Marcos Bosi Ferraz

Federal University of São Paulo | UNIFESP · Centro Paulista de Economia da Saúde (CEPES)

This is the validated version of OHIP-49 in Brazilian Portuguese.

Objectives: To investigate the internal consistency of the SF-6D as a health status index in the Brazilian urban population. Study design: Cross-sectional population based study. Methods: Five thousand individuals, older than the age of 15, were assessed in the five regions of the country. Two different methods of scoring the SF-6D where compa...

Background: Schizophrenia is a debilitating disorder that often requires the affected individual to receive care from a caregiver. Willingness to Pay (WTP) technique allows a valuation of the health state preferences by assessing the impact of the disease and translating it into monetary terms. Aims of the study: The objective was to determine t...

Avaliar as percepções de formadores de opinião, pacientes e acompanhantes em relação aos medicamentos genéricos. Foram entrevistados três grupos de participantes: (i) 50 clientes durante visitas em drogarias localizadas na cidade de São Paulo, Brasil; (ii) 25 pacientes e 25 acompanhantes durante a espera em ambulatórios clínicos; e (iii) 50 formado...

The US definition of comparative effectiveness research (CER) is a new field of knowledge in Brazil. However, in the last three decades, CER activities described by various terms such as evidence-based medicine, and health economics (mainly economic evaluation of healthcare interventions) were performed as part of the health technology assessment p...

Generic drugs (GDs) offer a way to reduce health spending without sacrificing quality. Despite this, there are doubts as to their acceptance by the population. This work aims to assess perceptions of GDs among the Brazilian population. We conducted a national household survey face-to-face between April and May 2013, with 5000 individuals aged over...

Schizophrenia is a complex disorder, and the knowledge about it can have a positive impact. The purpose of this study was to make the translation and cultural adaptation of the Knowledge About Schizophrenia Test (KAST) into Portuguese and determine the influence of clinical and socio-demographic factors on knowledge. The test was applied to 189 car...

The disability caused by the musculoskeletal signs and symptoms affects the quality of life of a population, especially that related to health. The objective of this study is to evaluate the functional capacity of individuals of the Brazilian population who presented musculoskeletal signs and symptoms (MSK-S). The prevalence of MSK-S was evaluated...

The objective of this study is to describe the prevalence of musculoskeletal symptoms (MSK-S) in the five urban geographical regions of Brazil using the Portuguese version of the Community Oriented Program for Control of Rheumatic Diseases (COPCORD) core questionnaire (CQ)-BRAZCO study. From April to May 2013, a population-based survey was conducte...

The exponential increase of knowledge in the life sciences field, more specifically in health sciences, in the past few years has brought additional levels of complexity when deciding and implementing strategies in the health care system. A predominantly paternalistic way to decide about available options to maintain or improve individual or collec...

This study describes the utility scores of the SF-6D, standardized for the Brazilian urban population. Five thousand individuals, over the age of 15, were assessed in the five regions of the country, in 16 capitals. The sample consisted of representative quotas of the Brazilian population. The selection of households was random. Face-to-face approa...

Health care is a highly complex, dynamic, and creative sector of the economy. While health economics has to continue its efforts to improve its methods and tools to better inform decisions, the application needs to be aligned with the insights and models of other social sciences disciplines. Decisions may be guided by four concept models based on e...

The US definition of comparative effectiveness research (CER) is a new field of knowledge in Brazil. However, in the last three decades, CER activities described by various terms such as evidence-based medicine, and health economics (mainly economic evaluation of healthcare interventions) were performed as part of the health technology assessment p...

Background The worldwide increase of diabetes, a long duration, slow progression disease, impacts health care costs. The aim of this study was to estimate, from the society’s perspective, the annual cost per patient with Type 2 Diabetes (T2DM) at a specialized, outpatient center in the city of São Paulo, capital of São Paulo state, Brazil. Methods...

Study objectives: To estimate the health utility score and quality-adjusted life-years (QALY) index of obstructive sleep apnea syndrome (OSAS) in patients over 1 y of continuous positive airway pressure (CPAP) treatment. Design: Longitudinal interventional study. Setting: The study was carried out in Sao Paulo Sleep Institute, Brazil. Patient...

To quantify modification of functional capacity in a three year period in a group of patients with rheumatoid arthritis (RA) using HAQ and EPM-ROM inventories. Forty patients with RA on methotrexate (MTX) as disease-modifying anti rheumatic drug (DMARD) were followed for up to three years. The functional status was assessed at the beginning and end...

Objective To quantify modification of functional capacity in a three year period in a group of patients with rheumatoid arthritis (RA) using HAQ and EPM‐ROM inventories. Methods Forty patients with RA on methotrexate (MTX) as disease‐modifying anti rheumatic drug (DMARD) were followed for up to three years. The functional status was assessed at th...

Background and aims: Regional differences in the clinical care of Type 1 diabetes (T1D) in Brazil have been recently described. This study aimed to estimate the costs of T1D from the public health care system's perspective across the regions of Brazil and to determine the components that influence these costs. This was a retrospective, cross-sectio...

The Federal Constitution of 1988 allowed the National Congress to contribute towards formulation of new public policies. The objective of this study was to analyze the legislative production that dealt with health issues that was in passage in the National Congress between January 2007 and December 2008. Descriptive-exploratory cross-sectional stud...

The burden of knee osteoarthritis (OA) in Latin America is unknown. To determine the demographic, clinical, and therapeutic characteristics of patients with OA in Argentina, Brazil, and Mexico. This is an observational, cross-sectional study of patients with symptomatic knee OA referred from first care medical centers to Rheumatology departments. W...

Objectives: The aim of this study was to gather qualitative and quantitative data on criteria considered by healthcare decision makers. Methods: Using snowball sampling and an online questionnaire with forty-three criteria organized into ten clusters, decision makers were invited by an international task force to report which criteria they consider...

To determine the direct medical costs of type 1 diabetes mellitus (T1DM) to the National Brazilian Health-Care System (NBHCS) and quantify the contribution of each individual component to the total cost. A retrospective, cross-sectional, nationwide multicentre study was conducted between 2008 and 2010 in 28 public clinics in 20 Brazilian cities. Th...

JUSTIFICATIVA E OBJETIVOS: A incidência de cólica renal tem aumentado nos países em desenvolvimento por diversos fatores e leva o indivíduo ao serviço de emergência em função da necessidade de alívio da dor aguda e intensa que esta provoca. O impacto econômico do diagnóstico e tratamento em caráter emergencial é desconhecido em nosso meio. O objeti...

Antecedentes La carga de la artrosis de rodilla (OA) en América Latina se desconoce. Objetivo Determinar las características demográficas, clínicas y terapéuticas de los pacientes con OA en Argentina, Brasil y México. Material y métodos Se trata de un estudio observacional, transversal, de pacientes con OA sintomática que son derivados de centros...

Objective: Conventional hemodialysis (HD) predominates over peritoneal dialysis (PD) around the world. Prospective and comparative studies comparing the costs of these modalities are scarce. In the present prospective assessment, we describe the resources used and total patient costs for both HD and PD. ♢ Methodology: We assessed 249 patients on...

In Latin America, social security and public sectors represent the largest financiers and providers of health care. Many countries in the region have compulsory packages of basic health care benefits. As part of an effort to improve quality of care and access, several health technology assessment agencies, both governmental and academia, among a nu...

As instituicoes hospitalares publicas do Estado de Sao Paulo tem adotado as comissoes hospitalares como um instrumento de gestao para oferecer servicos de qualidade aos usuarios. As comissoes hospitalares desempenham varias funcoes na instituicao, destacando-se a producao de indicadores relevantes para a gestao hospitalar e tambem contribuir para a...

Worldwide, there is a need for formalization of the priority setting processes in health. Recent research has used the term multicriteria decision analysis for methods that systematically include preferences for both equity and efficiency. The present study compares decision-makers' preferences at the country level for a set of equity and efficienc...

Worldwide data indicate that antibiotics are frequently used indiscriminately. The present study used a questionnaire in an attempt to quantify and qualify outpatient antibiotic consumption habits, including when the drug was used, who recommended it, and to what extent treatment was completed, and to question householders on the presence of antibi...

To assess QoL of obese patients in the Brazilian public healthcare system, before and after bariatric surgery, and to determine the appropriateness of the Moorehead-Ardelt Questionnaire II (M-A-QoLQII) compared with the Short-Form Health Survey (SF-36). Forty-one severe obese patients in a waiting-list, and 84 patients who underwent bariatric surge...

Background: An obesity epidemic is spreading worldwide. In addition to comorbidities, social and emotional problems contribute to reduce the quality of life (QoL) of obese people. Considering the heterogeneity of outcomes from clinical and surgical approaches, it is recommended that severely obese patients participate in their treatment decisions....

The health technology assessment (HTA) process has been developed locally. The aim of this study was to describe, analyze and compare the opinions of participants in international health economics symposia about the HTA process used in Brazil. Observational cross-sectional study at the 2006 and 2008 International Health Economics Symposia, in São P...

This study seeks to present the translation and validation of the SF-6D in the Brazilian context, based on the model and the version developed in the United Kingdom in 2002. An observational and transversal study. The tools for assessing quality of life were applied, namely HAQ, SF-36, EQ-5D and SF-6D (2002 version). Descriptive statistics and corr...

The aim of this study was to evaluate quality of life in patients undergoing hemodialysis (HD) or peritoneal dialysis (PD) in São Paulo, Brazil. Inclusion criteria for this is a 1-year prospective study included being 18 years of age or older and clinically stable receiving chronic dialysis. Quality of life was measured using the SF-12 and the Kidn...

To find preferences for treatment expressed by lupus patients and physicians (who were asked to assume they have lupus) and to explore if certain variables explain these preferences. One hundred seventy-two patients and 202 physicians were interviewed using a lupus nephritis decision board that describes the treatment options and their potential be...

The objective of this study was to assess the quality of life in the Brazilian adult population, based on the U.S. standard population. It involved a cross-sectional population-based study with probabilistic sampling of 2,420 individuals (725 men and 1695 women) aged 40 or more in different geographic regions of Brazil. A socio-demographic question...

Antioxidant nutrient intake and the lesser formation of free radicals seem to contribute to chronic diseases. The aim of the present study was to evaluate the intake profile of the main dietary antioxidants in a representative sample of the adult Brazilian population and discuss the main consequences of a low intake of these micronutrients on overa...

Healthcare investments should consider short and long-term demands. The objectives here were to compare the average tenures of ministers of health in Brazil and in another 22 countries and to evaluate the relationship between ministers' tenures and a number of indicators. Descriptive study conducted at Centro Paulista de Economia da Saúde (CPES). T...

To assess direct medical costs associated with schizophrenia relapses in mental health services. The study was conducted in three health facilities in the city of São Paulo: a public state hospital; a Brazilian National Health System (SUS)-contracted hospital; and a community mental health center. Medical records of 90 patients with schizophrenia w...

The present study describes resource utilisation in patients with ankylosing spondylitis (AS) treated at a tertiary public health facility over a one-year period. It also investigates the direct and indirect costs for society associated with the treatment of AS. Ninety AS patients were selected consecutively, and data was analysed retrospectively f...

Compare the preference measures derived from the SF-36, based on the two Brazilian versions of the Short Form 6 Dimensions questionnaire-Brazil (SF-6D Brazil). Observational and transversal study. The following quality of life assessment instruments were applied: HAQ, SF-36, EQ-5D and SF-6D (1998 and 2002 versions). Descriptive statistics and corre...

Objective: To compare the preference measures derived from the SF-36 by different methods, with preference measures derived from the Brazilian version of the Short Form-6 Dimensions - Brazil (SF-6D Brazil). Methods: Observational cross-sectional study. Quality of life measures were applied: HAQ, SF-36 and SF-6D. We obtained preference measures deri...

The BRAZOS (The Brazilian Osteoporosis Study) study is the first epidemiological and population-based study carried out in a representative sample of Brazilian men and women, 40 years or older, with the objective of identifying the prevalence and main clinical risk factors (CRF) associated with low-impact fractures. This report shows the main resul...

Aim: To compare the efficacy and effectiveness of conventional outpatient treatment for alcoholic patients [conventional treatment (CT)] with this same CT plus home visit (HV). Design: Randomized clinical trial evaluated alongside a 12-week. Setting: An outpatient clinic for alcohol dependents. Participants: One hundred twenty alcohol-dependent pat...

rESumO Introdução/Objetivos: O BRAZOS (The Brazilian Osteoporosis Study) é um estudo epidemiológico, de base populacional, realizado em amostra representativa de mulheres e homens brasileiros, de idade superior a 40 anos, com o objetivo de identificar os principais fatores clínicos de risco associados com fratura por baixo impacto. Nesse artigo são...

To estimate the direct annual cost of systemic arterial hypertension (SAH) treatment in Brazil's public and private health care systems, assess its economic impact on the total health care budget, and determine its proportion of the 2005 gross domestic product (GDP). A decision tree model was used to determine direct costs based on estimated use of...

The objective of this cost-of-illness analysis was to quantify the annual costs associated with hospital admission for people with diabetes and foot ulcers in Brazil. A hypothetical cohort was simulated using a decision tree model. Prevalence and incidence rates and clinical outcomes were estimated from published studies and applied to the general...

The objective of the study was to estimate the frequency of recurrent falls and identify the main associated risk factors. The BRAZOS is the first epidemiological study performed on a representative sample of the Brazilian population. Anthropometric data, living habits, previous fractures, falls, dietary intake, physical activity and quality of lif...

The purpose of this study was to compare the cost-effectiveness of conventional outpatient treatment for alcoholic patients (CT) with this same conventional treatment plus home visits (HV), a new proposal for intervention within the Brazilian outpatient treatment system. A cost-effectiveness evaluation alongside a 12-week randomized clinical trial...

AimsAnalyze the care received by hospitalized patients with diabetes mellitus and foot ulcers in Brazil, taking into account clinical and economic aspects.MethodsA cohort prospective study of 109 patients with diabetes hospitalized primarily for foot ulcers covered exclusively by the Brazilian public health system. All patients had type 2 diabetes...

OBJETIVO: Comparar as medidas de preferência derivadas do SF-36 a partir das duas versões brasileiras do questionário Short-Form 6 Dimensions - Brasil (SF-6D Brasil). MÉTODOS: Estudo observacional e transversal. Foram aplicados os instrumentos de avaliação de qualidade de vida: HAQ, SF-36, EQ-5D e SF-6D (versão de 1998 e 2002). Estatísticas descrit...

Objectives: The routine screening for macroprolactin of all hyperprolactinemic patients may avoid unnecessary imaging procedures and medication prescription. The study described the frequency and types of tests requested after a diagnosis of high serum prolactin concentration, and assessed whether the diagnosis of macroprolactinemia resulted in lo...

Experimental and clinical studies suggest that LOLA may have a favorable influence on hepatic encephalopathy due to the effect on the reduction of ammonia, and improvement of the symptoms and laboratory findings. To evaluate and to critically analyze the efficacy and/or effectiveness results of the use of LOLA when compared to placebo in the treatm...

Around 16% to 20% of women with breast cancer have advanced, metastasized breast cancer. At this stage, the disease is treatable, but not curable. The objective here was to assess the effectiveness of lapatinib for treating patients with advanced or metastasized breast cancer. Systematic review of the literature, developed at Centro Paulista de Eco...

To evaluate the construct validity of the SF-6D among a sample of Brazilian patients with rheumatoid arthritis. This was a validation and cross-cultural adaptation study. Preference evaluation instruments were applied: SF-6D, EQ-5D, VAS, TTO and SG. Clinical and sociodemographic parameters were obtained. Descriptive statistics, correlation coeffici...

Adequate nutrition plays an important role in bone mass accrual and maintenance and has been demonstrated as a significant tool for the prevention of fractures in individuals with osteoporosis. The aim of the present study was to evaluate bone health-related nutrients intake and its association with osteoporotic fractures in a representative sample...

Coffee and yerba maté beverages are widely consumed by the South American population. In adition to the stimulant characteristic, due the presence os caffeine in its composition, these beverages contribute to the intake of bioactive compounds such as phenolic compounds. The content of these compounds justify the several health benefi ts atributed t...

The aim of this study was to evaluate in relation to diagnosis and treatment for Rheumatoid Arthritis (RA) patients Brazilian population, and compare the management offered to patients who are followed up in the public and private sectors. An electronic questionnaire was sent to 650 rheumatologists, members of the Brazilian Rheumatology Society (SB...

To conduct a cross-cultural adaptation of the Foot Health Status Questionnaire into Brazilian-Portuguese and to assess its measurement properties. This instrument is an outcome measure with 10 domains with scores ranging from 0-100, worst to best, respectively. The translated instrument will improve the examinations and foot care of rheumatoid arth...

To examine health care use and expenditures by Brazilians covered by private health care plans in the last four years of life. Health plan provider enrollee files and death certificate data were used for 274 health plan beneficiaries who died in 1998, 1999, and 2000. Resources used for a beneficiary in the year of death and in the three years prior...

The Brazilian Osteoporosis Study (BRAZOS) is the first epidemiological study carried out in a representative sample of Brazilian men and women aged 40 years or older. The prevalence of fragility fractures is about 15.1% in the women and 12.8% in the men. Moreover, advanced age, sedentarism, family history of hip fracture, current smoking, recurrent...

Paradoxical sleep deprivation (PSD) produces alterations in dopaminergic systems and also modifies sexual behavior. In this work we evaluated PSD effects on the sexual response and tyrosine hydroxylase (TH) expression in dopaminergic pathways related to sexual behavior of naive and sexual experienced rats. Male Wistar rats had their sexual behavior...

The present study aimed to determine indirect costs of rheumatoid arthritis (RA) in a sample of patients followed at a public health-care facility in Brazil. Factors potentially associated with higher indirect costs in these patients were also investigated. This cross-sectional study included patients between 18 and 65 years old with RA according t...

Both depression and cardiovascular disease are major public health problems. Growing evidence shows that depression is a risk factor for the development of coronary artery disease (CAD). However, the exact mechanisms underlying the interplay between depression and CAD remain to be elucidated. Depression adversely affects autonomic and hormonal home...

Decision boards (DBs) help clinicians present options and include patients in the decision-making process. Our objective was to describe the steps to develop a DB to support shared decision making and assess reliability and construct validity. Systemic lupus erythematosus (SLE) scenarios were designed with the support of experts for disease severit...

To describe and analyze resource utilization in patients with rheumatoid arthritis (RA) treated at a tertiary public health facility over a one-year period. Costs for the patient and for society associated with the treatment of RA were also investigated. One hundred consecutively selected RA patients were included. Resource utilization was evaluate...

In spite of the worldwide occurrence of domestic cats and dogs, and their close relationship with humans, the number of published papers on free-ranging cats Felis catus and dogs Canis familiaris, is small. The diet of both species was estimated in a suburban and rural environment in July 2002 and January 2003. Visual observations and scat collecti...

OBJECTIVES: To translate into Brazilian Portuguese, cross-culturally adapt, and evaluate the psychometric properties, reliability, and validity of the Work Limitations Questionnaire (WLQ). METHODS: This cross-sectional observational study was performed in 2005 and 2006 at the Hospital São Paulo/Escola Paulista de Medicina of the Federal University...

To translate into Brazilian Portuguese, cross-culturally adapt, and evaluate the psychometric properties, reliability, and validity of the Work Limitations Questionnaire (WLQ). This cross-sectional observational study was performed in 2005 and 2006 at the Hospital São Paulo/Escola Paulista de Medicina of the Federal University of São Paulo, Brazil....

Drug-eluting stents represent an additional option to treat coronary artery disease. This technology represents a major breakthrough that may require additional funding in the short-term to enable its inclusion in procedures of the Unified Health System. To estimate the impact on the Unified Health System budget in the first year of use of drug-elu...

FUNDAMENTO: Stents farmacológicos representam opção adicional para o tratamento da doença arterial coronariana. Essa tecnologia representa importante inovação, para a qual pode ser necessário financiamento adicional, no curto prazo, para permitir incorporação no Sistema Único de Saúde brasileiro. OBJETIVOS: Estimar o impacto da incorporação do sten...

This study evaluates the cost of dialysis care in Brazil, including costs of ambulatory care and hospital admissions due to all causes and cardiovascular events. Data were analyzed for 200 patients with end-stage renal disease (ESRD) on chronic hemodialysis in Brazil between 2001 and 2004. Main end points were all-cause mortality, all-cause hospita...

CONTEXTO: A preocupação com a saúde e os benefícios das terapêuticas ao paciente continua sendo o foco da medicina, mas conhecer os custos envolvidos e fazer a gestão dos recursos disponíveis é fundamental na atualidade. OBJETIVO: Este artigo pretende fazer uma revisão sobre alguns conceitos utilizados nos estudos farmacoeconômicos, tais como tipos...

Brazilian society bears high economic costs in view of the problems resulting from the alcohol consumption. There is a lack of economic studies into alcohol misuse or dependence in Brazil due to the limited financial resources, despite the huge health problems the country has been facing. This paper aims to introduce basic concepts of Heath Economi...