Maree Farrow

Maree Farrow
University of Tasmania · Wicking Dementia Research and Education Centre

PhD

About

43
Publications
6,183
Reads
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1,040
Citations
Citations since 2017
2 Research Items
324 Citations
20172018201920202021202220230204060
20172018201920202021202220230204060
20172018201920202021202220230204060
20172018201920202021202220230204060
Additional affiliations
February 2012 - present
Australian National University
Position
  • Visiting Fellow
February 2007 - June 2015
Alzheimer's Australia
Alzheimer's Australia
Position
  • Research Associate

Publications

Publications (43)
Article
Full-text available
Objective To compare the use of the Continuous Performance Task (CPT) reaction time variability (intraindividual variability or standard deviation of reaction time), as a measure of vigilance in attention-deficit hyperactivity disorder (ADHD), and stimulant medication response, utilizing a simple CPT X-task vs an A-X-task. Method Comparative analy...
Article
Full-text available
Background: Attention-deficit/hyperactivity disorder (ADHD) symptoms are most commonly treated with stimulant medication such as methylphenidate (MPH); however, approximately 25% of patients show little or no symptomatic response. We examined the extent to which initial changes in brain functional connectivity (FC) associated with the first MPH do...
Article
Full-text available
Introduction Recent evidence suggests that attention‐deficit hyperactivity disorder (ADHD) is associated with brain functional connectivity (FC) abnormalities. Methods In this study, we use steady‐state visually evoked potential event‐related partial coherence as a measure of brain FC to examine functional connectivity differences between a typica...
Article
Full-text available
Introduction Recent evidence suggests that attention deficit hyperactivity disorder (ADHD) is associated with a range of brain functional connectivity abnormalities, with one of the most prominent being reduced inhibition of the default mode network (DMN) while performing a cognitive task. In this study, we examine the effects of a methylphenidate...
Article
Full-text available
Background: Encouraging middle-aged adults to maintain their physical and cognitive health may have a significant impact on reducing the prevalence of dementia in the future. Mobile phone apps and interactive websites may be one effective way to target this age group. However, to date there has been little research investigating the user experienc...
Article
Motor overflow is overt involuntary movement that accompanies voluntary movement. This study investigated the change in overflow production across a timed trial and the factors that affected this profile. Seventeen children (aged 8-11 years), 17 young adults (aged 18-35 years), and 17 older adults (aged 60-80 years) performed a 5-s finger pressing...
Article
Full-text available
Background Several modifiable health and lifestyle factors are consistently associated with dementia risk and it is estimated that significantly fewer people would develop dementia if the incidence of risk factors could be reduced. Despite this, Australians’ awareness of the health and lifestyle factors associated with dementia risk is low. Within...
Article
Impaired selective attention in Huntington disease (HD) may manifest as difficulty in identifying a single target embedded among a series of distractors in rapid serial visual presentation tasks. We used an attentional blink (AB) paradigm to examine whether attentional control is impaired in symptomatic HD. Fourteen HD patients and 13 age-matched h...
Article
The BOLD contrast signal history determined by lagged Unear correlation has a significant contribution to functional connectivity in activation data sets. It has been demonstrated that in resting state fMRI data, the major contribution to synchronous correlation between functionally connected areas arises from low frequency contributions (<0.1Hz) w...
Article
Motor overflow is involuntary overt movement or covert muscle activity that cooccurs with voluntary movement. Overflow is present in several pathological conditions, as well as in neurologically healthy children and older adults, and can be induced in healthy young adults under effortful conditions. This motor phenomenon may provide insight into th...
Article
Motor overflow refers to involuntary movement or muscle activity coinciding with voluntary movement. We examined whether 16 young adults (18-30 years) and 16 older adults (50-80 years) could voluntarily inhibit overflow. Participants performed a finger pressing task, exerting 50% of their maximal force. Overflow was concurrently recorded in the non...
Article
Motor overflow refers to involuntary movement or muscle activity that may coincide with voluntary movement. This study examined factors influencing motor overflow in 17 children (8–11 years), and 17 adults (18–35 years). Participants performed a finger pressing task by exerting either 33% or 66% of their maximal force output using their dominant or...
Article
Full-text available
The striatum and its projections are thought to be the earliest sites of Huntington's disease (HD) pathology. This study aimed to investigate progression of striatal pathology in symptomatic HD using diffusion tensor imaging. Diffusion weighted images were acquired in 18 HD patients and in 17 healthy controls twice, 1 year apart. Mean diffusivity (...
Article
Investigation of neurological soft signs (NSSs) in schizophrenia may allow for a greater understanding of its underlying pathology. Motor overflow, involuntary movement occurring during voluntary movement, is a NSS thought to occur to a greater degree in schizophrenia. The aim of the current study was to replicate the only objective investigation w...
Article
This study investigated the influence of attentional and motor demands on motor overflow in 17 healthy young (18-35 years) and 17 older adults (60-80 years). Participants performed a finger pressing task by exerting either 33% or 66% of their maximal force output using their dominant or nondominant hand. Overflow was concurrently recorded in the pa...
Article
Previous studies on aging and attention typically examine group differences between younger and older adults, rather than seeing aging as a continuous process. Using correlational analyses, this study examined progressive changes in the magnitude of the attentional blink (AB) associated with aging. Increased age was found to be significantly associ...
Article
Full-text available
Research in preclinical mutation carriers for Huntington's disease (HD) aims to find measures sensitive to preclinical decline. This study investigated attentional abilities in mutation carriers and noncarriers. Mutation carriers demonstrated a normal "attentional blink" during rapid serial visual presentation, normal covert visual orienting, and n...
Article
Cognitive deficits in Huntington's disease (HD) have been attributed to neuronal degeneration within the striatum; however, postmortem and structural imaging studies have revealed more widespread morphological changes. To examine the impact of HD-related changes in regions outside the striatum, we used functional magnetic resonance imaging (fMRI) i...
Article
Motor overflow refers to overt involuntary movement, or covert muscle activity, that sometimes co-occurs with voluntary movement. Various clinical populations exhibit overflow. Motor overflow is also present in healthy children and the elderly, although in young adults, overt overflow is considered abnormal unless elicited under conditions of extre...
Article
Huntington's disease is a progressive neurodegenerative disorder that results in deterioration and atrophy of various brain regions. To assess the functional connectivity between prefrontal brain regions in patients with Huntington's disease, compared with normal controls, using functional magnetic resonance imaging. 20 patients with Huntington's d...
Article
Neuroimaging studies of Huntington disease (HD) gene carriers have shown that characteristic striatal atrophy begins long before symptom onset, but findings regarding the presence of preclinical functional deficits are inconsistent. To further investigate potential motor and cognitive deficits in presymptomatic gene carriers (PSGCs), and relationsh...
Article
While research suggests that normal ageing is associated with compromised divided attentional processing abilities, such studies are comparatively few in comparison to other areas of attention (e.g. selective attention). The current study sought to examine age-related effects in divided attention using a global/local paradigm in three normal health...
Article
Full-text available
This study utilised a finger force task to investigate the influence of attention and age on the occurrence of motor overflow in the form of mirror movements in neurologically intact adults. Forty right-handed participants were recruited from three age groups: 20-30 years, 40-50 years, and 60-70 years. Participants were required to maintain a targe...
Article
We used an event related fMRI design to study the BOLD response in Huntington’s disease (HD) patients during performance of a Simon interference task. We hypothesised that HD patients will demonstrate significantly slower RTs than controls, and that there will be significant differences in the pattern of brain activation between groups. Seventeen H...
Chapter
Attention-deficit/hyperactivity disorder (ADHD) is a childhood psychiatric disorder, estimated to affect 3 to 5% of school-aged children (American Psychiatric Association, 1994; Barkley, 1997). Children diagnosed with ADHD vary widely in the type and severity of symptoms that they demonstrate, but the disorder is generally characterized by developm...
Article
The development of attention and executive functions in normal children (7-12 years) was investigated using a novel selective reaching task, which involved reaching as rapidly as possible towards a target, while at times having to ignore a distractor. The information processing paradigm allowed the measurement of various distinct dimensions of beha...
Article
Full-text available
We investigated both motor overflow and ability to control voluntary movement in patients with Huntington's disease (HD). We hypothesised that, compared with controls, overflow would be significantly greater in HD participants and that they would exhibit poorer control of voluntary movement. In a finger flexion task, participants had to maintain ta...
Article
The occurrence of motor dysfunction as a sign of schizophrenia, in addition to being a side effect of medication, has received considerable support in recent years. The current study aimed to systematically investigate both the presence and pattern of one such motor dysfunction, motor overflow. It was hypothesised that patients with schizophrenia w...
Article
The stop signal task (stop task) is designed to assess inhibitory control and is a frequently used research tool in clinical disorders such as ADHD and schizophrenia. Previous methods of setting stop signal delay and of assessing inhibitory control are problematic. The current study reports two modifications that improve the task as a measure of in...
Article
Full-text available
Current theories of dopaminergic and noradrenergic mechanisms, which are thought to be of importance in the regulation of attention are reviewed. A biphasic model of dopaminergic function is described, in which tonic dopamine exerts a suppressive influence on subcortical dopamine systems by altering tonic/phasic dopaminergic relationships. Noradren...
Article
Attentional performance in children with attention deficit hyperactivity disorder (ADHD) with and without comorbid disorders was examined using the Covert Orienting of Visuospatial Attention Task (COVAT) and the Continuous Performance Task (CPT). The relationship between these two tasks was also examined. The results showed no overall differences o...
Article
Full-text available
Symptoms of attention-deficit/hyperactivity disorder (ADHD) have been associated with frontal lobe deficits. We used a novel brain electrical imaging method to investigate rapid and continuous changes in brain activity during the continuous performance task (CPT) in normal boys and in boys with ADHD. The amplitude and latency topography of the stea...
Article
Attentional performance in children with attention deficit hyperactivity disorder (ADHD) with and without comorbid disorders was examined using the Covert Orienting of Visuospatial Attention Task (COVAT) and the Continuous Performance Task (CPT). The relationship between these two tasks was also examined. The results showed no overall differences o...
Article
Nine children meeting DSM-III-R criteria for Attention Deficit Hyperactivity Disorder (ADHD) and eighteen normal children participated in this study. A screening assessment revealed significantly more behavioural and academic problems in the ADHD group. Subjects performed a low demand visual vigilance task (the reference task) and the AX version of...

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