcutaneous auricular vagus nerve s...